Basic Aspects of Digestion and Absorption

Pediatric Gastrointestinal and Liver Disease

Volumn , Issue , 2006, Pages 11-23

  Wahbeh, Ghassan T ^a   Christie, Dennis L ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Division of Pulmonology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882903185     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7216-3924-6.50006-8     Document Type: Chapter

References (102)

1. Press Release 35 8 May 2002, World Health Organization., World Health Organization.
2. Alpers D. Digestion and absorption of carbohydrates and proteins. Physiology of the Gastrointestinal Tract 1994, 1723-1749. Raven Press, New York, NY. L. Johnson (Ed.).
3. Snow P., O'Dea K. Factors affecting the rate of hydrolysis of starch in food. Am J Clin Nutr 1981, 34:2721-2727.
4. Anderson H., Levine A.S., Levitt M.D. Incomplete absorption of the carbohydrate in all purpose wheat flour. N Eng J Med 1981, 304:890-892.
5. Zoppi G., Andreotti G., Pajno-Ferrara F., et al. Exocrine pancreas function in premature and full term neonates. Pediatr Res 1972, 6:880.
6. Layer P., Zinsmeister A.R., DiMagno E.P. Effects of decreasing intraluminal amylase activity on starch digestion and postprandial gastrointestinal function in humans. Gastroenterology 1986, 91:41.
7. Wu G.D., Wang W., Traber P.G. Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements. J Biol Chem 1992, 267:7863.
8. Hunziker W., Spiess M., Semena G., et al. The sucrase-isomaltase complex: primary structure, membrane orientation and evolution of a stalked intrinsic brush border protein. Cell 1986, 46:227-234.
9. Kruse T.A., Bolund L., Byskov A. Mapping of the human lactase-phlorizin hydrolase gene to chromosome 2. Cytogenet Cell Genet 1989, 51:1026.
10. Koldovsky O. Developmental dietary and hormonal control of intestinal disaccharidases in mammals (including man). Carbohydrate Metabolism and its Disorders 1981, 418-522. Academic Press, London. J.P. Randle, D.F. Steiner, W.J. Whelan, W.P. Whelan (Eds.).
11. Henning S.J. Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol Gastrointest Liver Physiol 1981, 241:G199-G214.
12. Semenza G., Auricchio S. Small intestinal disaccharidases. The Metabolic Basis of Inherited Disease 1989, 2975. McGraw-Hill, New York, NY. 4th edn. C.R. Scriver, A.L. Beaudet, W.S. Sey, D. Valle (Eds.).
13. Traber P. Carbohydrate assimilation. Textbook of Gastroenterology 2003, 400. Lippincott Williams & Wilkins, Philadelphia, PA. 4th edn. T. Yamada (Ed.).
14. Das B.C., Gray C.M. Intestinal sucrase: in vivo synthesis and degradation. Clin Res 1970, 18:378.
15. Marsh M.N., Riley S.A. Digestion and absorption of nutrients and vitamins. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology Diagnosis, Management 1998, 1471-1500. WB Saunders, Philadelphia, PA. 6th edn. M. Feldman, B.F. Scharschmidt, M.H. Sleisenger (Eds.).
16. Newcomer A.D., McGill D.B. Distribution of disaccharidase activity in the small bowel of normal and lactase deficient subjects. Gastroenterology 1966, 51:481-488.
17. Madara J.L. Loosening tight junctions: Lessons from the intestine. J Clin Invest 1989, 83:1089-1094.
18. Atisook K., Madara J.L. An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations. Gastroenterology 1991, 100:719-724.
19. Guy M.J., Deren J.J. Selective permeability of the small intestine for fructose. Am J Physiol 1971, 221:1051-1056.
20. Englyst H.N., Kingman S.M. Dietary fiber and resistant starch. A nutritional classification of plant polysaccharides. Dietary Fiber 1990, 49-65. Plenum Press, New York, NY. D. Kritchevsky, C. Bonfield, J.W. Anderson (Eds.).
21. Livesey G. The energy values of dietary fiber and sugar alcohols for man. Nutr Res Rev 1992, 5:61-84.
22. Aggett P.J., Agostoni C., Axelsson I., et al. Nondigestible carbohydrates in the diets of infants and young children: a commentary by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2003, 36(3):329-337.
23. Erickson R.H., Kim Y.S. Digestion and absorption of dietary proteins. Annu Rev Med 1990, 41:133-139.
24. Ford J.E. Some effects of overheating of protein on the digestion and absorption. Peptide Transport in Protein Nutrition 1992, 183-203. North-Holland Press, Amsterdam. D.M. Mathews, J.W. Payne (Eds.).
25. Friedman M. Dietary impact of food processing. Annu Rev Nutr 1992, 12:119-137.
26. Mellander O., Folsch G. Enzyme resistance and metal binding of phosphorylated peptides. International Encyclopedia of food and nutrition 1972, 569-579. Pergamon Press, Oxford. E.J. Bigwood (Ed.).
27. Seetharam B., Alpers D.H. Cellular uptake of cobalamine. Nutr Rev 1985, 43:97-102.
28. Udall J.N., Walker W.A. The physiologic and pathologic basis for the transport of macromolecules across the intestinal tract. J Pediatr Gastroenterol Nutr 1982, 1:295.
29. Samloff I.N. Pepsins, peptic activity, and peptic inhibitors. J Clin Gastroenterol 1981, 3:91.
30. Freeman H.G., Sleisenger M.H., Kim Y.S. Human protein digestion and absorption. Clin Gastroenterol 1983, 12:357-378.
31. Nordstrom C. Release of enteropeptidase and other brush border enzymes from the small intestine wall in the rat. Biochim Biophys Acta 1972, 289:376-377.
32. Hermon-Taylor J., Perrin J., Grant D.A.W. Immunofluorescent localization of enterokinase in human small intestine. Gut 1987, 28:259-265.
33. Nixon S.E., Mawer G.E. The digestion and absorption of protein in man. 2. The form in which digested protein is absorbed. Br J Nutr 1970, 24:241-258.
34. Adibi S. Glycyl-dipeptides: New substrates for protein nutrition. J Lab Clin Med 1989, 113:665.
35. Adibi S. Evidence for two different modes of tripeptide disappearance in human intestine. Uptake by peptide carrier systems and hydrolysis by peptide hydrolases. J Clin Invent 1975, 56:1355-1363.
36. Steinhardt H.J., Adibi S.A. Kinetics and characteristics of absorption from an equimolar mixture of 12 glycyl-dipeptides in human jejunum. Gastroenterology 1986, 90:579.
37. Curtis K.J., Gaines H.D., Kim Y.S. Protein digestion and absorption in rats with pancreatic duct occlusion. Gastroenterology 1978, 74:1271-1276.
38. Farrel J. Digestion and absorption of nutrients and vitamins. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management 2002, 1731. Saunders, Philadelphia, PA. 7th edn. M. Feldman, L.S. Friedman, M.H. Sleisenger (Eds.).
39. Ahnen D., Mircheff A., Santiago N. Intestinal surface amino-oligopeptidase. Distinct molecular forms during assembly in intra-cellular membranes in vivo. J Biol Chem 1983, 258:5960.
40. Kekuda R., Torres-Zamorano V., Fei Y.J., et al. Molecular and functional characterization of intestinal Na+-dependent neutral amino acid transporter. Am J Physiol 1997, 272:G1463.
41. Hoshide R., Ikeda Y., Karashima S., et al. Molecular cloning, tissue distribution and chromosomal localization of human cationic amino acid transporter 2. Genomics 1996, 38:174-178.
42. Hopfer U. Membrane transport mechanisms for hexoses and amino acids in the small intestine. Physiology of the Gastrointestinal Tract 1987, 1499-1526. Raven Press, New York, NY. 2nd edn. L.R. Johnson (Ed.).
43. Adibi S.A., Gray S.J., Menden E. The kinetics of amino acid absorption and alteration of plasma composition of free amino acids after intestinal perfusion of amino acid mixtures. Am J Clin Nutr 1967, 20:24-33.
44. Leibach F.H., Ganapathy V. Peptide transporters in the intestine and the kidney. Annu Rev Nutr 1996, 16:99.
45. Liang R., Fei Y.J., Prasad P.D., et al. Human intestinal H+ peptide cotransporter. Cloning, functional expression and chromosomal localization. J Biol Chem 1995, 270:6456.
46. Silk D.B.A. Disorders of nitrogen absorption. Clin Gastroenterol 1982, 11:47-72.
47. Ganapathy V., Brandsch M., Lelbach F. Intestinal transport of amino acids and peptides. Physiology of the Gastrointestinal Tract 1994, 1782. Raven Press, New York, NY. L.R. Johnson (Ed.).
48. Garlick P.J. Protein turnover in the whole animal and specific tissue. Comprehensive Biochemistry: Protein Metabolism 1980, 77-152. Elsevier Science, Amsterdam. M. Florkin, A. Neuberger, L.L.M. Deenen Van (Eds.).
49. Alpers D.H. Protein synthesis in intestinal mucosa: the effect of route of administration of precursor amino acids. J Clin Invest 1972, 51:167-173.
50. Levine G.M., Deren J.J., Steiger S., Zunio R. Role of oral intake in maintenance of gut mass and disaccharidase activity. Gastroenterology 1974, 67:975-982.
51. Report of the Task Force on Trans Fatty Acids 1987, British Nutrition Foundation., British Nutrition Foundation, London.
52. Borgstrom B. Phospholipid absorption. Lipid absorption: biochemical and clinical aspects 1976, 65-72. MTP Press, London. K. Rommel, H. Goebell, R. Bohmer (Eds.).
53. Carey M.C., Small D.M., Bliss C.M. Lipid digestion and absorption. Annu Rev Physiol 1983, 45:651-677.
54. Hamosh M., Burns W.A. Lipolytic activity of human lingual glands (von Ebner). Lab invest 1977, 37:603-608.
55. Liao T.H., Hamosh M. Fat digestion by lingual lipase: mechanism of lipolysis in the stomach and upper small intestine. Pediatr Res 1984, 18:402-409.
56. Grand R.J., Watkins J.B., Torti F.M. Development of the human gastrointestinal tract: a review. Gastroenterology 1976, 70:790-810.
57. Armand M., Hamosh M., Philpott J.R., et al. Gastric function in children with cystic fibrosis: effect of diet on gastric lipase levels and fat digestion. Pediatr Res 2004, 55(3):457-465.
58. Hernell O., Blackberg L., Bernback S. Digestion of human milk fat in early infancy. Acta Pediatr Scand 1989, 351:57.
59. Nalbone G., Larion D., Charbonnier-Augeire M., et al. Pancreatic phospholipase A2 hydrolysis of phosphatidyl cholines in various physicochemical states. Biochim Biophys Acta 1980, 620:612-625.
60. Baskys B., Klein E., Lever W.F. Lipases of blood and tissues. III. Purification and properties of pancreatic lipase. Arch Biochem Biophys 1963, 102:201-209.
61. Erlanson-Albertsson C., Larsson A. The activation peptide of pancreatic procolipase decreases food intake in rats. Regul Peptides 1988, 22:325-331.
62. Okada S., York D.A., Bray G.A., Erlanson-Albertsson C. Enterostatin (Val-Pro-Asp-Pro-Arg), the activation peptide of procolipase, selectively reduces fat intake. Physiol Behav 1991, 49:1185-1189.
63. Haslewood G.A.D. The Biological Importance of Bile Salts 1978, North-Holland, Amsterdam.
64. Hoffman A.F. Intestinal absorption of bile acids and biliary constituents. Physiology of the Gastrointestinal Tract 1994, 1845-1865. Raven Press, New York, NY. L.R. Johnson (Ed.).
65. Hoffman A.F., Mysels K.J. Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH and Ca2+. J Lipid Res 1992, 33:617-626.
66. Weiner I.M., Lack L. Bile salt absorption: enterohepatic circulation. Handbook of Physiology. Alimentary Canal 1968, 1439-1455. American Physiological Society, Washington, DC. C.F. Code (Ed.).
67. Weinberg S.L., Bruckhardt G., Wilson F.A. Taurocholate transport by rat intestinal basolateral membrane vesicles. Evidence for the presence of an anion exchange transport system. J Clin Invest 1986, 78:44-50.
68. Kraehenbuehl S., Talos C., Reichen J. Mitochondrial toxicity of hydrophobic bile acids and partial reversal by ursodeoxy-cholate. Hepatology 1992, 16:156A.
69. Hernell O., Staggers J.E., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat ingestion in healthy adult human beings. Biochemistry 1990, 29:2041.
70. Holt P.R., Fairchild B.M., Weiss J.A. Liquid crystalline phase in human intestinal contents during fat digestion. Lipids 1986, 21:444.
71. Strocchi A., Levitt M.D. A reappraisal of the magnitude and implications of the intestinal unstirred layer. Gastroenterology 1991, 101:843.
72. Westergaard H., Dietschy J.M. The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the mucosal cell. J Clin Invest 1976, 58:97-108.
73. Stremmel W. Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein. J Clin Invest 1988, 82:2001-2010.
74. Bhat S.G., Brockman H.L. The role of cholesteryl ester hydrolysis and synthesis in cholesterol transport across rat intestinal mucosal membrane: a new concept. Biochem Biophys Res Commun 1982, 109:486-492.
75. Ockner R.K., Manning J.A. Fatty acid binding protein in small intestine. Identification, isolation and evidence for its role in cellular fatty acid transport. J Clin Invest 1974, 54:326-338.
76. Davidson N.O., Magun A.M., Brasitus T.A., et al. Intestinal apolipoprotein A-I and B-48 metabolism: effects of sustained alterations in dietary triglyceride and mucosal cholesterol flux. J Lipid Res 1987, 28:388-402.
77. Dobbins W.O. An ultrastructural study of the intestinal mucosa in congenital β-lipoprotein deficiency with particular emphasis on intestinal absorptive cells. Gastroenterology 1970, 50:195-210.
78. Sabesin S.M., Frase S. Electron microscopic studies of the assembly, intracellular transport and secretion of chylomicrons by rat intestine. J Lipid Res 1977, 18:496.
79. Lebenthal E. Impact of digestion and absorption in the weaning period on infant feeding practices. Pediatrics 1985, 75(1):207-213.
80. Deren J.S. Development of structure and function in the fetal and newborn stomach. Am J Clin Nutr 1971, 24:144.
81. Christie D.L. Development of gastric function during the first month of life. Textbook of Gastroenterology and Nutrition in Infancy 1981, 109-120. Raven Press, New York, NY. E. Lebenthal (Ed.).
82. Lebenthal E., Lee P.C. Development of functional response in human exocrine pancreas. Pediatrics 1980, 66:556.
83. Hernell O. Specificity of human milk bile salt stimulated lipase. J Pediatr Gastroenterol Nutr 1985, 4:517-519.
84. Allen R.H., Seetheram B., Podell E., et al. Effect of proteolytic enzymes on the binding of cobalamine to R protein and intrinsic factor. in vitro evidence that a failure to partially degrade R protein is responsible for cobalamine malabsorption in pancreatic insufficiency. J Clin Invest 1978, 61:47.
85. Hagedorn C., Alpers D. Distribution of intrinsic factor vitamin B12 receptors in human intestine. Gastroenterology 1977, 73:1010.
86. +-dependent, electroneural L-ascorbate transport across brush border membrane vesicles from guinea pig small intestine. Biochim Biophys Acta 1979, 552:129.
87. Rose R.C. Intestinal absorption of water soluble vitamins. Physiology of the Gastrointestinal Tract 1987, 1581. Raven Press, New York, NY. 2nd edn. L.R. Johnson (Ed.).
88. Rigtrup K.M., Ong D.E. A retinyl ester hydrolase activity intrinsic to the brush border membrane of rat small intestine. Biochemistry 1992, 31:2920-2926.
89. Levin M.S. Intestinal absorption and metabolism of vitamin A. Physiology of the Gastrointestinal Tract 1994, 1957-1978. Raven Press, New York, NY. L. Johnson (Ed.).
90. Brasitis T.A., Sitrin M.D. Absorption and cellular actions of vitamin D. Physiology of the Gastrointestinal Tract 1994, 1935-1955. Raven Press, New York, NY. L. Johnson (Ed.).
91. Hollander D. Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations. Am J Clin Nutr 1976, 29:970-975.
92. Sitrin M.D., Pollack K.L., Bolt M.J.G., Rosernberg I.H. Comparison of vitamin hydroxyvitamin D absorption in the rat. Am J Physiol 1982, 242:G326-G332.
93. Bronner F. Intestinal calcium transport: The cellular pathway. Miner Electrolyte Metab 1990, 16:94.
94. Krejs G.J., Nicar M.J., Zerwekh J.E., et al. Effect of 1,25-dihydro yvitamin D3 on calcium and magnesium absorption in the healthy human jejunum and ileum. Am J Med 1983, 75:973.
95. Civitelli R., Avioli L.V. Calcium, phosphate and magnesium absorption. Physiology of the Gastrointestinal Tract 1994, 2173-2181. Raven Press, New York, NY. L. Johnson (Ed.).
96. Nemere I., Norman A.W. Transcaltachia, vesicular calcium transport and microtubule-associated calbindin-D28K: Energizing views of 1,25-dihydroxyvitamin D3-mediated intestinal calcium absorption. Miner Electrolyte Metab 1990, 16:109-114.
97. Favus M.J., Kathpalia S.C., Coe F.L. Kinetic characteristics of calcium absorption and secretion by rat colon. Am J Physiol 1981, 240:G350.
98. Cox T., Mazurier G., Spik G. Iron binding proteins and influx across the duodenal brush border. Evidence for specific lacto-transferrin receptors in the human intestine. Biochim Biophys Acta 1969, 588:120.
99. Taylor C.M., Bacon J.R., Aggett P.J., Bremner I. Homeostatic regulation of zinc absorption and endogenous losses in zinc-deprived men. Am J Clin Nutr 1991, 53:755-763.
100. Physiology of the Gastrointestinal Tract 1994, Raven Press, New York, NY. L. Johnson (Ed.).
101. Feldman M., Friedman L.S., Sleisenger M.H. Gastrointestinal and Liver Disease Pathology, Diagnosis, Management 2002, Elsevier Science, Amsterdam. 3rd edn.
102. Johnson L.R. Gastrointestinal Physiology - Year Book Inc 1997, Mosby, St. Louis, MO.