Uterine infusion of melatonin or melatonin receptor antagonist alters ovine feto-placental hemodynamics during midgestation

Biology of Reproduction

Volumn 89, Issue 2, 2013, Pages

  Lemley, Caleb O ^a   Camacho, Leticia E ^b   Vonnahme, Kimberly A ^b  

^a MISSISSIPPI STATE UNIVERSITY   (United States)

^b NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Luzindole; Melatonin; Placental efficiency; Sheep; Umbilical blood flow

Indexed keywords

LUZINDOLE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; MELATONIN; MELATONIN RECEPTOR; TRYPTAMINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTERY BLOOD FLOW; ARTICLE; CONTROLLED STUDY; DESCENDING AORTA; DIET SUPPLEMENTATION; EMBRYO; EXPERIMENTAL STUDY; FEMALE; FETUS; FETUS CIRCULATION; FETUS DEVELOPMENT; FETUS WEIGHT; GESTATIONAL AGE; HEART OUTPUT; HEMODYNAMICS; NONHUMAN; PLACENTA CIRCULATION; PLACENTA DEVELOPMENT; PLACENTA WEIGHT; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; UMBILICAL ARTERY; ANIMAL; BLOOD FLOW; DRUG ANTAGONISM; DRUG EFFECT; PHYSIOLOGY; PLACENTA; PLACENTAL EFFICIENCY; PREGNANCY; SHEEP; UMBILICAL CORD BLOOD FLOW; UTERUS; VASCULARIZATION;

LUZINDOLE; MELATONIN; PLACENTAL EFFICIENCY; SHEEP; UMBILICAL BLOOD FLOW;

ANIMALS; FEMALE; FETUS; HEMODYNAMICS; MELATONIN; PLACENTA; PREGNANCY; RECEPTORS, MELATONIN; REGIONAL BLOOD FLOW; SHEEP; TRYPTAMINES; UMBILICAL ARTERIES; UTERUS;

EID: 84882429033     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.109074     Document Type: Article

References (37)

1. Kwon H, Ford SP, Bazer FW, Spencer TE, Nathanielsz PW, Nijland MJ, Hess BW, Wu G. Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol Reprod 2004; 71:901-908.
2. Reynolds LP , Borowicz PP, Vonnahme KA, Johnson ML, Grazul-Bilska AT, Redmer DA, Caton JS. Placental angiogenesis in sheep models of compromised pregnancy. J Physiol 2005; 565:43-58.
3. Ford SP. Control of blood flow to the gravid uterus of domestic livestock species. J Anim Sci 1995; 73:1852-1860.
4. Redmer DA, Wallace JM, Reynolds LP. Effect of nutrient intake during pregnancy on fetal and placental growth and vascular development. Domest Anim Endocrinol 2004; 27:199-217.
5. Reynolds LP , Caton JS, Redmer DA, Grazul-Bilska AT, Vonnahme KA, Borowicz PP, Luther JS, Wallace JM, Wu G, Spencer TE. Evidence for altered placental blood flow and vascularity in compromised pregnancies. J Physiol 2006; 572:51-58.
6. Lemley CO , Meyer AM, Camacho LE, Neville TL, Newman DJ, Caton JS, Vonnahme KA. Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol 2012; 302: R454-R467.
7. Rigano S, Bozzo M, Ferrazzi E, Bellotti M, Battaglia FC, Galan HL. Early and persistent reduction in umbilical vein blood flow in the growthrestricted fetus: a longitudinal study. Am J Obstet Gynecol 2001; 185: 834-838.
8. Barker DJ, Clark PM. Fetal undernutrition and disease in later life. Rev Reprod 1997; 2:105-112.
9. Greenwood PL, Hunt AS, Hermanson JW, Bell AW. Effects of birth weight and postnatal nutrition on neonatal sheep: I. Body growth and composition, and some aspects of energetic efficiency. J Anim Sci 1998; 76:2354-2367.
10. Vonnahme KA, Lemley CO, Shukla P, O'Rourke ST. Placental programming: how the maternal environment can impact placental function J Anim Sci 2013; 91:2467-2480.
11. Paulis L, Simko F. Blood pressure modulation and cardiovascular protection by melatonin: potential mechanisms behind. Physiol Res 2007; 56:671-684.
12. Shibata S, Satake N, Takagi T, Usui H. Vasorelaxing action of melatonin in rabbit basilar artery. Gen Pharmacol 1989; 20:677-680.
13. Weekley LB . Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res 1991; 11:28-34.
14. Schrick FN, Surface RA, Pritchard JY, Dailey RA, Townsend EC, Inskeep EK. Ovarian structures during the estrous cycle and early pregnancy in ewes. Biol Reprod 1993; 49:1133-1140.
15. Lemley CO, Meyer AM, Camacho LE, Neville TL, Shukla P, O'Rourke ST, Caton JS, Vonnahme KA. Umbilical cord blood flow following melatonin supplementation in adequately fed or nutrient restricted ewes. Biol Reprod 2011;85(special issue):Abstract 458.
16. Rudolph AM, Heymann MA. The circulation of the fetus in utero. Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ Res 1967; 21:163-184.
17. Arduini D, Rizzo G. Prediction of fetal outcome in small for gestational age fetuses: comparison of Doppler measurements obtained from different fetal vessels. J Perinat Med 1992; 20:29-38.
18. Hecher K , Campbell S, Doyle P, Harrington K, Nicolaides K. Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation. Arterial, intracardiac, and venous blood flow velocity studies. Circulation 1995; 91:129-138.
19. Carr DJ, Aitken RP, Milne JS, David AL, Wallace JM. Fetoplacental biometry and umbilical artery Doppler velocimetry in the overnourished adolescent model of fetal growth restriction. Am J Obstet Gynecol 2012; 207:141.e6-141.e15.
20. Irion GL, Clark KE. Direct determination of the ovine fetal umbilical artery blood flow waveform. Am J Obstet Gynecol 1990; 162:541-549.
21. Abecia JA, Lozano JM, Forcada F. A preliminary study on the effects of dietary energy and melatonin on the ex vivo production of progesterone and prostaglandin F2alpha by the corpora lutea and endometrial tissue of ewes. Vet Res Commun 1999; 23:115-121.
22. Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC. Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. J Pineal Res 1993; 14:151-168.
23. Reiter RJ, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz GG, Acuna-Castroviejo D. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995; 18:1-11.
24. Arangino S, Cagnacci A, Angiolucci M, Vacca AM, Longu G, Volpe A, Melis GB. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999; 83: 1417-1419.
25. Abete P, Bianco S, Calabrese C, Napoli C, Cacciatore F, Ferrara N, Rengo F. Effects of melatonin in isolated rat papillary muscle. FEBS Lett 1997; 412:79-85.
26. Capsoni S, Viswanathan M, De Oliveira AM, Saavedra JM. Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis. Endocrinology 1994; 135:373-378.
27. Dubocovich ML. Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci 1995; 16:50-56.
28. Cook JS, Sauder CL, Ray CA. Melatonin differentially affects vascular blood flow in humans. Am J Physiol Heart Circ Physiol 2011; 300: H670-H674.
29. Geary GG, Krause DN, Duckles SP. Melatonin directly constricts rat cerebral arteries through modulation of potassium channels. Am J Physiol 1997; 273:H1530-H1536.
30. Das R, Balonan L, Ballard HJ, Ho S. Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. Int J Cardiol 2008; 126:340-345.
31. Dominguez-Rodriguez A, Abreu-Gonzalez P, Sanchez-Sanchez JJ, Kaski JC, Reiter RJ. Melatonin and circadian biology in human cardiovascular disease. J Pineal Res 2010; 49:14-22.
32. Torres-Farfan C, Valenzuela FJ, Mondaca M, Valenzuela GJ, Krause B, Herrera EA, Riquelme R, Llanos AJ, Seron-Ferre M. Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland. J Physiol 2008; 586:4017-4027.
33. Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Hum Reprod Update 2006; 12:747-755.
34. Thakor AS, Herrera EA, Seron-Ferre M, Giussani DA. Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms. J Pineal Res 2010; 49:399-406.
35. Richter HG , Hansell JA, Raut S, Giussani DA. Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy. J Pineal Res 2009; 46:357-364.
36. Blask DE, Sauer LA, Dauchy RT, Holowachuk EW, Ruhoff MS, Kopff HS. Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. Cancer Res 1999; 59:4693-4701.
37. Cos S, Sanchez-Barcelo EJ. Differences between pulsatile or continuous exposure to melatonin on MCF-7 human breast cancer cell proliferation. Cancer Lett 1994; 85:105-109.