High-throughput mass spectrometric cytochrome P450 inhibition screening

Methods in Molecular Biology

Volumn 987, Issue , 2013, Pages 25-50

  Lim, Kheng B ^a   Ozbal, Can C ^b   Kassel, Daniel B ^a  

^a Takeda San Diego Inc   (United States)

^b Agilent Technologies Inc   (United States)

Author keywords

Automation; CYP inhibition; High throughput; Liquid handling; MRM; Post assay pooling; Probe substrate; RapidFire; SPE MS MS

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; FURAFYLLINE; KETOCONAZOLE; MONTELUKAST; QUINIDINE; TRANYLCYPROMINE; CYTOCHROME P450; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; TRICHLOROACETIC ACID;

ARTICLE; AUTOMATION; CONTROLLED STUDY; DATA ANALYSIS; DATA EXTRACTION; DATA PROCESSING; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; INFORMATION PROCESSING; MASS SPECTROMETER; MASS SPECTROMETRY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; WORKFLOW; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; METHODOLOGY;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; INDICATORS AND REAGENTS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; TRICHLOROACETIC ACID;

EID: 84883025662     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-321-3_3     Document Type: Article

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