Polymyxin-B endotoxin removal device: Making the point on mechanisms of action, clinical effectiveness and possible future applications: Review

Infectious Disorders - Drug Targets

Volumn 13, Issue 2, 2013, Pages 128-132

  Ruberto, Franco ^a   Ianni, S ^a   Babetto, C ^a   Magnanimi, E ^a   Ferretti, G ^a   Novelli, G ^a   Pugliese, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Endotoxins; Gram negative bacteria; Gram negative sepsis; Polymyxin B; Toraymyxin

Indexed keywords

CD14 ANTIGEN; LIPOPOLYSACCHARIDE; POLYMYXIN B; TOLL LIKE RECEPTOR 4; ANTIINFECTIVE AGENT; ENDOTOXIN;

ABDOMINAL INFECTION; ENDOTOXIN REMOVAL DEVICE; HEMOPERFUSION; HUMAN; MEDICAL DEVICE; NONHUMAN; PATHOGENESIS; REVIEW; SEPTIC SHOCK; APHERESIS; BACTEREMIA; BLOOD; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PROCEDURES;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BLOOD COMPONENT REMOVAL; ENDOTOXINS; GRAM-NEGATIVE BACTERIA; HUMANS; POLYMYXIN B;

EID: 84882744970     PISSN: 18715265     EISSN: 18755852     Source Type: Journal    
DOI: 10.2174/18715265113139990025     Document Type: Review

References (25)

1. Moore, L.J.; Moore, F.A. Epidemiology of sepsis in surgical patients. Surg. Clin. North. Am., 2012, 92(6), 1425-43. doi: 10.1016/j.suc.2012.08.009.
2. Beutler, B., Rietschel, E.T. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol., 2003, 3(2),169-176.
3. Opal, S.M.; Glück, T. Endotoxin as a drug target. Crit. Care Med., 2003, 31, S57-64.
4. Reinhart, K.; Karzai, W. Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned. Crit. Care Med., 2001, 29, S121-125.
5. Marshall, J.C.; Foster, D. Vincent, J.L.; Cook, D.J.; Cohen, J.; Dellinger, R.P.; Opal, S.; Abraham, E.; Brett, S.J.; Smith, T.; Mehta, S.; Derzko, A.; Romaschin, A.; MEDIC study. Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J. Infect. Dis., 2004, 190(3), 527-534.
6. Bhor, V.M.; Thomas, C.J.; Surolia, N.; Surolia A. Polymyxin B: an ode to an old antidote for endotoxic shock. Mol Biosyst. 2005, 1(3), 213-222.
7. Vesentini, S.; Soncini, M.; Zaupa, A.; Silvestri, V.; Fiore, G.B.; Redaelli, A. Multi-scale analysis of the toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins. Int. J. Artif Organs. 2006, 29(2), 239-250.
8. Kodama, M.; Hanasawa, K.; Tani, T. New therapeutic method against septic shock--removal of endotoxin using extracorporeal circulation. Adv. Exp. Med. Biol., 1990, 256, 653-664.
9. Shoji, H. Extracorporeal endotoxin removal for the treatment of sepsis: endotoxin adsorption cartridge (Toraymyxin). Ther. Apher. Dial., 2003, 7(1), 108-114.
10. Shoji, H.; Tani, T.; Hanasawa, K.; Kodama, M. Extracorporeal endotoxin removal by polymyxin B immobilized fiber cartridge: designing and antiendotoxin efficacy in the clinical application. Ther. Apher., 1998, 2(1), 3-12.
11. Tani, T.; Shoji, H.; Guadagni, G.; Perego, A. Extracorporeal removal of endotoxin: the polymyxin B-immobilized fiber cartridge. Contrib. Nephrol., 2010, 167, 35-44.
12. Fiore, B.; Soncini, M.; Vesentini, S.; Penati, A.; Visconti, G.; Redaelli, A. Multi-scale analysis of the toraymyxin adsorption cartridge. Part II: computational fluid-dynamic study. Int. J. Artif. Organs., 2006, 29(2), 251-260.
13. Nishibori, M.; Takahashi, H.K.; Katayama, H.; Mori, S.; Saito, S.; Iwagaki, H.; Tanaka, N.; Morita, K.; Ohtsuka, A. Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column. Acta, Med. Okayama., 2009, 63(1), 65-69.
14. Abe, S.; Seo, Y.; Hayashi, H.; Matsuda, K.; Usuki, J.; Azuma, A.; Kudoh, S.; Gemma, A. Neutrophil adsorption by polymyxin Bimmobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study. Blood Purif., 2010, 29(4), 321-326.
15. Mitak, C.; Tomita, M. Polymyxin B-immobilized fiber column hemoperfusion therapy for septic shock. Shock., 2011, 36(4), 332-338.
16. Assenzio, B.; Pasero, D.; Romanazzi, G.M.; Pacitti, A.; Lanfranco, G.; Puntorieri, V.; Martin, E.L.; Mascia, L.; Monti, G.; Casella, G.; Segoloni, G.P.; Camussi, G.; Ranieri, V.M. Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors. Intensive Care Med., 2008, 34(9), 1638-1645.
17. Vincent, J.L.; Laterre, P.F.; Cohen, J.; Burchardi, H.; Bruining, H.; Lerma, F.A.; Wittebole, X.; De Backer, D.; Brett, S.; Marzo, D.; Nakamura, H.; John, S. A pilot-controlled study of a polymyxin Bimmobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock. 2005, 23(5), 400-405.
18. Cruz, D.N.; Perazella, M.A.; Bellomo, R.; de Cal, M.; Polanco, N.; Corradi, V.; Lentini, P.; Nalesso, F.; Ueno, T.; Ranieri, V.M.; Ronco, C. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit. Care., 2007, 11(2), R47.
19. Cruz, D.N.; Antonelli, M.; Fumagalli, R.; Foltran, F.; Brienza, N.; Donati, A.; Malcangi, V.; Petrini, F.; Volta, G.; Bobbio Pallavicini, F.M.; Rottoli, F., Giunta F, Ronco C. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA. 2009, 301(23), 2445-2452.
20. Vincent, J.L. Polymyxin B hemoperfusion and mortality in abdominal septic shock. JAMA. 2009, 302(18), 1968, author reply 1969-1970.
21. Berto, P.; Ronco, C.; Cruz, D.; Melotti, R.M.; Antonelli, M. Costeffectiveness analysis of polymyxin-B immobilized fiber column and conventional medical therapy in the management of abdominal septic shock in Italy. Blood Purif., 2011, 32(4), 331-340.
22. Businskas, A.; Peeler, A. Spectral announces results of first interim analysis by Data Safety and Monitoring Board. Spectral Diagnostics Inc. Toronto, Canada: February 4, 2013. http://www.spectraldx.com/press/rls-02.04.13.pdf.
23. Murakami, M.; Miyauchi, Y.; Nishida, M.; Okada, H.; Hamano, K. Direct hemoperfusion using polymyxin-B immobilized fiber for septic shock after cardiac surgery. Circ. J., 2009, 73(4), 658-661.
24. Ruberto, F.; Pugliese, F.; D'Alio, A.; Martelli, S.; Bruno, K.; Marcellino, V.; Summonti, D.; Celli, P.; Perrella, S.; Cappannoli, A.; Pietropaoli, C.; Tosi, A.; Diana, B.; Novelli, G.; Rossi, M.; Ginanni-Corradini, S.; Ferretti, G.; Berloco, P.B.; Pietropaoli, P. Clinical effects of direct hemoperfusion using a polymyxin-B immobilized column in solid organ transplanted patients with signs of severe sepsis and septic shock. A pilot study. Int. J. Artif. Organs., 2007, 30(10), 915-922
25. Novelli, G.; Morabito, V.; Ferretti, G.; Poli, L.; Novelli, S.; Ruberto, F.; Pugliese, F.; Mennini, G.; Rossi, M.; Berloco, P.B. Safety of polymyxin-B-based hemoperfusion in kidney and liver transplant recipients. Transplant Proc., 2012, 44(7), 1966-1972.