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Volumn 91, Issue 1, 2013, Pages 276-285

Deoxynivalenol and E.coli lipopolysaccharide alter epithelial proliferation and spatial distribution of apical junction proteins along the small intestinal axis

Author keywords

Apical junction complex; Crypt depth; Deoxynivalenol; Epithelial proliferation; Escherichia coli lipopolysaccharide; Pigs

Indexed keywords

BETA CATENIN; LIPOPOLYSACCHARIDE; PROTEIN ZO1; TRICHOTHECENE DERIVATIVE; VOMITOXIN;

EID: 84882645563     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-5453     Document Type: Article
Times cited : (27)

References (42)
  • 1
    • 66849115545 scopus 로고    scopus 로고
    • Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs
    • Bauchart-Thevret, C., B. Stoll, S. Chacko, and D. G. Burrin. 2009. Sulfur amino acid deficiency upregulates intestinal methionine cycle activity and suppresses epithelial growth in neonatal pigs. Am. J. Physiol. Endocrinol. Metab. 296:E1239-E1250.
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.296
    • Bauchart-Thevret, C.1    Stoll, B.2    Chacko, S.3    Burrin, D.G.4
  • 2
    • 84862509596 scopus 로고    scopus 로고
    • Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets
    • Bracarense, A.-P. F. L., J. Lucioli, B. Grenier, G. Drociunas Pacheco, W.-D. Moll, G. Schatzmayr, and I. P. Oswald. 2012. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br. J. Nutr. 107:1776-1786.
    • (2012) Br. J. Nutr , vol.107 , pp. 1776-1786
    • Bracarense, A.-P.F.L.1    Lucioli, J.2    Grenier, B.3    Pacheco, D.G.4    Moll, W.-D.5    Schatzmayr, G.6    Oswald, I.P.7
  • 3
    • 33646162632 scopus 로고    scopus 로고
    • The influence of different management systems and age on intestinal morphology, immune cell numbers and mucin production from goblet cells in post-weaning pigs
    • Brown, D. C., C. V. Maxwell, G. F. Erf, M. E. Davis, S. Singh, and Z. B. Johnson. 2006. The influence of different management systems and age on intestinal morphology, immune cell numbers and mucin production from goblet cells in post-weaning pigs. Vet. Immunol. Immunopathol. 111:187-198.
    • (2006) Vet. Immunol. Immunopathol , vol.111 , pp. 187-198
    • Brown, D.C.1    Maxwell, C.V.2    Erf, G.F.3    Davis, M.E.4    Singh, S.5    Johnson, Z.B.6
  • 4
    • 0030001891 scopus 로고    scopus 로고
    • Occurrence of Fusarium and fumonisins on food grains and in foods
    • Bullerman, L. B. 1996. Occurrence of Fusarium and fumonisins on food grains and in foods. Adv. Exp. Med. Biol. 392:27-38.
    • (1996) Adv. Exp. Med. Biol , vol.392 , pp. 27-38
    • Bullerman, L.B.1
  • 5
    • 28844488820 scopus 로고    scopus 로고
    • Fusariotoxin transfer in animal
    • Cavret, S., and S. Lecoeur. 2006. Fusariotoxin transfer in animal. Food Chem. Toxicol. 44:444-453.
    • (2006) Food Chem. Toxicol , vol.44 , pp. 444-453
    • Cavret, S.1    Lecoeur, S.2
  • 6
    • 84856476754 scopus 로고    scopus 로고
    • Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS)
    • Dänicke, S., B. Brosig, L. R. Klunker, S. Kahlert, J. Kluess, S. Döll, H. Valenta, and H.-J. Rothkötter. 2012. Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS). Food Chem. Toxicol. 50:979-988.
    • (2012) Food Chem. Toxicol , vol.50 , pp. 979-988
    • Dänicke, S.1    Brosig, B.2    Klunker, L.R.3    Kahlert, S.4    Kluess, J.5    Döll, S.6    Valenta, H.7    Rothkötter, H.-J.8
  • 7
    • 58149277977 scopus 로고    scopus 로고
    • Metabolism, kinetics and occurence of deoxynivalenol (DON) and zearalenone (ZON) in physiological samples of pigs, ruminants and poultry
    • I. Oswald and I. Taranu. ed. Transworld Res. Network, Trivandrum, India
    • Dänicke, S., S. Döll, T. Goyarts, K. Seeling, H. Valenta, and K. H. Ueberschär. 2008. Metabolism, kinetics and occurence of deoxynivalenol (DON) and zearalenone (ZON) in physiological samples of pigs, ruminants and poultry. Pages 235-273 in Mycotoxins in Farm Animals. I. Oswald and I. Taranu. ed. Transworld Res. Network, Trivandrum, India.
    • (2008) Mycotoxins In Farm Animals , pp. 235-273
    • Dänicke, S.1    Döll, S.2    Goyarts, T.3    Seeling, K.4    Valenta, H.5    Ueberschär, K.H.6
  • 8
    • 35348943278 scopus 로고    scopus 로고
    • Phospho-regulation of Beta-catenin adhesion and signaling functions
    • Daugherty, R. L., and C. J. Gottardi. 2007. Phospho-regulation of Beta-catenin adhesion and signaling functions. Physiology (Bethesda) 22:303-309.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 303-309
    • Daugherty, R.L.1    Gottardi, C.J.2
  • 9
    • 79952158502 scopus 로고    scopus 로고
    • Vulnerability of polarized intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application
    • Diesing, A.-K., C. Nossol, S. Dänicke, N. Walk, A. Post, S. Kahlert, H.-J. Rothkötter, and J. Kluess. 2011. Vulnerability of polarized intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application. PLoS ONE 6:e17472.
    • (2011) PLoS ONE , vol.6
    • Diesing, A.-K.1    Nossol, C.2    Dänicke, S.3    Walk, N.4    Post, A.5    Kahlert, S.6    Rothkötter, H.-J.7    Kluess, J.8
  • 10
    • 80053603016 scopus 로고    scopus 로고
    • The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding
    • Döll, S., and S. Dänicke. 2011. The Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) in animal feeding. Prev. Vet. Med. 102:132-145.
    • (2011) Prev. Vet. Med , vol.102 , pp. 132-145
    • Döll, S.1    Dänicke, S.2
  • 11
    • 8844247487 scopus 로고    scopus 로고
    • Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to deoxynivalenol (DON) as undesirable substance in animal feed
    • EFSA
    • EFSA, 2004. Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to deoxynivalenol (DON) as undesirable substance in animal feed. EFSA J. 73:1-42. http://www.efsa.eu.int/.
    • (2004) EFSA J , vol.73 , pp. 1-42
  • 12
    • 0023103518 scopus 로고
    • Protein synthesis inhibition by 8-oxo-12,13-epoxytrichothecenes
    • Ehrlich, K. C., and K. W. Daigle. 1987. Protein synthesis inhibition by 8-oxo-12,13-epoxytrichothecenes. Biochim. Biophys. Acta 923:206-213.
    • (1987) Biochim. Biophys. Acta , vol.923 , pp. 206-213
    • Ehrlich, K.C.1    Daigle, K.W.2
  • 13
    • 0032491391 scopus 로고    scopus 로고
    • The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
    • Fanning, A. S., B. J. Jameson, L. A. Jesaitis, and J. M. Anderson. 1998. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem. 273:29745-29753.
    • (1998) J. Biol. Chem , vol.273 , pp. 29745-29753
    • Fanning, A.S.1    Jameson, B.J.2    Jesaitis, L.A.3    Anderson, J.M.4
  • 15
    • 33745190944 scopus 로고    scopus 로고
    • Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes
    • Goyarts, T., S. Dänicke, U. Tiemann, and H.-J. Rothkötter. 2006b. Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol. In Vitro 20:858-867.
    • (2006) Toxicol. In Vitro , vol.20 , pp. 858-867
    • Goyarts, T.1    Dänicke, S.2    Tiemann, U.3    Rothkötter, H.-J.4
  • 16
    • 33749582285 scopus 로고    scopus 로고
    • Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig
    • Goyarts, T., N. Grove, and S. Dänicke. 2006a. Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig. Food Chem. Toxicol. 44:1953-1965.
    • (2006) Food Chem. Toxicol , vol.44 , pp. 1953-1965
    • Goyarts, T.1    Grove, N.2    Dänicke, S.3
  • 17
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • Gregorieff, A., and H. Clevers. 2005. Wnt signaling in the intestinal epithelium: From endoderm to cancer. Genes Dev. 19:877-890.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 18
    • 33744944559 scopus 로고    scopus 로고
    • Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties
    • Hedemann, M. S., M. Eskildsen, H. N. Laerke, C. Pedersen, J. E. Lindberg, P. Laurinen, and K. E. B. Knudsen. 2006. Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties. J. Anim. Sci. 84:1375-1386.
    • (2006) J. Anim. Sci , vol.84 , pp. 1375-1386
    • Hedemann, M.S.1    Eskildsen, M.2    Laerke, H.N.3    Pedersen, C.4    Lindberg, J.E.5    Laurinen, P.6    Knudsen, K.E.B.7
  • 19
    • 0242501524 scopus 로고    scopus 로고
    • Small intestinal morphology and activity of intestinal peptidases in piglets around weaning
    • Hedemann, M. S., S. Højsgaard, and B. B. Jensen. 2003. Small intestinal morphology and activity of intestinal peptidases in piglets around weaning. J. Anim. Physiol. Anim. Nutr. 87:32-41.
    • (2003) J. Anim. Physiol. Anim. Nutr , vol.87 , pp. 32-41
    • Hedemann, M.S.1    Højsgaard, S.2    Jensen, B.B.3
  • 20
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    • Itoh, M., M. Furuse, K. Morita, K. Kubota, M. Saitou, and S. Tsukita. 1999. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 147:1351-1363.
    • (1999) J. Cell Biol , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3    Kubota, K.4    Saitou, M.5    Tsukita, S.6
  • 21
    • 84856455725 scopus 로고    scopus 로고
    • Interactions of adiponectin and lipopolysaccharide from Porphyromonas gingivalis on human oral epithelial cells
    • Kraus, D., J. Winter, S. Jepsen, A. Jäger, R. Meyer, and J. Deschner. 2012. Interactions of adiponectin and lipopolysaccharide from Porphyromonas gingivalis on human oral epithelial cells. PLoS ONE 7:e30716.
    • (2012) PLoS ONE , vol.7
    • Kraus, D.1    Winter, J.2    Jepsen, S.3    Jäger, A.4    Meyer, R.5    Deschner, J.6
  • 23
    • 0028289669 scopus 로고
    • Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells
    • Näthke, I. S., L. Hinck, J. R. Swedlow, J. Papkoff, and W. J. Nelson. 1994. Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J. Cell Biol. 125:1341-1352.
    • (1994) J. Cell Biol , vol.125 , pp. 1341-1352
    • Näthke, I.S.1    Hinck, L.2    Swedlow, J.R.3    Papkoff, J.4    Nelson, W.J.5
  • 24
    • 77957929501 scopus 로고    scopus 로고
    • Parenteral and enteral feeding in preterm piglets differently affects extracellular matrix proteins, enterocyte proliferation and apoptosis in the small intestine
    • Oste, M., M. de Vos, E. van Haver, L. van Brantegem, T. Thymann, P. Sangild, A. Weyns, and C. van Ginneken. 2010. Parenteral and enteral feeding in preterm piglets differently affects extracellular matrix proteins, enterocyte proliferation and apoptosis in the small intestine. Br. J. Nutr. 104:989-997.
    • (2010) Br. J. Nutr , vol.104 , pp. 989-997
    • Oste, M.1    de Vos, M.2    van Haver, E.3    van Brantegem, L.4    Thymann, T.5    Sangild, P.6    Weyns, A.7    van Ginneken, C.8
  • 25
    • 34547840232 scopus 로고    scopus 로고
    • Deoxynivalenol: Toxicity, mechanism and animal health risks
    • Pestka, J. J. 2007. Deoxynivalenol: Toxicity, mechanism and animal health risks. Anim. Feed Sci. Technol. 137:283-298.
    • (2007) Anim. Feed Sci. Technol , vol.137 , pp. 283-298
    • Pestka, J.J.1
  • 27
    • 0029744696 scopus 로고    scopus 로고
    • Maintenance of villus height and crypt depth, and enhancement of disaccharide digestion and monosaccharide absorption, in piglets fed on cows' whole milk after weaning
    • Pluske, J. R., M. J. Thompson, C. S. Atwood, P. H. Bird, I. H. Williams, and P. E. Hartmann. 1996. Maintenance of villus height and crypt depth, and enhancement of disaccharide digestion and monosaccharide absorption, in piglets fed on cows' whole milk after weaning. Br. J. Nutr. 76:409-422.
    • (1996) Br. J. Nutr , vol.76 , pp. 409-422
    • Pluske, J.R.1    Thompson, M.J.2    Atwood, C.S.3    Bird, P.H.4    Williams, I.H.5    Hartmann, P.E.6
  • 29
    • 0028904649 scopus 로고
    • More newly formed T than B lymphocytes leave the intestinal mucosa via lymphatics
    • Rothkötter, H. J., C. Hriesik, and R. Pabst. 1995. More newly formed T than B lymphocytes leave the intestinal mucosa via lymphatics. Eur. J. Immunol. 25:866-869.
    • (1995) Eur. J. Immunol , vol.25 , pp. 866-869
    • Rothkötter, H.J.1    Hriesik, C.2    Pabst, R.3
  • 30
    • 78049258953 scopus 로고    scopus 로고
    • Morphology and enzymatic activity of the small intestinal mucosa of Iberian pigs as compared with a lean pig strain
    • Rubio, L. A., R. Ruiz, M. J. Peinado, and A. Echavarri. 2010. Morphology and enzymatic activity of the small intestinal mucosa of Iberian pigs as compared with a lean pig strain. J. Anim. Sci. 88:3590-3597.
    • (2010) J. Anim. Sci , vol.88 , pp. 3590-3597
    • Rubio, L.A.1    Ruiz, R.2    Peinado, M.J.3    Echavarri, A.4
  • 32
    • 0022165946 scopus 로고
    • Cell surface polarity in epithelia
    • Simons, K., and S. D. Fuller. 1985. Cell surface polarity in epithelia. Annu. Rev. Cell Biol. 1:243-288.
    • (1985) Annu. Rev. Cell Biol , vol.1 , pp. 243-288
    • Simons, K.1    Fuller, S.D.2
  • 34
    • 0023711361 scopus 로고
    • Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice
    • Tai, J. H., and J. J. Pestka. 1988. Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysaccharide in C3H/HeN and C3H/HeJ mice. Toxicol. Lett. 44:191-200.
    • (1988) Toxicol. Lett , vol.44 , pp. 191-200
    • Tai, J.H.1    Pestka, J.J.2
  • 35
    • 0025797174 scopus 로고
    • Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin
    • Taylor, M. J., C. Lafarge-Frayssinet, M. I. Luster, and C. Frayssinet. 1991. Increased endotoxin sensitivity following T-2 toxin treatment is associated with increased absorption of endotoxin. Toxicol. Appl. Pharmacol. 109:51-59.
    • (1991) Toxicol. Appl. Pharmacol , vol.109 , pp. 51-59
    • Taylor, M.J.1    Lafarge-Frayssinet, C.2    Luster, M.I.3    Frayssinet, C.4
  • 36
    • 78649926908 scopus 로고    scopus 로고
    • Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets
    • Thu, T. V., T. C. Loh, H. L. Foo, H. Yaakub, and M. H. Bejo. 2011. Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets. Trop. Anim. Health Prod. 43:69-75.
    • (2011) Trop. Anim. Health Prod , vol.43 , pp. 69-75
    • Thu, T.V.1    Loh, T.C.2    Foo, H.L.3    Yaakub, H.4    Bejo, M.H.5
  • 37
    • 33745212442 scopus 로고    scopus 로고
    • Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts
    • Tiemann, U., K.-P. Brüssow, L. Jonas, R. Pöhland, F. Schneider, and S. Dänicke. 2006. Effects of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected immunological and histological measurements in the spleen of gilts. J. Anim. Sci. 84:236-245.
    • (2006) J. Anim. Sci , vol.84 , pp. 236-245
    • Tiemann, U.1    Brüssow, K.-P.2    Jonas, L.3    Pöhland, R.4    Schneider, F.5    Dänicke, S.6
  • 38
    • 0037259924 scopus 로고    scopus 로고
    • Influence of the mycotoxins alpha- and beta-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells
    • Tiemann, U., T. Viergutz, L. Jonas, and F. Schneider. 2003. Influence of the mycotoxins alpha- and beta-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells. Reprod. Toxicol. 17:209-218.
    • (2003) Reprod. Toxicol , vol.17 , pp. 209-218
    • Tiemann, U.1    Viergutz, T.2    Jonas, L.3    Schneider, F.4
  • 39
    • 0021985348 scopus 로고
    • The toxicology of mycotoxins
    • Ueno, Y. 1985. The toxicology of mycotoxins. Crit. Rev. Toxicol. 14:99-132.
    • (1985) Crit. Rev. Toxicol , vol.14 , pp. 99-132
    • Ueno, Y.1
  • 40
    • 0033521140 scopus 로고    scopus 로고
    • Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3
    • Wittchen, E. S., J. Haskins, and B. R. Stevenson. 1999. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J. Biol. Chem. 274:35179-35185.
    • (1999) J. Biol. Chem , vol.274 , pp. 35179-35185
    • Wittchen, E.S.1    Haskins, J.2    Stevenson, B.R.3
  • 41
    • 77956903989 scopus 로고    scopus 로고
    • Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet
    • Wu, X., Z. Ruan, Y. Gao, Y. Yin, X. Zhou, L. Wang, M. Geng, Y. Hou, and G. Wu. 2010. Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet. Amino Acids 39:831-839.
    • (2010) Amino Acids , vol.39 , pp. 831-839
    • Wu, X.1    Ruan, Z.2    Gao, Y.3    Yin, Y.4    Zhou, X.5    Wang, L.6    Geng, M.7    Hou, Y.8    Wu, G.9
  • 42
    • 0033612199 scopus 로고    scopus 로고
    • Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol)
    • Zhou, H.-R., J. R. Harkema, D. Yan, and J. J. Pestka. 1999. Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol). J. Toxicol. Environ. Health Part A. 57:115-136.
    • (1999) J. Toxicol. Environ. Health Part A , vol.57 , pp. 115-136
    • Zhou, H.-R.1    Harkema, J.R.2    Yan, D.3    Pestka, J.J.4


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