Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model

International Journal of Cancer

Volumn 133, Issue 8, 2013, Pages 1792-1802

  Fu, Jen Fen ^a   Yen, Tzung Hai ^a   Chen, Yu ^b   Huang, Ying Jung ^b   Hsu, Cheng Lung ^b   Liang, Der Cherng ^c   Shih, Lee Yung ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

cooperating leukemogenesis; GPR125; KRAS; MLL AF10; myeloid sarcoma

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GPR125 PROTEIN; K RAS PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL ADHESION; CELL AGGREGATION; CELL IMMORTALIZATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; GENE MUTATION; GENE SILENCING; GENETIC TRANSDUCTION; GRANULOCYTIC SARCOMA; HUMAN; LATENT PERIOD; LEUKEMOGENESIS; MACROPHAGE; MALE; MONOCYTE; MOUSE; MYELOID LEUKEMIA; NONHUMAN; ONCOGENE RAS; PERITONEAL CAVITY; PERITONEUM; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RETROVIRUS; SCHOOL CHILD; SKIN;

COOPERATING LEUKEMOGENESIS; GPR125; KRAS; MLL/AF10; MYELOID SARCOMA;

ADOLESCENT; ADULT; ANIMALS; BONE MARROW TRANSPLANTATION; CELL ADHESION; CELL LINE, TUMOR; CELL LINEAGE; CHILD; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; FEMALE; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MIDDLE AGED; MUTATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASM TRANSPLANTATION; NEOPLASMS, ADIPOSE TISSUE; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; RNA, SMALL INTERFERING; SARCOMA, MYELOID; TRANSCRIPTION FACTORS; UP-REGULATION; YOUNG ADULT;

EID: 84881553162     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28195     Document Type: Article

References (31)

1. Tamai H, Inokuchi K,. 11q23/MLL acute leukemia: update of clinical aspects. J Clin Exp Hematop 2010; 50: 91-8.
2. Chen J, Odenike O, Rowley JD,. Leukaemogenesis: more than mutant genes. Nat Rev Cancer 2010; 10: 23-36.
3. Mahgoub N, Parker RI, Hosler MR, et al. RAS mutations in pediatric leukemias with MLL gene rearrangements. Genes Chromosomes Cancer 1998; 21: 270-5.
4. Liang DC, Shih LY, Fu JF, et al. K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements. Cancer 2006; 106: 950-6.
5. Pedersen-Bjergaard J, Andersen MK, Andersen MT, et al. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia 2008; 22: 240-8.
6. Tamai H, Miyake K, Takatori M, et al. Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model. Leukemia 2011; 25: 888-91.
7. Ono R, Kumagai H, Nakajima H, et al. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia 2009; 23: 2197-209.
8. Kim WI, Matise I, Diers MD, et al. RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia. Blood 2009; 113: 1086-96.
9. Brunning RD, Matutes E, Flandrin G, et al. Acute myeloid leukaemia not otherwise categorised. In:, Jaffe ES, Harris NL, Stein H, et al., eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press, 2001. 91-105.
10. Neiman RS, Barcos M, Berard C, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer 1981; 48: 1426-37.
11. Meis JM, Butler JJ, Osborne BM, et al. Granulocytic sarcoma in nonleukemic patients. Cancer 1986; 58: 2697-709.
12. Chang H, Shih LY, Kuo TT,. Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature. Ann Hematol 2003; 82: 435-9.
13. Johansson B, Fioretos T, Kullendorff CM, et al. Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements. Genes Chromosomes Cancer 2000; 27: 136-42.
14. Park KU, Lee DS, Lee HS, et al. Granulocytic sarcoma in MLL-positive infant acute myelogenous leukemia: fluorescence in situ hybridization study of childhood acute myelogenous leukemia for detecting MLL rearrangement. Am J Pathol 2001; 159: 2011-16.
15. Bresters D, Reus AC, Veerman AJ, et al. Congenital leukaemia: the Dutch experience and review of the literature. Br J Haematol 2002; 117: 513-24.
16. Douet-Guilbert N, Morel F, Le Bris MJ, et al. Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation. Leuk Lymphoma 2005; 46: 143-6.
17. Pileri SA, Ascani S, Cox MC, et al. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia 2007; 21: 340-50.
18. Fu JF, Hsu CL, Shih LY,. MLL/AF10(OM-LZ)-immortalized cells expressed cytokines and induced host cell proliferation in a mouse bone marrow transplantation model. Int J Cancer 2010; 126: 1621-9.
19. Shih LY, Liang DC, Fu JF, et al. Characterization of fusion partner genes in 114 patients with de novo acute myeloid leukemia and MLL rearrangement. Leukemia 2006; 20: 218-23.
20. Kogan SC, Ward JM, Anver MR, et al. Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 2002; 100: 238-45.
21. Bjarnadõttir TK, Geirardsdõttir K, Ingemansson M, et al. Identification of novel splice variants of adhesion G protein-coupled receptors. Gene 2007; 387: 38-48.
22. MacKenzie KL, Dolnikov A, Millington M, et al. Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood 1999; 93: 2043-56.
23. Zhang J, Wang J, Liu Y, et al. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 2009; 113: 1304-14.
24. Lillington DM, Jaju RJ, Shankar AG, et al. Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia. Br J Haematol 2000; 110: 547-51.
25. Campidelli C, Agostinelli C, Stitson R, et al. Myeloid sarcoma: extramedullary manifestation of myeloid disorders. Am J Clin Pathol 2009; 132: 426-37.
26. Bjarnadõttir TK, Fredriksson R, Höglund PJ, et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004; 84: 23-33.
27. Pickering C, Hägglund M, Szmydynger-Chodobska J, et al. The adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. BMC Neurosci 2008; 9: 97.
28. Yamamoto Y, Irie K, Asada M, et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene 2004; 23: 3889-97.
29. Chothia C, Jones EY,. The molecular structure of cell adhesion molecules. Annu Rev Biochem 1997; 66: 823-62.
30. Vallon M, Essler M,. Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. J Biol Chem 2006; 281: 34179-88.
31. Ishidate T, Matsumine A, Toyoshima K, et al. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 2000; 19: 365-72.