Examining the stability of genetic risk effect as evidence accumulates in the context of meta-analysis

Computers in Biology and Medicine

Volumn 43, Issue 9, 2013, Pages 1293-1299

  Zintzaras, Elias ^a,b  

^a UNIVERSITY OF THESSALY   (Greece)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cumulative meta analysis; Genetic association; Meta analysis; Monte Carlo test; Risk; Stability

Indexed keywords

GENETIC RISKS; GRAPHICAL APPROACH; META-ANALYSIS; MONTE CARLO TESTS; PERMUTATION TESTS; TIME STEP;

CONVERGENCE OF NUMERICAL METHODS; MONTE CARLO METHODS; RISKS; STABILITY; TESTING;

RISK ASSESSMENT;

ALCOHOLISM; ARTICLE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC STABILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; META ANALYSIS (TOPIC); MONTE CARLO METHOD; OSCILLATION; PRIORITY JOURNAL;

CUMULATIVE META-ANALYSIS; GENETIC ASSOCIATION; META-ANALYSIS; MONTE CARLO TEST; RISK; STABILITY;

FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MODELS, GENETIC; MONTE CARLO METHOD; RISK FACTORS;

EID: 84882673606     PISSN: 00104825     EISSN: 18790534     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2013.04.017     Document Type: Article

References (14)

1. Zintzaras E., Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J. Clin. Epidemiol. 2008, 61:634-645.
2. Lewis C.M. Genetic association studies: design, analysis and interpretation. Brief Bioinform. 2002, 3:146-153.
3. Lau J., Antman EM, Jimenez-Silva J., Kupelnick B., Mosteller F., Chalmers T.C. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N. Engl. J. Med. 1992, 327:248-254.
4. Ioannidis J., Lau J. Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalyses. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:831-836.
5. Lau J., Schmid C.H., Chalmers T.C. Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care. J. Clin. Epidemiol. 1995, 48:45-57.
6. Edgington E.S. Randomization Tests 1995, CRC Press, London.
7. Zintzaras E., Stefanidis I., Santos M., Vidal F. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?. Hepatology 2006, 43:352-361.
8. Zintzaras E., Raman G., Kitsios G., Lau J. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern. Med. 2008, 168:1077-1089.
9. IMSL Visual Numerics Inc, Huston, TX, 1997.
10. Zintzaras E. The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies. Stat. Appl. Genet. Mol. Biol. 2010, 9. Article21.
11. Zintzaras E. The power of generalized odds ratios in assessing association in genetic studies with known mode of inheritance. J. Appl. Stat. 2012, 39:2569-2581.
12. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1990, 1:43-46.
13. Bender R., Lange S. Adjusting for multiple testing--when and how?. J. Clin. Epidemiol. 2001, 54:343-349.
14. Xu J., Turner A., Little J., Bleecker E.R., Meyers D.A. Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?. Hum. Genet. 2002, 111:573-574.