메뉴 건너뛰기




Volumn 4, Issue 8, 2013, Pages

KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a

Author keywords

C Myc; Epithelial ovarian carcinoma; FOXO3a; KPNA2; Proliferation; Tumorigenicity

Indexed keywords

KARYOPHERIN ALPHA; KARYOPHERIN ALPHA 2; MYC PROTEIN; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

EID: 84882569092     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.256     Document Type: Article
Times cited : (88)

References (39)
  • 1
    • 33847176295 scopus 로고    scopus 로고
    • Molecular mechanism of the nuclear protein import cycle
    • Stewart M. Molecular mechanism of the nuclear protein import cycle. Nat Rev Mol Cell Biol 2007; 8: 195-208
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 195-208
    • Stewart, M.1
  • 2
    • 77955375151 scopus 로고    scopus 로고
    • Karyopherin alpha 7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors
    • Kelley JB, Talley AM, Spencer A, Gioeli D, Paschal BM. Karyopherin alpha 7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol 2010; 11: 63
    • (2010) BMC Cell Biol , vol.11 , pp. 63
    • Kelley, J.B.1    Talley, A.M.2    Spencer, A.3    Gioeli, D.4    Paschal, B.M.5
  • 3
    • 0028950991 scopus 로고
    • Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
    • Radu A, Blobel G, Moore MS. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci USA 1995; 92: 1769-1773
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1769-1773
    • Radu, A.1    Blobel, G.2    Moore, M.S.3
  • 4
    • 0028988731 scopus 로고
    • Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences
    • Weis K, Mattaj IW, Lamond AI. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science 1995; 268: 1049-1053
    • (1995) Science , vol.268 , pp. 1049-1053
    • Weis, K.1    Mattaj, I.W.2    Lamond, A.I.3
  • 5
    • 0029921174 scopus 로고    scopus 로고
    • A 41 amino acid motif in importin-α confers binding to importin-β and hence transit into the nucleus
    • Gorlich D, Henklein P, Laskey RA, Hartmann EA. 41 amino acid motif in importin-Alpha confers binding to importin-beta and hence transit into the nucleus. EMBO J 1996; 15: 1810-1817 (Pubitemid 26119217)
    • (1996) EMBO Journal , vol.15 , Issue.8 , pp. 1810-1817
    • Gorlich, D.1    Henklein, P.2    Laskey, R.A.3    Hartmann, E.4
  • 6
    • 0030010107 scopus 로고    scopus 로고
    • The conserved amino-terminal domain of hSRP1α is essential for nuclear protein import
    • Weis K, Ryder U, Lamond AI. The conserved amino-Terminal domain of hSRP1 alpha is essential for nuclear protein import. EMBO J 1996; 15: 1818-1825 (Pubitemid 26119218)
    • (1996) EMBO Journal , vol.15 , Issue.8 , pp. 1818-1825
    • Weis, K.1    Ryder, U.2    Lamond, A.I.3
  • 8
    • 62449215108 scopus 로고    scopus 로고
    • The karyopherin proteins, Crm1 and karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation
    • Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D et al. The karyopherin proteins, Crm1 and karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation. Int J Cancer 2009; 124: 1829-1840
    • (2009) Int J Cancer , vol.124 , pp. 1829-1840
    • Watt, P.J.1    Maske, C.P.2    Hendricks, D.T.3    Parker, M.I.4    Denny, L.5    Govender, D.6
  • 9
    • 77951082203 scopus 로고    scopus 로고
    • Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma
    • Sakai M, Sohda M, Miyazaki T, Suzuki S, Sano A, Tanaka N et al. Significance of karyopherin-{alpha} 2 (KPNA2) expression in esophageal squamous cell carcinoma. Anticancer Res 2010; 30: 851-856
    • (2010) Anticancer Res , vol.30 , pp. 851-856
    • Sakai, M.1    Sohda, M.2    Miyazaki, T.3    Suzuki, S.4    Sano, A.5    Tanaka, N.6
  • 10
    • 79953209000 scopus 로고    scopus 로고
    • Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome
    • Wang CI, Wang CL, Wang CW, Chen CD, Wu CC, Liang Y et al. Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int J Cancer 2011; 128: 2364-2372
    • (2011) Int J Cancer , vol.128 , pp. 2364-2372
    • Wang, C.I.1    Wang, C.L.2    Wang, C.W.3    Chen, C.D.4    Wu, C.C.5    Liang, Y.6
  • 11
    • 77957221380 scopus 로고    scopus 로고
    • Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis
    • Zheng M, Tang L, Huang L, Ding H, Liao WT, Zeng MS et al. Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis. Obstet Gynecol 2010; 116: 884-891
    • (2010) Obstet Gynecol , vol.116 , pp. 884-891
    • Zheng, M.1    Tang, L.2    Huang, L.3    Ding, H.4    Liao, W.T.5    Zeng, M.S.6
  • 12
    • 79952254227 scopus 로고    scopus 로고
    • KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy
    • Mortezavi A, Hermanns T, Seifert HH, Baumgartner MK, Provenzano M, Sulser T et al. KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res 2011; 17: 1111-1121
    • (2011) Clin Cancer Res , vol.17 , pp. 1111-1121
    • Mortezavi, A.1    Hermanns, T.2    Seifert, H.H.3    Baumgartner, M.K.4    Provenzano, M.5    Sulser, T.6
  • 13
    • 84866043312 scopus 로고    scopus 로고
    • Nuclear karyopherin a2: A novel biomarker for infiltrative astrocytomas
    • Gousias K, Becker AJ, Simon M, Niehusmann P. Nuclear karyopherin a2: A novel biomarker for infiltrative astrocytomas. J Neurooncol 2012; 109: 545-553
    • (2012) J Neurooncol , vol.109 , pp. 545-553
    • Gousias, K.1    Becker, A.J.2    Simon, M.3    Niehusmann, P.4
  • 15
    • 79953233320 scopus 로고    scopus 로고
    • High expression of karyopherin-Alpha2 defines poor prognosis in non-muscle invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy
    • Jensen JB, Munksgaard PP, Sorensen CM, Fristrup N, Birkenkamp-Demtroder K, Ulhoi BP et al. High expression of karyopherin-Alpha2 defines poor prognosis in non-muscle invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy. Eur Urol 2011; 59: 841-848
    • (2011) Eur Urol , vol.59 , pp. 841-848
    • Jensen, J.B.1    Munksgaard, P.P.2    Sorensen, C.M.3    Fristrup, N.4    Birkenkamp-Demtroder, K.5    Ulhoi, B.P.6
  • 17
    • 35848936501 scopus 로고    scopus 로고
    • KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ
    • DOI 10.1007/s00428-007-0513-5
    • Dankof A, Fritzsche FR, Dahl E, Pahl S, Wild P, Dietel M et al. KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ. Virchows Arch 2007; 451: 877-881 (Pubitemid 350060752)
    • (2007) Virchows Archiv , vol.451 , Issue.5 , pp. 877-881
    • Dankof, A.1    Fritzsche, F.R.2    Dahl, E.3    Pahl, S.4    Wild, P.5    Dietel, M.6    Hartmann, A.7    Kristiansen, G.8
  • 18
    • 49749117528 scopus 로고    scopus 로고
    • Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity
    • Gluz O, Wild P, Meiler R, Diallo-Danebrock R, Ting E, Mohrmann S et al. Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity. Int J Cancer 2008; 123: 1433-1438
    • (2008) Int J Cancer , vol.123 , pp. 1433-1438
    • Gluz, O.1    Wild, P.2    Meiler, R.3    Diallo-Danebrock, R.4    Ting, E.5    Mohrmann, S.6
  • 21
    • 0031040797 scopus 로고    scopus 로고
    • Differential expression and sequence-specific interaction of karyopherin α with nuclear localization sequences
    • DOI 10.1074/jbc.272.7.4310
    • Nadler SG, Tritschler D, Haffar OK, Blake J, Bruce AG, Cleaveland JS. Differential expression and sequence-specific interaction of karyopherin alpha with nuclear localization sequences. J Biol Chem 1997; 272: 4310-4315 (Pubitemid 27078503)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.7 , pp. 4310-4315
    • Nadler, S.G.1    Tritschler, D.2    Haffar, O.K.3    Blake, J.4    Bruce, A.G.5    Cleaveland, J.S.6
  • 22
    • 84867784579 scopus 로고    scopus 로고
    • Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in non-small cell lung cancer
    • Wang CI, Chien KY, Wang CL, Liu HP, Cheng CC, Chang YS et al. Quantitative proteomics reveals regulation of karyopherin subunit alpha-2 (KPNA2) and its potential novel cargo proteins in non-small cell lung cancer. Mol Cell Proteomics 2012; 11: 1105-1122
    • (2012) Mol Cell Proteomics , vol.11 , pp. 1105-1122
    • Wang, C.I.1    Chien, K.Y.2    Wang, C.L.3    Liu, H.P.4    Cheng, C.C.5    Chang, Y.S.6
  • 23
    • 0035690439 scopus 로고    scopus 로고
    • Karyopherins and nuclear import
    • DOI 10.1016/S0959-440X(01)00264-0
    • Chook YM, Blobel G. Karyopherins and nuclear import. Curr Opin Struc Biol 2001; 11: 703-715 (Pubitemid 34076632)
    • (2001) Current Opinion in Structural Biology , vol.11 , Issue.6 , pp. 703-715
    • Yuh, M.C.1    Blobel, G.2
  • 24
    • 14544272335 scopus 로고    scopus 로고
    • Regulation of nuclear transport: Central role in development and transformation?
    • DOI 10.1111/j.1600-0854.2005.00268.x
    • Poon IK, Jans DA. Regulation of nuclear transport: Central role in development and transformation. Traffic 2005; 6: 173-186 (Pubitemid 40298152)
    • (2005) Traffic , vol.6 , Issue.3 , pp. 173-186
    • Poon, I.K.H.1    Jans, D.A.2
  • 26
    • 28244451307 scopus 로고    scopus 로고
    • Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1
    • Tseng SF, Chang CY, Wu KJ, Teng SC. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J Biol Chem 2005; 280: 39594-39600
    • (2005) J Biol Chem , vol.280 , pp. 39594-39600
    • Tseng, S.F.1    Chang, C.Y.2    Wu, K.J.3    Teng, S.C.4
  • 27
    • 0034725636 scopus 로고    scopus 로고
    • Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53
    • Kim IS, Kim DH, Han SM, Chin MU, Nam HJ, Cho HP et al. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J Biol Chem 2000; 275: 23139-23145
    • (2000) J Biol Chem , vol.275 , pp. 23139-23145
    • Kim, I.S.1    Kim, D.H.2    Han, S.M.3    Chin, M.U.4    Nam, H.J.5    Cho, H.P.6
  • 28
    • 0037205419 scopus 로고    scopus 로고
    • Identification of a karyopherin α2 recognition site in PLAG1, which functions as a nuclear localization signal
    • DOI 10.1074/jbc.M112112200
    • Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML. Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. J Biol Chem 2002; 277: 19673-19678 (Pubitemid 34967482)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.22 , pp. 19673-19678
    • Braem, C.V.1    Kas, K.2    Meyen, E.3    Debiec-Rychter, M.4    Van De Ven, W.J.M.5    Voz, M.L.6
  • 29
    • 34548289502 scopus 로고    scopus 로고
    • Dynamic FoxO transcription factors
    • DOI 10.1242/jcs.001222
    • Huang H, Tindall DJ. Dynamic FoxO transcription factors. J Cell Sci 2007; 120: 2479-2487 (Pubitemid 47323857)
    • (2007) Journal of Cell Science , vol.120 , Issue.15 , pp. 2479-2487
    • Huang, H.1    Tindall, D.J.2
  • 30
    • 0022619033 scopus 로고
    • Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium
    • Shipley GD, Pittelkow MR, Wille JJ, Scott RE, Moses HL. Reversible inhibition of normal human prokeratinocyte proliferation by type 'b transforming growth factor-growth inhibitor in serum-free medium. Cancer Res 1986; 46: 2068-2071 (Pubitemid 16117909)
    • (1986) Cancer Research , vol.46 , Issue.4 , pp. 2068-2071
    • Shipley, G.D.1    Pittelkow, M.R.2    Wille Jr., J.J.3
  • 31
    • 0028910316 scopus 로고
    • Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor b1
    • Alexandrow MG, Kawabata M, Aakre M, Moses HL. Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor b1. Proc Natl Acad Sci USA 1995; 92: 3239-3243
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3239-3243
    • Alexandrow, M.G.1    Kawabata, M.2    Aakre, M.3    Moses, H.L.4
  • 32
    • 0028031981 scopus 로고
    • Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon γ: Antagonism by retinoic acid and transforming growth factor β1
    • Saunders NA, Jetten AM. Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1. J Biol Chem 1994; 269: 2016-2022 (Pubitemid 24035408)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.3 , pp. 2016-2022
    • Saunders, N.A.1    Jetten, A.M.2
  • 33
    • 0026335527 scopus 로고
    • Lnterferon-γ modulates terminal differentiation and the expression of desquamin in cultured keratinocytes
    • Brysk MM, Bell T, Hoida C, Tyring SK, Rajaraman S. Interferon-gamma modulates terminal differentiation and the expression of desquamin in cultured keratinocytes. Exp Cell Res 1991; 197: 140-147 (Pubitemid 121006415)
    • (1991) Experimental Cell Research , vol.197 , Issue.2 , pp. 140-147
    • Brysk, M.M.1    Bell, T.2    Hoida, C.3    Tyring, S.K.4    Rajaraman, S.5
  • 34
    • 0028985258 scopus 로고
    • Interferon-gammamediated inactivation of transcription of the 230-kDa bullous pemphigoid antigen gene (BPAG1) provides novel insight into keratinocyte differentiation
    • Tamai K, Li K, Silos S, Rudnicka L, Hashimoto T, Nishikawa T et al. Interferon-gammamediated inactivation of transcription of the 230-kDa bullous pemphigoid antigen gene (BPAG1) provides novel insight into keratinocyte differentiation. J Biol Chem 1995; 270: 392-396
    • (1995) J Biol Chem , vol.270 , pp. 392-396
    • Tamai, K.1    Li, K.2    Silos, S.3    Rudnicka, L.4    Hashimoto, T.5    Nishikawa, T.6
  • 35
    • 0023691647 scopus 로고
    • Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor b
    • Coffey RJ, Bascom CC, Sipes NJ, Graves-Deal R, Weissman BE, Moses HL. Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor b. Mol Cell Biol 1988; 8: 3088-3093
    • (1988) Mol Cell Biol , vol.8 , pp. 3088-3093
    • Coffey, R.J.1    Bascom, C.C.2    Sipes, N.J.3    Graves-Deal, R.4    Weissman, B.E.5    Moses, H.L.6
  • 36
    • 33847765717 scopus 로고    scopus 로고
    • Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1
    • Huang SM, Huang SP, Wang SL, Liu PY. Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1. Biochem J 2007; 402: 359-366
    • (2007) Biochem J , vol.402 , pp. 359-366
    • Huang, S.M.1    Huang, S.P.2    Wang, S.L.3    Liu, P.Y.4
  • 37
    • 84875881470 scopus 로고    scopus 로고
    • 2 attenuates FOXO3a functioning in a PML-dependent manner: Implications in human prostate cancer
    • 2 attenuates FOXO3a functioning in a PML-dependent manner: Implications in human prostate cancer. Cell Death Dis 2013; 4: E543
    • (2013) Cell Death Dis , vol.4
    • Chatterjee, A.1    Chatterjee, U.2    Ghosh, M.K.3
  • 38
    • 84875994423 scopus 로고    scopus 로고
    • PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-Treated colorectal cancer cells
    • Luo H, Yang Y, Duan J, Wu P, Jiang Q, Xu C. PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-Treated colorectal cancer cells. Cell Death Dis 2013; 4: E481
    • (2013) Cell Death Dis , vol.4
    • Luo, H.1    Yang, Y.2    Duan, J.3    Wu, P.4    Jiang, Q.5    Xu, C.6
  • 39
    • 50349090038 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 is a novel prognostic maker for breast cancer progression and overall patient survival
    • Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY et al. Astrocyte elevated gene-1 is a novel prognostic maker for breast cancer progression and overall patient survival. Clin cancer Res 2008; 14: 3319-3326
    • (2008) Clin cancer Res , vol.14 , pp. 3319-3326
    • Li, J.1    Zhang, N.2    Song, L.B.3    Liao, W.T.4    Jiang, L.L.5    Gong, L.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.