Ocular mucosal immunity

Mucosal Immunology, Two-Volume Set

Volumn , Issue , 2005, Pages 1477-1496

  O'Sullivan, Nancy L ^a   Montgomery, Paul C ^a   Sullivan, David A ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882906420     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012491543-5/50090-5     Document Type: Chapter

References (305)

1. Abelson M.B., Smith L.M. Mediators of ocular inflammation. Duane's Biomedical Foundations of Ophthalmology 1991, 1-10. Lippincott-Raven, Philadelphia. W. Tasman, E.A. Jaeger (Eds.).
2. Ahmed S.A., Aufdemorte T.B., Chen J.R., Montoya A.I., Olive D., Talal N. Estrogen induces the development of autoantibodies and promotes salivary gland lymphoid infiltrates in normal mice. J. Autoimmun. 1989, 2:543-552.
3. Allansmith M.R., Bloch K.J., Baird R.S., Sinclair K. Ocular anaphylaxis: Induction by local injection of antigen. Immunology 1981, 44:623-627.
4. Allansmith M.R., Gillette T.E. Secretory component in human ocular tissues. Am. J. Ophthalmol. 1980, 89:353-361.
5. Allansmith M.R., Greiner J.V., Baird R.S. Number of inflammatory cells in the normal conjunctiva. Am. J. Ophthalmol. 1978, 86:250-259.
6. Allansmith M.R., Gudmundsson O.G., Hann L.E., Keys C., Bloch K.J., Taubman M.A., Sullivan D.A. The immune response of the lacrimal gland to antigenic exposure. Curr. Eye Res. 1987, 6:921-927.
7. Allansmith M.R., Hahn G.S., Simon M.A. Tissue, tear, and serum IgE concentrations in vernal conjunctivitis. Am. J. Ophthalmol. 1976, 81:506-511.
8. Allansmith M.R., Kajiyama G., Abelson M.B., Simon M.A. Plasma cell content of main and accessory lacrimal glands and conjunctiva. Am. J. Ophthalmol. 1976, 82:819-826.
9. Allansmith M.R., McClellan B.H. Immunoglobulins in the human cornea. Am. J. Ophthalmol. 1975, 80:123-132.
10. Allansmith M.R., Radl J., Haaijman J.J., Mestecky J. Molecular forms of tear IgA and distribution of IgA subclasses in human lacrimal glands. J. Allergy Clin. Immunol. 1985, 76:569-576.
11. Ansar A.S., Penhale W.J., Talal N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am. J. Pathol. 1985, 121:531-551.
12. Arnold R.R., Russell J.E., Champion W.J., Brewer M., Gauthier J.J. Bacteriocidal activity of human lactoferrin: Differentiation from the stasis of iron deprivation. Infect. Immun. 1982, 35:792-799.
13. Axelrod A.J., Chandler J.W. Morphologic characteristics of conjunctival lymphoid tissue in the rabbit. Proceedings of the Second International Symposium on Immunology and Immunopathology of the Eye 1979, 292-301. Masson Publishing, New York. A.M. Silverstein, G.R. O'Connor (Eds.).
14. Azzarolo A.M., Bjerrum K., Mircheff A., Warren D.W. Dihydrotestosterone and prolactin reverse lacrimal gland regression after hypophysectomy of female. Invest. Ophthalmol. Vis. Sci. Suppl. 1992, 33:1290.
15. Azzarolo A.M., Mazaheri A.H., Mircheff A.K., Warren D.W. Sex-dependent parameters related to electrolyte, water and glycoprotein secretion in rabbit lacrimal glands. Curr. Eye Res. 1993, 12:795-802.
16. Barton K., Nava A., Monroy D.C., Pflugfelder S.C. Cytokines and tear function in ocular surface disease. Adv. Exp. Med. Biol. 1998, 438:461-469.
17. Befus A.D., Mathison R., Davison J. Integration of neuroendocrine immune responses in defense of mucosal surfaces. Am. J. Trop. Med. Hyg. 1999, 60:26-34.
18. Berczi I. Neurohormonal-immune interaction. Functional Endocrine Pathology 1990, 990-1004. Blackwell Scientific Publications Inc., Edinburgh, United Kingdom. K. Kovacs, S. Asa (Eds.).
19. Berczi I., Nagy E. Effects of hypophysectomy on immune function. Psychoneuroimmunology II 1990, 339-375. Academic Press, San Diego, CA. R. Ader, D.L. Felten, N. Cohen (Eds.).
20. Bergmann K.C., Waldman R.H., Tischner H., Pohl W.D. Antibody in tears, saliva and nasal secretions following oral immunization of humans with inactivated influenza virus vaccine. Int. Arch. Allergy Appl. Immunol. 1986, 80:107-109.
21. Besedovsky H.O., del Rey A. Immune-neuro-endocrine interactions: Facts and hypotheses. Endocr. Rev. 1996, 17:64-102.
22. Besedovsky H.O., del Rey A. The cytokine-HPA axis feedback circuit. Z. Rheumatol. 2000, 59(Suppl 2):26-30.
23. Bienenstock J. Neuroimmune interactions in the regulation of mucosal immunity. Immunophysiology of the Gut 1993, 171-181. Academic Press, New York. W.A. Walker, P.R. Harmatz, B.K. Wershil (Eds.).
24. Blalock J.E. The immune system as a sensory organ. J. Immunol. 1984, 132:1067-1070.
25. Blanch V.J., Piskurich J.F., Kaetzel C.S. Cutting edge: Coordinate regulation of IFN regulatory factor-1 and the polymeric Ig receptor by proinflammatory cytokines. J. Immunol. 1999, 162:1232-1235.
26. Bogart B.J., Sack R.A., Beaton A., Lew G., Kim H. sIgA, glycoproteins and soluble mucin in reflex and closed eye tears. Does the epithelium shed its membrane-bound mucin?. Invest. Ophthalmol. Vis. Sci. Suppl. 1994, 35:S1560.
27. Brandtzaeg P. Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand. J. Immunol. 1985, 22:111-146.
28. Brandtzaeg P., Gjeruldsen S.T., Korsrud F., Baklien K., Berdal P., Ek J. The human secretory immune system shows striking heterogeneity with regard to involvement of J chain-positive IgD immunocytes. J. Immunol. 1979, 122:503-510.
29. Brandtzaeg P., Kett K., Rognum T.O. Subclass distribution of IgG- and IgA-producing cells in secretory tissues and alterations related to gut diseases. Adv. Exp. Med. Biol. 1987, 216A:321-333.
30. Brink P.R., Walcott B., Roemer E., Grine E., Pastor M., Christ G.J., Cameron R.H. Cholinergic modulation of immunoglobulin secretion from avian plasma cells: The role of calcium. J. Neuroimmunol. 1994, 51:113-121.
31. Brissette-Storkus C.S., Reynolds S.M., Lepisto A.J., Hendricks R.L. Identification of a novel macrophage population in the normal mouse corneal stroma. Invest Ophthalmol. Vis. Sci. 2002, 43:2264-2271.
32. Burns J.C. Persistent cytomegalovirus infection-the etiology of Sjögren's syndrome. Med. Hypotheses 1983, 10:451-460.
33. Caccavo D., Pellegrino N.M., Altamura M., Rigon A., Amati L., Amoroso A., Jirillo E. Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application. J. Endotoxin. Res. 2002, 8:403-417.
34. Cameron R.H., Walcott B., Claros N., Mendel K., Brink P.R. Cholinergic modulation of immunoglobulin secretion from avian plasma cells: The role of cyclic mononucleotides. J. Neuroimmunol. 1995, 61:223-230.
35. Carr R.M., Lolachi C.M., Albaran R.G., Ridley D.M., Montgomery P.C., O'Sullivan N.L. Nasal-associated lymphoid tissue is an inductive site for rat tear IgA antibody responses. Immunol. Invest. 1996, 25:387-396.
36. Cavallero C. Relative effectiveness of various steroids in an androgen assay using the exorbital lacrimal gland of the castrated rat. Acta Endocrinol. Copenh. 1967, 55:119-130.
37. Centifanto Y., Norrild B., Andersen S.M., Karcioglu Z.A., Porretta E., Caldwell D.R. Herpes simplex virus-specific antibodies present in tears during herpes keratitis. Proc. Soc. Exp. Biol. Med. 1989, 192:87-94.
38. Chandler J.W., Gillette T. Immunologic defense mechanisms of the ocular surface. Ophthalmology 1983, 90:585-591.
39. Chao C.C., Stuebben A.M., Butala S.M. Characterization of ocular mucus extracts by crossed immuno-electrophoretic techniques. Invest Ophthalmol. Vis. Sci. 1990, 31:1127-1135.
40. Chao C.C., Vergnes J.P., Freeman I.L., Brown S.I. Biosynthesis and partial characterization of tear film glycoproteins. Incorporation of radioactive precursors by human lacrimal gland explants in vitro. Exp. Eye Res. 1980, 30:411-425.
41. Childers N.K., Bruce M., McGhee J.R. Molecular mechanisms of immunoglobulin A defense. Annu. Rev. Immunol. 1989, 43:503-536.
42. Chodosh J., Kennedy R.C. The conjunctival lymphoid follicle in mucosal immunology. DNA Cell Biol. 2002, 21:421-433.
43. Chodosh J., Nordquist R.E., Kennedy R.C. Anatomy of mammalian conjunctival lymphoepithelium. Adv. Exp. Med. Biol. 1998, 438:557-565.
44. Chodosh J., Nordquist R.E., Kennedy R.C. Comparative anatomy of mammalian conjunctival lymphoid tissue: A putative mucosal immune site. Dev. Comp Immunol. 1998, 22:621-630.
45. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 1995, 332:1351-1362.
46. Cornell-Bell A.H., Hann L.E., Bloch K.J., Allansmith M.R. Characterization of a localized basophil hypersensitivity lesion in guinea pig conjunctiva. Cell Immunol. 1986, 97:1-12.
47. Cornell-Bell A.H., Sullivan D.A., Allansmith M.R. Gender-related differences in the morphology of the lacrimal gland. Invest Ophthalmol. Vis. Sci. 1985, 26:1170-1175.
48. Couderc L.J., D'Agay M.F., Danon F., Harzic M., Brocheriou C., Clauvel J.P. Sicca complex and infection with human immunodeficiency virus. Arch. Intern. Med. 1987, 147:898-901.
49. Coyle P.K. Molecular analysis of IgA in multiple sclerosis. J. Neuroimmunol. 1989, 22:83-92.
50. Crago S.S., Kutteh W.H., Moro I., Allansmith M.R., Radl J., Haaijman J.J., Mestecky J. Distribution of IgA1-, IgA2-, and J chain-containing cells in human tissues. J. Immunol. 1984, 132:16-18.
51. Cripps M.M., Bromberg B.B., Welch M.H. Gender-dependent lacrimal protein secretion. Invest. Ophthalmol. Vis. Sci. Suppl. 1986, 27:25.
52. Czerkinsky C., Prince S.J., Michalek S.M., Jackson S., Moldoveanu Z., Russell M.W., McGhee J.R., Mestecky J. Oral immunization with bacterial antigen induces IgA-secreting cells in peripheral blood in humans. Adv. Exp. Med. Biol. 1987, 216B:1709-1719.
53. D'Orisio S., Panerai A.E. Neuropeptides and immunopeptides: Messengers in a neuroimmune axis. Ann. N.Y. Acad. Sci. 1990, 594:1-503.
54. Dannelly H.K., Liu Y., Ghosh S.K. Pseudomonas aeruginosa corneal infection affects cholinergic enzymes in rat lacrimal gland. Arch. Microbiol. 2001, 177:47-53.
55. Dartt D.A. Signal transduction and control of lacrimal gland protein secretion: A review. Curr. Eye Res. 1989, 8:619-636.
56. Dartt D.A. Physiology of tear production. The Dry Eye 1992, 65-69. Springer-Verlag, Berlin. M.A. Lemp, R. Marquerdt (Eds.).
57. Dartt D.A., Sullivan D.A. Wetting of the ocular surface. Principles and Practice of Ophthalmology 2000, Vol. 2:960-981. WB Saunders, Philadelphia. 2nd ed. D.M. Albertand, F.A. Jakobiec (Eds.).
58. Davidson H.J., Byrnes S.A., Montgomery P.C. The effect of immunization route on rat serum and tear antibody responses to Chlamydia trachomatis. Reg. Immunol. 1993, 5:114-119.
59. De Clerck L.S., Couttenye M.M., de Broe M.E., Stevens W.J. Acquired immunodeficiency syndrome mimicking Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum. 1988, 31:272-275.
60. Delacroix D.L., Dive C., Rambaud J.C., Vaerman J.P. IgA subclasses in various secretions and in serum. Immunology 1982, 47:383-385.
61. deLuise V.P., Ghoshe R., Tabbara K.F. The effects of age, sex, and pregnancy on the histopathology and immunopathology of lacrimal glands of NZB/NZW F1 hybrid mice. Invest. Ophthalmol. Vis. Sci. Suppl. 1982, 22:211.
62. Deviere J., Vaerman J.P., Content J., Denys C., Schandene L., Vandenbussche P., Sibille Y., Dupont E. IgA triggers tumor necrosis factor alpha secretion by monocytes: A study in normal subjects and patients with alcoholic cirrhosis. Hepatology 1991, 13:670-675.
63. Dilly P.N. Contribution of the epithelium to the stability of the tear film. Trans. Ophthalmol. Soc. U. K. 1985, 104:381-389. (Pt 4).
64. Dilly P.N. Structure and function of the tear film. Adv. Exp. Med. Biol. 1994, 350:239-247.
65. Drew P.A., Shearman D.J. Vaso-active intestinal peptide: A neurotransmitter which reduces human NK cell activity and increases Ig synthesis. Aust. J. Exp. Biol. Med. Sci. 1985, 63:313-318. (Pt 3).
66. Dua H.S., Gomes J.P., Jindal V.K., Appa S.N., Schwarting R., Eagle R.C.J., Donoso L.A., Laibson P.R. Mucosa specific lymphocytes in the human conjunctiva, corneoscleral limbus and lacrimal gland. Curr. Eye Res. 1994, 13:87-93.
67. Ebersole J.L., Steffen M.J., Pappo J. Secretory immune responses in aging rats. II. Phenotypic distribution of lymphocytes in secretory and lymphoid tissues. Immunol. 1988, 64:289-294.
68. Elenkov I.J., Wilder R.L., Chrousos G.P., Vizi E.S. The sympathetic nerve-an integrative interface between two super-systems: The brain and the immune system. Pharmacol. Rev. 2000, 52:595-638.
69. Elfaki M.G., O'Sullivan N.L., Skandera C.A., Montgomery P.C. Inhibition of lymphocyte adherence to rat lacrimal acinar epithelium by interleukin-4 and transforming growth factor-beta 1. Cell Immunol. 1994, 153:154-162.
70. Eskandari F., Sternberg E.M. Neural-immune interactions in health and disease. Ann. N.Y. Acad. Sci. 2002, 966:20-27.
71. Ferguson T.A., Hayashi J.D., Kaplan H.J. Regulation of the systemic immune response by visible light and the eye. FASEB J. 1988, 2:3017-3021.
72. Ford L.C., DeLange R.J., Petty R.W. Identification of a nonlysozymal bactericidal factor (beta lysin) in human tears and aqueous humor. Am. J. Ophthalmol. 1976, 81:30-33.
73. Fox R. Epstein-Barr virus and human autoimmune diseases: Possibilities and pitfalls. J. Virol. Methods 1988, 21:19-27.
74. Sjögren's syndrome. Rheum. Dis. Clin. North Am. 1992, 18. R.I. Fox (Ed.).
75. Fox R.I., Luppi M., Kang H.I., Pisa P. Reactivation of Epstein-Barr virus in Sjögren's syndrome. Springer Semin. Immunopathol. 1991, 13:217-231.
76. Fox R.I., Pearson G., Vaughan J.H. Detection of Epstein-Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J. Immunol. 1986, 137:3162-3168.
77. Fox R.I., Stern M. Sjögren's syndrome: Mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand. J. Rheumatol. 2002, 3-13. Suppl.
78. Franklin R.M. The ocular secretory immune system-A review. Curr. Eye Res. 1989, 8:599-606.
79. Franklin R.M., Kenyon K.R., Tomasi T.B. Immunohistologic studies of human lacrimal gland: Localization of immunoglobulins, secretory component and lactoferrin. J. Immunol. 1973, 110:984-992.
80. Franklin R.M., Malaty R., Amirpanahi F., Beuerman R. The role of substance P on neuro-immune mechanisms in the lacrimal gland. Invest. Ophthalmol. Vis. Sci. Suppl. 1989, 30:467.
81. Franklin R.M., McGee D.W., Amirpanahi F., Beuerman R. Neuroregulation of lacrimal gland function. Invest. Ophthalmol. Vis. Sci. Suppl. 1988, 29:66.
82. Franklin R.M., McGee D.W., Shepard K.F. Lacrimal gland-directed B cell responses. J. Immunol. 1985, 135:95-99.
83. Franklin R.M., Prendergast R.A., Silverstein A.M. Secretory immune system of rabbit ocular adnexa. Invest. Ophthalmol. Vis. Sci. 1979, 18:1093-1096.
84. Franklin R.M., Remus L.E. Conjunctival-associated lymphoid tissue: Evidence for a role in the secretory immune system. Invest. Ophthalmol. Vis. Sci. 1984, 25:181-187.
85. Franklin R.M., Shephard K.F. T-cell adherence to lacrimal gland: The event responsible for IgA plasma cell predominance in lacrimal gland. Reg. Immunol. 1990, 3:213-216.
86. Freier S., Eran M., Faber J. Effect of cholecystokinin and of its antagonist, of atropine, and of food on the release of immunoglobulin A and immunoglobulin G specific antibodies in the rat intestine. Gastroenterology 1987, 93:1242-1246.
87. + αEβ7 T cells around acinar epithelial cells with apoptosis in patients with Sjögren's syndrome. J. Immunol. 1999, 163:2226-2235.
88. Fullard R.J., Kaswan R.M., Bounous D.I., Hirsh S.G. Tear protein profiles vs. clinical characteristics of untreated and cyclosporine-treated canine KCS. J. Am. Optom. Assoc. 1995, 66:397-404.
89. Fung K., Morris C., Duncan M. Mass spectrometric techniques applied to the analysis of human tears: A focus on the peptide and protein constituents. Adv. Exp. Med. Biol. 2002, 506:601-605.
90. Gachon A.M., Lacazette E. Tear lipocalin and the eye's front line of defence. Br. J. Ophthalmol. 1998, 82:453-455.
91. Gao J., Lambert R.W., Wickham L.A., Banting G., Sullivan D.A. Androgen control of secretory component mRNA levels in the rat lacrimal gland. J. Steroid Biochem. Mol. Biol. 1995, 52:239-249.
92. Garner A., Rahi A.H. Practolol and ocular toxicity. Antibodies in serum and tears. Br. J. Ophthalmol. 1976, 60:684-686.
93. Garry R.F., Fermin C.D., Hart D.J., Alexander S.S., Donehower L.A., Luo-Zhang H. Detection of a human intracisternal A-type retroviral particle antigenically related to HIV. Science 1990, 250:1127-1129.
94. Gill R.F., Montgomery P.C. Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODN. Curr. Eye Res. 2002, 24:228-233.
95. Gillette T.E., Allansmith M.R. Lactoferrin in human ocular tissues. Am. J. Ophthalmol. 1980, 90:30-37.
96. Gillette T.E., Allansmith M.R., Greiner J.V., Janusz M. Histologic and immunohistologic comparison of main and accessory lacrimal tissue. Am. J. Ophthalmol. 1980, 89:724-730.
97. Gillette T.E., Greiner J.V., Allansmith M.R. Immunohistochemical localization of human tear lysozyme. Arch. Ophthalmol. 1981, 99:298-300.
98. Gipson I.K., Inatomi T. Cellular origin of mucins of the ocular surface tear film. Adv. Exp. Med. Biol. 1998, 438:221-227.
99. Glasgow B.J., Marshall G., Gasymov O.K., Adburagimov A.R., Yusifov T.N., Knobler C.M. Tear lipocalins: Potential lipid scavengers for the corneal surface. Invest. Ophthalmol. Vis. Sci. 1999, 40:3100-3107.
100. Green J.E., Hinrichs S.H., Vogel J., Jay G. Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature 1989, 341:72-74.
101. Gudmundsson O.G., Sullivan D.A., Bloch K.J., Allansmith M.R. The ocular secretory immune system of the rat. Exp. Eye Res. 1985, 40:231-238.
102. Gupta A.K., Sarin G.S. Serum and tear immunoglobulin levels in acute adenovirus conjunctivitis. Br. J. Ophthalmol. 1983, 67:195-198.
103. Hahn J.D. Effect of cyproterone acetate on sexual dimorphism of the exorbital lacrimal gland in rats. J. Endocrinol. 1969, 45:421-424.
104. Hamrah P., Liu Y., Zhang Q., Dana M.R. The corneal stroma is endowed with a significant number of resident dendritic cells. Invest. Ophthalmol. Vis. Sci. 2003, 44:581-589.
105. Hamrah P., Zhang Q., Liu Y., Dana M.R. Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest. Ophthalmol. Vis. Sci. 2002, 43:639-646.
106. Hann L.E., Allansmith M.R., Sullivan D.A. Impact of aging and gender on the Ig-containing cell profile of the lacrimal gland. Acta Ophthalmol. (Copenh) 1988, 66:87-92.
107. Hann L.E., Cornell-Bell A.H., Marten-Ellis C., Allansmith M.R. Conjunctival basophil hypersensitivity lesions in guinea pigs. Analysis of upper tarsal epithelium. Invest. Ophthalmol. Vis. Sci. 1985, 27:125-130.
108. Hann L.E., Kelleher R.S., Sullivan D.A. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland. Invest Ophthalmol. Vis. Sci. 1991, 32:2610-2621.
109. Hann L.E., Tatro J.B., Sullivan D.A. Morphology and function of lacrimal gland acinar cells in primary culture. Invest. Ophthalmol. Vis. Sci. 1989, 30:145-158.
110. Hart R., Dancygier H., Wagner F., Lersch C., Classen M. Effect of substance P on immunoglobulin and interferon-gamma secretion by cultured human duodenal mucosa. Immunol. Lett. 1990, 23:199-204.
111. Hayashi J.D., Kaplan H.J., Ferguson T.A. Contralateral HSV-1 retinitis is dependent upon visible light. Invest. Ophthalmol. Vis. Sci. Suppl. 1988, 29:152.
112. Haynes R.J., Tighe P.J., Dua H.S. Innate defence of the eye by antimicrobial defensin peptides. Lancet 1998, 352:451-452.
113. Herbort C.P., Weissman S.S., Payan D.G. Role of peptidergic neurons in ocular herpes simplex infection in mice. FASEB J. 1989, 3:2537-2541.
114. Hingorani M., Metz D., Lightman S.L. Characterization of the normal conjunctival leukocyte population. Exp. Eye Res. 1997, 64:905-912.
115. Holly F.J. Tear film physiology. Int. Ophthalmol. Clin. 1987, 27:2-6.
116. Homma M., Sugai S., Tojo T., Miyasaka N., Akizuki M. Sjögren's Syndrome: State of the Art 1994, Kugler Press, Amsterdam.
117. Homo-Delarche F., Durant S. Hormones, neurotransmitters and neuropeptides as modulators of lymphocyte functions. Handbook of Immunopharmacology 1994, 169-240. Academic Press Ltd, London. M. Rola-Pleszczynski (Ed.).
118. Homo-Delarche F., Fitzpatrick F., Christeff N., Nunez E.A., Bach J.F., Dardenne M. Sex steroids, glucocorticoids, stress and autoimmunity. J. Steroid Biochem. Mol. Biol. 1991, 40:619-637.
119. Huang A.J., Tseng S.C., Kenyon K.R. Paracellular permeability of corneal and conjunctival epithelia. Invest. Ophthalmol. Vis. Sci. 1989, 30:684-689.
120. Huang Z., Lambert R.W., Wickham L.A., Sullivan D.A. Analysis of cytomegalovirus infection and replication in acinar epithelial cells of the rat lacrimal gland. Invest. Ophthalmol. Vis. Sci. 1996, 37:1174-1186.
121. Hunt S., Spitznas M., Seifert P., Rauwolf M. Organ culture of human main and accessory lacrimal glands and their secretory behaviour. Exp. Eye Res. 1996, 62:541-554.
122. Jabs D.A., Alexander E.L., Green W.R. Ocular inflammation in autoimmune MRL/Mp mice. Invest. Ophthalmol. Vis. Sci. 1985, 26:1223-1229.
123. Jabs D.A., Prendergast R.A. Murine models of Sjögren's syndrome. Immunohistologic analysis of different strains. Invest. Ophthalmol. Vis. Sci. 1988, 29:1437-1443.
124. Jackson F.L., Hutson J.C. Altered responses to androgen in diabetic male rats. Diabetes 1984, 33:819-824.
125. Jackson S., Mestecky J. Oral-parenteral immunization leads to the appearance of IgG auto-anti-idiotypic cells in mucosal tissues. Cell Immunol. 1981, 60:498-502.
126. Jacoby R.O., Bhatt P.N., Jonas A.M. Pathogenesis of sialodacryoadenitis in gnotobiotic rats. Vet. Pathol. 1975, 12:196-209.
127. Janssen P.T., Muytjens H.L., van Bijsterveld O.P. Nonlysozyme antibacterial factor in human tears. Fact or fiction?. Invest. Ophthalmol. Vis. Sci. 1984, 25:1156-1160.
128. Janssen P.T., van Bijsterveld O.P. Origin and biosynthesis of human tear fluid proteins. Invest. Ophthalmol. Vis. Sci. 1983, 24:623-630.
129. Johansen F.E., Pekna M., Norderhaug I.N., Haneberg B., Hietala M.A., Krajci P., Betsholtz C., Brandtzaeg P. Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J. Exp. Med. 1999, 190:915-921.
130. Jumblatt M.M., McKenzie R.W., Jumblatt J.E. MUC5AC mucin is a component of the human precorneal tear film. Invest. Ophthalmol. Vis. Sci. 1999, 40:43-49.
131. Jumblatt J.E., North G.T., Hackmiller R.C. Muscarinic cholinergic inhibition of adenylate cyclase in the rabbit iris-ciliary body and ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 1990, 31:1103-1108.
132. Kahn M., Barney N.P., Briggs R.M., Bloch K.J., Allansmith M.R. Penetrating the conjunctival barrier. The role of molecular weight. Invest. Ophthalmol. Vis. Sci. 1990, 31:258-261.
133. Kelleher R.S., Hann L.E., Edwards J.A., Sullivan D.A. Endocrine, neural, and immune control of secretory component output by lacrimal gland acinar cells. J. Immunol. 1991, 146:3405-3412.
134. Kessing S.V. Mucous gland system of the conjunctiva. A quantitative normal anatomical study. Acta Ophthalmol. (Copenh) 1968, 95:1. (Suppl.).
135. Kett K., Brandtzaeg P., Radl J., Haaijman J.J. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J. Immunol. 1986, 136:3631-3635.
136. Kievits F., Kijlstra A. Inhibition of C3 deposition on solid-phase bound immune complexes by lactoferrin. Immunology 1985, 54:449-456.
137. Kijlstra A. The role of lactoferrin in the nonspecific immune response on the ocular surface. Reg. Immunol. 1990, 3:193-197.
138. Kijlstra A., Jeurissen S.H., Koning K.M. Lactoferrin levels in normal human tears. Br. J. Ophthalmol. 1983, 67:199-202.
139. Kincaid M.C. The eye in Sjögren's syndrome. Sjögren's Syndrome. Clinical and Immunological Aspects 1987, 25-33. Springer Verlag, Berlin. N. Talal, H.M. Moutsopoulos, S.S. Kassan (Eds.).
140. King-Smith P.E., Fink B.A., Fogt N., Nichols K.K., Hill R.M., Wilson G.S. The thickness of the human precorneal tear film: Evidence from reflection spectra. Invest. Ophthalmol. Vis. Sci. 2000, 41:3348-3359.
141. Knop E., Knop N. MALT tissue of the conjunctiva and nasolacrimal system in the rabbit and human. Vision Res. 1996, 1996:36-60.
142. Knop E., Knop N. Lacrimal drainage-associated lymphoid tissue (LDALT): A part of the human mucosal immune system. Invest. Ophthalmol. Vis. Sci. 2001, 42:566-574.
143. Knop N., Knop E. Conjunctiva-associated lymphoid tissue in the human eye. Invest. Ophthalmol. Vis. Sci. 2000, 41:1270-1279.
144. Kraehenbuhl J.P., Neutra M.R. Molecular and cellular basis of immune protection of mucosal surfaces. Physiol. Rev. 1992, 72:853-879.
145. Krueger G.R., Wassermann K., De Clerck L.S., Stevens W.J., Bourgeois N., Ablashi D.V., Josephs S.F., Balachandran N. Latent herpesvirus-6 in salivary and bronchial glands. Lancet 1990, 336:1255-1256.
146. Ksander B.R., Streilein J.W. Regulation of the immune response within privileged sites. Chem. Immunol. 1994, 58:117-145.
147. Kvale D., Brandtzaeg P., Lovhaug D. Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-alpha and gamma interferon. Scand. J. Immunol. 1988, 28:351-357.
148. Lambert R.W. Do cytokines have a role in the regulation of lacrimal gland acinar cell ion transport and protein secretion?. Adv. Exp. Med. Biol. 1998, 438:499-503.
149. Lambert R.W., Kelleher R.S., Wickham L.A., Vaerman J.-P., Sullivan D.A. Neuroendocrinimmune modulation of secretory component production by rat lacrimal, salivary, and intestinal epithelial cells. Invest. Ophthalmol. Vis. Sci. 1994, 35:1192-1201.
150. Lamberts D.W. Keratoconjunctivitis sicca. The Cornea: Scientific Foundations and Clinical Practice 1983, 293-308. Little, Brown and Co., Boston. G. Smolin, R.A. Thoft (Eds.).
151. Lambrecht B.N. Immunologists getting nervous: Neuropeptides, dendritic cells and T cell activation. Respir. Res. 2001, 2:133-138.
152. Latkovic S. Ultrastructure of M cells in the conjunctival epithelium of the guinea pig. Curr. Eye Res. 1989, 8:751-755.
153. Lauria A., Porcelli F. Leucine aminopeptidase (LAP) activity and sexual dimorphism in rat exorbital lacrimal gland. Basic Appl. Histochem. 1979, 23:171-177.
154. Lemp M.A. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J. 1995, 21:221-232.
155. Lemp M.A., Marquardt R. The Dry Eye: A Comprehensive Guide 1992, Springer-Verlag, Berlin.
156. Levine J., Pflugfelder S.C., Yen M., Crouse C.A., Atherton S.S. Detection of the complement (CD21)/Epstein-Barr virus receptor in human lacrimal gland and ocular surface epithelia. Reg. Immunol. 1990, 3:164-170.
157. Levite M. Nerve-driven immunity. The direct effects of neuro-transmitters on T-cell function. Ann. N. Y. Acad. Sci. 2000, 917:307-321.
158. Liu M., Richards S.M., Schirra F., Yamagami H., Sullivan B.D., Sullivan D.A. Identification of androgen-regulated genes in the lacrimal gland. Adv. Exp. Med. Biol. 2002, 506:129-135.
159. Liu Y., Hamrah P., Zhang Q., Taylor A.W., Dana M.R. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts. J. Exp. Med. 2002, 195:259-268.
160. Lubniewski A.J., Nelson J.D. Diagnosis and management of dry eye and ocular surface disorders. Ophthalmol. Clin. N.A. 1990, 3:575-594.
161. Lucca J.A., Farris R.L., Bielory L., Caputo A.R. Keratoconjunctivitis sicca in male patients infected with human immunodeficiency virus type 1. Ophthalmology 1990, 97:1008-1010.
162. Lycke N., Erlandsson L., Ekman L., Schon K., Leanderson T. Lack of J chain inhibits the transport of gut IgA and abrogates the development of intestinal antitoxic protection. J. Immunol. 1999, 163:913-919.
163. Mackie I.A., Seal D.V. Diagnostic implications of tear protein profiles. Br. J. Ophthalmol. 1984, 68:321-324.
164. Madia F., Liberati V., de Feo G., Marcozzi G. Variations of lacrimal fluid peroxidase activity in female and male rats. Ophthalmic Res. 2001, 33:176-179.
165. Maestroni G.J., Conti A., Pierpaoli W. The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Ann. N.Y. Acad. Sci. 1987, 496:67-77.
166. Maini R.N. The relationship of Sjögren's syndrome to rheumatoid arthritis. Sjögren's Syndrome: Clinical and Immunological Aspects 1987, 165-176. Springer Verlag, Berlin. N. Talal, H.M. Moutsopoulos, S.S. Kassan (Eds.).
167. Mannucci L.L., Pozzan M., Fregona I., Secchi A.G. The effect of extended wear contact lenses on tear immunoglobulins. CLAO J. 1984, 10:163-165.
168. Marcozzi F.G., Madia F., Del Bianco G., Mattei E., de Feo G. Lacrimal fluid peroxidase activity during the menstrual cycle. Curr. Eye Res. 2000, 20:178-182.
169. Mariette X., Gozlan J., Clerc D., Bisson M., Morinet F. Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjögren's syndrome. Am. J. Med. 1991, 90:286-294.
170. Mariette X., Zerbib M., Jaccard A., Schenmetzler C., Danon F., Clauvel J.P. Hepatitis C virus and Sjögren's syndrome. Arthritis Rheum. 1993, 36:280-281.
171. Mauduit P., Herman G., Rossignol B. Protein secretion induced by isoproterenol or pentoxifylline in lacrimal gland: Ca2+ effects. Am. J. Physiol. 1984, 246:C37-C44.
172. McClellan K.A. Mucosal defense of the outer eye. Surv. Ophthalmol. 1997, 42:233-246.
173. McCulley J.P., Shine W.E. The lipid layer: The outer surface of the ocular surface tear film. Biosci. Rep. 2001, 21:407-418.
174. McGee D.W., Franklin R.M. Lymphocyte migration into the lacrimal gland is random. Cell. Immunol. 1984, 86:75-82.
175. McMaster P.R., Aronson S.B., Bedford M.J. Mechanisms of the host response in the eye, IV: The anterior eye in germ-free animals. Arch. Ophthalmol. 1967, 77:392-399.
176. Mestecky J., McGhee J.R. Immunoglobulin A (IgA): Molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 1987, 40:153-245.
177. Mestecky J., McGhee J.R., Arnold R.R., Michalek S.M., Prince S.J., Babb J.L. Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. J. Clin. Invest. 1978, 61:731-737.
178. Mircheff A.K., Gierow J.P., Lee L., Lambert R.W., Akashi R.H., Hofman F.M. Class II antigen expression by lacrimal epithelial cells. An updated working hypothesis for antigen presentation by epithelial cells. Invest. Ophthalmol. Vis. Sci. 1991, 32:2302-2310.
179. Montgomery P.C., Rafferty D.E. Induction of secretory and serum antibody responses following oral administration of antigen with bioadhesive degradable starch microparticles. Oral Microbiol. Immunol. 1998, 13:139-149.
180. Montgomery P.C., Ayyildiz A., Lemaitre-Coelho I.M., Vaerman J.-P. Induction and expression of antibodies in secretions. Ann. NY Acad. Sci. 1983, 409:428-439.
181. Montgomery P.C., Majumdar A.S., Skandera C.A., Rockey J.H. The effect of immunization route and sequence of stimulation on the induction of IgA antibodies in tears. Curr. Eye Res. 1984, 3:861-865.
182. Montgomery P.C., O'Sullivan N.L., Martin L.B., Skandera C.A., Peppard J.V., Pockley A.G. Regulation of lacrimal gland immune responses. Adv. Exp. Med. Biol. 1994, 350:161-168.
183. Montgomery P.C., Peppard J.V., Skandera C.A. A comparison of lymphocyte subset distribution in rat lacrimal glands with cells from tissues of mucosal and non-mucosal origin. Curr. Eye Res. 1990, 9:85-93.
184. Montgomery P.C., Rockey J.H., Majumdar A.S., Lemaitre-Coelho I.M., Vaerman J.-P., Ayyildiz A. Parameters influencing the expression of IgA antibodies in tears. Invest. Ophthalmol. Vis. Sci. 1984, 25:369-373.
185. Montgomery P.C., Skandera C.A., Majumdar A.S. Evidence for migrating of IgA bearing lymphocytes between peripheral mucosal sites. Protides Biol. Fluids Colloquium 1985, 32:43-46.
186. Montgomery P.C., Whittum-Hudson J. Mucosal immunity in the ocular system. Mucosal Vaccines 1996, 403-423. Academic Press, San Diego, CA. H. Kiyono, P.L. Ogra, J.R. McGhee (Eds.).
187. Mooradian A.D., Morley J.E., Korenman S.G. Biological actions of androgens. Endocr. Rev. 1987, 8:1-28.
188. Motegi Y., Kita H. Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils. J. Immunol. 1998, 161:4340-4346.
189. Moutsopoulos H.M., Talal N. Immunologic abnormalities in Sjögren's syndrome. Sjögren's Syndrome: Clinical and Immunological Aspects 1987, 258-265. Springer Verlag, Berlin. N. Talal, H.M. Moutsopoulos, S.S. Kassan (Eds.).
190. Mulla A., Buckingham J.C. Regulation of the hypothalamo-pituitary-adrenal axis by cytokines. Baillieres Best Pract. Res. Clin. Endocrinol. Metab. 1999, 13:503-521.
191. Nelson J.L., Steinberg A.D. Sex steroids, autoimmunity, and autoimmune diseases. Hormones and Immunity 1987, 93-119. MTP Press Ltd., Lancaster, England. I. Berczi, K. Kovacs (Eds.).
192. Neves R.A., de Freitas D., Sato E., Oliveira C., Belfort J.R. Lacrimal dysfunction in pediatric acquired immunodeficiency syndrome. Adv. Exp. Med. Biol. 1994, 350:517-520.
193. Nichols R.L., Murray E.S., Nisson P.E. Use of enteric vaccines in protection against chlamydial infections of the genital tract and the eye of guinea pigs. J. Infect. Dis. 1978, 138:742-746.
194. Niederkorn J.Y. Immune privilege and immune regulation in the eye. Adv. Immunol. 1990, 48:191-226.
195. Nikkinen A., Lehtosalo J.I., Uusitalo H., Palkama A., Panula P. The lacrimal glands of the rat and the guinea pig are innervated by nerve fibers containing immunoreactivities for substance P and vasoactive intestinal polypeptide. Histochemistry 1984, 81:23-27.
196. Nikolova E.B., Russell M.W. Dual function of human IgA antibodies: Inhibition of phagocytosis in circulating neutrophils and enhancement of responses in IL-8-stimulated cells. J. Leukoc. Biol. 1995, 57:875-882.
197. Nikolova E.B., Tomana M., Russell M.W. All forms of human IgA antibodies bound to antigen interfere with complement (C3) fixation induced by IgG or by antigen alone. Scand. J. Immunol. 1994, 39:275-280.
198. Nilsen E.M., Johansen F.E., Kvale D., Krajci P., Brandtzaeg P. Different regulatory pathways employed in cytokine-enhanced expression of secretory component and epithelial HLA class I genes. Eur. J. Immunol. 1999, 29:168-179.
199. Noriega F.R., Losonsky G., Wang J.Y., Formal S.B., Levine M.M. Further characterization of delta aroA delta virG Shigella flexneri 2a strain CVD 1203 as a mucosal Shigella vaccine and as a live-vector vaccine for delivering antigens of enterotoxigenic Escherichia coli. Infect. Immun. 1996, 64:23-27.
200. O'Sullivan N.L., Montgomery P.C. Selective interactions of lymphocytes with neonatal and adult lacrimal gland tissues. Invest. Ophthalmol. Vis. Sci. 1990, 31:1615-1622.
201. O'Sullivan N.L., Raja R., Montgomery P.C. Lymphocyte adhesive interaction with lacrimal gland acinar epithelium involves carbohydrate recognition. Adv. Exp. Med. Biol. 1994, 350:181-184.
202. O'Sullivan N.L., Raja R., Montgomery P.C. Lymphocyte adhesive interactions with lacrimal gland acinar epithelial cells in primary culture. Invest. Ophthalmol. Vis. Sci. 1995, 36:2246-2253.
203. O'Sullivan N.L., Skandera C.A., Chin Y.H., Montgomery P.C. In vitro adhesive interactions between rat lymphocytes and lacrimal gland acinar epithelium. Phenotype of adherent lymphocytes and involvement of adhesion molecules. J. Immunol. 1994, 152:1684-1692.
204. O'Sullivan N.L., Skandera C.A., Montgomery P.C. Rat lacrimal glands contain activated and resting mature T cells, recent thymic emigrants, and possibly extrathymic populations. Adv. Exp. Med. Biol. 1998, 438:591-598.
205. O'Sullivan N.L., Skandera C.A., Montgomery P.C. Development of T cell lineages in rat lacrimal glands. Curr. Eye Res. 2001, 22:375-383.
206. Oeschger N.S., Amirpanahi F., Malaty R., Franklin R.M. Regulation of T-cell migration: Effect of neuropeptides and cell factors on the binding of T-cells to lacrimal gland epithelial cells. Invest. Ophthalmol. Vis. Sci. Suppl. 1989, 30:82.
207. Mucosal Immunology 1999, Academic Press, San Diego, CA. P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. McGhee, J. Bienenstock (Eds.).
208. Ohashi Y., So S.K., Minasi P.N., Tabbara K.F. The presence of cytotoxic autoantibody to lacrimal gland cells in NZB/W mice. Invest. Ophthalmol. Vis. Sci. 1985, 26:214-219.
209. Ota M., Kyakumoto S., Nemoto T. Demonstration and characterization of cytosol androgen receptor in rat exorbital lacrimal gland. Biochem. Int. 1985, 10:129-135.
210. Ottaway C.A. In vitro alteration of receptors for vasoactive intestinal peptide changes the in vivo localization of mouse T cells. J. Exp. Med. 1984, 160:1054-1069.
211. Pangerl A., Pangerl B., Jones D.J., Reiter R.J. Beta-adrenoceptors in the extraorbital lacrimal gland of the Syrian hamster. Characterization with [125I]-iodopindolol and evidence of sexual dimorphism. J. Neural Transm. 1989, 77:153-162.
212. Pappo J., Ebersole J.L., Taubman M.A. Phenotype of mononuclear leukocytes resident in rat major salivary and lacrimal glands. Immunol. 1988, 64:295-300.
213. Ocular Infection and Immunity 1996, Mosby, New York. J.S. Pepose, G. Holland, K. Wilhelmus (Eds.).
214. Peppard J.V., Mann R.V., Montgomery P.C. Antibody production in rats following ocular-topical or gastrointestinal immunization: Kinetics of local and systemic antibody production. Curr. Eye Res. 1988, 7:471-481.
215. Peppard J.V., Montgomery P.C. Studies on the origin and composition of IgA in rat tears. Immunology 1987, 62:193-198.
216. Peppard J.V., Montgomery P.C. Optimizing the expression of antibodies in tears: Manipulation of the common mucosal immune system?. Advances in Mucosal Immunology 1990, 513-517. Kluwer Academic Publishers, London. T.T. MacDonald, S.J. Challacombe, P.W. Bland, C.R. Stokes, R.V. Heatley, A. Mowat (Eds.).
217. Petrovsky N. Towards a unified model of neuroendocrine-immune interaction. Immunol. Cell Biol. 2001, 79:350-357.
218. Pflugfelder S.C., Crouse C.A., Monroy D., Yen M., Rowe M., Atherton S.S. Epstein-Barr virus and the lacrimal gland pathology of Sjögren's syndrome. Am. J. Pathol. 1993, 143:49-64.
219. Pleyer U., Bergmann L., Krause A., Hartmann C. Autoimmune diseases of the peripheral cornea. Immunopathology, clinical aspects and therapy. Klin. Monatsbl. Augenheilkd. 1996, 208:73-81.
220. Pockley A.G., Montgomery P.C. Identification of lacrimal gland associated immunomodulatory activities having differential effects on T and B cell proliferative responses. Reg Immunol. 1990, 3:198-203.
221. Pockley A.G., Montgomery P.C. The effects of interleukins 5 and 6 on immunoglobulin production in rat lacrimal glands. Reg. Immunol. 1990, 3:242-246.
222. Pockley A.G., Montgomery P.C. In vivo adjuvant effect of interleukins 5 and 6 on rat tear IgA antibody responses. Immunology 1991, 73:19-23.
223. Rafferty D.E., Elfaki M.G., Montgomery P.C. Preparation and characterization of a biodegradable microparticle antigen/cytokine delivery system. Vaccine 1996, 14:532-538.
224. Rafferty D.E., Montgomery P.C. Effects of transforming growth factor beta on immunoglobulin production in cultured rat lacrimal gland tissue fragments. Reg Immunol. 1993, 5:312-316.
225. Ramos-Remus C., Suarez-Almazor M., Russell A.S. Low tear production in patients with diabetes mellitus is not due to Sjögren's syndrome. Clin. Exp. Rheumatol. 1994, 12:375-380.
226. Richards S.M., Liu M., Sullivan B.D., Sullivan D.A. Gender-related differences in gene expression of the lacrimal gland. Adv. Exp. Med. Biol. 2002, 506:121-127.
227. Ridley Lathers D., Gill R.F., Montgomery P.C. Inductive pathways leading to rat tear IgA antibody responses. Invest. Ophthalmol. Vis. Sci. 1998, 39:1005-1011.
228. Robinson C.P., Cornelius J., Bounous D.E., Yamamoto H., Humphreys-Beher M.G., Peck A.B. Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune nod mice. Autoimmunity. 1998, 27:29-44.
229. Rocha E.M., Toda I., Wickham L.A., Da Silveira L.A., Sullivan D.A. Influence of gender, androgens and cyclophosphamide on cytokine mRNA levels in lacrimal tissue of a mouse model of Sjögren's syndrome. Invest. Ophthalmol. Vis. Sci. Suppl. 1997, 38.
230. Rolando M., Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv. Ophthalmol. 2001, 45(Suppl 2):S203-S210.
231. Rose R.C., Richer S.P., Bode A.M. Ocular oxidants and antioxidant protection. Proc. Soc. Exp. Biol. Med. 1998, 217:397-407.
232. Ruskell G.L. The distribution of autonomic post-ganglionic nerve fibres to the lacrimal gland in monkeys. J. Anat. 1971, 109:229-242.
233. Ruskell G.L. Organization and cytology of lymphoid tissue in the cynomolgus monkey conjunctiva. Anat. Rec. 1995, 243:153-164.
234. Sack R.A., Beaton A., Sathe S., Morris C., Willcox M., Bogart B. Towards a closed eye model of the pre-ocular tear layer. Prog. Retin. Eye Res. 2000, 19:649-668.
235. Sack R.A., Nunes I., Beaton A., Morris C. Host-defense mechanism of the ocular surfaces. Biosci. Rep. 2001, 21:463-480.
236. Sacks E.H., Wieczorek R., Jakobiec F.A., Knowles D.M. Lymphocytic subpopulations in the normal human conjunctiva. A monoclonal antibody study. Ophthalmology 1986, 93:1276-1283.
237. - αβ T cells. Invest. Ophthalmol. Vis. Sci. 2000, 41:138-144.
238. Sakimoto T., Shoji J., Inada N., Saito K., Iwasaki Y., Sawa M. Histological study of conjunctiva-associated lymphoid tissue in mouse. Jpn. J. Ophthalmol. 2002, 46:364-369.
239. Sand B., Jensen O.L., Eriksen J.S., Vinding T. Changes in the concentration of secretory immunoglobulin A in tears during post-operative inflammation of the eye. Acta Ophthalmol. (Copenh) 1986, 64:212-215.
240. Saruya S. Studies on allergic conjunctivitis. 5. Effects of castration and sex hormone administration on experimental allergic conjunctivitis. Acta. Soc. Ophthalmol. Jpn. 1968, 72:833-845.
241. Seifert P., Stuppi S., Spitznas M., Weihe E. Differential distribution of neuronal markers and neuropeptides in the human lacrimal gland. Graefes Arch. Clin. Exp. Ophthalmol. 1996, 234:232-240.
242. Sen D.K., Sarin G.S., Mathur G.P., Saha K. Biological variation of immunoglobulin concentrations in normal human tears related to age and sex. Acta Ophthalmol. (Copenh) 1978, 56:439-444.
243. Seto S.K., Gillette T.E., Chandler J.W. HLA-DR+/T6-Langerhans cells of the human cornea. Invest. Ophthalmol. Vis. Sci. 1987, 28:1719-1722.
244. Setzer P.Y., Nichols B.A., Dawson C.R. Unusual structure of rat conjunctival epithelium. Light and electron microscopy. Invest. Ophthalmol. Vis. Sci. 1987, 28:531-537.
245. Shani L., Szanton E., David R., Yassur Y., Sarov I. Studies on HSV specific IgA antibodies in lacrimal fluid from patients with herpes keratitis by solid phase radioimmunoassay. Curr. Eye Res. 1985, 4:103-111.
246. Shimada K., Silverstein A.M. Local antibody formation within the eye: A study of immunoglobulin class and antibody specificity. Invest. Ophthalmol. 1975, 14:573-583.
247. Shimeld C., Dyson H., Lewkowicz-Moss S., Hill T.J., Blyth W.A., Easty D.L. Spread of HSV-1 to the mouse eye after inoculation in the skin of the snout requires an intact nerve supply to the inoculation site. Curr. Eye Res. 1987, 6:9-12.
248. Sibille Y., Delacroix D.L., Merrill W.W., Chatelain B., Vaerman J.P. In vitro effects of IgA on human polymorphonuclear leukocytes. Adv. Exp. Med. Biol. 1987, 216A:573-579.
249. Sinha K., Dannelly H.K., Ghosh S.K. Effects of T-lymphocyte-dependent and -independent immunity on cholinergic enzyme activity in mouse lacrimal glands. Exp. Physiol. 2001, 86:169-176.
250. Smolin G. The defence mechanism of the outer eye. Trans. Ophthalmol. Soc. U.K. 1985, 104:363-366. (Pt 4).
251. Sollid L.M., Kvale D., Brandtzaeg P., Markussen G., Thorsby E. Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins. J. Immunol. 1987, 138:4303-4306.
252. Stanisz A.M., Befus D., Bienenstock J. Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer's patches, mesenteric lymph nodes, and spleen. J. Immunol. 1986, 136:152-156.
253. Stead R.H., Bienenstock J., Stanisz A.M. Neuropeptide regulation of mucosal immunity. Immunol. Rev. 1987, 100:333-359.
254. Stead R.H., Tomioka M., Pezzati P., Marshall J., Croitoru K., Perdue M., Stanisz M., Bienenstock J. Interaction of the mucosal immune and peripheral nervous systems. Psychoneuroimmunology 1991, 177-207. Academic Press, San Diego, CA. R. Adar, D.L. Felten, N. Cohen (Eds.).
255. Stern M., Beuerman R., Fox R., Mircheff A., Pflugfelder S. A unified theory of the role of the ocular surface in dry eye. Adv. Exp. Med. Biol. 1998, 438:643-651.
256. Stern M.E., Beuerman R.W., Fox R.I., Gao J., Mircheff A.K., Pflugfelder S.C. The pathology of dry eye: The interaction between the ocular surface and lacrimal glands. Cornea 1998, 17:584-589.
257. Streilein J.W., Masli S., Takeuchi M., Kezuka T. The eye's view of antigen presentation. Hum. Immunol. 2002, 63:435-443.
258. Sullivan D.A. Possible mechanisms involved in the reduced tear secretion in Sjögren's syndrome. Sjögren's Syndrome: State of the Art 1994, 13-19. Kugler Press, Amsterdam. M. Homma, S. Sugai, T. Tojo, N. Miyasaka, M. Akizuki (Eds.).
259. Sullivan D.A. Sex hormones and Sjögren's syndrome. J. Rheumatol. 1997, 24(Suppl 50):17-32.
260. Sullivan D.A. Ocular mucosal immunity. Mucosal Immunology 1999, 1241-1281. Academic Press, San Diego. P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J. McGhee (Eds.).
261. Sullivan D.A., Allansmith M.R. Source of IgA in tears of rats. Immunology 1984, 53:791-799.
262. Sullivan D.A., Allansmith M.R. The effect of aging on the secretory immune system of the eye. Immunology 1988, 63:403-410.
263. Sullivan D.A., Edwards J.A. Androgen stimulation of lacrimal gland function in mouse models of Sjögren's syndrome. J. Steroid Biochem. Mol. Biol. 1997, 60:237-245.
264. Sullivan D.A., Hann L.E., Soo C.H., Yee L., Edwards J.A., Allansmith M.R. Neural-immune interrelationship: Effect of optic, sympathetic, temporofacial, or sensory denervation on the secretory immune system of the lacrimal gland. Reg. Immunol. 1990, 3:204-212.
265. Sullivan D.A., Soo C., Allansmith M.R. Severe protein malnutrition: Impact on tear IgA levels during development and aging. Ocular Immunology Today 1990, 325-328. Elsevier Science Publishers, New York. M. Usui, S. Ohno, K. Aoki (Eds.).
266. Sullivan D.A., Wickham L.A., Krenzer K.L., Rocha E.M., Toda I. Aqueous tear deficiency. Oculodermal Diseases-Immunology of Bullous Oculo-Muco-Cutaneous Disorders 1997, 95-152. Aeolus Press, Buren, The Netherlands. U. Pleyer, C. Hartmann, W. Sterry (Eds.).
267. Sullivan D.A., Wickham L.A., Rocha E.M., Kelleher R.S., Da Silveira L.A., Toda I. Influence of gender, sex steroid hormones, and the hypothalamic-pituitary axis on the structure and function of the lacrimal gland. Adv. Exp. Med. Biol. 1998, 438:11-42.
268. Sullivan D.A., Wickham L.A., Rocha E.M., Krenzer K.L., Sullivan B.D., Steagall R., Cermak J.M., Dana M.R., Ullman M.D., Sato E.H., Gao J., Rocha F.J., Ono M., Silveira L.A., Lambert R.W., Kelleher R.S., Tolls D.B., Toda I. Androgens and dry eye in Sjögren's syndrome. Ann. N.Y. Acad. Sci. 1999, 876:312-324.
269. Sullivan D.A., Yee L., Conner A.S., Hann L.E., Olivier M., Allansmith M.R. Influence of ocular surface antigen on the postnatal accumulation of immunoglobulin-containing cells in the rat lacrimal gland. Immunology 1990, 71:573-580.
270. Takahashi M., Mimura Y., Hamano H., Haneji N., Yanagi K., Hayashi Y. Mechanism of the development of autoimmune dacryoadenitis in the mouse model for primary Sjögren's syndrome. Cell Immunol. 1996, 170:54-62.
271. Talal N., Ahmed S.A. Sex hormones and autoimmune disease: A short review. Int. J. Immunotherapy 1985, 3:65-70.
272. Tiffany J.M. Composition and biophysical properties of the tear film: Knowledge and uncertainty. Adv. Exp. Med. Biol. 1994, 350:231-238.
273. Toda I., Sullivan B.D., Rocha E.M., Silveira L.A., Wickham L.A., Sullivan D.A. Impact of gender on exocrine gland inflammation in mouse models of Sjögren's syndrome. Exp. Eye Res. 1999, 69:355-366.
274. Tsubata R., Tsubata T., Hiai H., Shinkura R., Matsumura R., Sumida T., Miyawaki S., Ishida H., Kumagai S., Nakao K., Honjo T. Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: A spontaneous model for Sjögren's syndrome. Eur. J. Immunol. 1996, 26:2742-2748.
275. Tsubota K., Fujishima H., Toda I., Katagiri S., Kawashima Y., Saito I. Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjögren's syndrome patients. Acta Ophthalmol. Scand. 1995, 73:425-430.
276. Ulirsch R.C., Jaffe E.S. Sjögren's syndrome-like illness associated with the acquired immunodeficiency syndrome-related complex. Hum. Pathol. 1987, 18:1063-1068.
277. Underdown B.J., Schiff J.M. Immunoglobulin A: Strategic defense initiative at the mucosal surface. Annu. Rev. Immunol. 1986, 4:389-417.
278. van Blokland S.C.A., Versnel M.A. Pathogenesis of Sjögren's syndrome: Characteristics of different mouse models for autoimmune exocrinopathy. Clin. Immunol. 2002, 103:111-124.
279. van Setten G., Schultz G. Transforming growth factor-alpha is a constant component of human tear fluid. Graefes Arch. Clin. Exp. Ophthalmol. 1994, 232:523-526.
280. Van Zaane D., Jermyn J., de Leeuw P.W. Mucosal antibody response of calves after oral and intrabronchial administration of rotavirus. Adv. Exp. Med. Biol. 1987, 216B:1855-1862.
281. Verhagen C., Breeboart A.C., Kijlstra A. Diffusion of immunoglobulin G from the vascular compartment into the normal rabbit cornea. Invest. Ophthalmol. Vis. Sci. 1990, 31:1519-1525.
282. Vinding T., Eriksen J.S., Nielsen N.V. The concentration of lysozyme and secretory IgA in tears from healthy persons with and without contact lens use. Acta Ophthalmol. (Copenh) 1987, 65:23-26.
283. Wakefield D., Lloyd A. The role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine 1992, 4:1-5.
284. Walcott B. Leu enkephalin-like immunoreactivity and the innervation of the rat exorbital gland. Invest. Ophthalmol. Vis. Sci. Suppl. 1990, 31:44.
285. Walcott B., Sibony P.A., Coyle P.K., KcKeon C., Keyser K.T. Protein and immunoglobulin release from lacrimal gland fragments. Invest. Ophthalmol. Vis. Sci. Suppl. 1986, 27:25.
286. Waldman R.H., Bergmann K.C. Stimulation of secretory antibody following oral antigen administration. Adv. Exp. Med. Biol. 1987, 216B:1677-1684.
287. Waterhouse J.P. Focal adenitis in salivary and lacrimal glands. Proc. R. Soc. Lond. 1963, 56:911-918.
288. Watson R.R., McMurray D.N., Martin P., Reyes M.A. Effect of age, malnutrition and renutrition on free secretory component and IgA in secretions. Am. J. Clin. Nutr. 1985, 42:281-288.
289. Webster J.I., Tonelli L., Sternberg E.M. Neuroendocrine regulation of immunity. Annu. Rev. Immunol. 2002, 20:125-163.
290. Weisz-Carrington P. Secretory immunology in the mammary gland. Hormones and Immunity 1987, 172-202. MTP Press, Lancaster, England. I. Berczi, K. Kovacs (Eds.).
291. Weisz-Carrington P., Roux M.E., McWilliams M., Phillips-Quagliata J.M., Lamm M.E. Hormonal induction of the secretory immune system in the mammary gland. Proc. Natl. Acad. Sci. U.S.A. 1978, 75:2928-2932.
292. Whitcher J.P. Clinical diagnosis of the dry eye. Int. Ophthalmol. Clin. 1987, 27:7-24.
293. Wickham L.A., Huang Z., Lambert R.W., Sullivan D.A. Effect of sialodacryoadenitis virus exposure on acinar epithelial cells from the rat lacrimal gland. Ocular. Immunol. Inflamm. 1997, 5:181-195.
294. Wickham L.A., Huang Z., Sullivan D.A. Measurement of cytokines in the lacrimal gland and tears: Analysis of various methods. Invest. Ophthalmol. Vis. Sci. Suppl. 1996, 37:S857.
295. Wieczorek R., Jakobiec F.A., Sacks E.H., Knowles D.M. The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology 1988, 95:100-109.
296. Wilder R.L. Neuroendocrine-immune system interactions and autoimmunity. Annu. Rev. Immunol. 1995, 13:307-338.
297. Wilhelmus K.R., Darougar S., Forsey T., Treharne J.D. Sequential antibody changes following ulcerative herpetic keratitis. Br. J. Ophthalmol. 1986, 70:354-356.
298. Williams R.M., Singh J., Sharkey K.A. Innervation and mast cells of the rat exorbital lacrimal gland: The effects of age. J. Auton. Nerv. Syst. 1994, 47:95-108.
299. Williams Textbook of Endocrinology 1985, WB Saunders, Philadelphia. J.D. Wilson, D.W. Foster (Eds.).
300. Wira C.R., Prabhala R. Sex hormone, glucocorticoid, and cytokine regulation of mucosal immunity: Hormonal influences on antibody levels and antigen presentation in the female genital tract. Immunophysiology of the Gut 1993, 183-205. Academic Press, New York. W.A. Walker, P.R. Harmatz, B.K. Wershil (Eds.).
301. Wood J. Enteric neuroimmune interactions. Immunophysiology of the Gut 1993, 207-227. Academic Press, New York. W.A. Walker, P.R. Harmatz, B.K. Wershil (Eds.).
302. Yang P., Gong X., Zhou H. Immunohistochemical studies on whole mounts of the cornea and iris-ciliary body after corneal transplantation. Chung Hua Yen Ko Tsa Chih 1998, 34:273-275.
303. Yoshida M., Hondo R. Transmission of herpes simplex virus infection via lacrimal canaliculi. Ophthalmologica 1992, 204:101-102.
304. Yoshino K., Garg R., Monroy D., Ji Z., Pflugfelder S.C. Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland. Curr. Eye Res. 1996, 15:615-624.
305. Yoshino K., Monroy D., Pflugfelder S.C. Cholinergic stimulation of lactoferrin and epidermal growth factor secretion by the human lacrimal gland. Cornea 1996, 15:617-621.