Antimicrobial photodynamic therapy to kill Gram-negative bacteria

Recent Patents on Anti-Infective Drug Discovery

Volumn 8, Issue 2, 2013, Pages 108-120

  Sperandio, Felipe F ^a,b,c,d   Huang, Ying Ying ^a,b,e   Hamblin, Michael R ^a,b,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d MINISTRY OF EDUCATION OF BRAZIL   (Brazil)

^e GUANGXI MEDICAL UNIVERSITY   (China)

^f HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Antimicrobial photodynamic therapy; Gram negative bacteria

Indexed keywords

BACTERIOCHLORIN; BACTERIOCHLOROPHYLL; CHLOROPHYLL; CLINDAMYCIN; FOOD DYE; FULLERENE DERIVATIVE; FUSIDIC ACID; LINCOMYCIN; MACROLIDE; METHYLENE BLUE; NANOPARTICLE; NOVOBIOCIN; PHOTOSENSITIZING AGENT; PHTHALOCYANINE; PHTHALOCYANINE DERIVATIVE; PORPHYRIN; RIFAMYCIN; TETRAPYRROLE DERIVATIVE; TOLONIUM CHLORIDE; XANTHENE DERIVATIVE;

ACTINOMYCES VISCOSUS; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; BACTERIAL CELL; BACTERIAL CLEARANCE; BACTERIAL OUTER MEMBRANE; DRUG MECHANISM; DRUG STRUCTURE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; HUMAN; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PORPHYROMONAS GINGIVALIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; STREPTOCOCCUS PYOGENES;

ANIMALS; ANTI-BACTERIAL AGENTS; DISEASE MODELS, ANIMAL; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; PATENTS AS TOPIC; PERMEABILITY; PHOTOCHEMOTHERAPY; PORPHYRINS;

EID: 84882739841     PISSN: 1574891X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574891X113089990012     Document Type: Review

References (119)

1. Fotinos N, Convert M, Piffaretti JC, Gurny R, Lange N. Effects on gram-negative and gram-positive bacteria mediated by 5-aminolevulinic Acid and 5-aminolevulinic acid derivatives. Antimicrob Agents Chemother 2008; 52:1366-73.
2. Nordmann P, Poirel L, Toleman MA, Walsh TR. Does broadspectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gramnegative bacteria? J Antimicrob Chemother 2011; 66: 689-92.
3. Wainwright M. Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother 1998; 42:13-28.
4. Zolfaghari PS, Packer S, Singer M, Nair SP, Bennett J, Street C, et al. In vivo killing of Staphylococcus aureus using a lightactivated antimicrobial agent. BMC Microbiol 2009; 9: 27.
5. Zeina B, Greenman J, Purcell WM, Das B. Killing of cutaneous microbial species by photodynamic therapy. Br J Dermatol. 2001; 144: 274-8.
6. Dai T, Huang YY, Hamblin MR. Photodynamic therapy for localized infections--state of the art. Photodiagnosis Photodyn Ther 2009; 6: 170-88.
7. Jori G, Fabris C, Soncin M, Ferro S, Coppellotti O, Dei D, et al. Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications. Lasers Surg Med. 2006; 38: 468-81.
8. Wilson M. Bactericidal effect of laser light and its potential use in the treatment of plaque-related diseases. Int Dent J 1994; 44: 181-9.
9. Wilson M. Photolysis of oral bacteria and its potential use in the treatment of caries and periodontal disease. J Appl Bacteriol 1993;75: 299-306.
10. Sperandio FF, Marotti J, Aranha AC, Eduardo Cde P. Photodynamic therapy for the treatment of recurrent herpes labialis: preliminary results. Gen Dent 2009; 57: 415-9.
11. Marotti J, Sperandio FF, Fregnani ER, Aranha AC, de Freitas PM, Eduardo Cde P. High-intensity laser and photodynamic therapy as a treatment for recurrent herpes labialis. Photomed Laser Surg. 2010; 28: 439-44.
12. Sperandio FF, Simoes A, Aranha AC, Correa L, Orsini Machado de Sousa SC. Photodynamic therapy mediated by methylene blue dye in wound healing. Photomed Laser Surg 2010; 28: 581-7.
13. Choudhary S, Nouri K, Elsaie ML. Photodynamic therapy in dermatology: a review. Lasers Med Sci 2009; 24: 971-80.
14. Sharma SK, Chiang LY, Hamblin MR. Photodynamic therapy with fullerenes in vivo: Reality or a dream? Nanomedicine (Lond). 2011; 6: 1813-25.
15. Castano AP DT, Hamblin MR. Mechanisms in photodynamic therapy: Part one-photosensitizers, photochemistry and cellular localization. Photodiagn Photodyn Ther 2004;1: 279-93.
16. Soncin M, Fabris C, Busetti A, Dei D, Nistri D, Roncucci G, et al. Approaches to selectivity in the Zn(II)-phthalocyaninephotosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochem Photobiol Sci 2002; 1: 815-9.
17. Hamblin MR, Dai T. Can surgical site infections be treated by photodynamic therapy? Photodiagnosis Photodyn Ther. 2010; 7:134-6.
18. Malik Z, Ladan H, Nitzan Y. Photodynamic inactivation of Gramnegative bacteria: Problems and possible solutions. J Photochem Photobiol B 1992; 14: 262-6.
19. Bourre L, Giuntini F, Eggleston IM, Mosse CA, Macrobert AJ, Wilson M. Effective photoinactivation of Gram-positive and Gram negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate. Photochem Photobiol Sci 2010; 9:1613-20.
20. Lambert PA. Cellular impermeability and uptake of biocides and antibiotics in gram-positive bacteria and mycobacteria. Symp Ser Soc Appl Microbiol 2002: 46S-54S.
21. Nikaido H, Vaara M. Molecular basis of bacterial outer membrane permeability. Microbiol Rev 1985; 49: 1-32.
22. Bertoloni G, Rossi F, Valduga G, Jori G, Ali H, van Lier JE. Photosensitizing activity of water-and lipid-soluble phthalocyanines on prokaryotic and eukaryotic microbial cells. Microbios 1992; 71: 33-46.
23. Hancock RE. Alterations in outer membrane permeability. Annu Rev Microbiol 1984; 38: 237-64.
24. Bertoloni G, Rossi F, Valduga G, Jori G, van Lier J. Photosensitizing activity of water-and lipid-soluble phthalocyanines on Escherichia coli. FEMS Microbiol Lett 1990; 59: 149-55.
25. Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, et al. Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria. J Antimicrob Chemother. 2002; 49: 941-51.
26. Tegos GP, Anbe M, Yang C, Demidova TN, Satti M, Mroz P, et al. Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother. 2006; 50:1402-10.
27. Nitzan Y, Gutterman M, Malik Z, Ehrenberg B. Inactivation of gram-negative bacteria by photosensitized porphyrins. Photochem Photobiol 1992; 55: 89-96.
28. Malik Z. GS, Nitzan Y. Effects of photoactivated hematoporphyrin derivative on bacteria and antibiotic resistance. Microbios Lett 1982; 21: 103-12.
29. Ehrenberg B, Malik Z, Nitzan Y. Fluorescence spectral changes of hematoporphyrin derivative upon binding to lipid vesicles, Staphylococcus aureus and Escherichia coli cells. Photochem Photobiol 1985; 41: 429-35.
30. Malik Z, Hanania J, Nitzan Y. Bactericidal effects of photoactivated porphyrins--an alternative approach to antimicrobial drugs. J Photochem Photobiol B 1990; 5: 281-93.
31. Nitzan Y, Gozhansky S, Malik Z. Effect of photoactivated hematoporphyrin derivative on the viability of Staphylococcus aureus. Curr Microbiol 1983; 8: 279-84.
32. Venezio FR, DiVincenzo C, Sherman R, Reichman M, Origitano TC, Thompson K, et al. Bactericidal effects of photoradiation therapy with hematoporphyrin derivative. J Infect Dis. 1985; 151: 166-9.
33. Nitzan Y, B. Shainberg and Z. Malik. Photodynamic effects of deuteroporphyrin on Gram positive bacteria. Curr Microbiol 1987;15: 251-8.
34. Bertoloni G, Salvato B, Dall'Acqua M, Vazzoler M, Jori G. Hematoporphyrin-sensitized photoinactivation of Streptococcus faecalis. Photochem Photobiol 1984; 39: 811-6.
35. Boye E, Moan J. The photodynamic effect of hematoporphyrin on DNA. Photochem Photobiol 1980; 31: 223-8.
36. Vaara M, Vaara T. Polycations sensitize enteric bacteria to antibiotics. Antimicrob Agents Chemother 1983; 24: 107-13.
37. Vaara M, Vaara T. Polycations as outer membrane-disorganizing agents. Antimicrob Agents Chemother 1983; 24: 114-22.
38. Boye EaJM. The photodynamic effect of hematoporphyrin on DNA. Phorochem Photobiol 1980;31.
39. Nir U, Ladan H, Malik Z, Nitzan Y. In vivo effects of porphyrins on bacterial DNA. J Photochem Photobiol B 1991; 11: 295-306.
40. Storm DR, Rosenthal KS, Swanson PE. Polymyxin and related peptide antibiotics. Annu Rev Biochem 1977; 46:723-63.
41. Leive L. The barrier function of the gram-negative envelope. Ann NY Acad Sci 1974; 235:109-29.
42. Biel, M.A. Apparatus and method of photodynamic eradication of organisms utilizing pyrrolnitrin. US6623513 (2003).
43. Malik Z, Ladan H, Nitzan Y, Ehrenberg B. The bactericidal activity of a deuteroporphyrin-hemin mixture on gram-positive bacteria. A microbiological and spectroscopic study. J Photochem Photobiol B. 1990; 6: 419-30.
44. Groisman EA. How bacteria resist killing by host-defense peptides. Trends Microbiol 1994; 2: 444-9.
45. Vaara M. Agents that increase the permeability of the outer membrane. Microbiol Rev 1992; 56: 395-411.
46. Minnock A, Vernon DI, Schofield J, Griffiths J, Parish JH, Brown ST. Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria. J Photochem Photobiol B 1996; 32: 159-64.
47. Minnock A, Vernon DI, Schofield J, Griffiths J, Parish JH, Brown SB. Mechanism of uptake of a cationic water-soluble pyridinium zinc phthalocyanine across the outer membrane of Escherichia coli. Antimicrob Agents Chemother 2000;44:522-7.
48. Vaara M. The outer membrane permeability-increasing action of linear analogues of polymyxin B nonapeptide. Drugs Exp Clin Res 1991;17:437-43.
49. Hansen LT, Gill TA. Solubility and antimicrobial efficacy of protamine on Listeria monocytogenes and Escherichia coli as influenced by pH. J Appl Microbiol 2000; 88:1049-55.
50. Christensen B, Fink J, Merrifield RB, Mauzerall D. Channelforming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc Natl Acad Sci USA 1988; 85: 5072-6.
51. Duclohier H, Molle G, Spach G. Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers. Biophys J 1989; 56:1017-21.
52. Ganz T. Biosynthesis of defensins and other antimicrobial peptides. Ciba Found Symp 1994;186: 62-71.
53. Gallis B, Mehl J, Prickett KS, Martin JA, Merriam J, March CJ, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther 1989;1:335-46.
54. Weiss J, Elsbach P, Shu C, Castillo J, Grinna L, Horwitz A, et al. Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serumresistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria. J Clin Invest 1992; 90:1122-30.
55. Tompkins GR, O'Neill MM, Cafarella TG, Germaine GR. Inhibition of bactericidal and bacteriolytic activities of poly-Dlysine and lysozyme by chitotriose and ferric iron. Infect Immun. 1991;59:655-64.
56. Helander IM, Alakomi HL, Latva-Kala K, Koski P. Polyethyleneimine is an effective permeabilizer of gram-negative bacteria. Microbiology 1997;143 (Pt 10):3193-9.
57. Soukos NS, Ximenez-Fyvie LA, Hamblin MR, Socransky SS, Hasan T. Targeted antimicrobial photochemotherapy. Antimicrob Agents Chemother 1998; 42: 2595-601.
58. Love, W.G., Cook, M.J., Russell, D.A. Porphyrin derivatives their use in photodynamic therapy and medical devices containing them. US6630128 (2003).
59. Love, W., Brundish, D., Rhys-williams, W., Feng, X.D., Pugin, B. Porphyrin derivatives and their use in photodynamic therapy. US7244841 (2007).
60. Love, W., Brundish, D., Rhys-williams, W., Feng, X.D., Pugin, B. Porphyrin derivatives and their use in photodynamic therapy. US8084602 (2011).
61. Dees, C.H., Scott, T.C., Wachter, E.A., Fisher, W.G., Smolik, J. Intracorporeal medicaments for photodynamic treatment of disease. US20050282889 (2005).
62. Dees, C.H., Scott, T.C., Wachter, E.A., Fisher, W.G., Smolik, J. Intracorporeal medicaments for photodynamic treatment of disease. US7402299 (2008).
63. Dees, C.H., Scott, T.C., Wachter, E.A., Fisher, W.G., Smolik, J. Intracorporeal medicaments for photodynamic treatment of disease. US20110097280 (2011).
64. Griffiths, J., Gorman, S.A., Bell, A. Photosensitisers and their uses. 7407948 (2008).
65. Wainwright M, Phoenix DA, Laycock SL, Wareing DR, Wright PA. Photobactericidal activity of phenothiazinium dyes against methicillin-resistant strains of Staphylococcus aureus. FEMS Microbiol Lett 1998;160:177-81.
66. Brown, S.B., O'grady, C.C., Griffiths, J., Mellish, K.J., Tunstall, R.G., Roberts, D.J.H., Vernon, D.I. Biologically active methylene blue derivatives. US20040147508 (2004).
67. Brown, S.B., O'grady, C.C., Griffiths, J., Mellish, K.J., Tunstall, R.G., Roberts, D.J.H., Vernon, D.I. Biologically active methylene blue derivatives. US20080312219 (2008).
68. Brown, S.B., O'grady, C.C., Griffiths, J., Mellish, K.J., Vernon, D.I. Biologically active methylene blue derivatives. US7915254 (2011).
69. Grafe, S., Gebhardt, P., Albrecht, V. Siderophore conjugates of photoactive dyes for photodynamic therapy. US20040186087 (2004).
70. Albrecht, V., Gitter, B. Antimicrobial photodynamic therapy compound and method of use. US20050049228 (2005).
71. Merchat M, Bertolini G, Giacomini P, Villanueva A, Jori G. Mesosubstituted cationic porphyrins as efficient photosensitizers of gram-positive and gram-negative bacteria. J Photochem Photobiol B 1996; 32: 153-7.
72. Love, W.G., Rhys-williams, W., Brundish, D. Novel uses of porphyrin compounds. US20070167619 (2007).
73. Loebel, N., Street, C. Photodynamic therapy process and photosensitizer compositions therefor. US20090093470 (2009).
74. Kim, H.-J., Lindsey, J.S. De novo synthesis of bacteriochlorins. US20090191130 (2009).
75. Lindsey, J.S., Laha, J.K., Chinnasamy, M., Borbas, E.K. Synthesis of chlorins and phorbines with enhanced red spectral features. US20090227553 (2009).
76. Chen, C.-T., Tsai, T., Chien, H., Wang, T. Microorganism-killing combination. US20100129432 (2010).
77. Bonnett R, Krysteva MA, Lalov IG, Artarsky SV. Water disinfection using photosensitizers immobilized on chitosan. Water Res 2006;40:1269-75.
78. Clements, D.J., Pearson, G.J., Williams, J.A., Colles, M.J. Method for photodynamic therapy and apparatus therefor. US20100305494 (2010).
79. Gitter, B., Grafe, S., Wiehe, A., Albrecht, V., Epple, M., Schwiertz, J., Ganesan, K. Calciumphosphate-based nanoparticles as carriersystems for photodynamic therapy. US20110257586 (2011).
80. Olson, M.E., Allan, N.D. Natural Photodynamic Agents and their use. US20100266716 (2010).
81. Riesenberg, D., Schroeckh, V., Gitter, B., Neuberger, W. Molecular probes for targeting of cell density-indicating compounds. US6416785 (2002).
82. Roncucci, G., Fantetti, L., De Filippis, M.P., Dei, D., Jori, G. Substituted metal-phthalocyanines, their preparation and the use thereof. US20030170178 (2003).
83. Roncucci, G., Chiti, G., Dei, D., Cocchi, A., Fantetti, L., Mascheroni, S. Phtalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and their use. US20090131392 (2009).
84. Roncucci, G., Chiti, G., Dei, D., Cocchi, A., Fantetti, L., Mascheroni, S. Phthalocyanine derivatives, process for their preparation, pharmaceutical compositions containing them and their use. US8067404 (2011).
85. Roncucci, G., Dei, D., Giuntini, F., Chiti, G., Nistri, D., Fantetti, L., Paschetta, V., Cocchi, A. Meso-substituted porphyrins. US7947674 (2011).
86. Jori G. Tumour photosensitizers: Approaches to enhance the selectivity and efficiency of photodynamic therapy. J Photochem Photobiol B 1996; 36: 87-93.
87. Scherz, A., Salomon, Y., Fiedor, L., Brandis, A. Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them. US6147195 (2000).
88. Scherz, A., Salomon, Y., Fiedor, L. Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them. US6740637 (2004).
89. Scherz, A., Brandis, A., Salomon, Y., Eren, D., Cohen, A. Catatonic bacteriochlorophyll derivatives. US20080076748 (2008).
90. Street, C., Pedigo, L., Loebel, N. Composition for photodynamic disinfection. US20100233022 (2010).
91. Tang HM, Hamblin MR, Yow CM. A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens. J Infect Chemother 2007;13:87-91.
92. O'Connor AE, Gallagher WM, Byrne AT. Porphyrin and nonporphyrin photosensitizers in oncology: Preclinical and clinical advances in photodynamic therapy. Photochem Photobiol 2009; 85: 1053-74.
93. Hamblin, M.R., Demidova, T.N. Photodynamic inactivation of bacterial spores. US20060223729 (2006).
94. Driks, A. Maximum shields: The assembly and function of the bacterial spore coat. Trends Microbiol 2002; 10: 251-4.
95. Kubin A, Wierrani F, Burner U, Alth G, Grunberger W. Hypericin--the facts about a controversial agent. Curr Pharm Des 2005;11:233-53.
96. Kairyte K, Lapinskas S, Gudelis V, Luksiene Z. Effective inactivation of food pathogens Listeria monocytogenes and Salmonella enterica by combined treatment of hypericin-based photosensitization and high power pulsed light. J Appl Microbiol 2012; 112:1144-51.
97. Yow CM, Tang HM, Chu ES, Huang Z. Hypericin-mediated photodynamic antimicrobial effect on clinically isolated pathogens. Photochem Photobiol 2012; 88: 626-32.
98. Hager B, Strauss WS, Falk H. Cationic hypericin derivatives as novel agents with photobactericidal activity: Synthesis and photodynamic inactivation of Propionibacterium acnes. Photochem Photobiol 2009; 85: 1201-6.
99. Engelhardt V, Krammer B, Plaetzer K. Antibacterial photodynamic therapy using water-soluble formulations of hypericin or mTHPC is effective in inactivation of Staphylococcus aureus. Photochem Photobiol Sci 2010; 9: 365-9.
100. Mondon K, Zeisser-Labouebe M, Gurny R, Moller M. MPEGhexPLA micelles as novel carriers for hypericin, a fluorescent marker for use in cancer diagnostics. Photochem Photobiol 2011; 87: 399-407.
101. Oseroff AR, Ohuoha D, Ara G, McAuliffe D, Foley J, Cincotta L. Intramitochondrial dyes allow selective in vitro photolysis of carcinoma cells. Proc Natl Acad Sci USA 1986; 83: 9729-33.
102. Sieber F, Spivak JL, Sutcliffe AM. Selective killing of leukemic cells by merocyanine 540-mediated photosensitization. Proc Natl Acad Sci USA 1984; 81: 7584-7.
103. Sieber F, Sieber-Blum M. Dye-mediated photosensitization of murine neuroblastoma cells. Cancer Res 1986; 46: 2072-6.
104. Sieber F, Rao S, Rowley SD, Sieber-Blum M. Dye-mediated photolysis of human neuroblastoma cells: Implications for autologous bone marrow transplantation. Blood 1986; 68: 32-6.
105. Itoh T, Messner HA, Jamal N, Tweeddale M, Sieber F. Merocyanine 540-sensitized photoinactivation of high-grade non-Hodgkin's lymphoma cells: Potential application in autologous BMT. Bone Marrow Transplant 1993; 12: 191-6.
106. Abd El-Aal RM, Younis M. Synthesis and antimicrobial activity of meso-substituted polymethine cyanine dyes. Bioorg Chem 2004; 32: 193-210.
107. Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 2007; 6: 1139-49.
108. Wharton, T., Gali, H., Hamblin, M.R. Photosensitizers for targeted photodynamic therapy. US20090076115 (2009).
109. Wang M, Huang L, Sharma SK, Jeon S, Thota S, Sperandio FF, et al. Synthesis and photodynamic effect of new highly photostable decacationically armed [60]-and [70]fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells. J Med Chem 2012;55: 4274-85.
110. Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR. Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria. J Photochem Photobiol B 2005; 81:15-25.
111. Rocchetta HL, Boylan CJ, Foley JW, Iversen PW, LeTourneau DL, McMillian CL, et al. Validation of a noninvasive, real-time imaging technology using bioluminescent Escherichia coli in the neutropenic mouse thigh model of infection. Antimicrob Agents Chemother 2001; 45: 129-37.
112. Francis KP, Joh D, Bellinger-Kawahara C, Hawkinson MJ, Purchio TF, Contag PR. Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct. Infect Immun 2000; 68: 3594-600.
113. Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, et al. Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun 2001; 69: 3350-8.
114. Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol 2002;75:51-7.
115. Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T. Optical monitoring and treatment of potentially lethal wound infections in vivo. J Infect Dis 2003; 187: 1717-25.
116. Dai T, Tegos GP, Lu Z, Huang L, Zhiyentayev T, Franklin MJ, et al. Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob Agents Chemother 2009; 53: 3929-34.
117. Maisch T, Hackbarth S, Regensburger J, Felgentrager A, Baumler W, Landthaler M, et al. Photodynamic inactivation of multiresistant bacteria (PIB)-a new approach to treat superficial infections in the 21st century. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG 2011;9:360-6.
118. Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J infect Dis 2008; 197: 1079-81.
119. Kharkwal GB, Sharma SK, Huang YY, Dai T, Hamblin MR. Photodynamic therapy for infections: Clinical applications. Lasers Surg Med 2011; 43: 755-67.