Polymorphisms in schizophrenia candidate gene UFD1L may contribute to cognitive deficits

Psychiatry Research

Volumn 209, Issue 1, 2013, Pages 110-113

  Ota, Vanessa K ^a   Berberian, Arthur A ^a   Gadelha, Ary ^a   Santoro, Marcos L ^a   Ottoni, Gustavo L ^b   Matsuzaka, Camila T ^a   Mari, Jair J ^a   Melaragno, Maria I ^a   Lara, Diogo R ^b   Smith, Marília A C ^a   Belangero, Sintia I ^a   Bressan, Rodrigo A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cognition; Executive functions; Gene

Indexed keywords

ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; GENE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HUMAN; LEARNING; MAJOR CLINICAL STUDY; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; SCHIZOPHRENIA; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE; UFD1L GENE; WORKING MEMORY;

COGNITION; EXECUTIVE FUNCTIONS; GENE;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; COGNITION DISORDERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; SCHIZOPHRENIA; VERBAL LEARNING;

EID: 84881548371     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2013.03.035     Document Type: Article

References (37)

1. Andreasen N.C., Paradiso S., O'Leary D.S. "Cognitive dysmetria" as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?. Schizophrenia Bulletin 1998, 24:203-218.
2. Arbuthnott K., Frank J. Trail making test, part B as a measure of executive control: validation using a set-switching paradigm. Journal of Clinical and Experimental Neuropsychology 2000, 22:518-528.
3. Barch D.M., Carter C.S., Arnsten A., Buchanan R.W., Cohen J.D., Geyer M., Green M.F., Krystal J.H., Nuechterlein K., Robbins T., Silverstein S., Smith E.E., Strauss M., Wykes T., Heinssen R. Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophrenia Bulletin 2009, 35:109-114.
4. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
5. Berberian A.A., Trevisan B.T., Moriyama T.S., Montiel J.M., Oliveira J.A., Seabra A.G. Working memory assessment in schizophrenia and its correlation with executive functions ability. Revista Brasileira de Psiquiatria 2009, 31:219-226.
6. Brandt J. The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. The Clinical Neuropsychologist 1991, 5:125-142.
7. De Luca A., Pasini A., Amati F., Botta A., Spalletta G., Alimenti S., Caccamo F., Conti E., Trakalo J., Macciardi F., Dallapiccola B., Novelli G. Association study of a promoter polymorphism of UFD1L gene with schizophrenia. American Journal of Medical Genetics 2001, 105:529-533.
8. Dickinson D., Ragland J.D., Calkins M.E., Gold J.M., Gur R.C. A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophrenia Research 2006, 85:20-29.
9. Fett A.K., Viechtbauer W., Dominguez M.D., Penn D.L., van Os J., Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neuroscience & Biobehavioral Reviews 2011, 35:573-588.
10. Freedman D., Brown A.S. The developmental course of executive functioning in schizophrenia. International Journal of Developmental Neuroscience 2011, 29:237-243.
11. Friedman N.P., Miyake A., Young S.E., Defries J.C., Corley R.P., Hewitt J.K. Individual differences in executive functions are almost entirely genetic in origin. Journal of Experimental Psychology: General 2008, 137:201-225.
12. Gladsjo J.A., McAdams L.A., Palmer B.W., Moore D.J., Jeste D.V., Heaton R.K. A six-factor model of cognition in schizophrenia and related psychotic disorders: relationships with clinical symptoms and functional capacity. Schizophrenia Bulletin 2004, 30:739-754.
13. Gur R.E., Calkins M.E., Gur R.C., Horan W.P., Nuechterlein K.H., Seidman L.J., Stone W.S. The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes. Schizophrenia Bulletin 2007, 33:49-68.
14. Jersild A.T. Mental set and shift. Archives of Psychology, Whole No. 89. Journal of Experimental Psychology 1927, 49A:29-50.
15. Kerns J.G., Nuechterlein K.H., Braver T.S., Barch D.M. Executive functioning component mechanisms and schizophrenia. Biological Psychiatry 2008, 64:26-33.
16. Kessler R.C., Chiu W.T., Demler O., Merikangas K.R., Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 2005, 62:617-627.
17. Kongs, S.K., Thompson, L.L., Iverson, G.L., Heaton, R.K., 2000. Wisconsin Card Sorting Test: 64-Card Computerized Version. Psychological Assessment Resources, Odessa, FL.
18. Levine S.Z., Rabinowitz J. Revisiting the 5 dimensions of the Positive and Negative Syndrome Scale. Journal of Clinical Psychopharmacology 2007, 27:431-436.
19. Levinson D.F., Duan J., Oh S., Wang K., Sanders A.R., Shi J., Zhang N., Mowry B.J., Olincy A., Amin F., Cloninger C.R., Silverman J.M., Buccola N.G., Byerley W.F., Black D.W., Kendler K.S., Freedman R., Dudbridge F., Pe'er I., Hakonarson H., Bergen S.E., Fanous A.H., Holmans P.A., Gejman P.V. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. American Journal of Psychiatry 2011, 168:302-316.
20. Mesholam-Gately R.I., Giuliano A.J., Goff K.P., Faraone S.V., Seidman L.J. Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 2009, 23:315-336.
21. Meyer H.H., Shorter J.G., Seemann J., Pappin D., Warren G. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. The EMBO Journal 2000, 19:2181-2192.
22. Morris N., Jones D.M. Memory updating in working memory: the role of the central executive. British Journal of Psychology 1990, 81:111-121.
23. Novelli G., Mari A., Amati F., Colosimo A., Sangiuolo F., Bengala M., Conti E., Ratti A., Bordoni R., Pizzuti A., Baldini A., Crinelli R., Pandolfi F., Magnani M., Dallapiccola B. Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L). Biochimica et Biophysica Acta 1998, 1396:158-162.
24. Nuechterlein K.H., Barch D.M., Gold J.M., Goldberg T.E., Green M.F., Heaton R.K. Identification of separable cognitive factors in schizophrenia. Schizophrenia Research 2004, 72:29-39.
25. Oliveira, R., 2002. Teste não verbal de inteligência. Vetor Editora Psico-Pedagógica, São Paulo.
26. Ota V.K., Belangero S.I., Gadelha A., Bellucco F.T., Christofolini D.M., Mancini T.I., Ribeiro-dos-Santos A.K., Santos S.E., Mari Jde J., Bressan R.A., Melaragno M.I., Smith Mde A. The UFD1L rs5992403 polymorphism is associated with age at onset of schizophrenia. Journal of Psychiatric Research 2010, 44:1113-1115.
27. Rogers R.D., Monsell S. Costs of a predictable switch between simple cognitive tasks. Journal of Experimental Psychology: General 1995, 124:207-231.
28. Saha S., Chant D., Welham J., McGrath J. A systematic review of the prevalence of schizophrenia. PLoS Medicine 2005, 2:e141.
29. Seabra, A.G., Dias, N.M., Macedo, E., in press. Teste de Stroop Computadorizado. Editora Memnon, Sao Paulo.
30. Seidman L.J., Giuliano A.J., Meyer E.C., Addington J., Cadenhead K.S., Cannon T.D., McGlashan T.H., Perkins D.O., Tsuang M.T., Walker E.F., Woods S.W., Bearden C.E., Christensen B.K., Hawkins K., Heaton R., Keefe R.S., Heinssen R., Cornblatt B.A. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Archives of General Psychiatry 2010, 67:578-588.
31. Shashi V., Francis A., Hooper S.R., Kranz P.G., Zapadka M., Schoch K., Ip E., Tandon N., Howard T.D., Keshavan M.S. Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms. European Journal of Human Genetics 2012, 20:1051-1057.
32. Sullivan P.F., Kendler K.S., Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Archives of General Psychiatry 2003, 60:1187-1192.
33. Szoke A., Schurhoff F., Mathieu F., Meary A., Ionescu S., Leboyer M. Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis. Psychological Medicine 2005, 35:771-782.
34. Trandafir A., Meary A., Schurhoff F., Leboyer M., Szoke A. Memory tests in first-degree adult relatives of schizophrenic patients: a meta-analysis. Schizophrenia Research 2006, 81:217-226.
35. Xie L., Ye L., Ju G., Xu Q., Zhang X., Liu S., Shi J., Yu Y., Wang Z., Shen Y., Wei J. A family- and population-based study of the UFD1L gene for schizophrenia. American Journal of Medical Genetics B. Neuropsychiatric Genetics 2008, 147B:1076-1079.
36. Yamagishi H., Garg V., Matsuoka R., Thomas T., Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science 1999, 283:1158-1161.
37. Yntema D.B. Keeping track of several things at once. Human Factors 1963, 5:7-17.