Periparturient dairy cows do not exhibit hepatic insulin resistance, yet adipose-specific insulin resistance occurs in cows prone to high weight loss

Journal of Dairy Science

Volumn 96, Issue 9, 2013, Pages 5656-5669

  Zachut, M ^a,b   Honig, H ^a   Striem, S ^c   Zick, Y ^c   Boura Halfon, S ^c   Moallem, U ^a  

^a VOLCANI CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Insulin receptor; Peripartum insulin resistance; Protein kinase B (Akt)

Indexed keywords

BOS;

INSULIN; INSULIN RECEPTOR; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE CARBOXYLASE;

ADIPOSE TISSUE; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CATTLE; ENZYMOLOGY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIVER; METABOLISM; PERINATAL PERIOD; PERIPARTUM INSULIN RESISTANCE; PHYSIOLOGY; PREGNANCY; PROTEIN KINASE B (AKT); REAL TIME POLYMERASE CHAIN REACTION; WEIGHT REDUCTION;

INSULIN RECEPTOR; PERIPARTUM INSULIN RESISTANCE; PROTEIN KINASE B (AKT);

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CATTLE; FEMALE; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LIVER; PERIPARTUM PERIOD; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PREGNANCY; PYRUVATE CARBOXYLASE; REAL-TIME POLYMERASE CHAIN REACTION; WEIGHT LOSS;

EID: 84882819641     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2012-6142     Document Type: Article

References (34)

1. Barthel A., Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am. J. Physiol. Endocrinol. Metab. 2003, 285:E685-E692.
2. Bauman D.E., Elliot J.M. Control of nutrient partitioning in lactating ruminants. Biochemistry of Lactation 1983, 437-468. Elsevier Science Publishers BV, Amsterdam, the Netherlands. T.B. Mepham (Ed.).
3. Bell A.W. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. J. Anim. Sci. 1995, 73:2804-2819.
4. Bell A.W., Bauman D.E. Adaptations of glucose metabolism during pregnancy and lactation. J. Mammary Gland Biol. Neoplasia 1997, 2:265-278.
5. Blondeau B., Garofano A., Czernichow P., Bréant B. Age-dependent inability of the endocrine pancreas to adapt to pregnancy: A long-term consequence of perinatal malnutrition in the rat. Endocrinology 1999, 140:4208-4213.
6. Bossaert P., Leroy J.L., De Vliegher S., Opsomer G. Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows. J. Dairy Sci. 2008, 91:3363-3371.
7. Boura-Halfon S., Zick Y. Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E581-E591.
8. Chagas L.M., Lucy M.C., Back P.J., Blache D., Lee J.M., Gore P.J., Sheahan A.J., Roche J.R. Insulin resistance in divergent strains of Holstein-Friesian dairy cows offered fresh pasture and increasing amounts of concentrate in early lactation. J. Dairy Sci. 2009, 92:216-222.
9. Graber M., Kohler S., Kaufmann T., Doherr M.G., Bruckmaier R.M., van Dorland H.A. A field study on characteristics and diversity of gene expression in the liver of dairy cows during the transition period. J. Dairy Sci. 2010, 93:5200-5215.
10. Gross J., van Dorland H.A., Schwarz F.J., Bruckmaier R.M. Endocrine changes and liver mRNA abundance of somatotropic axis and insulin system constituents during negative energy balance at different stages of lactation in dairy cows. J. Dairy Sci. 2011, 94:3484-3494.
11. Holtenius K., Agenäs S., Delavaud C., Chilliard Y. Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. J. Dairy Sci. 2003, 86:883-891.
12. Kahn C.R. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction. Metabolism 1978, 27:1893-1902.
13. Karpe F., Dickmann J.R., Frayn K.N. Fatty acids, obesity and insulin resistance: Time for a reevaluation. Diabetes 2011, 60:2441-2449.
14. Kerestes M., Faigl V., Kulcsár M., Balogh O., Földi J., Fébel H., Chilliard Y., Huszenicza G. Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis. Domest. Anim. Endocrinol. 2009, 37:250-261.
15. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
16. Lain K.Y., Catalano P.M. Factors that affect maternal insulin resistance and modify fetal growth and body composition. Metab. Syndr. Relat. Disord. 2006, 4:91-100.
17. Lisowski P., Pierzchała M., Gościk J., Pareek C.S., Zwierzchowski L. Evaluation of reference genes for studies of gene expression in the bovine liver, kidney, pituitary, and thyroid. J. Appl. Genet. 2008, 49:367-372.
18. Locher L.F., Meyer N., Weber E.M., Rehage J., Meyer U., Dänicke S., Huber K. Hormone-sensitive lipase protein expression and extent of phosphorylation in subcutaneous and retroperitoneal adipose tissues in the periparturient dairy cow. J. Dairy Sci. 2011, 94:4514-4523.
19. Lomax M.A., Baird G.D., Mallinson C.B., Symonds H.W. Differences between lactating and non-lactating dairy cows in concentration and secretion rate of insulin. Biochem. J. 1979, 180:281-289.
20. Meyer A.M., Reed J.J., Vonnahme K.A., Soto-Navarro S.A., Reynolds L.P., Ford S.P., Hess B.W., Caton J.S. Effects of stage of gestation and nutrient restriction during early to mid-gestation on maternal and fetal visceral organ mass and indices of jejunal growth and vascularity in beef cows. J. Anim. Sci. 2010, 88:2410-2424.
21. Nutrient Requirements of Dairy Cattle 1989, NRC, Natl. Acad. Sci., Washington, DC. 6th rev.
22. Opsomer G., Wensing T., Laevens H., Coryn M., de Kruif A. Insulin resistance: The link between metabolic disorders and cystic ovarian disease in high yielding dairy cows?. Anim. Reprod. Sci. 1999, 56:211-222.
23. Reynolds C.K., Aikman P.C., Lupoli B., Humphries D.J., Beever D.E. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. J. Dairy Sci. 2003, 86:1201-1217.
24. Ryan E.A., O'Sullivan M.J., Skyler J.S. Insulin action during pregnancy. Studies with the euglycemic clamp technique. Diabetes 1985, 34:380-389.
25. Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
26. Samuel V.T., Shulman G.I. Mechanisms for insulin resistance: Common threads and missing links. Cell 2012, 148:852-871.
27. Schoenberg K.M., Ehrhardt R.M., Overton T.R. Effects of plane of nutrition and feed deprivation on insulin responses in dairy cattle during late gestation. J. Dairy Sci. 2012, 95:670-682.
28. Sevillano J., de Castro J., Bocos C., Herrera E., Ramos M.P. Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy. Endocrinology 2007, 148:5933-5942.
29. Van Assche F.A., Aerts L., De Prins F. A morphological study of the endocrine pancreas in human pregnancy. Br. J. Obstet. Gynaecol. 1978, 85:818-820.
30. Van Assche F.A., Gepts W., Aerts L. Immunocytochemical study of the endocrine pancreas in the rat during normal pregnancy and during experimental diabetic pregnancy. Diabetologia 1980, 18:487-491.
31. White H.M., Koser S.L., Donkin S.S. Bovine pyruvate carboxylase 5' untranslated region variant expression during transition to lactation and feed restriction in dairy cows. J. Anim. Sci. 2011, 89:1881-1892.
32. Wilson L.A., Mills S.E., Finley E., Kilgour E., Buttery P.J., Vernon R.G. Effect of lactation on insulin signal transduction in sheep adipose tissue and skeletal muscle. J. Endocrinol. 1996, 151:469-480.
33. Zammit V.A. Role of insulin in hepatic fatty acid partitioning: Emerging concepts. Biochem. J. 1996, 314:1-14.
34. Zick Y. Insulin resistance: A phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 2001, 11:437-441.