메뉴 건너뛰기




Volumn 8, Issue 8, 2013, Pages

Nimotuzumab Enhances the Radiosensitivity of Cancer Cells In Vitro by Inhibiting Radiation-Induced DNA Damage Repair

Author keywords

[No Author keywords available]

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; NIMOTUZUMAB; PROTEIN KINASE C;

EID: 84881575090     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070727     Document Type: Article
Times cited : (44)

References (25)
  • 1
    • 77950867012 scopus 로고    scopus 로고
    • Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective
    • Verheij M, Vens C, van Triest B, (2010) Novel therapeutics in combination with radiotherapy to improve cancer treatment: Rationale, mechanisms of action and clinical perspective. Drug Resist Updat 13: 29-43.
    • (2010) Drug Resist Updat , vol.13 , pp. 29-43
    • Verheij, M.1    Vens, C.2    van Triest, B.3
  • 2
    • 19944427144 scopus 로고    scopus 로고
    • The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer
    • Raben D, Helfrich B, Chan DC, Ciardiello F, Zhao L, et al. (2005) The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer. Clin Cancer Res 11: 795-805.
    • (2005) Clin Cancer Res , vol.11 , pp. 795-805
    • Raben, D.1    Helfrich, B.2    Chan, D.C.3    Ciardiello, F.4    Zhao, L.5
  • 3
    • 77949409277 scopus 로고    scopus 로고
    • EGFR targeted therapy in non-small cell lung cancer: potential role of cetuximab
    • Reade CA, Ganti AK, (2009) EGFR targeted therapy in non-small cell lung cancer: potential role of cetuximab. Biologics 3: 215-24.
    • (2009) Biologics , vol.3 , pp. 215-224
    • Reade, C.A.1    Ganti, A.K.2
  • 4
    • 36749008023 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage
    • Chen DJ, Nirodi CS, (2007) The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res 13: 6555-60.
    • (2007) Clin Cancer Res , vol.13 , pp. 6555-6560
    • Chen, D.J.1    Nirodi, C.S.2
  • 5
    • 67650689632 scopus 로고    scopus 로고
    • Radiosensitizing effects of gefitinib at different administration times in vitro
    • Zhuang HQ, Sun J, Yuan ZY, Wang J, Zhao LZ, et al. (2009) Radiosensitizing effects of gefitinib at different administration times in vitro. Cancer Sci 100: 1520-25.
    • (2009) Cancer Sci , vol.100 , pp. 1520-1525
    • Zhuang, H.Q.1    Sun, J.2    Yuan, Z.Y.3    Wang, J.4    Zhao, L.Z.5
  • 6
    • 79957542319 scopus 로고    scopus 로고
    • The emerging role of nimotuzumab in the treatment of non-small cell lung cancer
    • Boland W, Bebb G, (2010) The emerging role of nimotuzumab in the treatment of non-small cell lung cancer. Biologics 4: 289-98.
    • (2010) Biologics , vol.4 , pp. 289-298
    • Boland, W.1    Bebb, G.2
  • 7
    • 79951826933 scopus 로고    scopus 로고
    • Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profile
    • Garrido G, Tikhomirov IA, Rabasa A, Yang E, Gracia E, et al. (2011) Bivalent binding by intermediate affinity of nimotuzumab: a contribution to explain antibody clinical profile. Cancer Biol Ther 11: 373-82.
    • (2011) Cancer Biol Ther , vol.11 , pp. 373-382
    • Garrido, G.1    Tikhomirov, I.A.2    Rabasa, A.3    Yang, E.4    Gracia, E.5
  • 8
    • 77953664765 scopus 로고    scopus 로고
    • Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin
    • Ramakrishnan MS, Eswaraiah A, Crombet T, Piedra P, Saurez G, et al. (2009) Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin. MAbs 1: 41-8.
    • (2009) MAbs , vol.1 , pp. 41-48
    • Ramakrishnan, M.S.1    Eswaraiah, A.2    Crombet, T.3    Piedra, P.4    Saurez, G.5
  • 9
    • 39449125850 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status
    • Akashi Y, Okamoto I, Iwasa T, Yoshida T, Suzuki M, et al. (2008) Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status. Br J Cancer 98: 749-55.
    • (2008) Br J Cancer , vol.98 , pp. 749-755
    • Akashi, Y.1    Okamoto, I.2    Iwasa, T.3    Yoshida, T.4    Suzuki, M.5
  • 10
    • 62549129875 scopus 로고    scopus 로고
    • Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies
    • Diaz Miqueli A, Rolff J, Lemm M, Fichtner I, Perez R, et al. (2009) Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies. Br J Cancer 100: 950-58.
    • (2009) Br J Cancer , vol.100 , pp. 950-958
    • Diaz Miqueli, A.1    Rolff, J.2    Lemm, M.3    Fichtner, I.4    Perez, R.5
  • 11
    • 77957579026 scopus 로고    scopus 로고
    • Nimotuzumab with chemoradiation confers a survival advantage in treatment-naïve head and neck tumors overexpressing EGFR
    • Basavaraj C, Sierra P, Shivu J, Melarkode R, Montero E, et al. (2010) Nimotuzumab with chemoradiation confers a survival advantage in treatment-naïve head and neck tumors overexpressing EGFR. Cancer Biol Ther 10: 673-81.
    • (2010) Cancer Biol Ther , vol.10 , pp. 673-681
    • Basavaraj, C.1    Sierra, P.2    Shivu, J.3    Melarkode, R.4    Montero, E.5
  • 13
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiation-induced EGFR nuclear import by C225(Cetuximab) suppresses DNA-PK activity
    • Dittmann K, Mayer C, Rodemann HP, (2005) Inhibition of radiation-induced EGFR nuclear import by C225(Cetuximab) suppresses DNA-PK activity. Radiother Oncol 76: 157-61.
    • (2005) Radiother Oncol , vol.76 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.P.3
  • 14
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, et al. (2005) Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 280: 31182-89.
    • (2005) J Biol Chem , vol.280 , pp. 31182-31189
    • Dittmann, K.1    Mayer, C.2    Fehrenbacher, B.3    Schaller, M.4    Raju, U.5
  • 15
    • 39749129748 scopus 로고    scopus 로고
    • Gefitinib Radiosensitizes Non-Small Cell Lung Cancer Cells by Suppressing Cellular DNA Repair Capacity
    • Tanaka T, Munshi A, Brooks C, Liu J, Hobbs ML, et al. (2008) Gefitinib Radiosensitizes Non-Small Cell Lung Cancer Cells by Suppressing Cellular DNA Repair Capacity. Clin Cancer Res 14: 1266-73.
    • (2008) Clin Cancer Res , vol.14 , pp. 1266-1273
    • Tanaka, T.1    Munshi, A.2    Brooks, C.3    Liu, J.4    Hobbs, M.L.5
  • 16
    • 17144371349 scopus 로고    scopus 로고
    • Mechanisms of Enhanced Radiation Response following Epidermal Growth Factor Receptor Signaling Inhibition by Erlotinib (Tarceva)
    • Chinnaiyan P, Huang S, Vallabhaneni G, Sato M, Minna JD, et al. (2005) Mechanisms of Enhanced Radiation Response following Epidermal Growth Factor Receptor Signaling Inhibition by Erlotinib (Tarceva). Cancer Res 65: 3328-35.
    • (2005) Cancer Res , vol.65 , pp. 3328-3335
    • Chinnaiyan, P.1    Huang, S.2    Vallabhaneni, G.3    Sato, M.4    Minna, J.D.5
  • 17
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, (2005) Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 23: 8646-54.
    • (2005) J Clin Oncol , vol.23 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3
  • 18
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J, (2006) Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354: 567-78.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 19
    • 79959195283 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with chemoradiation in patients with stage IIIA/B non-small-cell lung cancer: RTOG 0324
    • Blumenschein GR Jr, Paulus R, Curran WJ, Robert F, Fossella F, et al. (2011) Phase II study of cetuximab in combination with chemoradiation in patients with stage IIIA/B non-small-cell lung cancer: RTOG 0324. J Clin Oncol 29: 2312-8.
    • (2011) J Clin Oncol , vol.29 , pp. 2312-2318
    • Blumenschein Jr., G.R.1    Paulus, R.2    Curran, W.J.3    Robert, F.4    Fossella, F.5
  • 20
    • 79959587751 scopus 로고    scopus 로고
    • Combined treatment of nonsmall cell lung cancer NSCLC stage III with intensity-modulated RT radiotherapy and cetuximab: the NEAR trial
    • Jensen AD, Münter MW, Bischoff HG, Haselmann R, Haberkorn U, et al. (2011) Combined treatment of nonsmall cell lung cancer NSCLC stage III with intensity-modulated RT radiotherapy and cetuximab: the NEAR trial. Cancer 117: 2986-94.
    • (2011) Cancer , vol.117 , pp. 2986-2994
    • Jensen, A.D.1    Münter, M.W.2    Bischoff, H.G.3    Haselmann, R.4    Haberkorn, U.5
  • 21
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, et al. (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27: 663-71.
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5
  • 22
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
    • Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, et al. (2010) Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 28: 4697-705.
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3    Tabernero, J.4    Burkes, R.5
  • 23
    • 0037145332 scopus 로고    scopus 로고
    • Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibody
    • Crombet-Ramos T, Rak J, Pérez R, Viloria-Petit A, (2002) Antiproliferative, antiangiogenic and proapoptotic activity of h-R3: A humanized anti-EGFR antibody. Int J Cancer 101: 567-75.
    • (2002) Int J Cancer , vol.101 , pp. 567-575
    • Crombet-Ramos, T.1    Rak, J.2    Pérez, R.3    Viloria-Petit, A.4
  • 24
    • 33746088022 scopus 로고    scopus 로고
    • Blockage of epidermal growth factor receptor-Phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-ras mutated human tumor cells in vitro by affecting DNA repair
    • Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, et al. (2006) Blockage of epidermal growth factor receptor-Phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-ras mutated human tumor cells in vitro by affecting DNA repair. Clin Cancer Res 12: 4119-26.
    • (2006) Clin Cancer Res , vol.12 , pp. 4119-4126
    • Toulany, M.1    Kasten-Pisula, U.2    Brammer, I.3    Wang, S.4    Chen, J.5
  • 25
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, et al. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res 64: 2390-6.
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Löbrich, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.