The neuropsychiatric translational revolution still very early and still very challenging

JAMA Psychiatry

Volumn 70, Issue 8, 2013, Pages 777-779

  Braff, Lara ^a   Braff, David L ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED RESEARCH; AUTOSOMAL DOMINANT INHERITANCE; BASIC RESEARCH; CONNECTOME; GENE MUTATION; HEALTH SERVICE; HUMAN; HUNTINGTON CHOREA; MOLECULAR PATHOLOGY; NEUROBIOLOGY; NEUROPSYCHIATRY; NOTE; PSYCHOPHARMACOLOGY; QUESTIONNAIRE; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSLATIONAL RESEARCH;

EID: 84882395088     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2013.2184     Document Type: Note

References (17)

1. Karayiorgou M, Flint J, Gogos JA, Malenka RC; Genetic and Neural Complexity in Psychiatry 2011 Working Group. The best of times, the worst of times for psychiatric disease. Nat Neurosci. 2012;15(6):811-812.
2. Braff DL. Promises, challenges and caveats of translational research in neuropsychiatry. In: Barrett JE, Coyle JT,Williams M, eds. Translational Neuroscience: Applications in Neurology, Psychiatry, and Neurodevelopmental Disorders. Cambridge, England: Cambridge University Press; 2012:339-358.
3. Swerdlow NR. Are we studying and treating schizophrenia correctly? Schizophr Res. 2011;130(1-3):1-10.
4. Goldstein JL, Brown MS. From fatty streak to fatty liver: 33 years of joint publications in the JCI. J Clin Invest. 2008;118(4):1220-1222. (Pubitemid 351500405)
5. Braff DL, Braff L. Anatomy of the "neuropsychiatric translational research revolution": Challenges abound. Neuropsychopharmacology. 2012;38:S314-S446.
6. Collins FS. Reengineering translational science: The time is right. Sci Transl Med. 2011;3(90): 90cm17. doi:10.1126/scitranslmed.3002747.
7. Braff DL, Freedman R. Clinically responsible genetic testing in neuropsychiatric patients: A bridge too far and too soon. Am J Psychiatry. 2008;165(8):952-955.
8. Insel TR. Next-generation treatments for mental disorders. Sci Transl Med. 2012;4(155):155ps19.
9. Kaiser J. Human genetics: Genetic influences on disease remain hidden. Science. 2012;338(6110): 1016-1017.
10. Kolata G. How bright promise in cancer testing fell apart. New York Times. July 7, 2011.
11. Fisher M, Holland C, Merzenich MM, Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am J Psychiatry. 2009;166(7):805-811.
12. Insel TR, Collins FS. Psychiatry in the genomics era. Am J Psychiatry. 2003;160(4):616-620.
13. Collins FS. The Language of Life: DNA and the Revolution in Personalized Medicine. New York, NY: Harper Collins Publishers; 2010.
14. Williams M, Coyle JT. Historical perspectives on the discovery and development of drugs to treat neurological disorders. In: Barrett JE, Coyle JT, Williams M, eds. Translational Neuroscience: Applications in Neurology, Psychiatry, and Neurodevelopmental Disorders. Cambridge, England: Cambridge University Press; 2012: 129-148.
15. Kuhn T. The Structure of Scientific Revolutions. Chicago, IL: University of Chicago Press; 1962.
16. Roffman JL, Lamberti JS, Achtypes E, et al. Randomized Multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia [published online March 6, 2013]. JAMA Psychiatry. doi:10.1001/jamapsychiatry. 2013.900.
17. Brinton C. The Anatomy of Revolution. New York, NY: Random House; 1938.