Management of non-melanoma skin cancer

Seminars in Oncology Nursing

Volumn 29, Issue 3, 2013, Pages 182-194

  Lazareth, Victoria ^a,b  

^a UMASS MEMORIAL MEDICAL CENTER   (United States)

^b Kuchnir Dermatology and Dermatologic Surgery   (United States)

Author keywords

Basal cell cancer; Mohs micrographic surgery; Squamous cell carcinomas; Transplant dermatology; Treatment of non melanoma skin cancer

Indexed keywords

ARTICLE; BASAL CELL CANCER; BASAL CELL CARCINOMA; HUMAN; MOHS MICROGRAPHIC SURGERY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL CARCINOMAS; TRANSPLANT DERMATOLOGY; TREATMENT OF NON-MELANOMA SKIN CANCER; TUMOR RECURRENCE;

BASAL CELL CANCER; MOHS MICROGRAPHIC SURGERY; SQUAMOUS CELL CARCINOMAS; TRANSPLANT DERMATOLOGY; TREATMENT OF NON-MELANOMA SKIN CANCER;

CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; HUMANS; NEOPLASM RECURRENCE, LOCAL; SKIN NEOPLASMS;

EID: 84882252323     PISSN: 07492081     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soncn.2013.06.004     Document Type: Article

References (82)

1. Rogers H.W., Weinstock M.A., Harris A.R., et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol 2010, 146:283-287.
2. American Cancer Society. Cancer Facts & Figures 2013.Available at: (accessed January 31, 2013). http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-036845.pdf.
3. Chen J.G., Fleischer A.B., Smith E.D., et al. Cost of nonmelanoma skin cancer treatment in the United States. Dermatol Surg 2001, 27:1035-1038.
4. Cockerell C.J., Tran K.T., Carucci J., et al. Basal cell carcinoma. Cancer of the skin 2011, 101-103. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
5. Karagas M.R., Stukel T.A., Greenberg E.R., et al. Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. JAMA 1992, 267:3305-3310.
6. Ferrucci L.M., Cartmel B., Molinaro A.M., et al. Host-phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. J Invest Dermatol 2012, 132:1272-1279.
7. Marghoob A., Kopf A.W., Bart R.S., et al. Risk of another basal cell carcinoma developing after treatment of a basal cell carcinoma. J Am Acad Dermatol 1993, 28:22-28.
8. Alam M., Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001, 344:975-983.
9. The Skin Cancer Foundation. Squamous cell carcinoma (SCC). Available at: (accessed March 15, 2013). http://www.skincancer.org/skin-cancer-information/squamous-cell-carcinoma.
10. Frankel D.H., Hanusa B.H., Zitelli J.A. New primary nonmelanoma skin cancer in patients with a history of squamous cell carcinoma of the skin: implications and recommendations for follow-up. J Am Acad Dermatol 1992, 26:720-726.
11. Marcil I., Stern R.S. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol 2000, 136:1524-1530.
12. Silverman M.K., Kopf A.W., Bart R.S., et al. Recurrence rates of treated basal cell carcinomas. Part 3: surgical excision. J Dermatol Surg Oncol 1992, 18:471-476.
13. Rowe D.E., Carroll R.J., Day C.L. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol 1992, 26:976-990.
14. Beebe V. A review of Merkel cell carcinoma for dermatology nurses. J Dermatol Nurs Assoc 2009, 1:173-179.
15. Miller S.J., Alam M., Andersen J., et al. Basal cell and squamous cell skin cancers. J Natl Compr Canc Netw 2010, 8:836-864.
16. Joseph M.G., Zulueta W.P., Kennedy P.J. Squamous cell carcinoma of the skin of the trunk and limbs: the incidence ofmetastases and their outcome. Aust N Z J Surg 1992, 62:697-701.
17. Tull S., Nunley K., Sengelmann R. Nonsurgical treatment modalities for primary cutaneous malignancies. Dermatol Surg 2008, 34:859-872.
18. Love W.E., Bernhard J.D., Bordeaux J.S. Topical imiquimod or fluorouracil therapy for basal and squamous cell carcinoma: a systematic review. Arch Dermatol 2009, 145:1431-1438.
19. Williams V., Rosen T., Ceilley R.I., et al. Topical treatment of skin cancer. Cancer of the skin 2011, 462-466. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
20. Kokoszka A., Scheinfeld N. Evidence-based review of the use of cryosurgery in treatment of basal cell carcinoma. Dermatol Surg 2003, 29:566-571.
21. Kuflik E.G. Cryosurgery for skin cancer: 30-year experience and cure rates. Dermatol Surg 2004, 30:297-300.
22. Thissen M.R., Neumann M.H., Schouten L.J. A systematic review of treatment modalities for primary basal cell carcinomas. Arch Dermatol 1999, 135:1177-1183.
23. Neville J.A., Welch E., Leffell D.J. Management of nonmelanoma skin cancer 2007. Nature 2007, 4:462-469.
24. Werlinger K.D., Upton G., Moore A.Y. Recurrence rates of primary nonmelanoma skin cancers treated by surgical excision compared to electrodessication-curettage in a private dermatologic practice. Dermatol Surg 2002, 28:1138-1142.
25. Kopf A.W., Bart R.S., Schrager D., et al. Curettage-electrodessication treatment of basal cell carcinomas. Arch Dermatol 1977, 113:439-443.
26. Silverman M.K., Kopf A.W., Grin C.M., et al. Recurrence rates of treated basal cell carcinomas. Part 2: curettage-electrodessication. J Dermatol Surg Oncol 1991, 17:720-726.
27. Rogers H.W. A relative value unit-based cost comparison of treatment modalities for nonmelanoma skin cancer: effect of the loss of the Mohs multiple surgery reduction exemption. J Am Acad Dermatol 2009, 61:96-103.
28. Sheridan A.T., Dawber R.P. Curettage, electrosurgery and skin cancer. Australas J Dermatol 2000, 41:19-30.
29. Epstein E. Fluouracil paste treatment of thin basal cell carcinomas. Arch Dermatol 1985, 121:207-213.
30. Gaitanis G., Nomikos K., Vava E., et al. Immunocryosurgery for basal cell carcinoma: Results of a pilot prospective, open-label study of cryosurgery during continued imiquimod application. J Eur Acad Dermatol Venereol 2009, 23:1427-1431.
31. Gaitanis G., Alexopoulos E.C., Bassukas I.D. Cryosurgery is more effective in the treatment of primary, non-superficial basal cell carcinomas when applied during and not prior to a five week imiquimod course: a randomized, prospective, open-label study. Eur J Dermatol 2011, 21:952-958.
32. Neville J.A., Williford P.M., Jorizzo J.L. Pilot study using topical imiquimod 5% cream in the treatment of nodular basal cell carcinoma after initial treatment with curettage. J Drugs Dermatol 2007, 6:910-914.
33. Good L.M., Miller M.D., High W.A. Intralesional agents in the management of cutaneous malignancy: a review. J Am Acad Dermatol 2011, 64:413-422.
34. Marmur E.S., Schmults C.D., Goldberg D.J. A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer. Dermatol Surg 2004, 30:264-271.
35. Werner C.L., Cockerell C.J. Actinic keratoses and other precursors of keratinocytic cutaneous malignancies. Cancer of the skin 2011, 89-97. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
36. Choudhary S., Tang J., Elsaie M., et al. Lasers in the treatment of nonmelanoma skin cancer. Dermatol Surg 2011, 37:409-425.
37. Ibrahim S.F., Brown M.D. Surgical excision for non-melanoma skin cancer. Cancer of the skin 2011, 508-514. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
38. Gulleth Y., Goldberg N., Silverman R.P., et al. What is the best surgical margin for a basal cell carcinoma: a meta-analysis of the literature. Plast Reconstr Surg 2010, 126:1222-1231.
39. Zwald F.O., Brown M. Skin cancer in solid organ transplant recipients: advances in therapy and management. J Am Acad Dermatol 2011, 65:253-261.
40. Schadt C., Fine J.D. Genetic disorders predisposing to skin malignancy. Cancer of the skin 2011, 357-366. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
41. Rowe D.E., Carroll R.J., Day C.L. Mohs surgery is the treatment of choice for recurrent (previously treated) basal cell carcinoma. J Dermatol Surg Oncol 1989, 15:424-431.
42. Spencer J.M. Basal cell carcinoma. Treatment of skin disease: Comprehensive therapeutic strategies, expert consult 2010, Elsevier Saunders, China, 616:75-79. Ed3. M.G. Lebwohl, W.R. Heymann, J. Berth-Jones, I. Coulson (Eds.).
43. von Domarus H., Stevens P.J. Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature. J Am Acad Dermatol 1984, 10:1043-1060.
44. Snow S.N., Sahl W., Lo J.S., et al. Metastatic basal cell carcinoma. Report of five cases. Cancer 1994, 73:328-335.
45. Walling H.W., Fosko S.W., Geraminejad P.A., et al. Aggressive basal cell carcinoma: presentation, pathogenesis and management. Cancer Metastasis Rev 2004, 23:389-402.
46. th Edition of the AJCC Cancer Staging Manual. Ann Surg Oncol 2010, 17:1979-1980.
47. Farasat S., Yu S.S., Neel V.A., et al. A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol 2011, 64:1051-1059.
48. Bhambri S., Dinehart S., Bhambri A. Squamous cell carcinoma. Cancer of the skin 2011, 124-139. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
49. Wisgerhof H.C., Edelbroek J.R.J., deFijter J.W., et al. Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010, 89:1231-1238.
50. Moloney F.J., Comber H., O'Lorcain P., et al. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol 2006, 154:498-504.
51. Lazareth V.L. Dermatologic care of the transplant patient; Part I. J Dermatol Nurs Assoc 2010, 2:59-63.
52. Lindelof B., Sigurgeirsson B., Gabel H., et al. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol 2000, 143:513-519.
53. Lazareth V.L. Dermatologic care of the transplant patient; Part II. J Dermatol Nurs Assoc 2010, 2:198-205.
54. Clayman G.L., Lee J.J., Holsinger F.C., et al. Mortality risk from squamous cell skin cancer. J Clin Oncol 2005, 23:759-765.
55. Euvrard S., Kanitakis J., Pouteil-Noble C., et al. Skin cancers in organ transplant recipients. Ann Transplant 1997, 2:28-32.
56. Veness M.J. Treatment recommendations in patients diagnosed with high-risk cutaneous squamous cell carcinoma. Australas Radiol 2005, 49:365-376.
57. Bowles T.L., Ross M.I., Lazar A.J. Sarcomas of the skin. Cancer of the skin 2011, 157-167. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
58. Burns M.K., Chen S.P., Goldberg L.H. Microcystic adnexal carcinoma: ten cases treated by Mohs micrographic surgery. J Derm Surg Oncol 1994, 20:429-434.
59. Cooper P.H., Mills S.E. Microcystic adnexal carcinoma. J Am Acad Dermatol 1984, 10:908-914.
60. Chiller K., Passaro D., Schuller M., et al. Microcystic adnexal carcinoma: 48 cases, their treatment and their outcome. Arch Dermatol 2000, 136:1355-1359.
61. Gollard R., Weber R., Kosty M.P., et al. Merkel cell carcinoma: review of 22 cases with surgical, pathologic and therapeutic considerations. Cancer 2000, 88:1842-1851.
62. Young J.L., Ward K.C., Ries L.A.G. Cancer of rare sites. SEER survival monograph: cancer survival among adults: U.S. SEER Program, 1988-2001, patient and tumor characteristics 2007, 251-261. National Cancer Institute, Bethesda, MD, NIH Publ. No. 07-6215. L.A.G. Ries, J.L. Young, G.E. Keel (Eds.).
63. Agelli M., Clegg L.X. Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 2003, 49:832-841.
64. Ratz J.L., Loo-Duong S., Kulwin D.R. Sebaceous carcinoma of the eyelid treated with Mohs surgery. J Am Acad Dermatol 1986, 14:668-673.
65. Rowe D.E., Carroll R.J., Day C.L. Long term recurrence rates in previously untreated (primary) basal cell carcinoma: Implications for patient follow-up. J Dermatol Surg Oncol 1989, 15:315-328.
66. Mosterd K., Krekels G.A., Nieman F.H., et al. Surgical excision versus Mohs micrographic surgery for primary and recurrent basal cell carcinoma of the face: a prospective, randomized controlled trial with 5 years follow-up. Lancet Oncol 2008, 9:1149-1156.
67. Upjohn E., Taylor S. Mohs surgery. Cancer of the skin 2011, 515-525. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
68. Nguyen T., Ho D. Nonmelanoma skin cancer. Curr Treat Options Oncol 2002, 3:193-203.
69. AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association and the American Society for Mohs Surgery. J Am Acad Dermatol 2012, 67:531-550.
70. Brett H., Armand C., Stoddard E., et al. Superficial x-ray in the treatment of basal and squamous cell carcinomas: a viable option in select patients. J Am Acad Dermatol 2012, 67:1235-1241.
71. Cooper J. Radiation therapy in the treatment of skin cancers. Cancer of the skin 2011, 576-588. Elsevier Saunders, Philadelphia. Ed2. D.S. Rigel, J.K. Robinson, M. Ross, R.J. Friedman, C.J. Cockerell, H.W. Lim (Eds.).
72. Alam M., Nanda S., Mittal B.B., et al. The use of brachytherapy in the treatment of nonmelanoma skin cancer: a review. J Am Acad Dermatol 2011, 65:377-388.
73. Veness M., Richards S. Role of modern radiotherapy in treating skin cancer. Aust J Dermatol 2003, 44:159-166.
74. Caccialanza M., Piccinno R., Beretta M., et al. Results and side effects of dermatologic radiotherapy: a retrospective study of irradiated cutaneous epithelial neoplasm. J Am Acad Dermatol 1999, 41:589-594.
75. Karagas M.R., McDonald J.A., Greenberg E.R., et al. Risk of basal cell and squamous skin cancers after ionizing radiation therapy. For the Skin Cancer Prevention Study Group. J Natl Cancer Inst 1996, 88:1848-1853.
76. Veness M.J., Harris D. Role of radiotherapy in the management of organ transplant recipients diagnosed with non-melanoma skin cancers. Aust Radiol 2007, 51:12-20.
77. Wang J.T., Palme C.E., Morgan G.J., et al. Predictors of outcomes in patients with cutaneous metastatic head and neck squamous cell carcinoma involving cervical lymph nodes: improved survival with the addition of adjuvant radiotherapy. Head Neck 2012, 34:1524-1528.
78. Loescher L.J., Harris J.M., Curiel-Lewandrowski C. A systematic review of advanced practice nurses' skin cancer assessment barriers, skin lesion recognition skills, and skin cancer training activities. J Am Acad Nurs Pract 2011, xx:667-673.
79. Chen M., Sahay A.P., Sands L.P., et al. Variation in care for nonmelanoma skin cancer in a private practice and a veterans affairs clinic. Medical Care 2004, 42:1019-1026.
80. Moody N.B., Smith P.L., Glenn L.L. Client characteristics and practice patterns of nurse practitioners and physicians. Nurse Pract 1999, 24:94-96. 99-100, 102-103.
81. Cole F.L., Ramirez E. Procedures taught in family nurse practitioner programs in the United States. J Am Acad Nurs Pract 2003, 15:40-44.
82. Viola K.V., Tolpinrud W.L., Gross C.P., et al. Outcomes of referral to dermatology for suspicious lesions. Arch Dermatol 2011, 147:556-560.