메뉴 건너뛰기




Volumn 32, Issue 33, 2013, Pages 3886-3895

EZH2 promotes a bi-lineage identity in basal-like breast cancer cells

Author keywords

basal like; breast cancer; differentiation; EZH2; GATA3; Polycomb

Indexed keywords

TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR GATA 3;

EID: 84882452789     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.390     Document Type: Article
Times cited : (32)

References (44)
  • 1
    • 72749103664 scopus 로고    scopus 로고
    • Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis
    • Visvader JE. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 2009; 23: 2563-2577.
    • (2009) Genes Dev , vol.23 , pp. 2563-2577
    • Visvader, J.E.1
  • 2
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol 2011; 5: 5-23.
    • (2011) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 5
    • 58849100464 scopus 로고    scopus 로고
    • Do 'basal-like' breast cancers really exist?
    • Gusterson B. Do 'basal-like' breast cancers really exist? Nat Rev Cancer 2009; 9: 128-134.
    • (2009) Nat Rev Cancer , vol.9 , pp. 128-134
    • Gusterson, B.1
  • 6
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40: 499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6
  • 7
    • 68349130357 scopus 로고    scopus 로고
    • Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    • Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 2009; 15: 907-913.
    • (2009) Nat Med , vol.15 , pp. 907-913
    • Lim, E.1    Vaillant, F.2    Wu, D.3    Forrest, N.C.4    Pal, B.5    Hart, A.H.6
  • 8
    • 77956218241 scopus 로고    scopus 로고
    • BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    • Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 2010; 7: 403-417.
    • (2010) Cell Stem Cell , vol.7 , pp. 403-417
    • Molyneux, G.1    Geyer, F.C.2    Magnay, F.A.3    McCarthy, A.4    Kendrick, H.5    Natrajan, R.6
  • 10
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6: 846-856.
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    Van Lohuizen, M.2
  • 11
    • 77956222562 scopus 로고    scopus 로고
    • Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer
    • Sauvageau M, Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010; 7: 299-313.
    • (2010) Cell Stem Cell , vol.7 , pp. 299-313
    • Sauvageau, M.1    Sauvageau, G.2
  • 13
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100: 11606-11611.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 14
    • 84859831338 scopus 로고    scopus 로고
    • A complex Polycomb issue: The two faces of EZH2 in cancer
    • Hock H. A complex Polycomb issue: the two faces of EZH2 in cancer. Genes Dev 2012; 26: 751-755.
    • Genes Dev , vol.2012 , Issue.26 , pp. 751-755
    • Hock, H.1
  • 16
    • 84859099474 scopus 로고    scopus 로고
    • Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression
    • Alford SH, Toy K, Merajver SD, Kleer CG. Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression. Breast Cancer Res Treat 2012; 132: 429-37.
    • Breast Cancer Res Treat , vol.2012 , Issue.132 , pp. 429-437
    • Alford, S.H.1    Toy, K.2    Merajver, S.D.3    Kleer, C.G.4
  • 17
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003; 22: 5323-5335.
    • (2003) EMBO J , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 18
    • 60149096212 scopus 로고    scopus 로고
    • Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1
    • Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M et al. Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. Oncogene 2009; 28: 843-853.
    • (2009) Oncogene , vol.28 , pp. 843-853
    • Gonzalez, M.E.1    Li, X.2    Toy, K.3    Duprie, M.4    Ventura, A.C.5    Banerjee, M.6
  • 19
    • 65249101694 scopus 로고    scopus 로고
    • EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
    • Richter GH, Plehm S, Fasan A, Rossler S, Unland R, Bennani-Baiti IM et al. EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation. Proc Natl Acad Sci USA 2009; 106: 5324-5329.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 5324-5329
    • Richter, G.H.1    Plehm, S.2    Fasan, A.3    Rossler, S.4    Unland, R.5    Bennani-Baiti, I.M.6
  • 20
    • 35748937338 scopus 로고    scopus 로고
    • Integrative genomics analysis reveals silencing of beta-adrenergic signaling by Polycomb in prostate cancer
    • Yu J, Cao Q, Mehra R, Laxman B, Tomlins SA, Creighton CJ et al. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by Polycomb in prostate cancer. Cancer Cell 2007; 12: 419-431.
    • (2007) Cancer Cell , vol.12 , pp. 419-431
    • Yu, J.1    Cao, Q.2    Mehra, R.3    Laxman, B.4    Tomlins, S.A.5    Creighton, C.J.6
  • 22
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by Polycomb in human embryonic stem cells
    • Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006; 125: 301-313.
    • (2006) Cell , vol.125 , pp. 301-313
    • Lee, T.I.1    Jenner, R.G.2    Boyer, L.A.3    Guenther, M.G.4    Levine, S.S.5    Kumar, R.M.6
  • 24
    • 0037948854 scopus 로고    scopus 로고
    • Vitro propagation and transcriptional profiling of human mammary stem/ progenitor cells
    • Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ et al. In vitro propagation and transcriptional profiling of human mammary stem/ progenitor cells. Genes Dev 2003; 17: 1253-1270.
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1    Abdallah, W.M.2    Foley, J.M.3    Jackson, K.W.4    Clarke, M.F.5    Kawamura, M.J.6
  • 25
    • 73149110562 scopus 로고    scopus 로고
    • Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content
    • Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S et al. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 2010; 140: 62-73.
    • (2010) Cell , vol.140 , pp. 62-73
    • Pece, S.1    Tosoni, D.2    Confalonieri, S.3    Mazzarol, G.4    Vecchi, M.5    Ronzoni, S.6
  • 26
    • 34248650697 scopus 로고    scopus 로고
    • The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    • Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol 2007; 1: 84-96.
    • (2007) Mol Oncol , vol.1 , pp. 84-96
    • Kenny, P.A.1    Lee, G.Y.2    Myers, C.A.3    Neve, R.M.4    Semeiks, J.R.5    Spellman, P.T.6
  • 27
    • 25444443688 scopus 로고    scopus 로고
    • Modelling glandular epithelial cancers in three-dimensional cultures
    • Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005; 5: 675-688.
    • (2005) Nat Rev Cancer , vol.5 , pp. 675-688
    • Debnath, J.1    Brugge, J.S.2
  • 30
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature 2011; 479: 189-193.
    • (2011) Nature , vol.479 , pp. 189-193
    • Van Keymeulen, A.1    Rocha, A.S.2    Ousset, M.3    Beck, B.4    Bouvencourt, G.5    Rock, J.6
  • 31
    • 84863012487 scopus 로고    scopus 로고
    • A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer
    • Spike BT, Engle DD, Lin JC, Cheung SK, La J, Wahl GM. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell 2012; 10: 183-197.
    • (2012) Cell Stem Cell , vol.10 , pp. 183-197
    • Spike, B.T.1    Engle, D.D.2    Lin, J.C.3    Cheung, S.K.4    La Wahl, J.G.M.5
  • 32
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D et al. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 2008; 68: 4674-4682.
    • (2008) Cancer Res , vol.68 , pp. 4674-4682
    • Zhang, M.1    Behbod, F.2    Atkinson, R.L.3    Landis, M.D.4    Kittrell, F.5    Edwards, D.6
  • 33
    • 79551614327 scopus 로고    scopus 로고
    • Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate
    • Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, Sedic M et al. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 2011; 8: 149-163.
    • (2011) Cell Stem Cell , vol.8 , pp. 149-163
    • Proia, T.A.1    Keller, P.J.2    Gupta, P.B.3    Klebba, I.4    Jones, A.D.5    Sedic, M.6
  • 34
    • 33751202983 scopus 로고    scopus 로고
    • GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    • Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z. GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell 2006; 127: 1041-1055.
    • (2006) Cell , vol.127 , pp. 1041-1055
    • Kouros-Mehr, H.1    Slorach, E.M.2    Sternlicht, M.D.3    Werb, Z.4
  • 37
    • 83255186736 scopus 로고    scopus 로고
    • Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14
    • Asselin-Labat ML, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S et al. Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol 2011; 31: 4609-4622.
    • (2011) Mol Cell Biol , vol.31 , pp. 4609-4622
    • Asselin-Labat, M.L.1    Sutherland, K.D.2    Vaillant, F.3    Gyorki, D.E.4    Wu, D.5    Holroyd, S.6
  • 39
    • 29244481995 scopus 로고    scopus 로고
    • Identification of GATA3 as a breast cancer prognostic marker by global gene expression metaanalysis
    • Mehra R, Varambally S, Ding L, Shen R, Sabel MS, Ghosh D et al. Identification of GATA3 as a breast cancer prognostic marker by global gene expression metaanalysis. Cancer Res 2005; 65: 11259-11264.
    • (2005) Cancer Res , vol.65 , pp. 11259-11264
    • Mehra, R.1    Varambally, S.2    Ding, L.3    Shen, R.4    Sabel, M.S.5    Ghosh, D.6
  • 40
    • 21044455192 scopus 로고    scopus 로고
    • Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
    • Gusterson BA, Ross DT, Heath VJ, Stein T. Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res 2005; 7: 143-148.
    • (2005) Breast Cancer Res , vol.7 , pp. 143-148
    • Gusterson, B.A.1    Ross, D.T.2    Heath, V.J.3    Stein, T.4
  • 41
    • 78651454089 scopus 로고    scopus 로고
    • EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling
    • Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH et al. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling. Cancer Cell 2011; 19: 86-100.
    • (2011) Cancer Cell , vol.19 , pp. 86-100
    • Chang, C.J.1    Yang, J.Y.2    Xia, W.3    Chen, C.T.4    Xie, X.5    Chao, C.H.6
  • 42
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF- 10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF- 10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 43
    • 0031743608 scopus 로고    scopus 로고
    • Selfinactivating lentivirus vector for safe and efficient in vivo gene delivery
    • Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L et al. Selfinactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 1998; 72: 9873-9880.
    • (1998) J Virol , vol.72 , pp. 9873-9880
    • Zufferey, R.1    Dull, T.2    Mandel, R.J.3    Bukovsky, A.4    Quiroz, D.5    Naldini, L.6
  • 44
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5    Gillette, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.