Ginsenoside Rh2 improves learning and memory in mice

Journal of Medicinal Food

Volumn 16, Issue 8, 2013, Pages 772-776

  Hou, Jingang ^a   Xue, Jianjie ^a   Lee, Mira ^a   Liu, Lei ^a   Zhang, Dongliang ^a   Sun, Mengqi ^b   Zheng, Yinan ^c   Sung, Changkeun ^a  

^a Chungnam National University   (South Korea)

^b INSTITUTE OF MICROBIOLOGY   (China)

^c JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

cell genesis; cell survival; ginsenoside Rh2; hippocampus; learning and memory; supplement

Indexed keywords

BROXURIDINE; GINSENOSIDE RH 2; GINSENOSIDE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; DRUG EFFICACY; ENVIRONMENTAL ENRICHMENT; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL LEARNING; SPATIAL MEMORY; ANIMAL; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; LEARNING; MEMORY; PHYSIOLOGY; DRUG EFFECTS;

ANIMALS; GINSENOSIDES; HIPPOCAMPUS; LEARNING; MALE; MEMORY; MICE; MICE, INBRED ICR; PLANT EXTRACTS;

EID: 84882954863     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.2564     Document Type: Article

References (27)

1. Cameron HA, McKay R: Stem cells and neurogenesis in the adult brain. Curr Opin Neurobiols 1998;8:677-680.
2. Eriksson PS, Perfilieva E, Bjr-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH: Neurogenesis in the adult human hippocampus. Nat Med 1998;4:1313-1317.
3. Gould E, Reeves AJ, Fallah M, Tanapat P, Cross CG, Fuchs E: Hippocampal neurogenesis in adult old world primates. Proc Natl Acad Sci USA 1999;96:5263-5267.
4. Kempermann G, Kuhn HG, Gage FH: More hippocampal neurons in adult mice living in an enriched environment. Nature 1999;386:493-495.
5. Van Praag H, Kempermann G, Gag FH: Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999;2:266-270.
6. Liu J, Solway K, Messing RO, Sharp FR: Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 1998;18:7768-7778.
7. Parent JM, Yu TW, Leibowiz RT, Geschwind DH, Sloviter RS, Lowenstein DH: Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 1997;17:3727-3738.
8. Lemaire V, Koehl M, Le Moal M, Abrous DN: Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci USA 2000;97: 11032-11037.
9. Snyder JS, Hong NS, Mcdonald RJ, Wojtowicz JM: A role for adult neurogenesis in the spatial long-term memory. Neuroscience 2005;130:843-852.
10. Clelland CD, Choi M, Romberg C, Clemenson GD, Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ: A function role for adult hippocampal neurogenesis in spatial pattern separation. Science 2005;325:210-213.
11. Wen TC, Yoshimura H, Matsuda S, Sakanaka M: Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Acta Neuropathol 1996;91:15-22.
12. Shen LS, Zhang JT: Ginsenoside Rg1 increases ischemiainduced cell proliferation and survival in the dentate gyrus of adult gerbils. Neurosci Lett 2003;344:1-4.
13. Kim JH, Cho SY, Lee JH, Jeong SM, Yoon IS, Lee BH, Lee JH, Pyo MK, Lee SM, Chung JM, Kim S, Rhim H, Oh JW, Nah SY: Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res 2007;1136:190-199.
14. Bae EA, Han MJ, Choo MK, Park SY, Kime DH. Metabolism of 20(S)-and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull 2002;25:58-63.
15. Morris RGM, Garrud P, Pawlins JNP, O'Keefe J: Place navigation impaired in rats with hippocampal leisons. Nature 1982;297: 681-683.
16. Miller MW, Nowakowski RS: Use of bromodeoxyuridine- immunohistochemistry to examine the proliferation, migration and time of origin of cells in the central nervous system. Brain Res 1988;457:44-52.
17. Gage FH: Neurogenesis in the adult brain. J Neurosci 2002;22: 612-613.
18. Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH: Early determination and long-term persistence of adultgenerated new neurons in the hippocampus of mice. Development 2003;130:391-399.
19. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ: Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 1999;2:260-265.
20. Hastings NB, Gould E: Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol 1999; 413:146-154.
21. Wang YZ, Chen J, Chu SF, Wang YS, Wang XY, Chen NH, Zhang JT: Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. J Pharmacol Sci 2009;109:504-510.
22. Wang Q, Sun LH, Jia W, Liu XM, Dang HX, Mai WL, Wang N, Steinmetz A, Wang YQ, Xu CJ: Comparison of ginsenoside Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytother Res 2010; 24:1748-1754.
23. Shors TJ, Towsend, DA, Zhao M, Kozorovitskiy Y, Gould E: Neurogenesis may relate to some but not all types of hippocampal-dependent learning. Hippocampus 2002;12:578-584.
24. Ambrogini P, Orsini L, Mancini C, Ferri P, Ciaroni S, Cuppini R: Learning may reduce neurogenesis in adult rat dentate gyrus. Neuroscience 2004;359:13-16.
25. Shieh PC, Tsao CW, Li JS, Wu HT, Wen YJ, Kou DH, Cheng JT: Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes. Neurosci Lett 2008;434:1-5.
26. Yang JH, Han SJ, Ryu JH, Jang IS, Kim DH: Ginsenoside Rh2 ameliorates scopolamine-induced learning deficit in mice. Biol Pharm Bull 2009;32:1710-1715.
27. David GP, David DK: Generation of ginsenosides Rg3 and Rh2 from North American ginseng. Phytochemisty 2004;65:337-344.