Multi-scale analysis of the Toraymyxin adsorption cartridge part II: Computational fluid-dynamic study

International Journal of Artificial Organs

Volumn 29, Issue 2, 2006, Pages 251-260

  Fiore, Gianfranco B ^a   Soncini, M ^a   Vesentini, S ^a   Penati, A ^a   Visconti, G ^a   Redaelli, A ^a  

^a POLITECNICO DI MILANO   (Italy)

Author keywords

Computational fluid dynamics; Endotoxins; Multi scale modeling; Polymyxin B; Sepsis

Indexed keywords

MOLECULES; POROUS MATERIALS; SHEAR STRESS; SORBENTS; SORPTION; STATISTICS;

DYNAMIC STUDIES; ENDOTOXIN; ENDOTOXIN REMOVAL; MACROSCALES; MULTI SCALE ANALYSIS; MULTISCALE MODELING; POLYMYXIN B; SEPSIS; WALL SHEAR STRESS; WALL-SHEAR STRESS;

COMPUTATIONAL FLUID DYNAMICS;

ENDOTOXIN; POLYMYXIN B;

ADSORPTION; ARTICLE; BLOOD FLOW VELOCITY; BLOOD FLOWMETRY; CHEMICAL BOND; COMPUTER PROGRAM; CONTROLLED STUDY; FILTER; GEOMETRY; HEMODIALYSIS; HEMODYNAMICS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR INTERACTION; SEPSIS; SHEAR STRESS;

EID: 33645819996     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139880602900211     Document Type: Article

References (24)

1. Bone RC. Gram-negative sepsis: A dilemma of modern medicine. Clin Microbiol Rev 1993; 6: 57-68.
2. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr. Recombinant human protein C worldwide evaluation in severe sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
3. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time? Crit Care Med 1998; 26: 2078-86.
4. Balk RA. Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock. Crit Care Clin 2000; 16: 337-52.
5. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348: 1546-54.
6. Murphy SL. Deaths: Final data for 1998. Natl Vital Stat Rep 2000; 48: 1-105.
7. Opal SM, Gluck T. Endotoxin as a drug target. Crit Care Med 2003; 31 (suppl): S57-64.
8. Palmer JD, Rifkind D. Neutralization of the hemodynamic effects of endotoxin by polymyxin B. Surg Gynecol Obstet 1974; 138: 755-9.
9. From AH, Fong JS, Good RA. Polymyxin B sulfate modification of bacterial endotoxin: Effects on the development of endotoxin shock in dogs. Infect Immun 1979; 23: 660-4.
10. Baldwin G, Alpert G, Caputo GL, Baskin M, Parsonnet J, Gillis ZA, Thompson C, Siber GR, Fleisher GR. Effect of polymyxin B on experimental shock from meningococcal and Escherichia coli endotoxins. J Infect Dis 1991; 164: 542-9.
11. Cooperstock MS. Inactivation of endotoxin by polymyxin B. Antimicrob Agents Chemother 1974; 6: 422-5.
12. Danner RL, Joiner KA, Rubin M, Patterson WH, Johnson N, Ayers KM, Parrillo JE. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother 1989; 33: 1428-34.
13. Wheeler AP. Bacterial peritonitis: Innovative experimental treatment. Crit Care Med 1999; 27: 1055-6.
14. Suzuki H, Nemoto H, Nakamoto H, Okada H, Sugahara S, Kanno Y, Moriwaki K. Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure. Ther Apher 2002; 6: 234-40.
15. Shoji H. Extracorporeal endotoxin removal for the treatment of sepsis: Endotoxin adsorbtion cartridge (Toraymyxin). Ther Apher Dial 2003; 7: 108-14.
16. Kushi H, Miki T, Okamaoto K, Nakahara J, Saito T, Tanjoh K. Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. Crit Care 2005; 9: R653-61.
17. Nakamura T, Matsuda T, Suzuki Y, Shoji H, Koide H. Polymyxin B-immobilized fiber hemoperfusion in patients with sepsis. Dial Transplant 2003; 32: 602-7.
18. Nemoto H, Nakamoto H, Okada H, Sugahara S, Moriwaki K, Arai M, Kanno Y, Suzuki H. Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif 2001; 19, 361-9.
19. Vincent JL, Laterre PF, Cohen J, Burchardi H, Bruining H, Lerma FA, Wittebole X, De Backer D, Brett S, Marzo D, Nakamura H, John S. A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 2005; 23: 400-5.
20. Wells R. Syndromes of hyperviscosity. N Engl J Med 1970; 283: 183-6.
21. Fiore GB, Redaelli A, Guadagni G, Inzoli F, Fumero R. Development of a new disposable pulsatile pump for cardiopulmonary bypass: CFD design and in vitro tests. ASAIO J 2002; 48: 260-7.
22. Ronco C, Brendolan A, Scabardi M, Ronco F, Nakamura H. Blood flow distribution in a polymyxin coated fibrous bed for endotoxin removal. Effect of a new blood path design. Int J Artif Organs 2001; 24: 167-72.
23. Pennati G, Fiore GB, Migliavacca F, Lagana K, Dubini G, Fumero R. In vitro steady-flow analysis of systemic-to-pulmonary shunt haemodynamics. J Biomech 2001; 34: 23-30.
24. Wang NL, Keller KH. Augmented transport of extracellular solutes in concentrated erythrocyte suspensions in Couette flow. J Colloid Interface Sci 1985; 103: 210-25.