Alcoholic liver disease patients treated with S-adenosyl-l-methionine: An in-depth look at liver morphologic data comparing pre and post treatment liver biopsies

Experimental and Molecular Pathology

Volumn 95, Issue 2, 2013, Pages 187-191

  Le, Mary D ^a   Enbom, Elena ^a   Traum, Peter K ^a   Medici, Valentina ^b   Halsted, Charles H ^b   French, Samuel W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcoholic liver disease; Liver biopsies; S adenosyl l methionine; Smooth muscle actin

Indexed keywords

PLACEBO; S ADENOSYLMETHIONINE; SMOOTH MUSCLE ACTIN;

ALCOHOL LIVER DISEASE; APOPTOSIS; ARTICLE; CELL GRANULE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FATTY LIVER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KUPFFER CELL; LIVER BIOPSY; LIVER FIBROSIS; LIVER NECROSIS; LYMPHOCYTE; MALLORY BODY; METAPLASIA; MORPHOLOGY; NEUTROPHIL; NICK END LABELING; PROTEIN EXPRESSION; QUANTITATIVE STUDY; STAINING; STELLATE CELL;

ALCOHOLIC LIVER DISEASE; LIVER BIOPSIES; S-ADENOSYL-L-METHIONINE; SMOOTH MUSCLE ACTIN;

ACTINS; BIOPSY; HUMANS; LIVER DISEASES, ALCOHOLIC; MUSCLE, SMOOTH; S-ADENOSYLMETHIONINE;

EID: 84882807358     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2013.07.003     Document Type: Article

References (11)

1. Akpolat N., et al. The value of alpha-SMA in the evaluation of hepatic fibrosis severity in hepatitis B infection and cirrhosis development: a histopathological and immunohistochemical study. Histopathology 2005, 47:276-280.
2. Cederbaum A.I. Hepatoprotective effects of S-adenosyl-l-methionine against alcohol- and cytochrome P450 2E1-induced liver injury. World Journal of Gastroenterology 2010, 16:1366-1376.
3. Esfandiari F., et al. S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate deficient diet. Alcoholism: Clinical and Experimental Research 2007, 31:1231-1239.
4. French S.W., et al. VA cooperative study group 119. Seminars in Liver Disease 1993, 13:154-169.
5. Gong Z., et al. Effects of S-adenosylmethionine on liver methionine metabolism and steatosis with ethanol-induced liver injury in rats. Hepatology International 2008, 2:346-352.
6. Lau D.T., et al. Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis. Journal of Hepatology 2007, 42:273-281.
7. Medici V., et al. S-adenosyl-l-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcoholism, Clinical and Experimental Research 2011, 35:1960-1965.
8. O'Connor P.G., Schottenfeld R.S. Patients with alcohol problems. The New England Journal of Medicine 1998, 338:592-602.
9. Powell C.L., et al. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological Sciences 2010, 115:131-139.
10. Purohit V., et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. American Journal of Clinical Nutrition 2007, 86:14-24.
11. Villanueva J.A., et al. S-adenosyl-l-methionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcoholism, Clinical and Experimental Research 2007, 31:1934-1943.