Exposure of cyclosporin a in whole blood, cerebral spinal fluid, and brain extracellular fluid dialysate in adults with traumatic brain injury

Journal of Neurotrauma

Volumn 30, Issue 17, 2013, Pages 1484-1489

  Brophy, Gretchen M ^a   Mazzeo, Anna Teresa ^b   Brar, Satjit ^c   Alves, Oscar Luis ^d   Bunnell, Kristen ^e   Gilman, Charlotte ^a   Karnes, Tom ^a   Hayes, Ron L ^f   Bullock, Ross ^g  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d University of Porto   (Portugal)

^e Medical College of Virginia Campus ^*  (United States)

^f BANYAN BIOMARKERS INC   (United States)

^g UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclosporin; Neuroprotection; TBI

Indexed keywords

CYCLOSPORIN A; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DIALYSATE LEVEL; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG HALF LIFE; EXTRACELLULAR FLUID; FEMALE; HUMAN; HUMAN TISSUE; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; MICRODIALYSIS; MULTICENTER STUDY; PLASMA CONCENTRATION-TIME CURVE; RANDOMIZED CONTROLLED TRIAL; TIME TO MAXIMUM PLASMA CONCENTRATION; TRAUMATIC BRAIN INJURY;

ADOLESCENT; ADULT; BRAIN; BRAIN INJURIES; CYCLOSPORINE; EXTRACELLULAR FLUID; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MICRODIALYSIS; MIDDLE AGED; NEUROPROTECTIVE AGENTS; PROSPECTIVE STUDIES; VENTRICULOSTOMY; YOUNG ADULT;

EID: 84882724043     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2524     Document Type: Article

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