Insecticide discovery: An evaluation and analysis

Pesticide Biochemistry and Physiology

Volumn 107, Issue 1, 2013, Pages 8-17

  Sparks, Thomas C ^a  

^a DOW AGROSCIENCES LLC   (United States)

Author keywords

Development costs; Insecticide resistance management; Pesticide discovery time needed; Screening success; Vertebrate selectivity ratio

Indexed keywords

HEXAPODA; MAMMALIA; VERTEBRATA;

INSECTICIDE;

CHEMICAL INDUSTRY; COST; ECONOMICS; HISTORY; INSECTICIDE RESISTANCE; RESEARCH;

CHEMICAL INDUSTRY; COSTS AND COST ANALYSIS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; INSECTICIDE RESISTANCE; INSECTICIDES; RESEARCH;

EID: 84882265854     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2013.05.012     Document Type: Review

References (97)

1. National Research Council, Insect-Pest Management and Control, National Academy of Sciences, Washington D.C., 1969.
2. Insect Pest Management: Techniques for Environmental Protection 2000, Lewis Publishers, N.Y. J.E. Rechcigl, N.A. Rechcigl (Eds.).
3. Furtick W.R. Insecticides in food production. The Future for Insecticides: Needs and Prospects 1976, 1-15. Wiley-Interscience, NY. R.L. Metcalf, J.J. McKelvey (Eds.).
4. Smith R.F. Insecticides and integrated pest management. The Future for Insecticides: Needs and Prospects 1976, 489-506. Wiley-Interscience, NY. R.L. Metcalf, J.J. McKelvey (Eds.).
5. Georghiou G.P., Mellon R.B. Pesticide resistance in time and space. Pest Resistance to Pesticides 1983, 1-46. Plenum Press, N.Y. G.P. Georghiou, T. Saito (Eds.).
6. Georghiou G.P. Overview of insecticide resistance. Managing Resistance to Agrochemicals: From Fundamental Research to Practical Strategies 1990, 18-41. American Chemical Society, Washington D.C. M.B. Green, H.M. LeBaron, W.K. Moberg (Eds.).
7. Mota-Sanchez D., Bills P.S., Whalon M.E. Arthropod resistance to pesticides: Status and overview. Pesticides in Agriculture and the Environment 2002, 241-272. Marcel Dekker, N.Y. W.B. Wheeler (Ed.).
8. Whalon M.E., Mota-Sanchez D., Hollingworth R.M. Analysis of global pesticide resistance in arthropods. Global Pesticide Resistance in Arthropods 2008, 5-31. CAB International, Wallingford, UK. M.E. Whalon, D. Mota-Sanchez, R.M. Hollingworth (Eds.).
9. APRD - Arthropod Pesticide Resistance Database, Michigan State University, 2012, http://www.pesticideresistance.org/.
10. Roush R. Designing resistance management programs: how can you choose?. Pestic. Sci. 1989, 26:423-440.
11. Andow D.A., Fitt G.P., Grafius E.J., Jackson R.E., Radcliffe E.B., Ragsdale D.W., Rossiter L. Pesticide and transgenic plant resistance management in the field. Global Pesticide Resistance in Arthropods 2008, 5-31. CAB International, Wallingford, UK. M.E. Whalon, D. Mota-Sanchez, R.M. Hollingworth (Eds.).
12. Insect Resistance Management: Biology, Economics and Prediction 2008, Academic Press, N.Y. D.W. Onstad (Ed.).
13. Nauen R., Elbert A., Mccaffery A., Slater R., Sparks T.C. IRAC: insecticide resistance and mode of action classification of insecticides. Modern Crop Protection Compounds: Insecticides 2012, vol. 3:935-955. Wiley-VCH, Weinheim, GR. second ed.
14. Brooks G.T. Chlorinated Insecticides, Technology and Application 1974, vol. 1. CRC Press, Cleveland, OH.
15. Eto M. Organophosphorus Pesticides: Organic and Biological Chemistry 1974, CRC Press, Cleveland, OH.
16. Kuhr R.J., Dorough H.W. Carbamate Insecticides; Chemistry, Biochemistry and Toxicology 1976, CRC Press, Cleveland, OH.
17. Elliott M. Future use of natural and synthetic pyrethroids. The Future for Insecticides: Needs and Prospects 1976, 163-193. Wiley-Interscience, NY. R.L. Metcalf, J.J. McKelvey (Eds.).
18. Elliott M. The pyrethroids: early discovery, recent advances and the future. Pestic. Sci. 1989, 27:337-351.
19. Kagabu S. Discovery of imidacloprid and further developments from strategic molecular designs. J. Agric. Food Chem. 2011, 59:2887-2896.
20. Akayama A., Minamida I. Discovery of a new systemic insecticide, nitenpyram and its insecticidal properties. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor 1999, 127-148. Springer-Verlag, Tokyo. I. Yamamoto, J.E. Casida (Eds.).
21. Yamada T., Takahashi H., Hatano R. A novel insecticide, acetamiprid. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor 1999, 149-176. Springer-Verlag, Tokyo. I. Yamamoto, J.E. Casida (Eds.).
22. Maienfisch P., Brandl F., Kobel W., Rindlisbacher A., Senn R. CGA 293'343: a novel, broad-spectrum neonicotinoid insecticide. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor 1999, 177-209. Springer-Verlag, Tokyo. I. Yamamoto, J.E. Casida (Eds.).
23. Wakita T., Kinoshita K., Tamada E., Yasui N., Kawahara N., Naoi A., Nakaya M., Ebihara K., Matsuno H., Kodaka K. The discovery of dinotefuran: a novel neonicotinoid. Pest Manag. Sci. 2003, 59:1016-1022.
24. Sakamoto N., Saito S., Hirose T., Susuko M., Matsuo S., Izumi K., Nagatomi T., Ikegami H., Umeda K., Tsushima K., Matsuo N. The discovery of pyridalyl: a novel insecticidal agent for controlling lepidopterous pests. Pest Manag. Sci. 2003, 60:25-34.
25. Suzuki J., Ishida T., Kikuchi Y., Ito Y., Morikawa C., Tsukidate Y., Tanji I., Ota Y., Toda K. Synthesis and activity of novel acaricidal/insecticidal 2,4-diphenyl-1,3-oxazolines. J. Pestic. Sci. 2002, 27:1-8.
26. Kirst H.A., Michel K.H., Mynderase J.S., Chio E.H., Yao R.C., Nakasukasa W.M., Boeck L.D., Occlowitz J.L., Paschal J.W., Deeter J.B., Thompson G.D. Discovery, isolation, and structure elucidation of a family of structurally unique, fermentation-derived tetracyclic macrolides. Synthesis and Chemistry of Agrochemicals III 1992, 214-225. American Chemical Society, Washington D.C. D.R. Baker, J.G. Fenyes, J.J. Steffens (Eds.).
27. Thompson G.D., Dutton R., Sparks T.C. Spinosad - a case study: an example from a natural products discovery programme. Pest Manag. Sci. 2000, 56:696-702.
28. Lahm G.P., McCann S.F., Harrison C.R., Stevenson T.M., Shapiro R. Evolution of the sodium channel blocking insecticides: the discovery of indoxacarb. Agrochemical Discovery: Insect, Weed, and Fungal Control 2001, 20-34. American chemical Society, Washington D.C. D.R. Baker, N.K. Umetsu (Eds.).
29. Seo A., Tohnishi M., Nakao H., Furya T., Kodama H., Tsubata K., Fujioka S., Kodama H., Nishimatsu T., Hirooka T. Flubendiamide, a new insecticide characterized by its novel chemistry and biology. Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety 2007, 127-135. Wiley-VCH, Weiheim, GR. H. Ohkawa, H. Miyagawa, P.W. Lee (Eds.).
30. Lahm G.P., Stevenson T.M., Selby T.P., Freudenberger J.H., Dubas C.M., Smith B.K., Cordova D., Flexner L., Clark C.E., Bellin C.A., Hollingshaus J.G. Rynaxypyr™: a new anthranilic diamide insecticide acting at the ryanodine receptor. Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety 2007, 111-126. Wiley-VCH, Weiheim, GR. H. Ohkawa, H. Miyagawa, P.W. Lee (Eds.).
31. Sparks T.C., Crouse G.D., Dripps J.E., Anzeveno P., Martynow J., Gifford J. Artificial neural network-based QSAR and the discovery of spinetoram. J. Comput.-Aided Mol. Des. 2008, 22:393-401.
32. Zhu Y.M., Loso M.R., Watson G.B., Sparks T.C., Rogers R.B., Huang J.X., Gerwick B.C., Babcock J.M., Kelley D., Hegde V.B., Nugent B.M., Renga J.M., Denholm I., Gorman K., DeBoer G.J., Hasler J., Meade T., Thomas J.D. Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests. J. Agric. Food Chem. 2011, 59:2950-2957.
33. CropLife 2012. www.croplifeamerica.org/.
34. National Research Council The Future Role of Pesticides in US Agriculture 2000, National Academy Press, Washington D.C.
35. Holm R.E., Baron J.J. Evolution of the crop protection industry. Pesticides in Agriculture and the Environment 2002, 295-326. Marcel-Dekker, NY. W.B. Wheeler (Ed.).
36. Phillips McDougall, AgriFutura - Trends in, Industry and Development, (April) (2012) No. 150.
37. Wheeler W.B. Role of research and regulation in 50years of pest management in agriculture. J. Agric. Food Chem. 2002, 50:4151-5155.
38. Phillips McDougall, AgriFutura - Research and Development; Cost and Return. (March) (2010) No. 125.
39. Copping L. The evolution of crop protection companies. Pestic. Outlook 2003, (Dec):276-279.
40. Appleby A.P. Herbicide Company "Genology" 2007, Oregon State University, Jan.
41. Xue X.-Y., Mao Y.-B., Tao X.-Y., Huang Y.-P., Chen X.-Y. New approaches to agricultural insect pest control based on RNA interference. Insect Physiology, Small RNAs: Their diversity, Rules and Practical Uses 2012, vol. 42:73-118. Academic Press, N.Y. E.L. Locksmith (Ed.).
42. Braunholtz J.T. Pesticide development and the chemical manufacturer. Proceedings of XV International Congress of Entomology 1977, 747-755. Entomological Society of America, College Park, MD.
43. Menn J.J. Contemporary frontiers in chemical pesticide research. J. Agric. Food Chem. 1980, 28:2-8.
44. Metcalf R.L. Changing role of insecticides in crop protection. Ann. Rev. Entomol. 1980, 25:219-256.
45. Stetter J. Trends in the future development of pest and weed control - an industrial point of view. Regul. Toxicol. Pharmacol. 1993, 17:346-370.
46. Anonymous, R&D Transformed. www.agrowmag.com July 2006, pp. 10-12.
47. Wheelock C.E., Miyagawa H. The omicization of agricultural research. J. Pestic. Sci. 2006, 31:240-244.
48. Drewes M., Tiejen K., Sparks T.C. High throughput screening in agricultural research. Modern Methods in Crop Protection Research 2012, 3-20. Wiley-VCH, Weinheim, GR. P. Jeschke, W. Kramer, U. Schirmer, M. Witschel (Eds.).
49. Schleifer K.-J. Virtual screening in crop protection research. Pesticide Chemistry: Crop Protection, Public Health, Environmental Safety 2007, 77-88. Wiley-VCH, Weiheim, GR. H. Ohkawa, H. Miyagawa, P.W. Lee (Eds.).
50. Muller P.H. Dichloro-Diphenyl-Tirchloroethane and Newer Insecticides 1948, Nobel Prize Lecture, (Dec 11).
51. Schechter M.S., Green N., LaForge F.B. Synthesis of the cyclopentenolones of the type cinerolone. J. Am. Chem. Soc. 1949, 71:1517.
52. Gant D.B., Chalmers A.E., Wolff M.A., Hoffman H.B., Bushey D.F. Fipronil: action at the GABA receptor. Rev. Toxicol. 1998, 2:147-156.
53. Salgado V.L., Schnatterer S., Holmes K.A. Ligand-gated chloride channel antagonists (fipoles). Modern Crop Protection Compounds: Insecticides 2012, vol. 3:1283-1305. Wiley-VCH, Weinheim, GR. second ed.
54. McNew G.L. Concept of pest management. Pest Control Strategies for the Future 1972, 119-133. National Academy of Sciences, Washington D.C.
55. Metcalf R.L. Development of selective and biodegradable pesticides. Pest Control Strategies for the Future 1972, 137-156. National Academy of Sciences, Washington D.C.
56. Hollingworth R.M. The biochemical and physiological basis for selective toxicity. Insecticide Biochemistry and Physiology 1976, 431-506. Plenum Press, N.Y. C.F. Wilkinson (Ed.).
57. Menn J.J., Pallos F.M. Development of morphogenic agents in insect control. Insecticides of the Future 1975, 71-88. Marcel Dekker, N.Y. M. Jacobson (Ed.).
58. Bowers W.S. Hormone mimics. The Future for Insecticides: Needs and Prospects 1976, 421-441. Wiley-Interscience, NY. R.L. Metcalf, J.J. McKelvey (Eds.).
59. Sparks T.C. Endocrine-based insecticides. Safer Insecticides: Development and Use 1990, 103-154. Marcel Dekker, N.Y. E. Hodgson, R.J. Kuhr (Eds.).
60. Compendium of Pesticide Common Names - Insecticides. 2012,http://www.alanwood.net/pesticides/class_insecticides.html.
61. Henrick C.A. Juvenoids. Agrochemicals from Natural Products 1995, 147-213. Marcel Dekker, N.Y. C.R.A. Godfrey (Ed.).
62. Dhadialla T.S., Retnakaran A., Smagghe G. Insect growth- and development-disrupting insecticides. Insect Control: Biological and Synthetic Agents 2010, 121-181. Academic Press, N.Y. L.I. Gilbert, S.S. Gill (Eds.).
63. Takagi K., Hamaguchi H., Nishimatsu T., Konno T. Discovery of metaflumizone, a novel semicarbazone insecticide. Vet. Parasitol. 2007, 150:177-181.
64. Bretschneider T., Fischer R., Nauen R. Inhibitors of lipid synthesis: Acetyl-Co-Carboxylase inhibitors. Modern Crop Protection Compounds: Insecticides 2012, vol. 3:1108-1126. Wiley-VCH, Weinheim, GR. second ed.
65. Jeschke P., Nauen R. Neonicotinoids - from zero to hero in insecticide chemistry. Pest Manag. Sci. 2008, 64:1084-1098.
66. Jeschke P. Chemical structural features of commercialized neonicotinoids. Modern Crop Protection Compounds: Insecticides 2012, vol. 3:1165-1168. Wiley-VCH, Weinheim, GR. second ed.
67. Insecticide Resistance Action Committee (IRAC) 2012: http://www.irac-online.org/.
68. Ozoe Y., Asahi M., Ozoe F., Nakahira K., Mita T. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem. Biophys. Res. Commun. 2010, 391:744-749.
69. Lahm G.P., Cordova D., Barry J.D., Pahutski T.F., Smith B.K., Long J.K., Benner E.A., Holyoke C.W., Joraski K., Xu M., Schroeder M.E., Wagerle T., Mahaffey M.J., Smith R.M., Tong M-H. 4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel. Bioorg. Med. Chem. Lett. 2013, 23:3001-3006.
70. Thompson G.D., Matten S., Denholm I., Whalon M.E., Leonard P. The politics of resistance management: working towards pesticide resistance management globally. Global Pesticide Resistance in Arthropods 2008, 146-165. CAB International, Wallingford, UK. M.E. Whalon, D. Mota-Sanchez, R.M. Hollingworth (Eds.).
71. Sawicki R.M. Current insecticide management practices in cotton around the world - short-term successes or templates for the future. Pestic. Sci. 1989, 26:401-410.
72. Riley S.L. Pyrethroid resistance in Heliothis spp.: current monitoring management programs. Managing Resistance to Agrochemicals: From Fundamental Research to Practical Strategies 1990, 134-148. American Chemical Society, Washington D.C. M.B. Green, H.M. LeBaron, W.K. Moberg (Eds.).
73. Kolbezen M.J., Metcalf R.L., Fukuto T.R. Insecticidal activity of carbamate cholinesterase inhibitors. J. Agric. Food Chem. 1954, 2:864-870.
74. Metcalf R.L., Fukuto T.R., Winton M.Y. Alkoxyphenyl N-methylcarbamates as insecticides. J. Econ. Entomol. 1960, 53:828-832.
75. Weiden M.H.J., Moorefield H.H., Payne L.K. O-(Methylcarbamoyl) oximes: a new class of carbamates insecticide-acaricides. J. Econ. Entomol. 1965, 58:154-155.
76. Payne L.K., Stansbury H.A., Weiden M.H.J. The synthesis and insecticidal properties of some cholinergic trisubstituted acetaldehyde O-(methylcarbamoyl)oximes. J. Agric. Food Chem. 1966, 14:356-365.
77. Lorenz W., Sasse K. Gerhard Schrader and the development of organophosphorus compounds for crop protection. Pflanzenschutz-Nachrichten Bayer 1968, 21:5-44.
78. Fahmy M.A.H., Fukuto T.R., Meyers R.O., March R.B. The selective toxicity of new N-phosphorothioylcarbamte esters. J. Agric. Food Chem. 1970, 18:793-796.
79. Brooks G.T. Chlorinated insecticides: retrospect and prospect. Pesticide Chemistry in the 20th Century 1977, 1-20. American Chemical Society, Washington, D.C. J.R. Plimmer (Ed.).
80. Verloop A., Ferrell C.D. Benzoylphenyl ureas - a new group of larvicides interfering with chitin deposition. Pesticide Chemistry in the 20th Century 1977, 237-270. American Chemical Society, Washington, D.C. J.R. Plimmer (Ed.).
81. Wing K.D. RH 5849, a non-steroidal ecdysone agonist: effects on a Drosophila cell line. Science 1988, 241:467-469.
82. Maienfisch P., Huerlimann H., Rindlisbacher A., Gsell L., Dettwiler H., Haettenschwiler J., Sieger E., Walti M. The discovery of thiamethoxam: a second-generation neonicotinoid. Pest Manag. Sci. 2001, 57:165-176.
83. Yanagi M., Tsukamoto Y., Watanabe T., Kawagishi A. Development of a novel lepidopteran insect control agent, chromafenozide. J. Pestic. Sci. 2006, 31:163-164.
84. Ehrenfreund J. Inhibitors of oxidative phosphorylation. Modern Crop Protection Compounds: Insecticides 2012, vol. 3:1059-1070. Wiley-VCH, Weinheim, GR. second ed.
85. Sparks T.C., Thompson G.D., Kirst H.A., Hertlein M.B., Mynderse J.S., Turner J.R., Worden T.V. Fermentation-derived insect control agents. Biopesticides: Use and Delivery 1999, 171-188. Humana Press, Totowa, New Jersey. F.R. Hall, J.J. Menn (Eds.).
86. Ware G.W., Whitacre D.M. The Pesticide Book 2004, MeisterPro Information Resources, Willoughby, OH. sixth ed.
87. Temple J.H., Pommireddy P.L., Cook D.R., Macron P., Leonard B.R. Susceptibility of selected lepidopteran pests to rynaxypyr™, a novel insecticide. J. Cotton Sci. 2009, 13:23-31.
88. Metcalf C.L., Flint W.P., Metcalf R.L. Destructive and Useful Insects; Their Habits and Control 1962, McGraw-Hill Book Co., N.Y. fourth ed.
89. Adkisson P.L., Nemec S.J. Comparative effectiveness of certain insecticides for killing bollworms and tobacco budworms. Texas Agric. Expt. Station Rep. B-1048 1966, 4.
90. Lentz G.L. Efficacy of new insecticides against the bollworm and their effects on cotton yield, maturity, and fiber properties in West Tennessee. J. Agric. Entomic. 1985, 2:6-12.
91. Martin S.H., Elzen G.W., Graves J.B., Micinski S., Leonard B.R., Burris E. Toxicological responses of tobacco budworm (Lepidoptera: Noctuidae) from Louisiana, Mississippi, and Texas to selected insecticides. J. Econ. Entomic. 1995, 88:505-511.
92. Long J.L., Layton M.B., Williams M.R. Evaluation of insecticides for control of tobacco budworm on cotton, 1998. Arthropod Manag. Tests 1999, 24:F64.
93. Lance J.K., All J.N. Evaluation of selected insecticides for control of the bollworm complex in Georgia on cotton, 2003. Arthropod Manag. Test 2004, 29:F51.
94. Hopkins J.D., Johnson D.R., Lorenz G.M., Reaper J.D. Steward tank mix comparison for control of Heliothine complex on cotton, 2000. Arthropod Manag. Tests 2002, 27:F57.
95. Carson W.G., Kund G.S., Trumble J.T. Effect of insecticides on tomato insects, 2005. Arthropod Manag. Tests 2006, 31:E70.
96. Micinski S., Hayes J.A., Spaulding H.L. Efficacy of selected insecticides for control of the bollworm / tobacco budworm complex in conventional cotton, 2006. Arthropod Manag. Test 2007, 32:F30.
97. Agranova 2013 - www.agranova.co.uk.