A field study on characteristics and diversity of gene expression in the liver of dairy cows during the transition period

Journal of Dairy Science

Volumn 93, Issue 11, 2010, Pages 5200-5215

  Graber, M ^a,b   Kohler, S ^b   Kaufmann, T ^a   Doherr, M G ^a   Bruckmaier, R M ^a   van Dorland, H A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Swiss College of Agriculture   (Switzerland)

Author keywords

Dairy cow; Diversity; Liver; Metabolic adaptation

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA;

ANIMAL; ARTICLE; CATTLE; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETICS; LACTATION; LIVER; METABOLISM; PERIPARTUM PERIOD; PHYSIOLOGY; PREGNANCY;

ACETYL-COA CARBOXYLASE; ANIMALS; CATTLE; FEMALE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION STUDIES; GLYCEROLPHOSPHATE DEHYDROGENASE; LACTATION; LIVER; PERIPARTUM PERIOD; PREGNANCY; RNA, MESSENGER;

EID: 78649351334     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2010-3265     Document Type: Article

References (62)

1. Aeberhard K., Bruckmaier R.M., Blum J.W. Metabolic, enzymatic and endocrine status in high-yielding dairy cows - Part 2. J. Vet. Med. A Physiol. Pathol. Clin. Med. 2001, 48:111-127.
2. Arave C.W., Miller R.H., Lamb R.C. Genetic and environmental effects on serum cholesterol of dairy cattle of various ages. J. Dairy Sci. 1975, 58:423-427.
3. Baird G.D., van der Walts J.G., Bergman E.N. Whole-body metabolism of glucose and lactate in productive sheep and cows. Br. J. Nutr. 1983, 50:249-265.
4. Ballard F.J., Hanson R.W., Kronenfeld D.S., Raggi F. Metabolic changes in liver associated with spontaneous ketosis and starvation in cows. J. Nutr. 1968, 95:160-173.
5. Bauman D.E., Currie W.B. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis. J. Dairy Sci. 1980, 63:1514-1529.
6. Bell A.W. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. J. Anim. Sci. 1995, 73:2804-2819.
7. Bertics S.J., Grummer R.R., Cadorniga-Valino C., Stoddard E.E. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. J. Dairy Sci. 1992, 75:1914-1922.
8. Blum J.W., Kunz P.L., Leuenberger H., Gautschi K., Keller M. Thyroid hormones, blood plasma metabolites and haematological parameters in relationship to milk yield in dairy cows. Anim. Prod. 1983, 36:93-104.
9. Carriquiry M., Weber W.J., Fahrenkrug S.C., Crooker B.A. Hepatic gene expression in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation. J. Dairy Sci. 2009, 92:4889-4900.
10. Claycombe K.J., Jones B.H., Standridge M.K., Guo Y., Chun J.T., Taylor J.W. Insulin increases fatty acid synthase gene transcription in human adipocytes. Am. J. Physiol. 1998, 274:R1253-R1259.
11. Correa M.T., Erb H., Scarlett J. Path analysis for seven postpartum disorders of Holstein cows. J. Dairy Sci. 1993, 76:1305-1312.
12. Dann H.M., Douglas G.N., Overton T.R., Drackley J.K. Carnitine palmitoyltransferase activity in liver of periparturient dairy cows. J. Dairy Sci. 2000, 83(Suppl. 1):1056. (Abstr.).
13. Doepel L., Lapierre H., Kennelly J.J. Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. J. Dairy Sci. 2002, 85:2315-2334.
14. Drackley J.K. Biology of dairy cows during the transition period: the final frontier?. J. Dairy Sci. 1999, 82:2259-2273.
15. Drackley J.K., Heather M., Dann G., Douglas N., Janovick Guretzky N.A., Litherland N.B., Underwood J.P., Loor J.J. Physiological and pathological adaptations in dairy cows that may increase susceptibility to periparturient diseases and disorders. Ital. J. Anim. Sci. 2005, 4:323-344.
16. Duffield T.F., Kelton D.F., Leslie K.E., Lissemore K.D., Lumsden J.H. Use of test day milk fat and milk protein to detect subclinical ketosis in dairy cattle in Ontario. Can. Vet. J. 1997, 38:713-718.
17. Emery R.S., Liesman J.S., Herdt T.H. Metabolism of long chain fatty acids by ruminant liver. J. Nutr. 1992, 122:832-837.
18. Fleischmann M., Iynedjian P.B. Regulation of sterol regulatory-element binding protein 1 gene expression in liver: Role of insulin and protein kinase B/cAkt. Biochem. J. 2000, 349:13-17.
19. Greenfield R.B., Cecava M.J., Donkin S.S. Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation. J. Dairy Sci. 2000, 83:1228-1236.
20. Grum D.E., Drackley J.K., Younker R.S., LaCount D.W., Veenhuizen J.J. Nutrition during the dry period and hepatic lipid metabolism of periparturient dairy cows. J. Dairy Sci. 1996, 79:1850-1864.
21. Grummer R.R. Etiology of lipid-related metabolic disorders in periparturient dairy cows. J. Dairy Sci. 1993, 76:3882-3896.
22. Hachenberg S., Weinkauf C., Hiss S., Sauerwein H. Evaluation of classification modes potentially suitable to identify metabolic stress in healthy dairy cows during the peripartal period. J. Anim. Sci. 2007, 85:1923-1932.
23. Hammon H.M., Sauter S.N., Reist M., Zbinden Y., Philipona C., Morel C., Blum J.W. Dexamethasone and colostrums feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J. Anim. Sci. 2003, 81:3095-3106.
24. Hanson R.W., Ballard F.J. The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants. Biochem. J. 1967, 105:529-536.
25. Hartwell J.R., Cecava M.J., Donkin S.S. Rumen undegradable protein, rumen-protected choline and mRNA expression for enzymes in gluconeogenesis and ureagenesis in periparturient dairy cows. J. Dairy Sci. 2001, 84:490-497.
26. Ingvartsen K.L., Dewhurst R.J., Friggens N.C. On the relationship between lactational performance and health: Is it yield or metabolic imbalance that cause production diseases in dairy cattle? A position paper. Livest. Prod. Sci. 2003, 83:277-308.
27. Janovick N.A., Loor J.J., Dann H.M., Lewin H.A., Drackley J.K. Characterization of changes in hepatic expression of inflammation-associated genes during the peripartum period in multiparous Holstein cows using quantitative real time-PCR (RT-PCR). J. Dairy Sci. 2004, 87(Suppl. 1):460. (Abstr.).
28. Jorritsma R., Jorritsma H., Schukken Y.H., Wentink G.H. Relationship between fatty liver and fertility and some periparturient diseases in commercial dutch dairy herds. Theriogenology 2000, 54:1065-1074.
29. Jorritsma R., Jorritsma H., Schukkenc Y.H., Bartlettd P.C., Wensinga Th., Wentink G.H. Prevalence and indicators of post partum fatty infiltration of the liver in nine commercial dairy herds in The Netherlands. Livest. Prod. Sci. 2001, 68:53-60.
30. Kadarmideen H.N., Rohr P., Janss L.L.G. From genetical genomics to systems genetics: Potential applications in quantitative genomics and animal breeding. Mamm. Genome 2006, 17:548-564.
31. Kessel S., Stroehl M., Meyer H.H.D., Hiss S., Sauerwein H., Schwarz F.J., Bruckmaier R.M. Individual variability in physiological adaptation to metabolic stress during early lactation in dairy cows kept under equal conditions. J. Anim. Sci. 2008, 86:2903-2912.
32. Kim S., Sohnb I., Ahna J., Leea K., Leec Y.S., Lee Y.S. Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model. Gene 2004, 340:99-109.
33. Klucinski W., Miernik-Degorska E., Degorski A., Targowski A., Winnicka A. Effect of ketone bodies on the mitogenic response of bovine milk lymphocytes. Zentralbl. Veterinarmed. A 1988, 35:626-631.
34. Knight, C. H., D. E. Beever, and A. Sorensen. 1999. Metabolic loads to be expected from different genotypes under different systems. Metabolic Stress in Dairy Cows. Occasional Publication No. 24:27-36. Br. Soc. Anim. Sci., Edinburgh, UK.
35. Koundakjian P.P., Snoswell A.M. Ketone body and fatty acid metabolism in sheep tissues: 3-Hydroxybutyrate dehydrogenase, a cytoplasmic enzyme in sheep liver and kidney. Biochem. J. 1970, 119:49-57.
36. Loor J.J., Dann H.M., Everts R.E., Oliveira R., Green C.A., Janovick-Guretzky N.A., Litherland N., Rodriguez-Zas S.L., Lewin H.A., Drackley J.K. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol. Genomics 2006, 27:29-41.
37. Loor J.J., Dann H.M., Everts R.E., Oliveira R., Green C.A., Janovick Guretzky N.A., Rodriguez-Zas S.L., Lewin H.A., Drackley J.K. Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function. Physiol. Genomics 2005, 23:217-226.
38. Loor J.J., Everts R.E., Bionaz M., Dann H.M., Morin D.E., Oliveira R., Rodriguez-Zas S.L., Drackley J.K., Lewin H.A. Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiol. Genomics 2007, 32:105-116. doi:10.1152/physiolgenomics.00188.2007.
39. Lopes-Cardozo M., Mulder I., van Vugt F., Hermans P.G.C., van den Bergh S.G., Klazinga W., de Vries-Akkerman E. Aspects of ketogenesis: Control and mechanisms of ketone-body formation in isolated rat liver mitochondria. Mol. Cell. Biochem. 1975, 9:155-173.
40. Morris S.M. Regulation of enzymes of urea and arginine synthesis. Annu. Rev. Nutr. 1992, 12:81-101.
41. Murondoti A., Jorritsma R., Beynen A.C., Wensing T., Geelen M.J.H. Unrestricted feed intake during the dry period impairs the postpartum oxidation and synthesis of fatty acids in the liver of dairy cows. J. Dairy Sci. 2004, 87:672-679.
42. Nadal A., Marrero P.F., Haro D. Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: The role of the forkhead transcription factor FKHRL1. Biochem. J. 2002, 366:289-297.
43. Ness G.C., Chambers C.M. Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: The concept of cholesterol buffering capacity. Proc. Soc. Exp. Biol. Med. 2000, 224:8-19.
44. Nielsen N.C., Fleischer S. B-hydroxybutyrate dehydrogenase: Lack in ruminant liver mitochondria. Science 1969, 166:1017-1019.
45. Reynolds C.K., Aikman P.C., Lupoli B., Humphries D.J., Beever D.E. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. J. Dairy Sci. 2003, 86:1201-1217.
46. Reynolds C.K., Tyrrell H.F., Reynolds P.J. Effects of diet forage-to-concentrate ratio and intake on energy-metabolism in growing beef heifers-Net nutrient metabolism by visceral tissues. J. Nutr. 1991, 121:1004-1015.
47. Rukkwamsuk T., Wensing T., Geelen M.J.H. Effect of fatty liver on hepatic gluconeogenesis in periparturient dairy cows. J. Dairy Sci. 1999, 82:500-505.
48. SAS User's Guide: Statistics 2001, SAS Institute, SAS Inst. Inc., Cary, NC. Version 8 edition.
49. Sauerwein H., Heintges U., Hennies M., Selhorst T., Daxenberger A. Growth hormone induced alterations of leptin serum concentrations in dairys cows as measured by a novel enzyme immunoassay. Livest. Prod. Sci. 2004, 87:189-195.
50. Steffensen K.R., Gustafsson J. Putative metabolic effects of the liver X receptor (LXR). Diabetes 2004, 53(Suppl. 1):S36-S42.
51. Strang B.D., Bertics S.J., Grummer R.R., Armentano L.E. Effect of long-chain fatty acids on triglyceride accumulation, gluconeogenesis and ureagenesis in bovine hepatocytes. J. Dairy Sci. 1998, 81:728-739.
52. Suriyasathaporn W., Daemen A.J., Noordhuizen-Stassen E.N., Dieleman S.J., Nielen M., Schukken Y.H. Beta-hydroxybutyrate levels in peripheral blood and ketone bodies supplemented in culture media affect the in vitro chemotaxis of bovine leukocytes. Vet. Immunol. Immunopathol. 1999, 68:177-186.
53. Van den Top A.M., Geelen M.J.H., Wensing T., Wentink G.H., van't Klooster A.T.H., Beynen A.C. Higher postpartum hepatic triacylglycerol concentrations in dairy cows with free rather than restricted access to feed during the dry period are associated with lower activities of hepatic glycerolphosphate acyltransferase. J. Nutr. 1996, 126:76-85.
54. van Dorland H.A., Richter S., Morel I., Doherr M.G., Castro N., Bruckmaier R.M. Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows. J. Dairy Sci. 2009, 92:1924-1940.
55. Vicari T., van den Borne J.J.G.C., Gerrits W.J.J., Zbinden Y., Blum J.W. Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves. Domest. Anim. Endocrinol. 2008, 34:74-88.
56. Voet D., Voet J.G. Fundamentals of Biochemistry 2004, John Wiley and Sons, New York, NY. 3rd ed.
57. Xu C., Wang Z. Comparative proteomic analysis of livers from ketotic cows. Vet. Res. Commun. 2008, 32:263-273.
58. Zammit V.A. Regulation of hepatic fatty acid oxidation and ketogenesis. Proc. Nutr. Soc. 1983, 42:289-302.
59. Zammit V.A. Ketogenesis in the liver of ruminants-Adaptations to a challenge. J. Agric. Sci. (Camb.) 1990, 115:155-162.
60. Zammit V.A. Role of insulin in hepatic fatty acid partitioning: Emerging concepts. Biochem. J. 1996, 314:1-14.
61. Zelcer N., Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 2006, 116:607-614.
62. Zhu L.H., Armentano L.E., Bremmer D.R., Grummer R.R., Bertics S.J. Plasma concentration of urea, ammonia, glutamine around calving, and the relation of hepatic triglyceride, to plasma ammonia removal and blood acid-base balance. J. Dairy Sci. 2000, 83:734-740.