The activation effect of nobiletin on cystic fibrosis transmembrane conductance regulator chloride channel

Yaoxue Xuebao

Volumn 48, Issue 6, 2013, Pages 848-854

  Yang, Shuang ^a   Yu, Bo ^a   Zhang, Yao Fang ^a   Wang, Xue ^a   Yang, Hong ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

Author keywords

Activator; CFTR; Nobiletin

Indexed keywords

CHLORIDE CHANNEL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IODIDE; NOBILETIN; 3-((3-TRIFLUOROMETHYL)PHENYL)-5-((3-CARBOXYPHENYL)METHYLENE)-2-THIOXO-4-THIAZOLIDINONE; BENZOIC ACID DERIVATIVE; CFTR PROTEIN, HUMAN; FLAVONE DERIVATIVE; THIAZOLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BRONCHIECTASIS; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVATION; DRUG BINDING; DRUG EFFECT; EX VIVO STUDY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PATCH CLAMP; SECRETION (PROCESS); SUBMUCOSA; TRACHEA; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; EXOCRINE GLAND; FISCHER 344 RAT; HUMAN; METABOLISM; PATCH CLAMP TECHNIQUE; RAT; THYROID GLAND; TIME FACTOR;

ANIMALS; BENZOATES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; EXOCRINE GLANDS; FLAVONES; HUMANS; MICE; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED F344; THIAZOLIDINES; THYROID GLAND; TIME FACTORS; TRACHEA;

EID: 84882403187     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Riordan JR, Rommens JM, Kerem D, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA[J], Science, 1989, 245:1066-1073.
2. Kunzetmann K. The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport [J], Rev Physiol Biochem Pharmacol, 1999, 137:1-70.
3. Greger R. Role of CFTR in the colon [J], Annu Rev Physiol, 2000, 62:467-491.
4. Banales JM, Prieto J, Medina JF. Cholangiocyte anion exchange and biliary bicarbonate excretion [J], World J Gastroenterol, 2006, 12:3496-3511.
5. Riordan JR. CFTR function and prospects for therapy [J]. Annu Rev Biochem, 2008, 77:701-726.
6. Dalemans W, Barbry P, Champigny G, et al. Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation [J], Nature, 1991, 354:526-528.
7. Cohn JA, Friedman KJ, Noone PG, et al. Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis [J]. N Engl J Med, 1998, 339:653-658.
8. Pratha VS, Hogan DL, Martensson BA, et al. Identification of transport abnormalities in duodenal mucosa and duodenal enterocytes from patients with cystic fibrosis [J], Gastroenterology, 2000, 118:1051-1060.
9. Minagawa A, Otani Y, Kubota T, et al. The citrus flavonoid, nobiletin inhibits peritoneal dissemination of human gastric earcinomain SCID mice [J], Jpn J Cancer Res, 2001, 92:1322-1328.
10. Chen J, Montanari AM. Isolation and identification of new polymethoxyflavonoids from dancy tangerine leaves [J]. Agric Food Chem, 1998, 46:1235-1238.
11. Xu LL, He YQ, Guo X, et al. Identification of metabolites of nobiletin in rats using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry [J], Acta Pharm Sin, 2011, 46:1483-1487.
12. He C, Zhang H, Su Z, et al. Synthesis and characterization of a small molecule thiazolidinone CFTR chloride channel inhibitor [J], Chem Res Chin Univ, 2004, 20:334-337.
13. Galietta LV, Jayaraman S, Verkman AS. Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists [J]. Am J Physiol Cell Physiol, 2001, 281:C1734-1742.
14. Zegarra-Moran O, Romio L, Folli C, et al. Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07 [J]. Br J Pharmacol, 2002, 137:504-512.
15. Yang H, Shelat AA, Guy RK, et al. Nanomolar affinity small molecule correctors of defective {delta}F508-CFTR chloride channel gating [J], J Biol Chem, 2003, 278:35079-35085.
16. Bompadre SG, Ai T, Cho JH, et al. CFTR gating I: characterization of the ATP-dependent gating of a phosphorylationindependent CFTR channel (DeltaR-CFTR) [J], J Gen Physiol, 2005, 125:361-375.
17. Zhu FX, Liu ZL, Qu HG, et al. Post-translational ligation and function of dual-vector transferred split CFTR gene [J]. Acta Pharm Sin, 2010, 45:60-65.
18. Song Y, Verkman AS. Aquaporin-5 dependent fluid secretion in airway submucosal glands [J], J Biol Chem, 2001, 276:41288-41292.
19. + (KCNQI) channels [J]. Br J Anaesth, 2007, 99:245-251.
20. - ion channels by phosphorylation and déphosphorylation [J], Adv Second Messenger Phosphoprotein Res, 1999, 33:79-106.
21. - channel [J], Trends Pharmacol Sci, 1999, 20:448-453.
22. Flume PA, O'Sullivan BP, Robinson KA, et al. Cystic fibrosis foundation, pulmonary therapies committee. Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung health [J]. Am J Respir Crit Care Med, 2007, 176:957-969.
23. Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter-and intracellular signaling [J], Clin Rev Allergy Immunol, 2008, 34:146-162.