메뉴 건너뛰기




Volumn 25, Issue 1, 2013, Pages 79-89

LGR5 is a promising biomarker for patients with stage I and II gastric cancer

Author keywords

Biomarker; Cancer stem cell; Gastric cancer; Leucine rich repeat containing G protein coupled receptor 5 (LGR5); Prognosis

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG;

EID: 84881559381     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.3978/j.issn.1000-9604.2013.01.07     Document Type: Article
Times cited : (31)

References (40)
  • 3
    • 0037263849 scopus 로고    scopus 로고
    • Gastric cancer epidemiology and risk factors
    • DOI 10.1016/S0895-4356(02)00534-6, PII S0895435602005346
    • Kelley JR, Duggan JM. Gastric cancer epidemiology and risk factors. J Clin Epidemiol 2003;56:1-9. (Pubitemid 36183309)
    • (2003) Journal of Clinical Epidemiology , vol.56 , Issue.1 , pp. 1-9
    • Kelley, J.R.1    Duggan, J.M.2
  • 4
    • 33745547767 scopus 로고    scopus 로고
    • Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data
    • DOI 10.1200/JCO.2005.05.0245
    • Wagner AD, Grothe W, Haerting J, et al. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006;24:2903-9. (Pubitemid 46630593)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.18 , pp. 2903-2909
    • Wagner, A.D.1    Grothe, W.2    Haerting, J.3    Kleber, G.4    Grothey, A.5    Fleig, W.E.6
  • 5
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptorrelated protein mediates Wnt signalling in mice
    • Pinson KI, Brennan J, Monkley S, et al. An LDL-receptorrelated protein mediates Wnt signalling in mice. Nature 2000;407:535-8.
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3
  • 7
    • 0037369658 scopus 로고    scopus 로고
    • Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations
    • DOI 10.1053/jhep.2003.50029
    • Yamamoto Y, Sakamoto M, Fujii G, et al. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology 2003;37:528-33. (Pubitemid 36258773)
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 528-533
    • Yamamoto, Y.1    Sakamoto, M.2    Fujii, G.3    Tsuiji, H.4    Kanetaka, K.5    Asaka, M.6    Hirohashi, S.7
  • 8
    • 51349161304 scopus 로고    scopus 로고
    • G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
    • Tanese K, Fukuma M, Yamada T, et al. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol 2008;173:835-43.
    • (2008) Am J Pathol , vol.173 , pp. 835-843
    • Tanese, K.1    Fukuma, M.2    Yamada, T.3
  • 9
    • 70350266821 scopus 로고    scopus 로고
    • In pursuit of leucinerich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus
    • Sun X, Jackson L, Dey SK, et al. In pursuit of leucinerich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. Endocrinology 2009;150:5065-73.
    • (2009) Endocrinology , vol.150 , pp. 5065-5073
    • Sun, X.1    Jackson, L.2    Dey, S.K.3
  • 10
    • 33646419556 scopus 로고    scopus 로고
    • Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors
    • McClanahan T, Koseoglu S, Smith K, et al. Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. Cancer Biol Ther 2006;5:419-26.
    • (2006) Cancer Biol Ther , vol.5 , pp. 419-426
    • McClanahan, T.1    Koseoglu, S.2    Smith, K.3
  • 11
    • 58449088387 scopus 로고    scopus 로고
    • Gastrointestinal stem cells in development and cancer
    • Brabletz S, Schmalhofer O, Brabletz T. Gastrointestinal stem cells in development and cancer. J Pathol 2009;217:307-17.
    • (2009) J Pathol , vol.217 , pp. 307-317
    • Brabletz, S.1    Schmalhofer, O.2    Brabletz, T.3
  • 12
    • 73049116186 scopus 로고    scopus 로고
    • Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
    • Barker N, Huch M, Kujala P, et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell 2010;6:25-36.
    • (2010) Cell Stem Cell , vol.6 , pp. 25-36
    • Barker, N.1    Huch, M.2    Kujala, P.3
  • 13
    • 79953849217 scopus 로고    scopus 로고
    • Gastric cancer surveillance in a high-risk population in tuscany (Central Italy): Preliminary results
    • Filomena A, Saieva C, Lucchetti V, et al. Gastric cancer surveillance in a high-risk population in tuscany (Central Italy): preliminary results. Digestion 2011;84:70-7.
    • (2011) Digestion , vol.84 , pp. 70-77
    • Filomena, A.1    Saieva, C.2    Lucchetti, V.3
  • 14
    • 76549100947 scopus 로고    scopus 로고
    • Prognosis of hormone-dependent breast cancers: Implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet
    • McCune K, Bhat-Nakshatri P, Thorat MA, et al. Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet. Cancer Res 2010;70:685-96.
    • (2010) Cancer Res , vol.70 , pp. 685-696
    • McCune, K.1    Bhat-Nakshatri, P.2    Thorat, M.A.3
  • 15
    • 77953288698 scopus 로고    scopus 로고
    • Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin
    • Fan XS, Wu HY, Yu HP, et al. Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin. Int J Colorectal Dis 2010;25:583-90.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 583-590
    • Fan, X.S.1    Wu, H.Y.2    Yu, H.P.3
  • 17
    • 0032897996 scopus 로고    scopus 로고
    • Clonal analysis of mouse intestinal epithelial progenitors
    • DOI 10.1016/S0016-5085(99)70222-2
    • Bjerknes M, Cheng H. Clonal analysis of mouse intestinal epithelial progenitors. Gastroenterology 1999;116:7-14. (Pubitemid 29013487)
    • (1999) Gastroenterology , vol.116 , Issue.1 , pp. 7-14
    • Bjerknes, M.1    Cheng, H.2
  • 19
    • 84859937671 scopus 로고    scopus 로고
    • The spatial distribution of LGR5+ cells correlates with gastric cancer progression
    • Simon E, Petke D, Böger C, et al. The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS One 2012;7:e35486.
    • (2012) PLoS One , vol.7
    • Simon, E.1    Petke, D.2    Böger, C.3
  • 20
    • 79955800644 scopus 로고    scopus 로고
    • Significance of Lgr5(+ve) cancer stem cells in the colon and rectum
    • Takahashi H, Ishii H, Nishida N, et al. Significance of Lgr5(+ve) cancer stem cells in the colon and rectum. Ann Surg Oncol 2011;18:1166-74.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1166-1174
    • Takahashi, H.1    Ishii, H.2    Nishida, N.3
  • 21
    • 0000437998 scopus 로고    scopus 로고
    • Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region
    • Hsu SY, Liang SG, Hsueh AJ. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol Endocrinol 1998;12:1830-45. (Pubitemid 28544179)
    • (1998) Molecular Endocrinology , vol.12 , Issue.12 , pp. 1830-1845
    • Hsu, S.Y.1    Liang, S.-G.2    Hsueh, A.J.W.3
  • 24
    • 80051926611 scopus 로고    scopus 로고
    • Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    • de Lau W, Barker N, Low TY, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature 2011;476:293-7.
    • (2011) Nature , vol.476 , pp. 293-297
    • De Lau, W.1    Barker, N.2    Low, T.Y.3
  • 25
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, De Sousa E Melo F, van der Heijden M, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010;12:468-76.
    • (2010) Nat Cell Biol , vol.12 , pp. 468-476
    • Vermeulen, L.1    De Sousa E Melo, F.2    Van Der Heijden, M.3
  • 26
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 2009;457:608-11.
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 29
    • 73349125059 scopus 로고    scopus 로고
    • CD133 expression defines a tumor initiating cell population in primary human ovarian cancer
    • Curley MD, Therrien VA, Cummings CL, et al. CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells 2009;27:2875-83.
    • (2009) Stem Cells , vol.27 , pp. 2875-2883
    • Curley, M.D.1    Therrien, V.A.2    Cummings, C.L.3
  • 31
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • DOI 10.1158/0008-5472.CAN-05-2018
    • Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005;65:10946-51. (Pubitemid 41713363)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 32
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007;67:1030-7.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 35
    • 51649111430 scopus 로고    scopus 로고
    • Single- cell cloning of colon cancer stem cells reveals a multi- lineage differentiation capacity
    • Vermeulen L, Todaro M, de Sousa Mello F, et al. Single- cell cloning of colon cancer stem cells reveals a multi- lineage differentiation capacity. Proc Natl Acad Sci U S A 2008;105:13427-32.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    De Sousa Mello, F.3
  • 36
    • 79960885004 scopus 로고    scopus 로고
    • LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines
    • Walker F, Zhang HH, Odorizzi A, et al. LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. PLoS One 2011;6:e22733.
    • (2011) PLoS One , vol.6
    • Walker, F.1    Zhang, H.H.2    Odorizzi, A.3
  • 37
    • 79851502476 scopus 로고    scopus 로고
    • Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis
    • Takeda K, Kinoshita I, Shimizu Y, et al. Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Anticancer Res 2011;31:263-70.
    • (2011) Anticancer Res , vol.31 , pp. 263-270
    • Takeda, K.1    Kinoshita, I.2    Shimizu, Y.3
  • 38
    • 77954652500 scopus 로고    scopus 로고
    • Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer
    • Uchida H, Yamazaki K, Fukuma M, et al. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer Sci 2010;101:1731-7.
    • (2010) Cancer Sci , vol.101 , pp. 1731-1737
    • Uchida, H.1    Yamazaki, K.2    Fukuma, M.3
  • 39
    • 79951850400 scopus 로고    scopus 로고
    • LgR5 expression and cancer stem cell hypothesis: Clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
    • von Rahden BH, Kircher S, Lazariotou M, et al. LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus? J Exp Clin Cancer Res 2011;30:23.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 23
    • Von Rahden, B.H.1    Kircher, S.2    Lazariotou, M.3
  • 40
    • 77950519192 scopus 로고    scopus 로고
    • Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma
    • Becker L, Huang Q, Mashimo H. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. Dis Esophagus 2010;23:168-74.
    • (2010) Dis Esophagus , vol.23 , pp. 168-174
    • Becker, L.1    Huang, Q.2    Mashimo, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.