Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 18, 2013, Pages 5195-5198

  Ramos Hunter, Susan J ^a,c   Engers, Darren W ^a,b   Kaufmann, Kristian ^a   Du, Yu ^a   Lindsley, Craig W ^a,b,c   Weaver, C David ^a   Sulikowski, Gary A ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Activators; GIRK Kir3.x; Thallium flux

Indexed keywords

G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM 1 CHANNEL ACTIVATOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM 2 CHANNEL ACTIVATOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM 4 CHANNEL ACTIVATOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; ML 297; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG; VU 0259369; VU 0456810;

ARTICLE; DRUG SYNTHESIS; MOUSE; NONHUMAN;

ACTIVATORS; GIRK; K(IR)3.X; THALLIUM FLUX;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; MICE; MOLECULAR PROBES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882667740     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.002     Document Type: Article

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