The UFD1L rs5992403 polymorphism is associated with age at onset of schizophrenia

Journal of Psychiatric Research

Volumn 44, Issue 15, 2010, Pages 1113-1115

  Ota, Vanessa Kiyomi ^a   Belangero, Sintia Iole ^a   Gadelha, Ary ^a   Bellucco, Fernanda Teixeira ^a   Christofolini, Denise Maria ^a   Mancini, Tatiane Iris ^a   Ribeiro dos Santos, Ândrea Kelly ^b   Santos, Sidney Emanuel ^b   de Jesus Mari, Jair ^a   Bressan, Rodrigo Affonseca ^a   Melaragno, Maria Isabel ^a   de Arruda Cardoso Smith, Marilia ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARÁ   (Brazil)

Author keywords

22q11.2; Age at onset; Early onset schizophrenia; Schizophrenia; UFD1L

Indexed keywords

UBIQUITIN; UBIQUITIN FUSION DEGRADATION 1L PROTEIN; UNCLASSIFIED DRUG;

ADULT; CHROMOSOME 22Q; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TELENCEPHALON;

AGE OF ONSET; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; ODDS RATIO; POLYMORPHISM, GENETIC; PROTEINS; SCHIZOPHRENIA;

EID: 77958153222     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2010.04.008     Document Type: Letter

References (11)

1. De Luca A., Pasini A., Amati F., Botta A., Spalletta G., Alimenti S., et al. Association study of a promoter polymorphism of UFD1L gene with schizophrenia. American Journal of Medical Genetics 2001, 105:529-533.
2. Kumra S., Charles Schulz S. Editorial: research progress in early-onset schizophrenia. Schizophrenia Bulletin 2008, 34:15-17.
3. Lieberman J.A., Perkins D., Belger A., Chakos M., Jarskog F., Boteva K., Gilmore J. The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biological Psychiatry 2001, 50:884-897.
4. Luoma S., Hakko H., Ollinen T., Järvelin M.R., Lindeman S. Association between age of onset and clinical features of schizophrenia: the Northern Finland 1966 birth cohort study. European Psychiatry 2008, 23:331-335.
5. Meyer H.H., Shorter J.G., Seemann J., Pappin D., Warren G. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. The EMBO Journal 2000, 19:2181-2192.
6. Novelli G., Mari A., Amati F., Colosimo A., Sangiuolo F., Bengala M., et al. Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L). Biochimica et Biophysica Acta 1998, 1396:158-162.
7. Santos N.P., Ribeiro-Rodrigues E.M., Ribeiro-dos-Santos A.K., Pereira R., Gusmão L., Amorim A., et al. Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel. Human Mutation 2010, 31:184-190.
8. Schultz S.K., Ho B.C., Andreasen N.C. Clinical features characterizing young-onset and intermediate-onset schizophrenia. The Journal of Neuropsychiatry and Clinical Neurosciences 2000, 12:502-505.
9. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 1987, 44:660-669.
10. Xie L., Ye L., Ju G., Xu Q., Zhang X., Liu S., et al. A family- and population-based study of the UFD1L gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatry Genetics 2008, 147B:1076-1079.
11. Yamagishi H., Garg V., Matsuoka R., Thomas T., Srivastava D. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects. Science 1999, 283:1158-1161.