In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs

Bone

Volumn 56, Issue 2, 2013, Pages 449-453

  Aref, Mohammad ^a   Gallant, Maxime A ^a   Organ, Jason M ^a   Wallace, Joseph M ^b   Newman, Christopher L ^a   Burr, David B ^a   Brown, Drew M ^a   Allen, Matthew R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Indiana University Purdue University Indianapolis   (United States)

Author keywords

Bone mechanics; Bone remodeling; Indentation; Osteoporosis treatments

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; RALOXIFENE; SODIUM CHLORIDE;

ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BONE REMODELING; BONE TOUGHNESS; COMPUTER PROGRAM; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG MECHANISM; ENERGY ABSORPTION; FEMALE; INDENTATION DISTANCE INCREASE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSTEOPOROSIS; REFERENCE POINT INDENTATION; TIBIA SHAFT; TREATMENT DURATION;

BONE MECHANICS; BONE REMODELING; INDENTATION; OSTEOPOROSIS TREATMENTS;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; BONE REMODELING; DISEASE MODELS, ANIMAL; DOGS; FEMALE; OSTEOPOROSIS; RALOXIFENE;

EID: 84882664454     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.07.009     Document Type: Article

References (12)

1. Kanis J.A. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002, 359:1929-1936.
2. Riggs B., Melton L. Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res 2002, 17:11-14.
3. Sarkar S., Mitlak B.H., Wong M., Stock J.L., Black D.M., Harper K.D. Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 2002, 17:1-10.
4. Hansma P., Turner P., Drake B., Yurtsev E., Proctor A., Mathews P., et al. The bone diagnostic instrument II: indentation distance increase. Rev Sci Instrum 2008, 79. [064303-064303-8].
5. Gallant M.A., Brown D.M., Organ J.M., Allen M.R., Burr D.B. Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing. Bone 2013, 53:301-305.
6. Diez-Perez A., Güerri R., Nogues X., Cáceres E., Peña M., Mellibovsky L., et al. Microindentation for in vivo measurement of bone tissue mechanical properties in humans. J Bone Miner Res 2010, 25:1877-1885.
7. Güerri-Fernández R.C., Nogués X., Quesada Gómez J.M., Torres del Pliego E., Puig L., García-Giralt N., et al. Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls. J Bone Miner Res 2012, 28:162-168.
8. Allen M., Hogan H., Hobbs W., Koivuniemi A., Koivuniemi M., Burr D. Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone. Endocrinology 2007, 148:3908-3913.
9. Allen M.R., Iwata K., Sato M., Burr D.B. Raloxifene enhances vertebral mechanical properties independent of bone density. Bone 2006, 39:1130-1135.
10. Allen M., Kubek D., Burr D. Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs. J Bone Miner Res 2010, 25:98-105.
11. Keaveny T.M., Hoffmann P.F., Singh M., Palermo L., Bilezikian J.P., Greenspan S.L., et al. Femoral bone strength and its relation to cortical and trabecular changes after treatment with PTH, Alendronate, and their combination as assessed by finite element analysis of quantitative CT scans. J Bone Miner Res 2008, 23:1974-1982.
12. Allen M.R., Burr D.B. Mineralization, microdamage, and matrix: how bisphosphonates influence material properties of bone. IBMS BoneKEy 2007, 4:49-60.