A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 34, 2013, Pages 13815-13820

  Christensen, Quin H ^a   Grove, Tyler L ^b   Booker, Squire J ^b   Greenberg, E Peter ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Bacterial communication; Cell cell signaling; Enzyme inhibitors

Indexed keywords

ACYLTRANSFERASE INHIBITOR; BACTERIAL PROTEIN; BMAI1 PROTEIN; N ACYLHOMOSERINE LACTONE; N ACYLHOMOSERINE LACTONE SYNTHASE; N ACYLHOMOSERINE LACTONE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BURKHOLDERIA MALLEI; CATALYSIS; CELL ASSAY; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING; SIGNAL TRANSDUCTION; YERSINIA PESTIS;

BACTERIAL COMMUNICATION; CELL-CELL SIGNALING; ENZYME INHIBITORS;

ACYL-BUTYROLACTONES; ENZYME INHIBITORS; ESCHERICHIA COLI; FLUORESCENCE; GENE EXPRESSION REGULATION, BACTERIAL; HIGH-THROUGHPUT SCREENING ASSAYS; INHIBITORY CONCENTRATION 50; KINETICS; LIGASES; MOLECULAR STRUCTURE; OXAZINES; PROTEOBACTERIA; QUORUM SENSING;

EID: 84882751330     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313098110     Document Type: Article

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