Anti-donor HLA class i antibodies: Pathways to endothelial cell activation and cell-mediated allograft rejection

Transplantation

Volumn 96, Issue 3, 2013, Pages 258-266

  Naemi, Fatmah M A ^a   Carter, Vaughan ^b   Kirby, John A ^a   Ali, Simi ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Alloantibodies; Allotransplantation; Chemotaxis; Endothelial activation

Indexed keywords

ANTIBODY; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; EPITHELIAL CELL ADHESION MOLECULE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HLA ANTIGEN CLASS 1 ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RANTES; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIBODY RESPONSE; ARTICLE; CELL ACTIVATION; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; LEUKOCYTE; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MICROVASCULAR ENDOTHELIAL CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

CELL LINE; CHEMOTAXIS, LEUKOCYTE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOKINES; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; ISOANTIBODIES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 84881614191     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182985504     Document Type: Article

References (38)

1. Wiebe C, Gibson IW, Blydt-Hansen TD, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant 2012; 12: 1157.
2. Sellares J, de Freitas DG, Mengel M, et al. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012; 12: 388.
3. Abu-Elmagd KM,Wu G, Costa G, et al. Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver. Am J Transplant 2012; 12: 3047.
4. Hachem R. Antibody-mediated lung transplant rejection. Curr Respir Care Rep 2012; 1: 157.
5. Torrealba JR, Samaniego M, Pascual J, et al. C4d-positive interacinar capillaries correlates with donor-specific antibody-mediated rejection in pancreas allografts. Transplantation 2008; 86: 1849.
6. Chih S, Chruscinski A, Ross HJ, Tinckam K, Butany J, Rao V. Antibody-mediated rejection: an evolving entity in heart transplantation. J Transplant 2012; 2012: 210210.
7. Hirohashi T, Uehara S, Chase CM, et al. Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice. Am J Transplant 2010; 10: 510.
8. Thiyagarajan UM, Bagul A, Frost J, Horsburgh T, Nicholson ML. Role of human leukocyte antigen, donor-specific antibodies, and their impact in renal transplantation. Transplant Proc 2012; 44: 1231.
9. Schreiber AB, Schlessinger J, Edidin M. Interaction between major histocompatibility complex antigens and epidermal growth factor receptors on human cells. J Cell Biol 1984; 98: 725.
10. Zhang X, Rozengurt E, Reed EF. HLA class I molecules partner with integrin beta4 to stimulate endothelial cell proliferation and migration. Sci Signal 2011; 3: ra85.
11. Jindra PT, Jin YP, Rozengurt E, Reed EF. HLA class I antibodymediated endothelial cell proliferation via the mTOR pathway. J Immunol 2008; 180: 2357.
12. Chang F, Steelman LS, Lee JT, et al. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 2003; 17: 1263.
13. Jindra PT, Hsueh A, Hong L, et al. Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts. J Immunol 2008; 180: 2214.
14. Jin YP, Singh RP, Du ZY, Rajasekaran AK, Rozengurt E, Reed EF. Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actindependent manner. J Immunol 2002; 168: 5415.
15. Bieri M, Oroszlan M, Farkas A, Ligeti N, Bieri J,Mohacsi P. Anti-HLA I antibodies induce VEGF production by endothelial cells, which increases proliferation and paracellular permeability. Int J Biochem Cell Biol 2009; 41: 2422.
16. Bian H, Harris PE, Reed EF. Ligation of HLA class I molecules on smooth muscle cells with anti-HLA antibodies induces tyrosine phosphorylation, fibroblast growth factor receptor expression and cell proliferation. Int Immunol 1998; 10: 1315.
17. Smith JD, Lawson C, Yacoub MH, Rose ML. Activation of NF-kappa B in human endothelial cells induced by monoclonal and allospecific HLA antibodies. Int Immunol 2000; 12: 563.
18. Nath N, Bian H, Reed EF, Chellappan SP. HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J Immunol 1999; 162: 5351.
19. Kobayashi A, Takahashi T, Horita S, et al. Activation of the transcription factor c-Jun in acute cellular and antibody-mediated rejection after kidney transplantation. Hum Pathol 2010; 41: 1682.
20. Iwasaki K, Miwa Y, Haneda M, Uchida K, Nakao A, Kobayashi T. Significance of HLA class I antibody-induced antioxidant gene expression for endothelial cell protection against complement attack. Biochem Biophys Res Commun 2010; 391: 1210.
21. Caro-Oleas JL, Gonzalez-Escribano MF, Gentil-Govantes MA, et al. Clinical relevance of anti-HLA donor-specific antibodies detected by Luminex assay in the development of rejection after renal transplantation. Transplantation 2012; 94: 338.
22. Yousem SA, Zeevi A. The histopathology of lung allograft dysfunction associated with the development of donor-specific HLA alloantibodies. Am J Surg Pathol 2012; 36: 987.
23. Papadimitriou JC, Drachenberg CB, Munivenkatappa R, et al. Glomerular inflammation in renal allografts biopsies after the first year: cell types and relationship with antibody-mediated rejection and graft outcome. Transplantation 2010; 90: 1478.
24. Fahim T, Bohmig GA, Exner M, et al. The cellular lesion of humoral rejection: predominant recruitment of monocytes to peritubular and glomerular capillaries. Am J Transplant 2007; 7: 385.
25. Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem 1999; 68: 821.
26. Sakamoto KM, Frank DA. CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res 2009; 15: 2583.
27. Wen AY, Sakamoto KM, Miller LS. The role of the transcription factor CREB in immune function. J Immunol 2010; 185: 6413.
28. Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS. MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol 2002; 22: 2871.
29. Sun P, Enslen H, Myung PS, Maurer RA. Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev 1994; 8: 2527.
30. Narayanan K, Jendrisak MD, Phelan DL,Mohanakumar T. HLA class I antibody mediated accommodation of endothelial cells via the activation of PI3K/cAMP dependent PKA pathway. Transpl Immunol 2006; 15: 187.
31. Reyes-Vargas E, Pavlov IY,Martins TB, Schwartz JJ,HillHR,Delgado JC. Binding of anti-HLA class I antibody to endothelial cells produce an inflammatory cytokine secretory pattern. J Clin Lab Anal 2009; 23: 157.
32. Sun H, Chung WC, Ryu SH, et al. Cyclic AMP-responsive element binding protein-and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila) 2008; 1: 316.
33. Schubert SY, Benarroch A, Ostvang J, Edelman ER. Regulation of endothelial cell proliferation by primary monocytes. Arterioscler Thromb Vasc Biol 2008; 28: 97.
34. McGilvray ID, Lu Z, Bitar R, Dackiw AP, Davreux CJ, Rotstein OD. VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogenactivated protein kinase. J Biol Chem 1997; 272: 10287.
35. Sandig M, Negrou E, Rogers KA. Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture. J Cell Sci 1997; 110: 2807.
36. Narayanan K, Jaramillo A, PhelanDL, Mohanakumar T. Pre-exposure to sub-saturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement-mediated lysis by regulating Bad through the phosphatidylinositol 3-kinase/Akt pathway. Eur J Immunol 2004; 34: 2303.
37. Carter NM, Ali S, Kirby JA. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. J Cell Sci 2003; 116: 3591.
38. Wain JH, Kirby JA, Ali S. Leucocyte chemotaxis: examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1,-2,-3 and-4. Clin Exp Immunol 2002; 127: 436.