Effects of decreased vitamin D and accumulated uremic toxin on human CYP3A4 activity in patients with end-stage renal disease

Toxins

Volumn 5, Issue 8, 2013, Pages 1475-1485

  Tsujimoto, Masayuki ^a   Nagano, Yui ^a   Hosoda, Satomi ^a   Shiraishi, Asuka ^a   Miyoshi, Ayaka ^a   Hiraoka, Shima ^a   Furukubo, Taku ^b   Izumi, Satoshi ^b   Yamakawa, Tomoyuki ^b   Minegaki, Tetsuya ^a   Nishiguchi, Kohshi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY   (Japan)

Author keywords

1,25 dihydroxyvitamin D; CYP3A4; End stage renal disease; Uremic toxins; Vitamin D receptor (VDR)

Indexed keywords

3 (3 CARBOXY 4 METHYL 5 PROPYL 2 FURYL)PROPIONIC ACID; CALCITRIOL; CYTOCHROME P450 3A4; HIPPURIC ACID; INDICAN; INDOLEACETIC ACID; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROPIONIC ACID; UNCLASSIFIED DRUG; UREMIC TOXIN;

ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYP24A1 GENE; CYP3A4 GENE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; KIDNEY FAILURE; LIVER CLEARANCE; LIVER MICROSOME; MDR1 GENE; PROTEIN EXPRESSION; STEROID HYDROXYLATION;

EID: 84882755856     PISSN: 20726651     EISSN: None     Source Type: Journal    
DOI: 10.3390/toxins5081475     Document Type: Article

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