메뉴 건너뛰기




Volumn 7, Issue 2, 2013, Pages 89-95

Influence of serum and albumin on echinocandin in vitro potency and pharmacodynamics

Author keywords

Albumin; Anidulafungin; Caspofungin; Echinocandins; Micafungin; Protein binding; Serum

Indexed keywords

ALBUMIN; ANIDULAFUNGIN; CASPOFUNGIN; ECHINOCANDIN; GLUCAN SYNTHASE; MICAFUNGIN;

EID: 84882861743     PISSN: 19363761     EISSN: 1936377X     Source Type: Journal    
DOI: 10.1007/s12281-013-0136-z     Document Type: Article
Times cited : (11)

References (56)
  • 1
    • 34447105864 scopus 로고    scopus 로고
    • Resistance to echinocandin-class antifungal drugs
    • 17569573 10.1016/j.drup.2007.04.002 1:CAS:528:DC%2BD2sXnslWksr0%3D
    • Perlin DS. Resistance to echinocandin-class antifungal drugs. Drug Resist Updat. 2007;10:121-30.
    • (2007) Drug Resist Updat , vol.10 , pp. 121-130
    • Perlin, D.S.1
  • 2
    • 32344440108 scopus 로고    scopus 로고
    • Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp
    • 16455878 10.1128/JCM.44.2.324-326.2006 1:CAS:528:DC%2BD28XitFShtLg%3D
    • Messer SA, Diekema DJ, Boyken L, et al. Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp. J Clin Microbiol. 2006;44:324-6.
    • (2006) J Clin Microbiol , vol.44 , pp. 324-326
    • Messer, S.A.1    Diekema, D.J.2    Boyken, L.3
  • 3
    • 27744433240 scopus 로고    scopus 로고
    • In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole
    • 16272464 10.1128/JCM.43.11.5425-5427.2005 1:CAS:528:DC%2BD2MXht12itLnI
    • Pfaller MA, Boyken L, Hollis RJ, et al. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole. J Clin Microbiol. 2005;43:5425-7.
    • (2005) J Clin Microbiol , vol.43 , pp. 5425-5427
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3
  • 4
    • 0031943562 scopus 로고    scopus 로고
    • In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743,792), against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi
    • 9582584 10.1016/S0732-8893(97)00246-0 1:CAS:528:DyaK1cXivFajurs%3D
    • Pfaller MA, Marco F, Messer SA, Jones RN. In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743,792), against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi. Diagn Microbiol Infect Dis. 1998;30:251-5.
    • (1998) Diagn Microbiol Infect Dis , vol.30 , pp. 251-255
    • Pfaller, M.A.1    Marco, F.2    Messer, S.A.3    Jones, R.N.4
  • 5
    • 0037137576 scopus 로고    scopus 로고
    • Comparison of caspofungin and amphotericin B for invasive candidiasis
    • 12490683 10.1056/NEJMoa021585 1:CAS:528:DC%2BD38Xps1Ojtbs%3D
    • Mora-Duarte J, Betts R, Rotstein C, et al. Comparison of caspofungin and amphotericin B for invasive candidiasis. N Engl J Med. 2002;347:2020-9.
    • (2002) N Engl J Med , vol.347 , pp. 2020-2029
    • Mora-Duarte, J.1    Betts, R.2    Rotstein, C.3
  • 6
    • 34247564562 scopus 로고    scopus 로고
    • Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: A phase III randomised double-blind trial
    • Kuse ER, Chetchotisakd P, da Cunha CA, et al. Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial. Lancet. 2007;369:1519-27.
    • (2007) Lancet , vol.369 , pp. 1519-1527
    • Kuse, E.R.1    Chetchotisakd, P.2    Da Cunha, C.A.3
  • 7
    • 34848928703 scopus 로고    scopus 로고
    • Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis
    • 17806055 10.1086/520980 1:CAS:528:DC%2BD2sXhtFOntr7I
    • Pappas PG, Rotstein CM, Betts RF, et al. Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis. Clin Infect Dis. 2007;45:883-93.
    • (2007) Clin Infect Dis , vol.45 , pp. 883-893
    • Pappas, P.G.1    Rotstein, C.M.2    Betts, R.F.3
  • 8
    • 34250341787 scopus 로고    scopus 로고
    • Anidulafungin versus fluconazole for invasive candidiasis
    • 17568028 10.1056/NEJMoa066906 1:CAS:528:DC%2BD2sXms1Sis7w%3D
    • Reboli AC, Rotstein C, Pappas PG, et al. Anidulafungin versus fluconazole for invasive candidiasis. N Engl J Med. 2007;356:2472-82.
    • (2007) N Engl J Med , vol.356 , pp. 2472-2482
    • Reboli, A.C.1    Rotstein, C.2    Pappas, P.G.3
  • 9
    • 38149134281 scopus 로고    scopus 로고
    • In vitro susceptibility of invasive isolates of Candida spp. To anidulafungin, caspofungin, and micafungin: Six years of global surveillance
    • 18032613 10.1128/JCM.01901-07 1:CAS:528:DC%2BD1cXhs1aqtb8%3D
    • Pfaller MA, Boyken L, Hollis RJ, et al. In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance. J Clin Microbiol. 2008;46:150-6.
    • (2008) J Clin Microbiol , vol.46 , pp. 150-156
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3
  • 10
    • 0033199604 scopus 로고    scopus 로고
    • International surveillance of blood stream infections due to Candida species in the European SENTRY Program: Species distribution and antifungal susceptibility including the investigational triazole and echinocandin agents. SENTRY Participant Group (Europe)
    • 10529877 10.1016/S0732-8893(99)00046-2 1:CAS:528:DyaK1MXmt1emsbs%3D
    • Pfaller MA, Jones RN, Doern GV, et al. International surveillance of blood stream infections due to Candida species in the European SENTRY Program: species distribution and antifungal susceptibility including the investigational triazole and echinocandin agents. SENTRY Participant Group (Europe). Diagn Microbiol Infect Dis. 1999;35:19-25.
    • (1999) Diagn Microbiol Infect Dis , vol.35 , pp. 19-25
    • Pfaller, M.A.1    Jones, R.N.2    Doern, G.V.3
  • 11
    • 12244253742 scopus 로고    scopus 로고
    • Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: A comparative study with M27-A microdilution method
    • 12493803 10.1093/jac/dkg018 1:CAS:528:DC%2BD38XpslOgtr0%3D
    • Arevalo MP, Carrillo-Munoz AJ, Salgado J, et al. Antifungal activity of the echinocandin anidulafungin (VER002, LY-303366) against yeast pathogens: a comparative study with M27-A microdilution method. J Antimicrob Chemother. 2003;51:163-6.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 163-166
    • Arevalo, M.P.1    Carrillo-Munoz, A.J.2    Salgado, J.3
  • 12
    • 0036895274 scopus 로고    scopus 로고
    • In vitro activity of micafungin (FK-463) against Candida spp.: Microdilution, time-kill, and postantifungal-effect studies
    • 12435687 10.1128/AAC.46.12.3846-3853.2002 1:CAS:528:DC%2BD38XptVyntL0%3D
    • Ernst EJ, Roling EE, Petzold CR, et al. In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studies. Antimicrob Agents Chemother. 2002;46:3846-53.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3846-3853
    • Ernst, E.J.1    Roling, E.E.2    Petzold, C.R.3
  • 13
    • 77952620735 scopus 로고    scopus 로고
    • In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species
    • 20385855 10.1128/AAC.01584-09 1:CAS:528:DC%2BC3cXos1Ohu7k%3D
    • Andes D, Diekema DJ, Pfaller MA, et al. In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species. Antimicrob Agents Chemother. 2010;54:2497-506.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2497-2506
    • Andes, D.1    Diekema, D.J.2    Pfaller, M.A.3
  • 14
    • 28844486224 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: Importance of persistence of caspofungin in tissues to understanding drug activity
    • 16304173 10.1128/AAC.49.12.5058-5068.2005 1:CAS:528:DC%2BD2MXhtlSqsr3M
    • Louie A, Deziel M, Liu W, et al. Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity. Antimicrob Agents Chemother. 2005;49:5058-68.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 5058-5068
    • Louie, A.1    Deziel, M.2    Liu, W.3
  • 15
    • 28844490053 scopus 로고    scopus 로고
    • Attenuation of the activity of caspofungin at high concentrations against candida albicans: Possible role of cell wall integrity and calcineurin pathways
    • 16304189 10.1128/AAC.49.12.5146-5148.2005 1:CAS:528:DC%2BD2MXhtlSqsrrK
    • Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways. Antimicrob Agents Chemother. 2005;49:5146-8.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 5146-5148
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Prince, R.A.3    Lewis, R.E.4
  • 16
    • 4944230721 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: Evidence of concentration-dependent activity
    • 15378439 10.1086/424465 1:CAS:528:DC%2BD2cXps1amtL8%3D
    • Wiederhold NP, Kontoyiannis DP, Chi J, et al. Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity. J Infect Dis. 2004;190:1464-71.
    • (2004) J Infect Dis , vol.190 , pp. 1464-1471
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Chi, J.3
  • 17
    • 38649131783 scopus 로고    scopus 로고
    • In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model
    • 18070979 10.1128/AAC.01061-07 1:CAS:528:DC%2BD1cXhtlSqu78%3D
    • Andes D, Diekema DJ, Pfaller MA, et al. In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model. Antimicrob Agents Chemother. 2008;52:539-50.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 539-550
    • Andes, D.1    Diekema, D.J.2    Pfaller, M.A.3
  • 18
    • 54049088997 scopus 로고    scopus 로고
    • In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. Glabrata in a neutropenic murine candidiasis model
    • 18625768 10.1128/AAC.00478-08 1:CAS:528:DC%2BD1cXht1SrtbjI
    • Andes DR, Diekema DJ, Pfaller MA, et al. In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model. Antimicrob Agents Chemother. 2008;52:3497-503.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3497-3503
    • Andes, D.R.1    Diekema, D.J.2    Pfaller, M.A.3
  • 19
    • 0036272920 scopus 로고    scopus 로고
    • Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. And Crytococcus neoformans via time-kill methods
    • 12052624 10.1016/S0732-8893(02)00361-9 1:CAS:528:DC%2BD38XktFyhsrY%3D
    • Roling EE, Klepser ME, Wasson A, et al. Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods. Diagn Microbiol Infect Dis. 2002;43:13-7.
    • (2002) Diagn Microbiol Infect Dis , vol.43 , pp. 13-17
    • Roling, E.E.1    Klepser, M.E.2    Wasson, A.3
  • 20
    • 10744224705 scopus 로고    scopus 로고
    • Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States
    • 14506023 10.1128/AAC.47.10.3149-3154.2003 1:CAS:528:DC%2BD3sXnvVWmsbY%3D
    • Ostrosky-Zeichner L, Rex JH, Pappas PG, et al. Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States. Antimicrob Agents Chemother. 2003;47:3149-54.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3149-3154
    • Ostrosky-Zeichner, L.1    Rex, J.H.2    Pappas, P.G.3
  • 21
    • 3843088493 scopus 로고    scopus 로고
    • Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species
    • 15297486 10.1128/JCM.42.8.3475-3482.2004 1:CAS:528:DC%2BD2cXnt1Ogtr0%3D
    • Odds FC, Motyl M, Andrade R, et al. Interlaboratory comparison of results of susceptibility testing with caspofungin against Candida and Aspergillus species. J Clin Microbiol. 2004;42:3475-82.
    • (2004) J Clin Microbiol , vol.42 , pp. 3475-3482
    • Odds, F.C.1    Motyl, M.2    Andrade, R.3
  • 22
    • 33750577895 scopus 로고    scopus 로고
    • In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility
    • 16940061 10.1128/AAC.00538-06 1:CAS:528:DC%2BD28XhtFOktL7M
    • Cota J, Carden M, Graybill JR, et al. In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility. Antimicrob Agents Chemother. 2006;50:3926-8.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3926-3928
    • Cota, J.1    Carden, M.2    Graybill, J.R.3
  • 23
    • 34248397536 scopus 로고    scopus 로고
    • In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera
    • 17307976 10.1128/AAC.00105-07 1:CAS:528:DC%2BD2sXlt1yjsrg%3D An early in vitro study demonstrating normalization of echinocandin potency in the presence of serum and an assocation with in vivo outcomes
    • •Wiederhold NP, Najvar LK, Bocanegra R, et al. In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera. Antimicrob Agents Chemother. 2007;51:1616-20. An early in vitro study demonstrating normalization of echinocandin potency in the presence of serum and an assocation with in vivo outcomes.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1616-1620
    • Wiederhold, N.P.1    Najvar, L.K.2    Bocanegra, R.3
  • 24
    • 34250175817 scopus 로고    scopus 로고
    • Serum differentially alters the antifungal properties of echinocandin drugs
    • 17420211 10.1128/AAC.01536-06 1:CAS:528:DC%2BD2sXmtlKrt7s%3D A large in vitro and in vivo study of the influence of serum on the potency of the echinocandins against various Candida species. Aspergillus isolates were also evaluated in vitro
    • ••Paderu P, Garcia-Effron G, Balashov S, et al. Serum differentially alters the antifungal properties of echinocandin drugs. Antimicrob Agents Chemother. 2007;51:2253-6. A large in vitro and in vivo study of the influence of serum on the potency of the echinocandins against various Candida species. Aspergillus isolates were also evaluated in vitro.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2253-2256
    • Paderu, P.1    Garcia-Effron, G.2    Balashov, S.3
  • 25
    • 35848946410 scopus 로고    scopus 로고
    • Effects of serum on in vitro susceptibility testing of echinocandins
    • 17785512 10.1128/AAC.01589-06 1:CAS:528:DC%2BD2sXht1ygtLjP
    • Odabasi Z, Paetznick V, Rex JH, Ostrosky-Zeichner L. Effects of serum on in vitro susceptibility testing of echinocandins. Antimicrob Agents Chemother. 2007;51:4214-6.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 4214-4216
    • Odabasi, Z.1    Paetznick, V.2    Rex, J.H.3    Ostrosky-Zeichner, L.4
  • 26
    • 70349317373 scopus 로고    scopus 로고
    • Antifungal activity of micafungin in serum
    • 19687246 10.1128/AAC.01404-08 1:CAS:528:DC%2BD1MXht1KkurbF
    • Ishikawa J, Maeda T, Matsumura I, et al. Antifungal activity of micafungin in serum. Antimicrob Agents Chemother. 2009;53:4559-62.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 4559-4562
    • Ishikawa, J.1    Maeda, T.2    Matsumura, I.3
  • 27
    • 84857237557 scopus 로고    scopus 로고
    • Influence of serum on in vitro susceptibility testing of echinocandins for Candida parapsilosis and Candida guilliermondii
    • 21668525 1:CAS:528:DC%2BC38XlvFSjtro%3D
    • Saribas Z, Yurdakul P, Cetin-Hazirolan G, Arikan-Akdagli S. Influence of serum on in vitro susceptibility testing of echinocandins for Candida parapsilosis and Candida guilliermondii. Mycoses. 2012;55:156-60.
    • (2012) Mycoses , vol.55 , pp. 156-160
    • Saribas, Z.1    Yurdakul, P.2    Cetin-Hazirolan, G.3    Arikan-Akdagli, S.4
  • 28
    • 84865378162 scopus 로고    scopus 로고
    • In vitro and in vivo effects of echinocandins against Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis
    • 22635526 10.1093/jac/dks180 1:CAS:528:DC%2BC38Xht1egt7rI
    • Spreghini E, Orlando F, Tavanti A, et al. In vitro and in vivo effects of echinocandins against Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. J Antimicrob Chemother. 2012;67:2195-202.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2195-2202
    • Spreghini, E.1    Orlando, F.2    Tavanti, A.3
  • 29
    • 84863783265 scopus 로고    scopus 로고
    • Effect of 50 % human serum on the killing activity of micafungin against eight Candida species using time-kill methodology
    • 22726529 10.1016/j.diagmicrobio.2012.05.011 1:CAS:528: DC%2BC38XptVyhs7s%3D
    • Foldi R, Szilagyi J, Kardos G, et al. Effect of 50 % human serum on the killing activity of micafungin against eight Candida species using time-kill methodology. Diagn Microbiol Infect Dis. 2012;73:338-42.
    • (2012) Diagn Microbiol Infect Dis , vol.73 , pp. 338-342
    • Foldi, R.1    Szilagyi, J.2    Kardos, G.3
  • 30
    • 84859634534 scopus 로고    scopus 로고
    • Effect of protein binding on the activity of voriconazole alone or combined with anidulafungin against Aspergillus spp. Using a time-kill methodology
    • 22488542
    • Cafini F, Sevillano D, Alou L, et al. Effect of protein binding on the activity of voriconazole alone or combined with anidulafungin against Aspergillus spp. using a time-kill methodology. Rev Esp Quimioter. 2012;25:47-55.
    • (2012) Rev Esp Quimioter , vol.25 , pp. 47-55
    • Cafini, F.1    Sevillano, D.2    Alou, L.3
  • 31
    • 79955549399 scopus 로고    scopus 로고
    • Improved detection of Candida sp. Fks hot spot mutants by using the method of the CLSI M27-A3 document with the addition of bovine serum albumin
    • 21383097 10.1128/AAC.01350-10 1:CAS:528:DC%2BC3MXhsFClsLzK In vitro study demonstrating the influece of bovine serum albumin on echinocandin potency and the potential for identifying Candida isolates with acquired resistance to this antifungal class
    • • Garcia-Effron G, Park S, Perlin DS. Improved detection of Candida sp. fks hot spot mutants by using the method of the CLSI M27-A3 document with the addition of bovine serum albumin. Antimicrob Agents Chemother. 2011;55:2245-55. In vitro study demonstrating the influece of bovine serum albumin on echinocandin potency and the potential for identifying Candida isolates with acquired resistance to this antifungal class.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2245-2255
    • Garcia-Effron, G.1    Park, S.2    Perlin, D.S.3
  • 32
    • 0034425852 scopus 로고    scopus 로고
    • Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus
    • 11083631 10.1128/AAC.44.12.3302-3305.2000 1:CAS:528:DC%2BD3MXhs1Kitrk%3D
    • Chiller T, Farrokhshad K, Brummer E, Stevens DA. Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus. Antimicrob Agents Chemother. 2000;44:3302-5.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 3302-3305
    • Chiller, T.1    Farrokhshad, K.2    Brummer, E.3    Stevens, D.A.4
  • 33
    • 78649706279 scopus 로고    scopus 로고
    • The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery
    • 21119731 10.1038/nrd3287 1:CAS:528:DC%2BC3cXhsV2jurfI Excellent review of the influence of protein binding on drugs and the free drug hypothesis
    • •• Smith DA, Di L, Kerns EH. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat Rev Drug Discov. 2010;9:929-39. Excellent review of the influence of protein binding on drugs and the free drug hypothesis.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 929-939
    • Smith, D.A.1    Di, L.2    Kerns, E.H.3
  • 34
    • 73749084743 scopus 로고    scopus 로고
    • Fungal echinocandin resistance. Fungal genetics and biology
    • 19770064 10.1016/j.fgb.2009.09.003 1:CAS:528:DC%2BC3cXnsFWqtw%3D%3D
    • Walker LA, Gow NA, Munro CA. Fungal echinocandin resistance. Fungal genetics and biology. Fungal Genet Biol. 2010;47:117-26.
    • (2010) Fungal Genet Biol , vol.47 , pp. 117-126
    • Walker, L.A.1    Gow, N.A.2    Munro, C.A.3
  • 35
    • 77952648499 scopus 로고    scopus 로고
    • Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    • 20368396 10.1128/AAC.01711-09 1:CAS:528:DC%2BC3cXos1Ogs7Y%3D
    • Castanheira M, Woosley LN, Diekema DJ, et al. Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains. Antimicrob Agents Chemother. 2010;54:2655-9.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2655-2659
    • Castanheira, M.1    Woosley, L.N.2    Diekema, D.J.3
  • 36
    • 33744504444 scopus 로고    scopus 로고
    • Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1
    • 16723566 10.1128/AAC.01653-05 1:CAS:528:DC%2BD28XlsVOitbg%3D
    • Balashov SV, Park S, Perlin DS. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob Agents Chemother. 2006;50:2058-63.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2058-2063
    • Balashov, S.V.1    Park, S.2    Perlin, D.S.3
  • 37
    • 0030671386 scopus 로고    scopus 로고
    • Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors
    • 9371352 1:CAS:528:DyaK2sXntFKms7k%3D
    • Douglas CM, D'Ippolito JA, Shei GJ, et al. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother. 1997;41:2471-9.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2471-2479
    • Douglas, C.M.1    D'Ippolito, J.A.2    Shei, G.J.3
  • 38
    • 23044471740 scopus 로고    scopus 로고
    • Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. Isolates
    • 16048935 10.1128/AAC.49.8.3264-3273.2005 1:CAS:528:DC%2BD2MXntFChtb8%3D
    • Park S, Kelly R, Kahn JN, et al. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. Antimicrob Agents Chemother. 2005;49:3264-73.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3264-3273
    • Park, S.1    Kelly, R.2    Kahn, J.N.3
  • 39
    • 34248375952 scopus 로고    scopus 로고
    • Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase
    • 17325225 10.1128/AAC.00067-07
    • Kahn JN, Garcia-Effron G, Hsu MJ, et al. Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase. Antimicrob Agents Chemother. 2007;51:1876-8.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1876-1878
    • Kahn, J.N.1    Garcia-Effron, G.2    Hsu, M.J.3
  • 40
    • 44449153708 scopus 로고    scopus 로고
    • Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment
    • 18378714 10.1128/AAC.01568-07 1:CAS:528:DC%2BD1cXmvVaitbo%3D
    • Cleary JD, Garcia-Effron G, Chapman SW, Perlin DS. Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment. Antimicrob Agents Chemother. 2008;52:2263-5.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2263-2265
    • Cleary, J.D.1    Garcia-Effron, G.2    Chapman, S.W.3    Perlin, D.S.4
  • 41
    • 55849137651 scopus 로고    scopus 로고
    • Caspofungin-resistant C. Tropicalis breakthrough fungemia in high risk hematology patients
    • 18794386 10.1128/AAC.00802-08 1:CAS:528:DC%2BD1cXhtlCgs7fN
    • Garcia-Effron G, Kontoyiannis DP, Lewis RE, Perlin DS. Caspofungin-resistant C. tropicalis breakthrough fungemia in high risk hematology patients. Antimicrob Agents Chemother. 2008;52:4181-3.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4181-4183
    • Garcia-Effron, G.1    Kontoyiannis, D.P.2    Lewis, R.E.3    Perlin, D.S.4
  • 42
    • 46249106060 scopus 로고    scopus 로고
    • A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility
    • 18443110 10.1128/AAC.00262-08 1:CAS:528:DC%2BD1cXot1Oitrg%3D
    • Garcia-Effron G, Katiyar SK, Park S, et al. A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility. Antimicrob Agents Chemother. 2008;52:2305-12.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 2305-2312
    • Garcia-Effron, G.1    Katiyar, S.K.2    Park, S.3
  • 43
    • 84055199809 scopus 로고    scopus 로고
    • Antifungal drug resistance: Mechanisms, epidemiology, and consequences for treatment
    • 22196207 10.1016/j.amjmed.2011.11.001 1:CAS:528:DC%2BC3MXhs12hsbnM
    • Pfaller MA. Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am J Med. 2012;125:S3-S13.
    • (2012) Am J Med , vol.125
    • Pfaller, M.A.1
  • 44
    • 79955538785 scopus 로고    scopus 로고
    • Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria
    • 21353623 10.1016/j.drup.2011.01.004 1:CAS:528:DC%2BC3MXntlGktL8%3D
    • Pfaller MA, Diekema DJ, Andes D, et al. Clinical breakpoints for the echinocandins and Candida revisited: integration of molecular, clinical, and microbiological data to arrive at species-specific interpretive criteria. Drug Resist Updat. 2011;14:164-76.
    • (2011) Drug Resist Updat , vol.14 , pp. 164-176
    • Pfaller, M.A.1    Diekema, D.J.2    Andes, D.3
  • 45
    • 73949126140 scopus 로고    scopus 로고
    • Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp
    • 19923478 10.1128/JCM.01590-09 1:CAS:528:DC%2BC3cXhvFKqtLY%3D
    • Pfaller MA, Boyken L, Hollis RJ, et al. Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp. J Clin Microbiol. 2010;48:52-6.
    • (2010) J Clin Microbiol , vol.48 , pp. 52-56
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3
  • 46
    • 32644437364 scopus 로고    scopus 로고
    • Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values
    • 16643517 10.1111/j.1469-0691.2006.01377.x 1:CAS:528:DC%2BD28XlsFWjtr0%3D
    • Turnidge J, Kahlmeter G, Kronvall G. Statistical characterisation of bacterial wild-type MIC value distributions and the determination of epidemiological cut-off values. Clin Microbiol Infect. 2006;12:418-25.
    • (2006) Clin Microbiol Infect , vol.12 , pp. 418-425
    • Turnidge, J.1    Kahlmeter, G.2    Kronvall, G.3
  • 47
    • 73849119181 scopus 로고    scopus 로고
    • Echinocandin susceptibility testing of Candida species: Comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, disk diffusion, and agar dilution methods with RPMI and isosensitest media
    • 19884370 10.1128/AAC.01256-09 1:CAS:528:DC%2BC3cXht1ShsLc%3D An in vitro study comparing the CLSI and EUCAST antifungal susceptibility testing methods in the presence of albumin and the ability of each to detect acquired mechanisms of resistance
    • • Arendrup MC, Garcia-Effron G, Lass-Florl C, et al. Echinocandin susceptibility testing of Candida species: comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, disk diffusion, and agar dilution methods with RPMI and isosensitest media. Antimicrob Agents Chemother. 2010;54:426-39. An in vitro study comparing the CLSI and EUCAST antifungal susceptibility testing methods in the presence of albumin and the ability of each to detect acquired mechanisms of resistance.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 426-439
    • Arendrup, M.C.1    Garcia-Effron, G.2    Lass-Florl, C.3
  • 48
    • 0002753264 scopus 로고
    • The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms
    • 18871882 10.1084/jem.88.1.99 1:CAS:528:DyaH1cXjt1egsQ%3D%3D
    • Eagle H, Musselman AD. The rate of bactericidal action of penicillin in vitro as a function of its concentration, and its paradoxically reduced activity at high concentrations against certain organisms. J Exp Med. 1948;88:99-131.
    • (1948) J Exp Med , vol.88 , pp. 99-131
    • Eagle, H.1    Musselman, A.D.2
  • 49
    • 0036841154 scopus 로고    scopus 로고
    • In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies
    • 12384379 10.1128/AAC.46.11.3634-3636.2002 1:CAS:528:DC%2BD38Xot1yku7k%3D
    • Ramage G, VandeWalle K, Bachmann SP, et al. In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies. Antimicrob Agents Chemother. 2002;46:3634-6.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3634-3636
    • Ramage, G.1    Vandewalle, K.2    Bachmann, S.P.3
  • 50
    • 4344587092 scopus 로고    scopus 로고
    • Paradoxical effect of caspofungin: Reduced activity against Candida albicans at high drug concentrations
    • 15328104 10.1128/AAC.48.9.3407-3411.2004 1:CAS:528:DC%2BD2cXnsVehs74%3D
    • Stevens DA, Espiritu M, Parmar R. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations. Antimicrob Agents Chemother. 2004;48:3407-11.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3407-3411
    • Stevens, D.A.1    Espiritu, M.2    Parmar, R.3
  • 51
    • 37849008993 scopus 로고    scopus 로고
    • Comparative in vitro pharmacodynamics of caspofungin, micafungin, and anidulafungin against germinated and nongerminated Aspergillus conidia
    • 17938191 10.1128/AAC.00699-07 1:CAS:528:DC%2BD1cXkslensA%3D%3D
    • Antachopoulos C, Meletiadis J, Sein T, et al. Comparative in vitro pharmacodynamics of caspofungin, micafungin, and anidulafungin against germinated and nongerminated Aspergillus conidia. Antimicrob Agents Chemother. 2008;52:321-8.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 321-328
    • Antachopoulos, C.1    Meletiadis, J.2    Sein, T.3
  • 52
    • 22844431862 scopus 로고    scopus 로고
    • Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin
    • 16110824 10.1080/13693780400029023 1:CAS:528:DC%2BD2MXpsVaisbY%3D
    • Gardiner RE, Souteropoulos P, Park S, Perlin DS. Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin. Med Mycol. 2005;43 Suppl 1:S299-305.
    • (2005) Med Mycol , vol.43 , Issue.SUPPL. 1
    • Gardiner, R.E.1    Souteropoulos, P.2    Park, S.3    Perlin, D.S.4
  • 53
    • 35848948967 scopus 로고    scopus 로고
    • Eagle-like effect of caspofungin against Candida and Aspergillus spp.: Association with homeostatic mechanisms of cell wall integrity (abstract M-1682)
    • October 30 to November 2, Washington, DC
    • Wiederhold NP, Kontoyiannis DP, Prince RA, Lewis RE. Eagle-like effect of caspofungin against Candida and Aspergillus spp.: association with homeostatic mechanisms of cell wall integrity (abstract M-1682). Presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, October 30 to November 2, 2004, Washington, DC.
    • (2004) 44th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Wiederhold, N.P.1    Kontoyiannis, D.P.2    Prince, R.A.3    Lewis, R.E.4
  • 54
    • 79956329166 scopus 로고    scopus 로고
    • Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum
    • 21422223 10.1128/AAC.00999-10 1:CAS:528:DC%2BC3MXnt1KitLo%3D In vitro study demonstrating that the paradoxical effect observed at high echinocandin concentrations is no longer present with the addition of physiological concentrations of serum
    • • Shields RK, Nguyen MH, Du C, et al. Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum. Antimicrob Agents Chemother. 2011;55:2641-7. In vitro study demonstrating that the paradoxical effect observed at high echinocandin concentrations is no longer present with the addition of physiological concentrations of serum.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2641-2647
    • Shields, R.K.1    Nguyen, M.H.2    Du, C.3
  • 55
    • 0036093584 scopus 로고    scopus 로고
    • Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits
    • 12019101 10.1128/AAC.46.6.1857-1869.2002 1:CAS:528:DC%2BD38XktFCmsLg%3D
    • Petraitis V, Petraitiene R, Groll AH, et al. Comparative antifungal activities and plasma pharmacokinetics of micafungin (FK463) against disseminated candidiasis and invasive pulmonary aspergillosis in persistently neutropenic rabbits. Antimicrob Agents Chemother. 2002;46:1857-69.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1857-1869
    • Petraitis, V.1    Petraitiene, R.2    Groll, A.H.3
  • 56
    • 28844507822 scopus 로고    scopus 로고
    • Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis
    • 16304147 10.1128/AAC.49.12.4867-4875.2005 1:CAS:528:DC%2BD2MXhtlSqsr7O
    • Clemons KV, Espiritu M, Parmar R, Stevens DA. Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis. Antimicrob Agents Chemother. 2005;49:4867-75.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4867-4875
    • Clemons, K.V.1    Espiritu, M.2    Parmar, R.3    Stevens, D.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.