Synthesis and characterization of monodisperse uniformly shaped respirable aerosols

AIChE Journal

Volumn 59, Issue 9, 2013, Pages 3184-3194

  Fromen, Catherine A ^a   Shen, Tammy W ^b   Larus, Abigail E ^c   Mack, Peter ^d   Maynor, Benjamin W ^d   Luft, J Christopher ^e   Desimone, Joseph M ^a,b,f  

^a North Carolina State University   (United States)

^b UNC Hamner Institute for Drug Safety Sciences   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

^d Liquidia Technologies   (United States)

^e UNIVERSITY OF NORTH CAROLINA   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Aerosols; Biomedical engineering; Nanotechnology; Particle technology; Particle count measurements

Indexed keywords

AERODYNAMIC PARTICLE SIZER; GEOMETRIC STANDARD DEVIATIONS; MEDIAN AERODYNAMIC DIAMETERS; MICROMOLDING TECHNIQUES; PARTICLE SIZE AND SHAPE; PARTICLE TECHNOLOGY; PARTICLE/COUNT/MEASUREMENTS; SYNTHESIS AND CHARACTERIZATIONS;

AERODYNAMICS; AEROSOLS; BIOMEDICAL ENGINEERING; NANOTECHNOLOGY; POWDERS;

AERODYNAMIC DRAG;

EID: 84881663204     PISSN: 00011541     EISSN: 15475905     Source Type: Journal    
DOI: 10.1002/aic.14157     Document Type: Article

References (42)

1. Weers JG, Bell J, Chan HK, Cipolla D, Dunbar C, Hickey AJ, Smith IJ. Pulmonary formulations: what remains to be done? J Aerosol Med Pulm Drug Deliv. 2010;23(Suppl 2):S5-23.
2. Daniher DI, Zhu J. Dry powder platform for pulmonary drug delivery. Particuology. 2008;6:225-238.
3. Calvert G, Ghadiri M, Tweedie R. Aerodynamic dispersion of cohesive powders: A review of understanding and technology. Adv Powder Technol. 2009;20:4-16.
4. Kleinstreuer C, Zhang Z, Donohue JF. Targeted drug-aerosol delivery in the human respiratory system. Annu Rev Biomed Eng. 2008;10:195-220.
5. Hassan MS, Lau RW. Effect of particle shape on dry particle inhalation: study of flowability, aerosolization, and deposition properties. AAPS PharmSciTech. 2009;10:1252-1262.
6. Louey MD, Oort MV, Hickey AJ. Aerosol dispersion of respirable particles in narrow size distributions using drug-alone and lactose-blend formulations. Pharm Res. 2004;21:1207-1213.
7. Usmani OS, Biddiscombe MF, Barnes PJ. Regional lung deposition and bronchodilator response as a function of beta2-agonist particle size. Am J Respir Crit Care Med. 2005;172:1497-1504.
8. Brand P, Meyer T, Sommerer K, Weber N, Scheuch G. Alveolar deposition of monodisperse aerosol particles in the lung of patients with chronic obstructive pulmonary disease. Exp Lung Res. 2002;28:39-54.
9. Hinds WC. Aerosol Technology: Properties, Behavoir and Measurement of Airborne Particles. New York: Wiley-Interscience; 1999.
10. Zastawny M, Mallouppas G, Zhao F, van Wachem B. Derivation of drag and lift force and torque coefficients for non-spherical particles in flows. Int J Multiphase Flow. 2012;39:227-239.
11. Crowder TM, Rosati JA, Schroeter JD, Hickey AJ, Martonen TB. Fundamental effects of particle morphology on lung delivery: predictions of Stokes' law and the particlular relevance to dry powder inhaler formulation and development. Pharm Res. 2002;19:239-245.
12. Lippmann M. Size-selective health hazard sampling. In: Air Sampling Instruments for Evaluation of Atmospheric Contaminants. Cincinnati, OH: ACGIH; 1995.
13. Loth E. Drag of non-spherical solid particles of regular and irregular shape. Powder Technol. 2008;182:342-353.
14. Cheng Y-S, Yeh H-C, Allen MD. Dynamic shape factor of a plate-like particle. Aerosol Sci Technol. 1988;8:109-123.
15. Johnson DL, Leith D, Reist PC. Drag on non-spherical, orthotropic, aerosol particles. J Aerosol Sci. 1987;18:87-97.
16. Cheng Y-S. Drag forces on nonspherical aerosol particles. Chem Eng Commun. 1991;108:201-223.
17. Davies CN. Particle-Fluid Interaction. J Aerosol Sci. 1979;10:477-513.
18. Leith D. Drag on nonspherical objects. Aerosol Sci Technol. 1987;6:153-161.
19. Brockmann JE, Rader DJ. APS Response to nonspherical particles and experimental determination of dynamic shape factor. Aerosol Sci Technol. 1990;13:162-172.
20. Geiser M, Schurch S, Gehr P. Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer. J Appl Physiol. 2003;94:1793-1801.
21. Champion JA, Mitragotri S. Shape induced inhibition of phagocytosis of polymer particles. Pharm Res. 2009;26:244-249.
22. Gratton SE, Ropp PA, Pohlhaus PD, Luft JC, Madden VJ, Napier ME, DeSimone JM. The effect of particle design on cellular internalization pathways. Proc Nat Acad Sci USA. 2008;105:11613-11618.
23. Patton JS, Byron PR. Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov. 2007;6:67-74.
24. Rolland JP, Maynor BW, Euliss LE, Exner AE, Denison GM, DeSimone JM. Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. J Am Chem Soc. 2005;127:10096-10100.
25. Kelly JY, DeSimone JM. Shape-specific, monodisperse nano-molding of protein particles. J Am Chem Soc. 2008;130:5438-5439.
26. Garcia A, Mack P, Williams S, Fromen C, Shen T, Tully J, Pillai J, Kuehl P, Napier M, Desimone JM, Maynor BW. Microfabricated engineered particle systems for respiratory drug delivery and other pharmaceutical applications. J Drug Deliv. 2012;2012:941243.
27. Lee C-T, Leith D. Drag force on agglomerated spheres in creeping flow. J Aerosol Sci. 1989;20:503-513.
28. Kasper G, Niida T, Yang M. Measurements of viscous drag on cylinders and chains of spheres with aspect ratios between 2 and 50. J Aerosol Sci. 1985;16:535-556.
29. Baron PA. Calibration and use of the aerodynamic particle sizer (APS 3300). Aerosol Sci Technol. 1986;5:55-67.
30. Wang H-C, John W. A simple iteration procedure to correct for the density effect in the aerodynamic particle sizer. Aerosol Sci Technol. 1989;10:501-505.
31. Tsai C-J, Chen S-C, Huang C-H, Chen D-R. A universal calibration curve for the TSI aerodynamic particle sizer. Aerosol Sci Technol. 2004;38:467-474.
32. Marshall IA, Mitchell JP, Griffiths WD. The behaviour of regular-shaped non-spherical particles in a TSA aerodynamic particle sizer. J Aerosol Sci. 1991;22:73-89.
33. Cheng YS, Chen BT, Yeh HC. Behaviour of isometric nonsperical aerosol particles in the aerodynamic particle sizer. J Aerosol Sci. 1990;21:701-710.
34. Cheng YS, Chen BT, Yeh HC, Marshall IA, Mitchell JP, Griffiths WD. Behavior of compact nonspherical particles in the TSI aerodynamic particle sizer model aps33b: ultra-stokesian drag forces. Aerosol Sci Technol. 1993;19:255-267.
35. Rasband WS. Image J. In: Health USNIo, ed. Bethesda, MD; 1997-2012.
36. Density Determination of Solids. In: Instruction Manual for Mettler-Toledo Density Kit. Mettler-Toledo; 2002.
37. Chapter 601-Physical tests and determinations: aerosols USP 26-NF 21. 2003:2105-2123.
38. MATLAB. In: Natick, MA: The MathWorks, Inc.; 2003.
39. BGI Incorporated. Collision Nebulizer Droplet Number Output. Available at: http://www.bgiusa.com/agc/droplet_number_output.htm. Accessed: July 1, 2012.
40. Thiel CG. Can in vitro particle size measurements be used to predict pulmonary deposition of aerosol from inhalers? J Aerosol Med. 1998;11:S-43-S-52.
41. Edwards DA. Large porous particles for pulmonary drug delivery. Science. 1997;276:1868-1872.
42. Tu J, Kiao I, Ahmadi G. Computational Fluid and Particle Dynamics in the Human Respiratory System: New York: Springer; 2013.