Chemical cocktail party in East Greenland: A first time evaluation of human organohalogen exposure from consumption of ringed seal and polar bear tissues and possible health implications

Toxicological and Environmental Chemistry

Volumn 95, Issue 5, 2013, Pages 853-859

  Sonne, Christian ^a   Dietz, Rune ^a   Letcher, Robert J ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b CARLETON UNIVERSITY   (Canada)

Author keywords

Arctic; blubber; endocrine disruption; exposure; Greenlanders; polar bears

Indexed keywords

ARCTIC; BLUBBER; ENDOCRINE DISRUPTION; EXPOSURE; GREENLANDERS; POLAR BEARS;

ESTIMATION; HEALTH RISKS; ORGANIC POLLUTANTS; PHYSIOLOGICAL MODELS; RISK PERCEPTION; TISSUE;

MAMMALS;

BEAR; BIOACCUMULATION; CHLORDANE; FOOD CONSUMPTION; HEALTH RISK; ORGANOHALOGEN; PINNIPED; POLLUTION EXPOSURE; SUBSISTENCE; TOXICITY;

ARCTIC; EAST GREENLAND; GREENLAND;

MAMMALIA; PHOCA HISPIDA; URSUS MARITIMUS;

EID: 84881666415     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772248.2013.809917     Document Type: Article

References (45)

1. Arctic Monitoring and Assessment Programme (AMAP). 1998. AMAP Assessment Report 1998: Arctic Pollution Issues, Oslo 1998. http://www.amap.no
2. Arctic Monitoring and Assessment Programme (AMAP). 2004. AMAP Assessment Report 2002: Persistent Organic Pollutants in the Arctic, Oslo 2004. http://www.amap.no
3. Arctic Monitoring and Assessment Programme (AMAP). 2009. AMAP Assessment Report 2009: Human Health in the Arctic, Oslo 2009. http://www.amap.no
4. Bjerregaard, P., E. Dewailly, P. Ayotte, T. Pars, L. Ferron, and G. Mulvad. 2001. "Exposure of Inuit in Greenland to Organochlorines Through the Marine Diet." Journal of Toxicology and Environmental Health 62: 69-81.
5. Bossi, R., F.F. Rigét, and R. Dietz. 2005. "Temporal and Spatial Trends of Perfluorinated Compounds in Ringed Seal (Phoca Hispida) from Greenland." Environmental Science & Technology 39: 7416-7422.
6. Bradley, M., S.J. Kutz, E. Jenkins, and T.M. O'Hara. 2005. "The Potential Impact of Climate Change on Infectious Diseases of Arctic Fauna." International Journal of Circumpolar Health 64: 468-77.
7. Côté, S., P. Ayotte, S. Dodin, C. Blanchet, G. Mulvad, H.S. Petersen, G. Gingras, and E. Dewailly. 2006. "Plasma Organochlorine Concentrations and Bone Ultrasound Measurements: A Cross-sectional Study in Peri-and Postmenopausal Inuit Women from Greenland." Environmental Health 5: 33.
8. Dallaire, F., E. Dewailly, C. Vézina, G. Muckle, J.P. Weber, S. Bruneau, and P. Ayotte. 2006. "Effect of Prenatal Exposure to Polychlorinated Biphenyls on Incidence of Acute Respiratory Infections in Preschool Inuit Children." Environmental Health Perspectives 114: 1301-1305.
9. Deutch, B., J. Dyerberg, H.S. Pedersen, G. Asmund, P. Møller, and J.C. Hansen. 2006. "Dietary Composition and Contaminants in North Greenland in the 1970s and 2004." Science of the Total Environment 370: 372-381.
10. Dietz, R., F.F. Rigét, C. Sonne, R.J. Letcher, E.W. Born, and D.C.G. Muir. 2004. "Seasonal and Temporal Trends in Polychlorinated Biphenyls and Organochlorine Pesticides in East Greenland Polar Bears (Ursus maritimus), 1990-2001." Science of the Total Environment 331: 107-124.
11. Dietz, R., F.F. Rigét, C.T. Sonne, D.C.G. Muir, S. Backus, E.W. Born, M. Kirkegaard, and R.J. Letcher. 2007. "Age and Seasonal Variability of Polybrominated Diphenyl Ethers in Free-ranging East Greenland Polar Bears (Ursus maritimus)." Environmental Pollution 146: 177-184.
12. Dietz, R., F.F. Rigét, C. Sonne, E.W. Born, T. Bechshøft, M.A. McKinney, and R.J. Letcher. Forthcoming-a. "Three Decades (1984-2010) of Legacy Contaminant Trends in East Greenland Polar Bears (Ursus maritimus). Part I: Legacy Organochlorine Contaminants." Environment International. http://dx.doi.org/10.1016/j.envint.2012.09.004
13. Dietz, R., F.F. Rigét, C. Sonne, E.W. Born, T. Bechshøft, M.A. McKinney, R. Drimmei, D.C.G. Muir, and R.J. Letcher. Forthcoming-b. "Three Decades (1984-2010) of Flame Retardant Trends in East Greenland Polar Bears (Ursus maritimus). Part II: Brominated Flame Retardants." Environment International. http://dx.doi.org/10.1016/j.envint.2012.09.008
14. Gebbink, W.A., C. Sonne, R. Dietz, M. Kirkegaard, F.F. Rigét, E.W. Born, D.C.G. Muir, and R.J. Letcher. 2008. "Tissue-specific Congener Composition of Organohalogen and Metabolite Contaminants in East Greenland Polar Bears (Ursus maritimus)." Environmental Pollution 152: 621-629.
15. Greer, A., V. Ng, and D. Fisman. 2008. "Climate Change and Infectious Diseases in North America: the Road Ahead." Canadian Medical Association Journal 178: 715-722.
16. Hertz-Picciotto, I., H.Y. Park, M. Dostal, A. Kocan, T. Trnovec, and R. Sram. 2008. "Prenatal Exposures to Persistent and Non-persistent Organic Compounds and Effects on Immune System Development." Basic Clinical Pharmacology & Toxicology 102: 146-154.
17. Hueffer, K., T.M. O'Hara, and E.H. Follmann. 2011. "Adaptation of Mammalian Host-pathogen Interactions in a Changing Arctic Environment." Acta Veterinaria Scandinavica 53: 17.
18. Janeway, C.A., P. Travers, M. Walport, and M. Shlomchik. 2001. Immune Biology - The Immune System in Health and Disease. 5th ed. New York: Garland Publishing, Taylor and Francis
19. Jenssen, B.M. 2003. "Marine Pollution: The Future Challenge is to Link Human and Wildlife Studies." Environmental Health Perspectives 111: A198-A199
20. Jenssen, B.M. 2006. "Endocrine-disrupting Chemicals and Climate Change: a Worst-case Combination for Arctic Marine Mammals and Seabirds?" Environmental Health Perspectives 114: 76-80.
21. Johansen, P., D.C.G. Muir, G. Asmund, and F.F. Rigét. 2004. "Human Exposure to Contaminants in the Traditional Greenland Diet." Science of the Total Environment 331: 189-206.
22. Klecha, A.J., M.L. Barreiro Arcos, L. Frick, A.M. Genaro, and G. Cremaschi. 2008. "Immune-endocrine Interactions in Autoimmune Thyroid Diseases." Neuroimmunomodulation 15: 68-75.
23. Lagueux, J., D. Pereg, P. Ayotte, E. Dewailly, and G.G. Poirier. 1999. "Cytochrome P450 CYP1A1 Enzyme Activity and DNA Adducts in Placenta of Women Environmentally Exposed to Organochlorines." Environmental Research 80: 369-382.
24. Letcher, R.J., J.O. Bustnes, R. Dietz, B.M. Jenssen, E.H. Jørgensen, C. Sonne, J. Verreault, M.M. Vijayan, and G.W. Gabrielsen. 2010. "Exposure and Effects Assessment of Persistent Organic Pollutants in Arctic Wildlife and Fish." Science of the Total Environment 408: 2995-3043.
25. Macdonald, R.W., T. Harner, and J. Fyfe. 2005. "Recent Climate Change in the Arctic and Its Impact on Contaminant Pathways and Interpretation of Temporal Trend Data." Science of the Total Environment 342: 5-86.
26. McKinney, M., S. Iverson, A. Fisk, C. Sonne, F.F. Rigét, R. Letcher, M. Arts, E.W. Born, A. Rosing-Asvid, and R. Dietz. 2013. "Causes and Consequences of Long-term Change in East Greenland Polar Bears Diets: Investigation Using Quantitative Fatty Acid Estimates and Fatty Acid Carbon Isotope Patterns." Global Change Biology 19: 2360-2372.
27. Medehouenou, T.C., C. Larochelle, P. Dumas, E. Dewailly, and P. Ayotte. 2010. "Determinants of AhR-mediated Transcriptional Activity Induced by Plasma Extracts from Nunavik Inuit Adults." Chemosphere 80: 75-82.
28. Nielsen, E., J.C. Larsen, and O. Ladefoged. 2006. Risk Assessment of Contaminant Intake from Traditional Greenland Food Items. Denmark: Danish Veterinary and Food Administration. www.dfvf.dk
29. Noyes, P.D., M.K. McElwee, H.D. Miller, B.W. Clark, L.A. Van Tiem, K.C. Walcott, K.N. Erwin, and E.D. Levin. 2009. "The Toxicology of Climate Change: Environmental Contaminants in a Warming World." Environment International 35: 971-986.
30. Parkinson, A.J., and J.C. Butler. 2005. "Potential Impacts of Climate Change on Infectious Diseases in the Arctic." International Journal of Circumpolar Health 64: 478-486.
31. Pars, T., M. Osler, and P. Bjerregaard. 2001. "Contemporary Use of Traditional and Imported Food Among Greenlandic Inuit." Arctic 54: 22-31.
32. Polder, A., G.W. Gabrielsen, J.Ø. Odland, T.N. Savinova, A. Tkachev, K.B. Løken, and J.U. Skaare. 2008. "Spatial and Temporal Changes of Chlorinated Pesticides, PCBs, Dioxins (PCDDs/PCDFs) and Brominated Flame Retardants in Human Breast Milk from Northern Russia." Science of the Total Environment 391: 41-54.
33. Rigét, F., J. Vikelsøe, and R. Dietz. 2005. "Levels and Temporal Trends of PCDD/PCDFs and Non-ortho PCBs in Ringed Seals from East Greenland." Marine Pollution Bulletin 50: 1523-1529.
34. Rigét, F.F., K. Vorkamp, R. Dietz, and S.C. Rastogi. 2006. "Temporal Trend Studies on Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) in Ringed Seals from East Greenland." Journal of Environmental Monitoring 8: 1000-1005.
35. Sandau, C.D., P. Ayotte, E. Dewailly, J. Duffe, and R.J. Norstrom. 2002. "Pentachlorophenol and Hydroxylated Polychlorinated Biphenyl Metabolites in Umbilical cord Plasma of Neonates from Coastal Populations in Québec." Environmental Health Perspectives 110: 411-417.
36. Simmonds, M.P., K. Haraguchi, T. Endo, F. Cipriano, S.R. Palumbi, and G.M. Troisi. 2002. "Human Health Significance of Organochlorine and Mercury Contaminants in Japanese Whale Meat." Journal of Toxicology and Environmental Health 65: 1211-1235.
37. Sonne, C. 2010. "Health Effects from Long-range Transported Contaminants in Arctic Top Predators: An Integrated Review Based on Studies of Polar Bears and Relevant Model Species." Environment International 36: 461-491.
38. Sonne, C., K. Gustavson, F.F. Rigét, R. Dietz, M. Birkved, R.J. Letcher, D.C.G. Muiret al., 2009. "Reproductive Performance in East Greenland Polar Bears (Ursus maritimus) may be Affected by Organohalogen Contaminants as Shown by Physiologically Based Pharmacokinetic (PBPK) Modelling." Chemosphere 77: 1558-1568.
39. Sonne, C., P.S. Leifsson, R. Dietz, E.W. Born, R.J. Letcher, M. Kirkegaard, D.C.G. Muir, L.W. Andersen, F.F. Rigét, and L. Hyldstrup. 2005. "Enlarged Clitoris in Wild Polar Bears (Ursus maritimus) can be Misdiagnosed as Pseudohermaphroditism." Science of the Total Environment 337: 45-58.
40. Sonne, C., R.J. Letcher, T.Ø. Bechshøft, F.F. Rigét, D.C.G. Muir, P.S. Leifsson, E.W. Born et al., 2012. "Two Decades of Biomonitoring Polar Bear Health in Greenland: A Review." Acta Veterinaria Scandinavica 54: S15.
41. Tryphonas, H. 1994. "Immunotoxicity of Polychlorinated-biphenyls - Present Status and Future Considerations". Experimental and Clinical Immunogenetics 11: 149-162.
42. van den Berg, M., L. Birnbaum, A.T.C. Bosveld, B. Brunstrom, P. Cook, M. Freely, J.P. Giesy, et al. 1998. "Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for Humans and Wildlife." Environmental Health Perspectives 106: 775-792.
43. van Leeuwen, F.X., M. Feeley, D. Schrenk, J.C. Larsen, W. Fraland, and M. Younes.2000. "Dioxins: WHO's tolerable daily intake (TDI) revisited." Chemosphere 40: 1095-1101.
44. Vorkamp, K., R. Bossi, F.F. Rigét, and R. Dietz. 2011. "Time Trends of Hexabromocyclododecane, Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls in Ringed Seals from East Greenland." Environmental Science & Technology 45: 1243-1249.
45. Vos, J.G., and M.I. Luster. 1989. "Immune Alterations." In Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins, and Related Products, edited by R.D. Kimbrough, and A.D. Jensen, 295-322. Amsterdam: Elsevier.