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Volumn 10, Issue 1, 2013, Pages

Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis

Author keywords

Antiretroviral prophylaxis; Breast milk; Clonal amplification; Drug resistant variant; HIV transmission; K103N; Mother to child transmission; Nevirapine; Transmitted virus

Indexed keywords

NEVIRAPINE; POL PROTEIN; VIRUS DNA; VIRUS ENVELOPE PROTEIN;

EID: 84883033139     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-88     Document Type: Article
Times cited : (10)

References (37)
  • 1
    • 84871639561 scopus 로고    scopus 로고
    • Available at, Global report
    • Global report UNAIDS report on the global AIDS epidemic 2012, Available at http://www.unaids.org/globalreport/documents/20101123_GlobalReport_full_en.pdf, Global report.
    • (2012) UNAIDS report on the global AIDS epidemic
  • 3
    • 0034606875 scopus 로고    scopus 로고
    • Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality
    • WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality
    • WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality. Lancet 2000, 355:451-455. WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality.
    • (2000) Lancet , vol.355 , pp. 451-455
  • 4
    • 42649087440 scopus 로고    scopus 로고
    • Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in Zambia
    • 10.1097/QAI.0b013e31816e39a3, 2814597, 18344878
    • Fox MP, Brooks D, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Mwiya M, Horsburgh R, Thea DM. Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in Zambia. J Acquir Immune Defic Syndr 2008, 48:90-96. 10.1097/QAI.0b013e31816e39a3, 2814597, 18344878.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 90-96
    • Fox, M.P.1    Brooks, D.2    Kuhn, L.3    Aldrovandi, G.4    Sinkala, M.5    Kankasa, C.6    Mwiya, M.7    Horsburgh, R.8    Thea, D.M.9
  • 5
    • 64349102343 scopus 로고    scopus 로고
    • Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children
    • 10.1093/ije/dyn249, 2734073, 19047077
    • Fox MP, Brooks DR, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Horsburgh R, Thea DM. Role of breastfeeding cessation in mediating the relationship between maternal HIV disease stage and increased child mortality among HIV-exposed uninfected children. Int J Epidemiol 2009, 38:569-576. 10.1093/ije/dyn249, 2734073, 19047077.
    • (2009) Int J Epidemiol , vol.38 , pp. 569-576
    • Fox, M.P.1    Brooks, D.R.2    Kuhn, L.3    Aldrovandi, G.4    Sinkala, M.5    Kankasa, C.6    Horsburgh, R.7    Thea, D.M.8
  • 6
    • 76749167483 scopus 로고    scopus 로고
    • Milk mysteries: why are women who exclusively breast-feed less likely to transmit HIV during breast-feeding?
    • 2843095, 20121425
    • Kuhn L. Milk mysteries: why are women who exclusively breast-feed less likely to transmit HIV during breast-feeding?. Clin Infect Dis 2010, 50:770-772. 2843095, 20121425.
    • (2010) Clin Infect Dis , vol.50 , pp. 770-772
    • Kuhn, L.1
  • 7
    • 0141518673 scopus 로고    scopus 로고
    • Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial
    • 10.1016/S0140-6736(03)14341-3, 13678973
    • Jackson JB, Musoke P, Fleming T, Guay LA, Bagenda D, Allen M, Nakabiito C, Sherman J, Bakaki P, Owor M, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003, 362:859-868. 10.1016/S0140-6736(03)14341-3, 13678973.
    • (2003) Lancet , vol.362 , pp. 859-868
    • Jackson, J.B.1    Musoke, P.2    Fleming, T.3    Guay, L.A.4    Bagenda, D.5    Allen, M.6    Nakabiito, C.7    Sherman, J.8    Bakaki, P.9    Owor, M.10
  • 8
    • 84871227063 scopus 로고    scopus 로고
    • Pooled individual data analysis of 5 randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission
    • 10.1093/cid/cis808, 22997212
    • Hudgens MG, Taha TE, Omer SB, Jamieson DJ, Lee H, Mofenson LM, Chasela C, Kourtis AP, Kumwenda N, Ruff A, et al. Pooled individual data analysis of 5 randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission. Clin Infect Dis 2013, 56:131-139. 10.1093/cid/cis808, 22997212.
    • (2013) Clin Infect Dis , vol.56 , pp. 131-139
    • Hudgens, M.G.1    Taha, T.E.2    Omer, S.B.3    Jamieson, D.J.4    Lee, H.5    Mofenson, L.M.6    Chasela, C.7    Kourtis, A.P.8    Kumwenda, N.9    Ruff, A.10
  • 9
    • 35548942272 scopus 로고    scopus 로고
    • Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis
    • 10.1093/ije/dym104, 17533166
    • Arrive E, Newell ML, Ekouevi DK, Chaix ML, Thiebaut R, Masquelier B, Leroy V, Perre PV, Rouzioux C, Dabis F, et al. Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis. Int J Epidemiol 2007, 36:1009-1021. 10.1093/ije/dym104, 17533166.
    • (2007) Int J Epidemiol , vol.36 , pp. 1009-1021
    • Arrive, E.1    Newell, M.L.2    Ekouevi, D.K.3    Chaix, M.L.4    Thiebaut, R.5    Masquelier, B.6    Leroy, V.7    Perre, P.V.8    Rouzioux, C.9    Dabis, F.10
  • 11
    • 0035913939 scopus 로고    scopus 로고
    • Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012)
    • 10.1097/00002030-200110190-00006, 11600822
    • Eshleman SH, Mracna M, Guay LA, Deseyve M, Cunningham S, Mirochnick M, Musoke P, Fleming T, Glenn Fowler M, Mofenson LM, et al. Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012). AIDS 2001, 15:1951-1957. 10.1097/00002030-200110190-00006, 11600822.
    • (2001) AIDS , vol.15 , pp. 1951-1957
    • Eshleman, S.H.1    Mracna, M.2    Guay, L.A.3    Deseyve, M.4    Cunningham, S.5    Mirochnick, M.6    Musoke, P.7    Fleming, T.8    Glenn Fowler, M.9    Mofenson, L.M.10
  • 12
    • 33646474114 scopus 로고    scopus 로고
    • Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission
    • 10.1073/pnas.0602033103, 1459023, 16641095
    • Palmer S, Boltz V, Martinson N, Maldarelli F, Gray G, McIntyre J, Mellors J, Morris L, Coffin J. Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission. Proc Natl Acad Sci U S A 2006, 103:7094-7099. 10.1073/pnas.0602033103, 1459023, 16641095.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7094-7099
    • Palmer, S.1    Boltz, V.2    Martinson, N.3    Maldarelli, F.4    Gray, G.5    McIntyre, J.6    Mellors, J.7    Morris, L.8    Coffin, J.9
  • 13
    • 51849085325 scopus 로고    scopus 로고
    • Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission
    • 10.1086/591503, 2587235, 18684096
    • Church JD, Omer SB, Guay LA, Huang W, Lidstrom J, Musoke P, Mmiro F, Jackson JB, Eshleman SH. Analysis of nevirapine (NVP) resistance in Ugandan infants who were HIV infected despite receiving single-dose (SD) NVP versus SD NVP plus daily NVP up to 6 weeks of age to prevent HIV vertical transmission. J Infect Dis 2008, 198:1075-1082. 10.1086/591503, 2587235, 18684096.
    • (2008) J Infect Dis , vol.198 , pp. 1075-1082
    • Church, J.D.1    Omer, S.B.2    Guay, L.A.3    Huang, W.4    Lidstrom, J.5    Musoke, P.6    Mmiro, F.7    Jackson, J.B.8    Eshleman, S.H.9
  • 14
    • 58149464331 scopus 로고    scopus 로고
    • Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants
    • 10.1371/journal.pone.0004096, 2606064, 19119321
    • Moorthy A, Gupta A, Bhosale R, Tripathy S, Sastry J, Kulkarni S, Thakar M, Bharadwaj R, Kagal A, Bhore AV, et al. Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants. PLoS One 2009, 4:e4096. 10.1371/journal.pone.0004096, 2606064, 19119321.
    • (2009) PLoS One , vol.4
    • Moorthy, A.1    Gupta, A.2    Bhosale, R.3    Tripathy, S.4    Sastry, J.5    Kulkarni, S.6    Thakar, M.7    Bharadwaj, R.8    Kagal, A.9    Bhore, A.V.10
  • 16
    • 34249882818 scopus 로고    scopus 로고
    • Emergence of NNRTI drug resistance mutations after single-dose nevirapine exposure in HIV type 1 subtype C-infected infants in India
    • 10.1089/aid.2006.0167, 17530993
    • Kurle SN, Gangakhedkar RR, Sen S, Hayatnagarkar SS, Tripathy SP, Paranjape RS. Emergence of NNRTI drug resistance mutations after single-dose nevirapine exposure in HIV type 1 subtype C-infected infants in India. AIDS Res Hum Retroviruses 2007, 23:682-685. 10.1089/aid.2006.0167, 17530993.
    • (2007) AIDS Res Hum Retroviruses , vol.23 , pp. 682-685
    • Kurle, S.N.1    Gangakhedkar, R.R.2    Sen, S.3    Hayatnagarkar, S.S.4    Tripathy, S.P.5    Paranjape, R.S.6
  • 19
    • 66049139947 scopus 로고    scopus 로고
    • Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
    • 10.1084/jem.20090378, 2715054, 19487424
    • Salazar-Gonzalez JF, Salazar MG, Keele BF, Learn GH, Giorgi EE, Li H, Decker JM, Wang S, Baalwa J, Kraus MH, et al. Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection. J Exp Med 2009, 206:1273-1289. 10.1084/jem.20090378, 2715054, 19487424.
    • (2009) J Exp Med , vol.206 , pp. 1273-1289
    • Salazar-Gonzalez, J.F.1    Salazar, M.G.2    Keele, B.F.3    Learn, G.H.4    Giorgi, E.E.5    Li, H.6    Decker, J.M.7    Wang, S.8    Baalwa, J.9    Kraus, M.H.10
  • 20
    • 3342913702 scopus 로고    scopus 로고
    • Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing
    • 10.1128/AAC.48.8.3122-3126.2004, 478552, 15273130
    • Rhee SY, Liu T, Ravela J, Gonzales MJ, Shafer RW. Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. Antimicrob Agents Chemother 2004, 48:3122-3126. 10.1128/AAC.48.8.3122-3126.2004, 478552, 15273130.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3122-3126
    • Rhee, S.Y.1    Liu, T.2    Ravela, J.3    Gonzales, M.J.4    Shafer, R.W.5
  • 21
    • 0034608864 scopus 로고    scopus 로고
    • Production of resistant HIV mutants during antiretroviral therapy
    • 10.1073/pnas.97.14.7681, 16603, 10884399
    • Ribeiro RM, Bonhoeffer S. Production of resistant HIV mutants during antiretroviral therapy. Proc Natl Acad Sci U S A 2000, 97:7681-7686. 10.1073/pnas.97.14.7681, 16603, 10884399.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7681-7686
    • Ribeiro, R.M.1    Bonhoeffer, S.2
  • 22
    • 79953745195 scopus 로고    scopus 로고
    • Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
    • 10.1001/jama.2011.375, 3325645, 21467286
    • Li JZ, Paredes R, Ribaudo HJ, Svarovskaia ES, Metzner KJ, Kozal MJ, Hullsiek KH, Balduin M, Jakobsen MR, Geretti AM, et al. Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis. JAMA 2011, 305:1327-1335. 10.1001/jama.2011.375, 3325645, 21467286.
    • (2011) JAMA , vol.305 , pp. 1327-1335
    • Li, J.Z.1    Paredes, R.2    Ribaudo, H.J.3    Svarovskaia, E.S.4    Metzner, K.J.5    Kozal, M.J.6    Hullsiek, K.H.7    Balduin, M.8    Jakobsen, M.R.9    Geretti, A.M.10
  • 23
    • 79953690521 scopus 로고    scopus 로고
    • HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis
    • 10.1371/journal.pmed.1000430, 3066134, 21468304
    • Zeh C, Weidle PJ, Nafisa L, Lwamba HM, Okonji J, Anyango E, Bondo P, Masaba R, Fowler MG, Nkengasong JN, et al. HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis. PLoS Med 2011, 8:e1000430. 10.1371/journal.pmed.1000430, 3066134, 21468304.
    • (2011) PLoS Med , vol.8
    • Zeh, C.1    Weidle, P.J.2    Nafisa, L.3    Lwamba, H.M.4    Okonji, J.5    Anyango, E.6    Bondo, P.7    Masaba, R.8    Fowler, M.G.9    Nkengasong, J.N.10
  • 25
    • 77957308970 scopus 로고    scopus 로고
    • Restricted genetic diversity of HIV-1 subtype C envelope glycoprotein from perinatally infected Zambian infants
    • 10.1371/journal.pone.0009294, 2823783, 20174636
    • Zhang H, Tully DC, Hoffmann FG, He J, Kankasa C, Wood C. Restricted genetic diversity of HIV-1 subtype C envelope glycoprotein from perinatally infected Zambian infants. PLoS One 2010, 5:e9294. 10.1371/journal.pone.0009294, 2823783, 20174636.
    • (2010) PLoS One , vol.5
    • Zhang, H.1    Tully, D.C.2    Hoffmann, F.G.3    He, J.4    Kankasa, C.5    Wood, C.6
  • 26
    • 64049089430 scopus 로고    scopus 로고
    • Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants
    • 10.1128/JVI.02132-08, 2663249, 19193811
    • Abrahams MR, Anderson JA, Giorgi EE, Seoighe C, Mlisana K, Ping LH, Athreya GS, Treurnicht FK, Keele BF, Wood N, et al. Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants. J Virol 2009, 83:3556-3567. 10.1128/JVI.02132-08, 2663249, 19193811.
    • (2009) J Virol , vol.83 , pp. 3556-3567
    • Abrahams, M.R.1    Anderson, J.A.2    Giorgi, E.E.3    Seoighe, C.4    Mlisana, K.5    Ping, L.H.6    Athreya, G.S.7    Treurnicht, F.K.8    Keele, B.F.9    Wood, N.10
  • 27
    • 84874465405 scopus 로고    scopus 로고
    • Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes
    • 10.1089/aid.2012.0197, 23075434
    • Russell ES, Ojeda S, Fouda GG, Meshnick SR, Montefiori D, Permar SR, Swanstrom R. Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes. AIDS Res Hum Retroviruses 2013, 29:511-515. 10.1089/aid.2012.0197, 23075434.
    • (2013) AIDS Res Hum Retroviruses , vol.29 , pp. 511-515
    • Russell, E.S.1    Ojeda, S.2    Fouda, G.G.3    Meshnick, S.R.4    Montefiori, D.5    Permar, S.R.6    Swanstrom, R.7
  • 30
    • 77957199746 scopus 로고    scopus 로고
    • Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis
    • 10.1128/JVI.00543-10, 2950573, 20660189
    • Gantt S, Carlsson J, Heath L, Bull ME, Shetty AK, Mutsvangwa J, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA, et al. Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis. J Virol 2010, 84:10812-10819. 10.1128/JVI.00543-10, 2950573, 20660189.
    • (2010) J Virol , vol.84 , pp. 10812-10819
    • Gantt, S.1    Carlsson, J.2    Heath, L.3    Bull, M.E.4    Shetty, A.K.5    Mutsvangwa, J.6    Musingwini, G.7    Woelk, G.8    Zijenah, L.S.9    Katzenstein, D.A.10
  • 31
    • 77954994113 scopus 로고    scopus 로고
    • Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission
    • 10.1371/journal.pone.0010213, 2857876, 20422033
    • Heath L, Conway S, Jones L, Semrau K, Nakamura K, Walter J, Decker WD, Hong J, Chen T, Heil M, et al. Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission. PLoS One 2010, 5:e10213. 10.1371/journal.pone.0010213, 2857876, 20422033.
    • (2010) PLoS One , vol.5
    • Heath, L.1    Conway, S.2    Jones, L.3    Semrau, K.4    Nakamura, K.5    Walter, J.6    Decker, W.D.7    Hong, J.8    Chen, T.9    Heil, M.10
  • 32
    • 70349626976 scopus 로고    scopus 로고
    • Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations
    • 10.1371/journal.pone.0007122, 2741601, 19771165
    • Bull M, Learn G, Genowati I, McKernan J, Hitti J, Lockhart D, Tapia K, Holte S, Dragavon J, Coombs R, et al. Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations. PLoS One 2009, 4:e7122. 10.1371/journal.pone.0007122, 2741601, 19771165.
    • (2009) PLoS One , vol.4
    • Bull, M.1    Learn, G.2    Genowati, I.3    McKernan, J.4    Hitti, J.5    Lockhart, D.6    Tapia, K.7    Holte, S.8    Dragavon, J.9    Coombs, R.10
  • 35
    • 77649195668 scopus 로고    scopus 로고
    • Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection
    • 10.1128/JVI.01863-09, 2820937, 20015984
    • Schnell G, Price RW, Swanstrom R, Spudich S. Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection. J Virol 2010, 84:2395-2407. 10.1128/JVI.01863-09, 2820937, 20015984.
    • (2010) J Virol , vol.84 , pp. 2395-2407
    • Schnell, G.1    Price, R.W.2    Swanstrom, R.3    Spudich, S.4
  • 36
    • 33746579474 scopus 로고    scopus 로고
    • Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D
    • 10.1097/01.qai.0000221686.67810.20, 16773030
    • Flys TS, Chen S, Jones DC, Hoover DR, Church JD, Fiscus SA, Mwatha A, Guay LA, Mmiro F, Musoke P, et al. Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D. J Acquir Immune Defic Syndr 2006, 42:610-613. 10.1097/01.qai.0000221686.67810.20, 16773030.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , pp. 610-613
    • Flys, T.S.1    Chen, S.2    Jones, D.C.3    Hoover, D.R.4    Church, J.D.5    Fiscus, S.A.6    Mwatha, A.7    Guay, L.A.8    Mmiro, F.9    Musoke, P.10
  • 37
    • 79955535358 scopus 로고    scopus 로고
    • Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C
    • 10.1128/AAC.01505-10, 3088272, 21402856
    • Armstrong KL, Lee TH, Essex M. Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C. Antimicrob Agents Chemother 2011, 55:2146-2153. 10.1128/AAC.01505-10, 3088272, 21402856.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2146-2153
    • Armstrong, K.L.1    Lee, T.H.2    Essex, M.3


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