In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative

Pharmaceutical Biology

Volumn 51, Issue 9, 2013, Pages 1087-1090

  Lucarini, Rodrigo ^a   Bernardes, Wagner A ^a   Ferreira, Daniele S ^a   Tozatti, Marcos G ^a   Furtado, Ricardo ^b   Bastos, Jairo K ^b   Pauletti, Patrícia M ^a   Januário, Ana H ^a   Silva, Márcio L Andrade E ^a   Cunha, Wilson R ^a  

^a UNIVERSIDADE DE FRANCA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antinociceptive activity; Formalin test; Lamiaceae; Paw edema

Indexed keywords

ACETYL ESTER DERIVATIVE; INDOMETACIN; MORPHINE; PLANT MEDICINAL PRODUCT; ROSMARINIC ACID; ROSMARINUS OFFICINALIS EXTRACT; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PAIN; PAW EDEMA; PLANT LEAF; PLANT STEM; TREATMENT OUTCOME;

ACETYLATION; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; BRAZIL; CINNAMATES; DEPSIDES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHNOPHARMACOLOGY; MALE; MEDICINE, TRADITIONAL; MICE; NEURALGIA; NEUROGENIC INFLAMMATION; PLANT EXTRACTS; PLANT LEAVES; PLANT STEMS; RATS; RATS, WISTAR; ROSMARINUS;

EID: 84882342360     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.776613     Document Type: Article

References (23)

1. Amaral GP, de Carvalho NR, Barcelos RP, et al. (2012). Protective action of ethanol extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats. Food Chem Toxicol 55C: 48-55.
2. Bernardes WA, Lucarini R, Tozatti MG, et al. (2010). Antimicrobial activity of Rosmarinus officinalis against oral pathogens: Relevance of carnosic acid and carnosol. Chem Biodivers 7: 1835-1840.
3. Diaz AM, Abad MJ, Fernadez L, et al. (2000). In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. Biol Pharm Bull 23: 1307-13.
4. Fahim FA, Esmat AY, Fadel HM, Hassan KF. (1999). Allied studies on the effect of Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis. Int J Food Sci Nutr 5: 413-27.
5. Frankel E, Huang S, Aeschbach R, Prior E. (1996). Antioxidant activity of rosemary extract and its constituents, carnosic acid, carnosol, and rosmarinic acid, in bulk oil and oil-in-water emulsion. J Agric Food Chem 44: 131-5.
6. Furtado RA, De Araújo FRR, Rezende FA, et al. (2010). Protective effect of rosmarinic acid on V79 cells evaluated by the micronucleus and comet assays. J Appl Toxicol 30: 254-9.
7. González-Trujano ME, Peña EI, Martínez AL, et al. (2007). Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. J Ethnopharmacol 111: 476-82.
8. Hosseinzadeh H, Nourbakhsh M. (2003). Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice. Phytother Res 17: 938-41.
9. Husnkaar S, Hole K. (1987). The formalin test in mice: Dissociation between inflammatory and non-inflamatory pain. Pain 30: 103-19.
10. Jordán MJ, Lax V, Rota MC, et al. (2012). Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidante and antimicrobial activities of Rosmarinus officinalis (L.) methanol extracts. J Agric Food Chem 60: 9603-8.
11. Koster R, Anderson M, Beer EJ. (1959). Acetic acid for analgesic screening. Fed Proc 18: 412-16.
12. Koşar M, Göger F, Can Başer KH. (2008). In vitro antioxidant properties and phenolic composition of Salvia virgata Jacq. from Turkey. J Agric Food Chem 56: 2369-74.
13. Kuruuzum-Uz A, Suleyman H, Cadirci E, et al. (2012). Investigation on anti-inflammatory and antiulcer activities of Anchusa azurea extracts and their major constituent rosmarinic acid. Z Naturforsch C, 67: 360-6.
14. Machado DG, Cunha MP, Neis VB, et al. (2013). Antidepressant-lke effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis. Food Chem 136: 999-1005.
15. Martínez AL, González-Trujano ME, Cháves M, Pellicer F. (2012). Antinociceptive effectiveness of triterpenes from rosemary in visceral nociception. J Ethnopharmacol 142: 28-34.
16. Okpo SO, Fatokun F, Adeyemu OO. (2001). Analgesic and antiinflammatory activity of Crinum glaucum aqueous extract. J Ethnopharmacol 78: 207-11.
17. Ono K, Hasegawa K, Naiki H, Yamada M. (2004). Curcumin has potent anti-amyloidogenic effects for Alzheimers b-amyloid fibrils in vitro. J Neurosci Res 75: 742-50.
18. Osakabe N, Yasuda A, Natsume M, Yoshikawa T. (2004). Rosmarinic acid inhibits epidermal inflammatory responses: Anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis 25: 549-57.
19. Ozcan, M. (2003). Antioxidant activity of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil. J Med Food 6: 267-70.
20. Petersen M, Simmonds MSJ. (2003). Rosmarinic acid. Phytochemistry 62: 121-5.
21. Rasooli I, Fakoor MH, Yadegarinia D, et al. (2008). Antimycotoxigenic characteristics of Rosmarinus officinalis and Trachyspermun copticum L. essential oils. Int J Food Microbiol 122: 135-9.
22. Shibata M, Ohkubo T, Takahashi H, Inoki R. (1989). Modified formalin test, characteristic biphasic pain response. Pain 38: 347-52.
23. Winter CA, Risley GW. (1962). Carrageenin-induced in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111: 544-7.