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Volumn 9, Issue 1, 2013, Pages 235-245

Addressing the need for rapid treatment of agitation in schizophrenia and bipolar disorder: Focus on inhaled loxapine as an alternative to injectable agents

Author keywords

Agitation; Antipsychotic; Bipolar disorder; Inhaled loxapine; Mania; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; CHLORPROMAZINE; HALOPERIDOL; LORAZEPAM; LOXAPINE; OLANZAPINE; PLACEBO; ZIPRASIDONE;

EID: 84881598696     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S31484     Document Type: Review
Times cited : (33)

References (41)
  • 1
    • 67349105137 scopus 로고    scopus 로고
    • Agitation III: Pharmacologic treatment of agitation
    • Baltimore, MD, Lippincott Williams and Wilkins
    • Citrome L. Agitation III: pharmacologic treatment of agitation. In: Glick RL, Berlin JS, Fishkind AB, Zeller SL, editors. Emergency Psychiatry: Principles and Practice. Baltimore, MD: Lippincott Williams and Wilkins; 2008:137-148.
    • (2008) Emergency Psychiatry: Principles and Practice , pp. 137-148
    • Citrome, L.1
  • 2
    • 0032806109 scopus 로고    scopus 로고
    • Violent patients in the emergency setting
    • Citrome L, Volavka J. Violent patients in the emergency setting. Psychiatr Clin North Am. 1999;22(4):789-801.
    • (1999) Psychiatr Clin North Am , vol.22 , Issue.4 , pp. 789-801
    • Citrome, L.1    Volavka, J.2
  • 3
    • 69049095981 scopus 로고    scopus 로고
    • Staff and patient views of the reasons for aggressive incidents: A prospective, incident-based study
    • Nolan KA, Shope CB, Citrome L, Volavka J. Staff and patient views of the reasons for aggressive incidents: a prospective, incident-based study. Psychiatr Q. 2009;80(3):167-172.
    • (2009) Psychiatr Q , vol.80 , Issue.3 , pp. 167-172
    • Nolan, K.A.1    Shope, C.B.2    Citrome, L.3    Volavka, J.4
  • 4
    • 7044222806 scopus 로고    scopus 로고
    • Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder
    • Nolan KA, Volavka J, Czobor P, et al. Aggression and psychopathology in treatment-resistant inpatients with schizophrenia and schizoaffective disorder. J Psychiatr Res. 2005;39(1):109-115.
    • (2005) J Psychiatr Res , vol.39 , Issue.1 , pp. 109-115
    • Nolan, K.A.1    Volavka, J.2    Czobor, P.3
  • 5
    • 0037773201 scopus 로고    scopus 로고
    • Characteristics of assaultive behavior among psychiatric inpatients
    • Nolan KA, Czobor P, Roy BB, et al. Characteristics of assaultive behavior among psychiatric inpatients. Psychiatr Serv. 2003;54(7):1012-1016.
    • (2003) Psychiatr Serv , vol.54 , Issue.7 , pp. 1012-1016
    • Nolan, K.A.1    Czobor, P.2    Roy, B.B.3
  • 6
    • 80052240843 scopus 로고    scopus 로고
    • Pathways to aggression in schizophrenia affect results of treatment
    • Volavka J, Citrome L. Pathways to aggression in schizophrenia affect results of treatment. Schizophr Bull. 2011;37(5):921-929.
    • (2011) Schizophr Bull , vol.37 , Issue.5 , pp. 921-929
    • Volavka, J.1    Citrome, L.2
  • 7
    • 47149103828 scopus 로고    scopus 로고
    • Heterogeneity of violence in schizophrenia and implications for long-term treatment
    • Volavka J, Citrome L. Heterogeneity of violence in schizophrenia and implications for long-term treatment. Int J Clin Pract. 2008;62(8): 1237-1245.
    • (2008) Int J Clin Pract , vol.62 , Issue.8 , pp. 1237-1245
    • Volavka, J.1    Citrome, L.2
  • 8
    • 75749128259 scopus 로고    scopus 로고
    • A brief overview of iatrogenic akathisia
    • Advokat C. A brief overview of iatrogenic akathisia. Clin Schizophr Relat Psychoses. 2010;3(4):226-236.
    • (2010) Clin Schizophr Relat Psychoses , vol.3 , Issue.4 , pp. 226-236
    • Advokat, C.1
  • 10
    • 0025099349 scopus 로고
    • The dangerous agitated patient
    • What to do right now
    • Citrome L, Green L. The dangerous agitated patient. What to do right now. Postgrad Med. 1990;87(2):231-236.
    • (1990) Postgrad Med , vol.87 , Issue.2 , pp. 231-236
    • Citrome, L.1    Green, L.2
  • 11
    • 3042797525 scopus 로고    scopus 로고
    • Clinical management of persistent aggressive behavior in schizophrenia
    • Part I: definitions, epidemiology, assessment, and acute treatment
    • Citrome L, Volavka J. Clinical management of persistent aggressive behavior in schizophrenia. Part I: definitions, epidemiology, assessment, and acute treatment. Essent Psychopharmacol. 2002;5(1):1-16.
    • (2002) Essent Psychopharmacol , vol.5 , Issue.1 , pp. 1-16
    • Citrome, L.1    Volavka, J.2
  • 12
    • 77952523421 scopus 로고    scopus 로고
    • Chlorpromazine for psychosis induced aggression or agitation
    • [review], CD007445
    • Ahmed U, Jones H, Adams CE. Chlorpromazine for psychosis induced aggression or agitation [review]. Cochrane Database Syst Rev. 2010;4:CD007445.
    • (2010) Cochrane Database Syst Rev , vol.4
    • Ahmed, U.1    Jones, H.2    Adams, C.E.3
  • 13
    • 84872195737 scopus 로고    scopus 로고
    • Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation)
    • [review], CD009377
    • Powney MJ, Adams CE, Jones H. Haloperidol for psychosis-induced aggression or agitation (rapid tranquillisation) [review]. Cochrane Database Syst Rev. 2012;11:CD009377.
    • (2012) Cochrane Database Syst Rev , vol.11
    • Powney, M.J.1    Adams, C.E.2    Jones, H.3
  • 14
    • 84876237328 scopus 로고    scopus 로고
    • Limited evidence on effects of haloperidol alone for rapid tranquillisation in psychosis-induced aggression
    • Citrome L. Limited evidence on effects of haloperidol alone for rapid tranquillisation in psychosis-induced aggression. Evid Based Ment Health. 2013;16(2):47.
    • (2013) Evid Based Ment Health , vol.16 , Issue.2 , pp. 47
    • Citrome, L.1
  • 15
    • 69949103030 scopus 로고    scopus 로고
    • The cognitive cost of anticholinergic burden: Decreased response to cognitive training in schizophrenia
    • Vinogradov S, Fisher M, Warm H, Holland C, Kirshner MA, Pollock BG. The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia. Am J Psychiatry. 2009;166(9):1055-1062.
    • (2009) Am J Psychiatry , vol.166 , Issue.9 , pp. 1055-1062
    • Vinogradov, S.1    Fisher, M.2    Warm, H.3    Holland, C.4    Kirshner, M.A.5    Pollock, B.G.6
  • 16
    • 38049002952 scopus 로고    scopus 로고
    • Comparison of intramuscular ziprasidone, olanzapine, or aripiprazole for agitation: A quantitative review of efficacy and safety
    • Citrome L. Comparison of intramuscular ziprasidone, olanzapine, or aripiprazole for agitation: a quantitative review of efficacy and safety. J Clin Psychiatry. 2007;68(12):1876-1885.
    • (2007) J Clin Psychiatry , vol.68 , Issue.12 , pp. 1876-1885
    • Citrome, L.1
  • 17
    • 84863397147 scopus 로고    scopus 로고
    • The psychopharmacology of agitation: Consensus statement of the American Association for Emergency Psychiatry Project Beta Psychopharmacology workgroup
    • Wilson MP, Pepper D, Currier GW, Holloman GH Jr, Feifel D. The psychopharmacology of agitation: consensus statement of the American Association for Emergency Psychiatry Project Beta Psychopharmacology workgroup. West J Emerg Med. 2012;13(1):26-34.
    • (2012) West J Emerg Med , vol.13 , Issue.1 , pp. 26-34
    • Wilson, M.P.1    Pepper, D.2    Currier, G.W.3    Holloman Jr., G.H.4    Feifel, D.5
  • 18
    • 84857270280 scopus 로고    scopus 로고
    • December 21, 2012, US Food and Drug Administration, Silver Spring, MD: US Food and Drug Administration; 2012, Accessed March 17
    • US Food and Drug Administration. NDA Approval Letter, December 21, 2012. Silver Spring, MD: US Food and Drug Administration; 2012. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2012/022549Orig1s000ltr.pdf. Accessed March 17, 2013.
    • (2013) NDA Approval Letter
  • 20
    • 84881569015 scopus 로고    scopus 로고
    • Alexza receives marketing authorization for Adasuve® (Staccato® loxapine) in the European Union
    • [press release]. Mountain View, CA: Alexza Pharmaceuticals; 2013, Accessed March 17
    • Alexza Pharmaceuticals. Alexza receives marketing authorization for Adasuve® (Staccato® loxapine) in the European Union [press release]. Mountain View, CA: Alexza Pharmaceuticals; 2013. Available from: http://phx.corporate-ir.net/phoenix.zhtml?c=196151&p=irolnewsArticle&ID=1787494. Accessed March 17, 2013.
    • (2013) Alexza Pharmaceuticals
  • 21
    • 79955432850 scopus 로고    scopus 로고
    • [webpage on the Internet]. Mountain View, CA: Alexza Pharmaceuticals; 2012, Accessed March 17
    • Adasuve®: summary of product characteristics [webpage on the Internet]. Mountain View, CA: Alexza Pharmaceuticals; 2012. Available from: http://www.adasuve.com/index-eu.php. Accessed March 17, 2013.
    • (2013) Adasuve®: Summary of Product Characteristics
  • 22
    • 79958061760 scopus 로고    scopus 로고
    • Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: A randomized, double-blind, placebo-controlled trial
    • Allen MH, Feifel D, Lesem MD, et al. Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2011;72(10):1313-1321.
    • (2011) J Clin Psychiatry , vol.72 , Issue.10 , pp. 1313-1321
    • Allen, M.H.1    Feifel, D.2    Lesem, M.D.3
  • 23
    • 78651474093 scopus 로고    scopus 로고
    • Rapid acute treatment of agitation in individuals with schizophrenia: Multicentre, randomised, placebo-controlled study of inhaled loxapine
    • Lesem MD, Tran-Johnson TK, Riesenberg RA, et al. Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine. Br J Psychiatry. 2011;198(1):51-58.
    • (2011) Br J Psychiatry , vol.198 , Issue.1 , pp. 51-58
    • Lesem, M.D.1    Tran-Johnson, T.K.2    Riesenberg, R.A.3
  • 24
    • 84856884690 scopus 로고    scopus 로고
    • Rapid acute treatment of agitation in patients with bipolar I disorder: A multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine
    • Kwentus J, Riesenberg RA, Marandi M, et al. Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine. Bipolar Disord. 2012;14(1):31-40.
    • (2012) Bipolar Disord , vol.14 , Issue.1 , pp. 31-40
    • Kwentus, J.1    Riesenberg, R.A.2    Marandi, M.3
  • 25
    • 84881584044 scopus 로고    scopus 로고
    • Alexza Pharmaceuticals, Mountain View, CA: Alexza Pharmaceuticals; 2011, Accessed March 19
    • Alexza Pharmaceuticals. Adasuve ® (Loxapine) Inhalation Powder NDA 022549: Psychopharmacologic Drug Advisory Committee Briefing Document. Mountain View, CA: Alexza Pharmaceuticals; 2011. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/PsychopharmacologicDrugsAdvisoryCommittee/UCM282900.pdf. Accessed March 19, 2013.
    • (2013) Adasuve ® (Loxapine) Inhalation Powder NDA 022549: Psychopharmacologic Drug Advisory Committee Briefing Document
  • 26
    • 84881584044 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD: US Food and Drug Administration; 2011, Accessed March 19
    • US Food and Drug Administration. Adasuve® (Loxapine) Inhalation Powder NDA 022549: Psychopharmacologic Drug Advisory Committee Briefing Document. Silver Spring, MD: US Food and Drug Administration; 2011. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/PsychopharmacologicDrugsAdvisoryCommittee/UCM282897.pdf. Accessed March 19, 2013.
    • (2013) Adasuve® (Loxapine) Inhalation Powder NDA 022549: Psychopharmacologic Drug Advisory Committee Briefing Document
  • 27
    • 84881592897 scopus 로고    scopus 로고
    • European Medicines Agency, London: European Medicines Agency; 2012, Accessed March 17
    • European Medicines Agency. Adasuve® Assessment Report. London: European Medicines Agency; 2012. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002400/WC500139407.pdf. Accessed March 17, 2013.
    • (2013) Adasuve® Assessment Report
  • 28
    • 79951656747 scopus 로고    scopus 로고
    • Aerosolised antipsychotic assuages agitation: Inhaled loxapine for agitation associated with schizophrenia or bipolar disorder
    • Citrome L. Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder. Int J Clin Pract. 2011;65(3):330-340.
    • (2011) Int J Clin Pract , vol.65 , Issue.3 , pp. 330-340
    • Citrome, L.1
  • 29
    • 84857366492 scopus 로고    scopus 로고
    • Inhaled loxapine for agitation revisited: Focus on effect sizes from two Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder
    • Citrome L. Inhaled loxapine for agitation revisited: focus on effect sizes from two Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder. Int J Clin Pract. 2012;66(3): 318-325.
    • (2012) Int J Clin Pract , vol.66 , Issue.3 , pp. 318-325
    • Citrome, L.1
  • 30
    • 77954709796 scopus 로고    scopus 로고
    • The Staccato® system: Inhaler design characteristics for rapid treatment of CNS disorders
    • Noymer P, Myers D, Glazer M, Fishman R., Cassella JV. The Staccato® system: inhaler design characteristics for rapid treatment of CNS disorders. Respiratory Drug Delivery. 2010;1:11-20.
    • (2010) Respiratory Drug Delivery , vol.1 , pp. 11-20
    • Noymer, P.1    Myers, D.2    Glazer, M.3    Fishman, R.4    Cassella, J.V.5
  • 31
    • 78650175544 scopus 로고    scopus 로고
    • In vitro aerosol characterization of Staccato®loxapine
    • Dinh K, Myers DJ, Glazer M, et al. In vitro aerosol characterization of Staccato®loxapine. Int J Pharm. 2011;403(1-2):101-108.
    • (2011) Int J Pharm , vol.403 , Issue.1-2 , pp. 101-108
    • Dinh, K.1    Myers, D.J.2    Glazer, M.3
  • 32
    • 77955444920 scopus 로고    scopus 로고
    • In vitro aerosol deposition in the oropharyngeal region for Staccato® loxapine
    • Dinh KV, Myers DJ, Noymer PD, Cassella JV. In vitro aerosol deposition in the oropharyngeal region for Staccato® loxapine. J Aerosol Med Pulm Drug Deliv. 2010;23(4):253-260.
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , Issue.4 , pp. 253-260
    • Dinh, K.V.1    Myers, D.J.2    Noymer, P.D.3    Cassella, J.V.4
  • 33
    • 0032909923 scopus 로고    scopus 로고
    • Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic
    • Ereshefsky L. Pharmacologic and pharmacokinetic considerations in choosing an antipsychotic. J Clin Psychiatry. 1999;60(Suppl 10): 20-30.
    • (1999) J Clin Psychiatry , vol.60 , Issue.SUPPL. 10 , pp. 20-30
    • Ereshefsky, L.1
  • 34
    • 75749120639 scopus 로고    scopus 로고
    • Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers
    • Spyker DA, Munzar P, Cassella JV. Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers. J Clin Pharmacol. 2010;50(2):169-179.
    • (2010) J Clin Pharmacol , vol.50 , Issue.2 , pp. 169-179
    • Spyker, D.A.1    Munzar, P.2    Cassella, J.V.3
  • 35
    • 84881591123 scopus 로고    scopus 로고
    • [webpage on the Internet]. Bethesda, MD: National Institute of Health; 2010, Accessed November 12
    • Amoxapine tablet drug label [webpage on the Internet]. Bethesda, MD: National Institute of Health; 2010. Available from: http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=19651. Accessed November 12, 2010.
    • (2010) Amoxapine Tablet Drug Label
  • 36
    • 43549112900 scopus 로고    scopus 로고
    • Compelling or irrelevant? Using number needed to treat can help decide
    • Citrome L. Compelling or irrelevant? Using number needed to treat can help decide. Acta Psychiatr Scand. 2008;117(6):412-419.
    • (2008) Acta Psychiatr Scand , vol.117 , Issue.6 , pp. 412-419
    • Citrome, L.1
  • 37
    • 84881571558 scopus 로고    scopus 로고
    • Rapid improvement in the five-item Positive and Negative Syndrome - Excited Component (PANSS-EC) scale for agitation with inhaled loxapine
    • June 14-17, 2010; Boca Raton, FL, USA
    • Cassella J, Spyker D, Kwentus J, Lesem M, Fishman R. Rapid improvement in the five-item Positive and Negative Syndrome - Excited Component (PANSS-EC) scale for agitation with inhaled loxapine. 50th Meeting of the NCDEU; June 14-17, 2010; Boca Raton, FL, USA.
    • 50th Meeting of the NCDEU
    • Cassella, J.1    Spyker, D.2    Kwentus, J.3    Lesem, M.4    Fishman, R.5
  • 38
    • 67749114366 scopus 로고    scopus 로고
    • Quantifying risk: The role of absolute and relative measures in interpreting risk of adverse reactions from product labels of antipsychotic medications
    • Citrome L. Quantifying risk: the role of absolute and relative measures in interpreting risk of adverse reactions from product labels of antipsychotic medications. Curr Drug Saf. 2009;4(3):229-237.
    • (2009) Curr Drug Saf , vol.4 , Issue.3 , pp. 229-237
    • Citrome, L.1
  • 39
    • 84881591519 scopus 로고    scopus 로고
    • US Food and Drug Administration, Silver Spring, MD: US Food and Drug Administration; 2012, Accessed March 17
    • US Food and Drug Administration. Adasuve ® (loxapine) Inhalation Powder: Risk Evaluation and Mitigation Strategy. Silver Spring, MD: US Food and Drug Administration; 2012. Available from: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM333242.pdf. Accessed March 17, 2013.
    • (2013) Adasuve ® (loxapine) Inhalation Powder: Risk Evaluation and Mitigation Strategy
  • 40
    • 84863786453 scopus 로고    scopus 로고
    • On-label on the table: What the package insert informs us about the tolerability profile of oral atypical antipsychotics, and what it does not
    • Citrome L, Nasrallah HA. On-label on the table: what the package insert informs us about the tolerability profile of oral atypical antipsychotics, and what it does not. Expert Opin Pharmacother. 2012;13(11):1599-1613.
    • (2012) Expert Opin Pharmacother , vol.13 , Issue.11 , pp. 1599-1613
    • Citrome, L.1    Nasrallah, H.A.2
  • 41
    • 79956119718 scopus 로고    scopus 로고
    • Evidence-based medicine: It's not just about the evidence
    • Citrome L. Evidence-based medicine: it's not just about the evidence. Int J Clin Pract. 2011;65(6):634-635.
    • (2011) Int J Clin Pract , vol.65 , Issue.6 , pp. 634-635
    • Citrome, L.1


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