High-throughput fluorescence assay for cytochrome P450 mechanism-based inactivators

Methods in Molecular Biology

Volumn 987, Issue , 2013, Pages 61-69

  Kenaan, Cesar ^a   Zhang, Haoming ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cytochrome P450; Fluorescence; Highthroughput assay; Mechanism based inactivation; Time dependent inhibition

Indexed keywords

CYTOCHROME P450 INHIBITOR; DRUG METABOLIZING ENZYME; CYTOCHROME P450;

ARTICLE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; IN VITRO STUDY; PRIORITY JOURNAL; ANIMAL; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVATION; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; METHODOLOGY; RAT; SPECTROFLUOROMETRY;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; RATS; SPECTROMETRY, FLUORESCENCE;

EID: 84883005874     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-321-3_5     Document Type: Article

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