The sumoylation of zinc-fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity

Journal of Cellular Biochemistry

Volumn 114, Issue 10, 2013, Pages 2323-2333

  Chen, Shuliang ^a,b   Yu, Xiao ^a,b   Lei, Quan ^a   Ma, Lixin ^b   Guo, Deyin ^a  

^a WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY   (China)

Author keywords

SUMO; SUMOYLATION; TRANSCRIPTIONAL ACTIVITY; ZHX1

Indexed keywords

PROTEIN UBC9; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO PROTEIN; TRANSCRIPTION FACTOR ZHX1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; DNA LIBRARY; HUMAN; HYBRID; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SUMOYLATION; UBIQUITINATION;

EID: 84882396950     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24579     Document Type: Article

References (35)

1. Barthelemy I, Carramolino L, Gutierrez J, Barbero JL, Marquez G, Zaballos A,. 1996. Zhx-1: A novel mouse homeodomain protein containing two zinc-fingers and five homeodomains. Biochem Biophys Res Commun 224: 870-876.
2. Cai Q, Verma SC, Kumar P, Ma M, Robertson ES,. 2010. Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS ONE 5: e9720.
3. Desterro JM, Rodriguez MS, Hay RT,. 1998. SUMO-1 modification of Ikappa Balpha inhibits NF-kappaB activation. Mol Cell 2: 233-239.
4. Gareau JR, Lima CD,. 2010. The SUMO pathway: Emerging mechanisms that shape specificity, conjugation and recognition. Nat Rev Mol Cell Biol 11: 861-871.
5. Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY,. 2004. A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet 36: 837-841.
6. Han KJ, Jiang L, Shu HB,. 2008. Regulation of IRF2 transcriptional activity by its sumoylation. Biochem Biophys Res Commun 372: 772-778.
7. Hecker CM, Rabiller M, Haglund K, Bayer P, Dikic I,. 2006. Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem 281: 16117-16127.
8. Hirano S, Yamada K, Kawata H, Shou Z, Mizutani T, Yazawa T, Kajitani T, Sekiguchi T, Yoshino M, Shigematsu Y, Mayumi M, Miyamoto K,. 2002. Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer. Gene 290: 107-114.
9. Hou Y, Yuan J, Zhou X, Fu X, Cheng H, Zhou R,. 2012. DNA demethylation and USF regulate the meiosis-specific expression of the mouse Miwi. PLoS Genet 8: e1002716.
10. Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S,. 2003. Sequential modification of NEMO/IKK gamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115: 565-576.
11. Kim SH, Park J, Choi MC, Kim HP, Park JH, Jung Y, Lee JH, Oh DY, Im SA, Bang YJ, Kim TY,. 2007. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Biochem Biophys Res Commun 355: 318-323.
12. Kosoy R, Concannon P,. 2005. Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes. Genes Immun 6: 231-235.
13. Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB,. 2006. Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. J Biol Chem 281: 36221-36227.
14. Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH,. 2003. SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J Biol Chem 278: 31043-31048.
15. Lomeli H, Vazquez M,. 2011. Emerging roles of the SUMO pathway in development. Cell Mol Life Sci 68: 4045-4064.
16. Meulmeester E, Melchior F,. 2008. Cell biology: SUMO. Nature 452: 709-711.
17. Muller S, Berger M, Lehembre F, Seeler JS, Haupt Y, Dejean A,. 2000. c-Jun and p53 activity is modulated by SUMO-1 modification. J Biol Chem 275: 13321-13329.
18. Percherancier Y, Germain-Desprez D, Galisson F, Mascle XH, Dianoux L, Estephan P, Chelbi-Alix MK, Aubry M,. 2009. Role of SUMO in RNF4-mediated promyelocytic leukemia protein (PML) degradation: Sumoylation of PML and phospho-switch control of its SUMO binding domain dissected in living cells. J Biol Chem 284: 16595-1608.
19. Poukka H, Karvonen U, Janne OA, Palvimo JJ,. 2000. Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc Natl Acad Sci USA 97: 14145-14150.
20. Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ, Polychronakos C,. 2005. Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. Nat Genet 37: 111-112; author reply 112-113.
21. Rodriguez MS, Desterro JM, Lain S, Midgley CA, Lane DP, Hay RT,. 1999. SUMO-1 modification activates the transcriptional response of p53. EMBO J 18: 6455-6461.
22. Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G,. 2002. Transcription factor Sp3 is silenced through SUMO modification by PIAS1. EMBO J 21: 5206-5215.
23. Shou Z, Yamada K, Inazu T, Kawata H, Hirano S, Mizutani T, Yazawa T, Sekiguchi T, Yoshino M, Kajitani T, Okada K, Miyamoto K,. 2003. Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Gene 302: 83-94.
24. Shou Z, Yamada K, Kawata H, Yokoyama O, Miyamoto K,. 2004. A mechanism of induction of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene expression by interleukin-2. Biochem Biophys Res Commun 314: 885-890.
25. Stindt MH, Carter S, Vigneron AM, Ryan KM, Vousden KH,. 2011. MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle 10: 3176-3188.
26. Ulrich HD,. 2005. Mutual interactions between the SUMO and ubiquitin systems: A plea of no contest. Trends Cell Biol 15: 525-532.
27. Wang J, Feng XH, Schwartz RJ,. 2004. SUMO-1 modification activated GATA4-dependent cardiogenic gene activity. J Biol Chem 279: 49091-49098.
28. Xu H, Fu J, Ha SW, Ju D, Zheng J, Li L, Xie Y,. 2012. The CCAAT box-binding transcription factor NF-Y regulates basal expression of human proteasome genes. Biochim Biophys Acta 1823: 818-825.
29. Yamada K, Kawata H, Matsuura K, Shou Z, Hirano S, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K,. 2002. Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1). Biochem Biophys Res Commun 297: 368-374.
30. Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, Sekiguchi T, Yoshino M, Kajitani T, Miyamoto K,. 2003. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: Molecular cloning and characterization of a member of the ZHX family, ZHX3. Biochem J 373: 167-178.
31. Yamada K, Osawa H, Granner DK,. 1999a. Identification of proteins that interact with NF-YA. FEBS Lett 460: 41-45.
32. Yamada K, Printz RL, Osawa H, Granner DK,. 1999b. Human ZH X1: Cloning, chromosomal location, and interaction with transcription factor NF-Y. Biochem Biophys Res Commun 261: 614-621.
33. Yang SH, Sharrocks AD,. 2004. SUMO promotes HDAC-mediated transcriptional repression. Mol Cell 13: 611-617.
34. Zheng Z, Cai C, Omwancha J, Chen SY, Baslan T, Shemshedini L,. 2006. SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. J Biol Chem 281: 4002-4012.
35. Zhu D, Zhong X, Tan R, Chen L, Huang G, Li J, Sun X, Xu L, Chen J, Ou Y, Zhang T, Yuan D, Zhang Z, Shu W, Ma L,. 2010. High-throughput cloning of human liver complete open reading frames using homologous recombination in Escherichia coli. Anal Biochem 397: 162-167.