Physiological effects of housing density on C57BL/6J mice over a 9-month period

Journal of Animal Science

Volumn 90, Issue 13, 2012, Pages 5182-5192

  Paigen, B ^a   Svenson, K L ^a   Von Smith, R ^a   Marion, M A ^a   Stearns, T ^a   Peters, L L ^a   Smith, A L ^b  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adrenal weight; Animal husbandry; Animal well being; Cage air microenvironment; Heart rate; Mouse housing density

Indexed keywords

ADRENAL GLAND; ANIMAL; ANIMAL HOUSING; ANIMAL WELFARE; ARTICLE; C57BL MOUSE; DRINKING BEHAVIOR; FEEDING BEHAVIOR; GROWTH, DEVELOPMENT AND AGING; INDOOR AIR POLLUTION; MOUSE; PHYSIOLOGY; STANDARD;

ADRENAL GLANDS; AIR POLLUTION, INDOOR; ANIMAL WELFARE; ANIMALS; DRINKING BEHAVIOR; FEEDING BEHAVIOR; HOUSING, ANIMAL; MICE; MICE, INBRED C57BL;

EID: 84882704594     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-5417     Document Type: Article

References (40)

1. ACGIH. 1996. 996 threshold limit values for chemical substances and physical agents and biological exposure indices. Am. Conf. Gov. Ind. Hygienists, Cincinnati, OH.
2. Agresti, A. 2007. Chapter 5: Building and applying logistic regression models. Page 138 in An Introduction to Categorical Data Analysis. Wiley, Hoboken, NJ.
3. Bernberg, E., I. J. Andersson, S. Tidstrand, M. E. Johansson, and G. Bergstrom. 2009. Repeated exposure to stressors do not accelerate atherosclerosis in apoe-/- mice. Atherosclerosis 204:90-95.
4. Broderson, J. R., J. R. Lindsey, and J. E. Crawford. 1976. The role of environmental ammonia in respiratory mycoplasmosis of rats. Am. J. Pathol. 85:115-130.
5. Davidson, L. P., A. L. Chedester, and M. N. Cole. 2007. Effects of cage density on behavior in young adult mice. Comp. Med. 57:355-359.
6. Fairchild, K. D., J. J. Saucerman, L. L. Raynor, J. A. Sivak, Y. Xiao, D. E. Lake, and J. R. Moorman. 2009. Endotoxin depresses heart rate variability in mice: Cytokine and steroid effects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297(4):R1019-R1027.
7. Friedman, B. H. 2007. An autonomic flexibility-neurovisceral integration model of anxiety and cardiac vagal tone. Biol. Psychol. 74(2):185-199.
8. Fullwood, S., T. A. Hicks, J. C. Brown, R. L. Norman, and J. J. Mc-Glone. 1998. Floor space needs for laboratory mice: C56bl/6 males in solid-bottom cages with bedding. ILAR J. 39:29-36.
9. Gaburro, S., O. Stiedl, P. Giusti, S. B. Sartori, R. Landgraf, and N. Singewald. 2011. A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment. Int. J. Neuropsychopharmacol. 14(10):1341-1355.
10. Gaskill, B. N., C. J. Gordon, E. A. Pajor, J. R. Lucas, J. K. Davis, and J. P. Garner. 2012. Heat or insulation: Behavioral titration of mouse preference for warmth or access to a nest. PLoS One 7(3):e32799.
11. Gaskill, B. N., S. A. Rohr, E. A. Pajor, J. R. Lucas, and J. P. Garner. 2009. Some like it hot: Mouse temperature preferences in laboratory housing. Applied Anim. Behav. Sci. 116:279-285.
12. Gilmore, A. J., R. L. Billing, and R. Einstein. 2008. The effects on heart rate and temperature of mice and vas deferens responses to noradrenaline when their cage mates are subjected to daily restraint stress. Lab. Anim. 42:140-148.
13. Gordon, C. J. 2004. Effect of cage bedding on temperature regulation and metabolism of group-housed female mice. Comp. Med. 54:63-68.
14. Gordon, C. J., K. L. Kimm-Brinson, B. Padnos, and J. S. Ramsdell. 2001. Acute and delayed thermoregulatory response of mice exposed to brevetoxin. Toxicon 39:1367-1374.
15. Harper, J. M., A. T. Galecki, D. T. Burke, S. L. Pinkosky, and R. A. Miller. 2003. Quantitative trait loci for insulin-like growth factor i, leptin, thyroxine, and corticosterone in genetically heterogeneous mice. Physiol. Genomics. 15:44-51.
16. Laber, K., L. M. Veatch, M. F. Lopez, J. K. Mulligan, and D. M. Lathers. 2008. Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in balb/c and c57bl/6 mice. J. Am. Assoc. Lab. Anim. Sci. 47:16-23.
17. McGlone, J. J., D. L. Anderson, and R. L. Norman. 2001. Floor space needs for laboratory mice: Balb/cj males or females in solid-bottom cages with bedding. Contemp. Top. Lab. Anim. Sci. 40:21-25.
18. Meijer, M. K., P. L. Van Loo, and V. Baumans. 2009. There's a rat in my room! Now what? Mice show no chronic physiological response to the presence of rats. J. Appl. Anim. Welfare Sci. 12:293-305.
19. Murakami, H., and K. Kinoshita. 1978. Temperature preference of adolescent mice. Lab. Anim. Sci. 28:277-281.
20. Naidu, S., C. M. Winget, J. W. Jenner, G. Mele, and D. C. Holley. 1995. Effects of housing density on mouse physiology and behavior in the NASA animal enclosure module simulators. J. Grav. Physiol. 2:140.
21. National Research Council. 2011. Guide for the Care and Use of Laboratory Animals, 8th ed. Public Health Service, Washington, DC.
22. Nicholson, A., R. D. Malcolm, P. L. Russ, K. Cough, C. Touma, R. Palme, and M. V. Wiles. 2009. The response of c57bl/6j and balb/ cj mice to increased housing density. J. Am. Assoc. Lab. Anim. Sci. 48:740-753.
23. Ortiz, R., A. Armario, and J. M. Castellanos. 1984. Post-weaning differential housing and testosterone secretion in male mice. Experientia 40:1428-1429.
24. Ortiz, R., A. Armario, J. M. Castellanos, and J. Balasch. 1985. Post-weaning crowding induces corticoadrenal hyperreactivity in male mice. Physiol. Behav. 34:857-860.
25. Peters, A., and M. Festing. 1990. Population density and growth rate in laboratory mice. Lab. Anim. 24:273-279.
26. Peters, L. L., E. M. Cheever, H. R. Ellis, P. A. Magnani, K. L. Sven-son, R. Von Smith, and M. A. Bogue. 2002. Large-scale, high-throughput screening for coagulation and hematologic pheno-types in mice. Physiol. Genomics. 11:185-193.
27. Pham, H., A. C. Bonham, K. E. Pinkerton, and C. Y. Chen. 2009. Central neuroplasticity and decreased heart rate variability after particulate matter exposure in mice. Environ. Health Perspect. 117(9):1448-1453.
28. Rakowski-Anderson, T., H. Wong, B. Rothermel, P. Cain, C. Lavilla, J. K. Pullium, and C. Hoeffer. 2012. Fecal corticosterone levels in RCAN1 mutant mice. Comp. Med. 62:87-94.
29. Reeb, C. K., R. B. Jones, D. W. Bearg, H. Bedigian, D. D. Myers, and B. Paigen. 1998. Microenvironment in ventilated animal cages with differing ventilation rates, mice populations, and frequency of bedding changes. Contemp. Topics Lab. Anim. Sci. 37:43-49.
30. Reeb-Whitaker, C. K., B. Paigen, W. G. Beamer, R. T. Bronson, G. A. Churchill, I. B. Schweitzer, and D. D. Myers. 2001. The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages. Lab. Anim. 35:58-73.
31. Schmidt, M. V., S. H. Scharf, C. Liebl, D. Harbich, B. Mayer, F. Hols-boer, and M. B. Muller. 2010. A novel chronic social stress paradigm in female mice. Hormones Behav. 57:415-420.
32. Smith, A. L., and D. J. Corrow. 2005. Modifications to husbandry and housing conditions of laboratory rodents for improved well-being. ILAR J. 46:140-147.
33. Smith, A. L., S. L. Mabus, C. Muir, and Y. Woo. 2005. Effects of housing density and cage floor space on three strains of young adult inbred mice. Comp. Med. 55:368-376.
34. Smith, A. L., S. L. Mabus, J. D. Stockwell, and C. Muir. 2004. Effects of housing density and cage floor space on c57bl/6j mice. Comp. Med. 54:656-663.
35. Sterlemann, V., K. Ganea, C. Liebl, D. Harbich, S. Alam, F. Holsboer, M. B. Muller, and M. V. Schmidt. 2008. Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: Implications for stress-related disorders. Hormones Behav. 53:386-394.
36. Svenson, K. L., M. A. Bogue, and L. L. Peters. 2003. Invited review: Identifying new mouse models of cardiovascular disease: A review of high-throughput screens of mutagenized and inbred strains. J. Appl. Physiol. 94:1650-1659 (discussion 1673).
37. Svenson, K. L., R. Von Smith, P. A. Magnani, H. R. Suetin, B. Paigen, J. K. Naggert, R. Li, G. A. Churchill, and L. L. Peters. 2007. Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations. J Appl. Physiol. 102:2369-2378.
38. Van Loo, P. L., N. Kuin, R. Sommer, H. Avsaroglu, T. Pham, and V. Baumans. 2007. Impact of 'living apart together' on postoperative recovery of mice compared with social and individual housing. Lab. Anim. 41:441-455.
39. Van Loo, P. L., J. A. Mol, J. M. Koolhaas, B. F. Van Zutphen, and V. Baumans. 2001. Modulation of aggression in male mice: Influence of group size and cage size. Physiol. Behav. 72:675-683.
40. Van Loo, P. L., H. A. Van de Weerd, B. F. Van Zutphen, and V. Bau-mans. 2004. Preference for social contact versus environmental enrichment in male laboratory mice. Lab. Anim. 38:178-188.