Cytochalasin B induces apoptosis through the mitochondrial apoptotic pathway in HeLa human cervical carcinoma cells

Oncology Reports

Volumn 30, Issue 4, 2013, Pages 1929-1935

  Hwang, Jiyoung ^a   Yi, Myeongjin ^a   Zhang, Xin ^a,b   Xu, Yi ^a   Jung, Jee H ^c   Kim, Dong Kyoo ^a  

^a Inje University   (South Korea)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c Pusan National University   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; Cytochalasin B; Mitochondrial pathway; Reactive oxygen species

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHALASIN B; DNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; DNA REPLICATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHALASIN B; DNA REPLICATION; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; S PHASE CELL CYCLE CHECKPOINTS; UTERINE CERVICAL NEOPLASMS;

EID: 84882566861     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2617     Document Type: Article

References (38)

1. Fleury C, Mignotte B and Vayssière JL: Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84: 131-141, 2002.
2. Preeta R and Nair RR: Stimulation of cardiac fibroblast proliferation by cerium: a superoxide anion-mediated response. J Mol Cell Cardiol 31: 1573-1580, 1999.
3. Nicotera TM, Privalle C, Wang TC, et al: Differential proliferative responses of Syrian hamster embryo fibroblasts to paraquat-generated superoxide radicals depending on tumor suppressor gene function. Cancer Res 54: 3884-3888, 1994.
4. Morel I, Lescoat G, Cillard J, et al: Kinetic evaluation of freemalondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Involvement of free radicals. Biochem Pharmacol 39: 1647-1655, 1990.
5. Randerath K, Randerath E, Smith CV and Chang J: Structural origins of bulky oxidative DNA adducts (type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence. Chem Res Toxicol 9: 247-254, 1996.
6. Ames BN: Endogenous DNA damage as related to cancer and aging. Mutat Res 214: 41-46, 1989.
7. Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798, 1991.
8. Chan WH, Wu CC and Yu JS: Curcumin inhibits UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma A431 cells. J Cell Biochem 90: 327-338, 2003.
9. Earnshaw WC: Nuclear changes in apoptosis. Curr Opin Cell Biol 7: 337-343, 1995.
10. Miao C, Du J, Dang HT, et al: Apoptotic activity of fatty acid derivatives may correlate with their inhibition of DNA replication. Int J Oncol 33: 1291-1298, 2008.
11. Zhang X, Zhao J, Kang S, et al: A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway. Int J Oncol 39: 1609-1617, 2011.
12. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
13. Brown JM and Wouters BG: Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59: 1391-1399, 1999.
14. Reed JC and Green DR: Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis. Mol Cell 9: 1-3, 2002.
15. Wang C and Youle RJ: The role of mitochondria in apoptosis. Ann Rev Genet 43: 95-118, 2009.
16. Ghobrial IM, Witzig TE and Adjei AA: Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194, 2005.
17. Marzo I, Brenner C, Zamzami N, et al: The permeability transition pore complex: a target for apoptosis regulation by caspases and Bcl-2 related proteins. J Exp Med 187: 1261-1271, 1998.
18. Kuwana T and Newmeyer DD: Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 15: 691-699, 2003.
19. Boldin MP, Varfolomeev EE, Pancer Z, et al: A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem 270: 7796-7798, 1995.
20. Chinnaiyan AM, O'Rourke KO, Tewari M and Dixit VM: FADD, a novel death domain-containing protein, interacts with death domain of Fas and initiates apoptosis. Cell 81: 505-512, 1995.
21. Wilkinson CR: Symbiotic interactions between marine sponges and algae. In: Algae and Symbioses. Reisser W (ed). Biopress, Bristol, pp112-151, 1992.
22. Kim EL, Li JL, Dang HT, et al: Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorg Med Chem Lett 22: 3126-3129, 2012.
23. Spooner BS: Cytochalasins as probes in selected morphogenetic processes. In: Cytochalasins. Biochemical and Cell Biological Aspects. Tanenbaum SW (ed). Elsevier/North Holland Biomedical Press, Amsterdam, pp161-189, 1978.
24. Bonder EM and Mooseker MS: Cytochalasin B slows but does not prevent monomer addition at the barbed end of the actin filament. J Cell Biol 102: 282-288, 1986.
25. Foissner I and Wasteneys GO: Wide-ranging effects of eight cytochalasins and latrunculin A and B on intracellular motility and actin filament reorganization in characean internodal cells. Plant Cell Physiol 48: 585-587, 2007.
26. Ohmori H, Toyama S and Toyama S: Direct proof that the primary site of action of cytochalasin on cell motility processes is actin. J Cell Biol 116: 933-941, 1992.
27. Kulms D, Düssmann H, Pöppelmann B, et al: Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1). Cell Death Differ 9: 598-608, 2002.
28. Tominaga H, Ishiyama M, Ohseto F, et al: A water-soluble tetrazolium salt useful for colorimetric cell viability assay. Anal Commun 36: 47-50, 1999.
29. Lin SY, Liu JD, Chang HC, et al: Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 84: 532-544, 2002.
30. Bobyleva V, Pazienza TL, Maseroli R, et al: Decrease in mitochondrial energy coupling by thyroid hormones: a physiological effect rather than a pathological hyperthyroidism consequence. FEBS Lett 430: 409-413, 1998.
31. Qi F, Li A, Zhao L, et al: Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol 128: 654-661, 2010.
32. Sánchez I and Dynlacht BD: New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol 16: 311-321, 2005.
33. Lee S, Christakos S and Small MB: Apoptosis and signal transduction: clues to a molecular mechanism. Curr Opin Cell Biol 5: 286-291, 1993.
34. Smith DM, Gao G, Zhang X, et al: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review). Int J Mol Med 6: 503-507, 2000.
35. Park MT, Kim MJ, Kang YH, et al: Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. Blood 105: 1724-1733, 2005.
36. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
37. Jiang YH, Ahn EY, Ryu SH, et al: Cytotoxicity of psammaplin A from a two-sponge association may correlate with the inhibition of DNA replication. BMC Cancer 4: 70, 2004.
38. Qi F, Inagaki Y, Gao B, et al: Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways. Cancer Sci 102: 951-958, 2011.