Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice

Physiological Genomics

Volumn 11, Issue , 2003, Pages 185-193

  Peters, Luanne L ^a   Cheever, Eleanor M ^b   Ellis, Heather R ^a   Magnani, Phyllis A ^a   Svenson, Karen L ^a   Von Smith, Randy ^a   Bogue, Molly A ^a  

^a JACKSON LABORATORY   (United States)

^b Dade Behring Inc   (United States)

Author keywords

Hematology; Hemostasis; Mouse phenome; NHLBI Program for Genomic Applications

Indexed keywords

REAGENT; BLOOD CLOTTING FACTOR 8; PROTEIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOANALYZER; BLOOD CELL COUNT; BLOOD CLOTTING; CONTROLLED STUDY; EUTHANASIA; FEMALE; HEMATOLOGY; HEMOSTASIS; INBRED STRAIN; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SAMPLE SIZE; SCREENING; ANIMAL; ANIMAL MODEL; AUTOMATION; BLOOD CLOTTING TEST; BLOOD EXAMINATION; C57BL MOUSE; INTERNET; METHODOLOGY; MOUSE STRAIN; REPRODUCIBILITY; SPECIES DIFFERENCE;

ANIMALIA;

ANIMALS; AUTOMATION; BLOOD CELL COUNT; BLOOD COAGULATION TESTS; FACTOR VIII; FEMALE; HEMATOLOGIC TESTS; INTERNET; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MODELS, ANIMAL; PHENOTYPE; PROTEIN C; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY;

EID: 0141745002     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00077.2002     Document Type: Article

References (11)

1. Clark AT, Goldowitz D, Takahashi JS, Vitaterna MH, Siepkas SM, Peters LL, Frankel WN, Carlson GA, Nadeau J, and Justice MJ. A summary of ENU mutagenesis activities in North America. Genetica In press.
2. Denis C, Methia N, Frennette PS, Rayburn H, Ullman-Cullere M, Hynes RO, and Wagner DD. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci USA 95: 9524-9529, 1998.
3. Fleming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, and Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16: 383-386, 1997.
4. Jalbert LR, Rosen ED, Moons L, Chan JCY, Carmeliet P, Collen D, and Castellino FJ. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 102: 1481-1488, 1998.
5. Moon BC and Friedman JM. The molecular basis of the obese mutation in ob2J mice. Genomics 42: 152-156, 1997.
6. Paigen K and Eppig JT. A mouse phenome project. Mamm Genome 11: 715-717, 2000.
7. Paigen K. Understanding the human condition: experimental strategies in mammalian genetics. ILAR J 43: 123-135, 2002.
8. Peters LL and Barker JE. Hematology, clotting, and thrombosis (accession no. MPD:62). Mouse Phenome Database Web Site [Online]. Bar Harbor, ME: The Jackson Laboratory, 2001. http://www.jax.org/phenome.
9. Sugiyama F, Churchill GA, Higgins DC, Johns C, Makaritsis KP, Gavras H, and Paigen B. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71: 70-77, 2001.
10. Tsakiris DA, Scudder L, Hodivala Dilke K, Hynes RO, and Coller BS. Hemostasis in the mouse (Mus musculus): a review. Thromb Haemost 81: 177-188, 1999.
11. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, and Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21: 195-199, 1999.