Mitochondrial-dependent anticancer activity of δ-tocotrienol and its synthetic derivatives in HER-2/neu overexpressing breast adenocarcinoma cells

BioFactors

Volumn 39, Issue 4, 2013, Pages 485-493

  Viola, Valentina ^a   Ciffolilli, Silvia ^a   Legnaioli, Silvia ^a   Piroddi, Marta ^a   Betti, Michele ^b   Mazzini, Francesco ^a   Pierpaoli, Elisa ^c   Provinciali, Mauro ^c   Galli, Francesco ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c INRCA   (Italy)

Author keywords

Breast cancer; HER 2 neu oncogene; Mitochondria; Tocotrienols; Vitamin E

Indexed keywords

6 HYDROXY 2,5,7,8 TETRAMETHYLCHROMANE 2 CARBOXYETHYL ACID; ADENOSINE TRIPHOSPHATE; ALPHA TOCOTRIENOL; ALPHA TOCOTRIENYLSUCCINATE; CASPASE; DELTA TOCOTRIENOL; DELTA TOCOTRIENYLAMINE; DELTA TOCOTRIENYLSUCCINYLAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMMA TOCOTRIENOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TOCOPHEROL DERIVATIVE; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; TOCOTRIENOL, DELTA;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CARCINOMA CELL; CELL SURVIVAL; CELL VIABILITY; CELLULAR STRESS RESPONSE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUCCINYLATION; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; ANIMAL; BREAST TUMOR; DRUG EFFECTS; DRUG SCREENING; FEMALE; IC50; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; TUMOR CELL LINE;

MURINAE; TOSCANA VIRUS;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; RECEPTOR, ERBB-2; VITAMIN E;

EID: 84881670345     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1089     Document Type: Article

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