Alzheimer's disease risk genes and the age-at-onset phenotype

Neurobiology of Aging

Volumn 34, Issue 11, 2013, Pages 2696.e1-2696.e5

  Thambisetty, Madhav ^a   An, Yang ^a   Tanaka, Toshiko ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Age at onset; Alzheimer's disease; APOE; Gene; PICALM; Risk

Indexed keywords

APOLIPOPROTEIN E; CLATHRIN ASSEMBLY PROTEIN; PHOSPHATIDYLINOSITOL CLATHRIN ASSEMBLY LYMPHOID MYELOID LEUKEMIA; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; APOE GENE; ARTICLE; COHORT ANALYSIS; DISEASE PREDISPOSITION; FEMALE; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HEREDITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PHENOTYPIC VARIATION; PICALM GENE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGE AT ONSET; ALZHEIMER'S DISEASE; APOE; GENE; PICALM; RISK;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; PHENOTYPE; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84881545290     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.05.028     Document Type: Article

References (41)

1. Alexopoulos P., Guo L.H., Kratzer M., Westerteicher C., Kurz A., Perneczky R. Impact of SORL1 single nucleotide polymorphisms on Alzheimer's disease cerebrospinal fluid markers. Dement. Geriatr. Cogn. Disord. 2011, 32:164-170.
2. Beekly D.L., Ramos E.M., Lee W.W., Deitrich W.D., Jacka M.E., Wu J., Hubbard J.L., Koepsell T.D., Morris J.C., Kukull W.A. The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis. Assoc. Disord. 2007, 21:249-258.
3. Beekly D.L., Ramos E.M., van Belle G., Deitrich W., Clark A.D., Jacka M.E., Kukull W.A. The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database. Alzheimer Dis. Assoc. Disord. 2004, 18:270-277.
4. Bekris L.M., Millard S., Lutz F., Li G., Galasko D.R., Farlow M.R., Quinn J.F., Kaye J.A., Leverenz J.B., Tsuang D.W., Yu C.E., Peskind E.R. Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease. Am. J. Med. Genet B Neuropsychiatr. Genet. 2012, 159B:874-883.
5. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J.R. Stat. Soc. Ser B 1995, 57:289-300.
6. Blacker D., Haines J.L., Rodes L., Terwedow H., Go R.C., Harrell L.E., Perry R.T., Bassett S.S., Chase G., Meyers D., Albert M.S., Tanzi R. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology 1997, 48:139-147.
7. Brookmeyer R., Gray S., Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am. J. Public Health 1998, 88:1337-1342.
8. Carrasquillo M.M., Belbin O., Hunter T.A., Ma L., Bisceglio G.D., Zou F., Crook J.E., Pankratz V.S., Sando S.B., Aasly J.O., Barcikowska M., Wszolek Z.K., Dickson D.W., Graff-Radford N.R., Petersen R.C., Passmore P., Morgan K., Younkin S.G. Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study. Mol. Neurodegener. 2011, 6:54. Alzheimer's Research UK (ARUK) consortium.
9. Cruchaga C., Kauwe J.S., Harari O., Jin S.C., Cai Y., Karch C.M., Benitez B.A., Jeng A.T., Skorupa T., Carrell D., Bertelsen S., Bailey M., McKean D., Shulman J.M., De Jager P.L., Chibnik L., Bennett D.A., Arnold S.E., Harold D., Sims R., Gerrish A., Williams J., Van Deerlin V.M., Lee V.M., Shaw L.M., Trojanowski J.Q., Haines J.L., Mayeux R., Pericak-Vance M.A., Farrer L.A., Schellenberg G.D., Peskind E.R., Galasko D., Fagan A.M., Holtzman D.M., Morris J.C., Alzheimer's Disease Neuroimaging Initiative (ADNI), Goate A.M. GWAS of cerebrospinal fluid tau levels identified risk variants for Alzheimer's disease. Neuron 2013, 78:256-268. GERAD Consortium, Alzheimer Disease Genetic Consortium (ADGC)Alzheimer Disease Genetic Consortium (ADGC).
10. Daw E.W., Heath S.C., Wijsman E.M. Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. Am. J. Hum. Genet. 1999, 64:839-851.
11. Daw E.W., Payami H., Nemens E.J., Nochlin D., Bird T.D., Schellenberg G.D., Wijsman E.M. The number of trait loci in late-onset Alzheimer disease. Am. J. Hum. Genet. 2000, 66:196-204.
12. Dickson M.R., Li J., Wiener H.W., Perry R.T., Blacker D., Bassett S.S., Go R.C. Agenomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B:784-792.
13. Duffy B.H. The Alzheimer's Association national policy agenda. N.C. Med. J. 2005, 66:24-26.
14. Friedman W.J. Memory for the time of past events. Psychol. Bull. 1993, 113:44-66.
15. Furney S.J., Simmons A., Breen G., Pedroso I., Lunnon K., Proitsi P., Hodges A., Powell J., Wahlund L.O., Kloszewska I., Mecocci P., Soininen H., Tsolaki M., Vellas B., Spenger C., Lathrop M., Shen L., Kim S., Saykin A.J., Weiner M.W., Lovestone S. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol. Psychiatry 2011, 16:1130-1138. Alzheimer's Disease Neuroimaging Initiative, AddNeuroMed ConsortiumAddNeuroMed Consortium.
16. Han M.R., Schellenberg G.D., Wang L.S. Genome-wide association reveals genetic effects on human Abeta42 and tau protein levels in cerebrospinal fluids: a case control study. BMC Neurol. 2010, 10:90.
17. Harold D., Abraham R., Hollingworth P., Sims R., Gerrish A., Hamshere M.L., Pahwa J.S., Moskvina V., Dowzell K., Williams A., Jones N., Thomas C., Stretton A., Morgan A.R., Lovestone S., Powell J., Proitsi P., Lupton M.K., Brayne C., Rubinsztein D.C., Gill M., Lawlor B., Lynch A., Morgan K., Brown K.S., Passmore P.A., Craig D., McGuinness B., Todd S., Holmes C., Mann D., Smith A.D., Love S., Kehoe P.G., Hardy J., Mead S., Fox N., Rossor M., Collinge J., Maier W., Jessen F., Schürmann B., Heun R., van den Bussche H., Heuser I., Kornhuber J., Wiltfang J., Dichgans M., Frölich L., Hampel H., Hüll M., Rujescu D., Goate A.M., Kauwe J.S., Cruchaga C., Nowotny P., Morris J.C., Mayo K., Sleegers K., Bettens K., Engelborghs S., De Deyn P.P., Van Broeckhoven C., Livingston G., Bass N.J., Gurling H., McQuillin A., Gwilliam R., Deloukas P., Al-Chalabi A., Shaw C.E., Tsolaki M., Singleton A.B., Guerreiro R., Mühleisen T.W., Nöthen M.M., Moebus S., Jöckel K.H., Klopp N., Wichmann H.E., Carrasquillo M.M., Pankratz V.S., Younkin S.G., Holmans P.A., O'Donovan M., Owen M.J., Williams J. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet. 2009, 41:1088-1093.
18. Hollingworth P., Harold D., Sims R., Gerrish A., Lambert J.C., Carrasquillo M.M., Abraham R., Hamshere M.L., Pahwa J.S., Moskvina V., Dowzell K., Jones N., Stretton A., Thomas C., Richards A., Ivanov D., Widdowson C., Chapman J., Lovestone S., Powell J., Proitsi P., Lupton M.K., Brayne C., Rubinsztein D.C., Gill M., Lawlor B., Lynch A., Brown K.S., Passmore P.A., Craig D., McGuinness B., Todd S., Holmes C., Mann D., Smith A.D., Beaumont H., Warden D., Wilcock G., Love S., Kehoe P.G., Hooper N.M., Vardy E.R., Hardy J., Mead S., Fox N.C., Rossor M., Collinge J., Maier W., Jessen F., Rüther E., Schürmann B., Heun R., Kölsch H., van den Bussche H., Heuser I., Kornhuber J., Wiltfang J., Dichgans M., Frölich L., Hampel H., Gallacher J., Hüll M., Rujescu D., Giegling I., Goate A.M., Kauwe J.S., Cruchaga C., Nowotny P., Morris J.C., Mayo K., Sleegers K., Bettens K., Engelborghs S., De Deyn P.P., Van Broeckhoven C., Livingston G., Bass N.J., Gurling H., McQuillin A., Gwilliam R., Deloukas P., Al-Chalabi A., Shaw C.E., Tsolaki M., Singleton A.B., Guerreiro R., Mühleisen T.W., Nöthen M.M., Moebus S., Jöckel K.H., Klopp N., Wichmann H.E., Pankratz V.S., Sando S.B., Aasly J.O., Barcikowska M., Wszolek Z.K., Dickson D.W., Graff-Radford N.R., Petersen R.C., Alzheimer's Disease Neuroimaging Initiative, van Duijn C.M., Breteler M.M., Ikram M.A., DeStefano A.L., Fitzpatrick A.L., Lopez O., Launer L.J., Seshadri S., Berr C., Campion D., Epelbaum J., Dartigues J.F., Tzourio C., Alpérovitch A., Lathrop M., Feulner T.M., Friedrich P., Riehle C., Krawczak M., Schreiber S., Mayhaus M., Nicolhaus S., Wagenpfeil S., Steinberg S., Stefansson H., Stefansson K., Snaedal J., Björnsson S., Jonsson P.V., Chouraki V., Genier-Boley B., Hiltunen M., Soininen H., Combarros O., Zelenika D., Delepine M., Bullido M.J., Pasquier F., Mateo I., Frank-Garcia A., Porcellini E., Hanon O., Coto E., Alvarez V., Bosco P., Siciliano G., Mancuso M., Panza F., Solfrizzi V., Nacmias B., Sorbi S., Bossù P., Piccardi P., Arosio B., Annoni G., Seripa D., Pilotto A., Scarpini E., Galimberti D., Brice A., Hannequin D., Licastro F., Jones L., Holmans P.A., Jonsson T., Riemenschneider M., Morgan K., Younkin S.G., Owen M.J., O'Donovan M., Amouyel P., Williams J. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011, 43:429-435. CHARGE consortium, EADI1 consortiumEADI1 consortium.
19. Holmans P., Hamshere M., Hollingworth P., Rice F., Tunstall N., Jones S., Moore P., Wavrant DeVrieze F., Myers A., Crook R., Compton D., Marshall H., Meyer D., Shears S., Booth J., Ramic D., Williams N., Norton N., Abraham R., Kehoe P., Williams H., Rudrasingham V., O'Donovan M., Jones L., Hardy J., Goate A., Lovestone S., Owen M., Williams J. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005, 135B:24-32.
20. Hu X., Pickering E., Liu Y.C., Hall S., Fournier H., Katz E., Dechairo B., John S., Van Eerdewegh P., Soares H. Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. PLoS One 2011, 6:e16616.
21. Jones E.L., Mok K., Hanney M., Harold D., Sims R., Williams J., Ballard C. Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome. Neurobiol Aging 2013, [Epub ahead of print].
22. Jun G., Naj A.C., Beecham G.W., Wang L.S., Buros J., Gallins P.J., Buxbaum J.D., Ertekin-Taner N., Fallin M.D., Friedland R., Inzelberg R., Kramer P., Rogaeva E., St George-Hyslop P., Cantwell L.B., Dombroski B.A., Saykin A.J., Reiman E.M., Bennett D.A., Morris J.C., Lunetta K.L., Martin E.R., Montine T.J., Goate A.M., Blacker D., Tsuang D.W., Beekly D., Cupples L.A., Hakonarson H., Kukull W., Foroud T.M., Haines J., Mayeux R., Farrer L.A., Pericak-Vance M.A., Schellenberg G.D. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch. Neurol. 2010, 67:1473-1484. Alzheimer's Disease Genetics Consortium.
23. Kauwe J.S., Cruchaga C., Karch C.M., Sadler B., Lee M., Mayo K., Latu W., Su'a M., Fagan A.M., Holtzman D.M., Morris J.C., Alzheimer's Disease Neuroimaging Initiative, Goate A.M. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. PLoS One 2011, 6:e15918.
24. Kim S., Swaminathan S., Shen L., Risacher S.L., Nho K., Foroud T., Shaw L.M., Trojanowski J.Q., Potkin S.G., Huentelman M.J., Craig D.W., DeChairo B.M., Aisen P.S., Petersen R.C., Weiner M.W., Saykin A.J., Alzheimer's Disease Neuroimaging Initiative Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology 2011, 76:69-79.
25. Lambert J.C., Heath S., Even G., Campion D., Sleegers K., Hiltunen M., Combarros O., Zelenika D., Bullido M.J., Tavernier B., Letenneur L., Bettens K., Berr C., Pasquier F., Fiévet N., Barberger-Gateau P., Engelborghs S., De Deyn P., Mateo I., Franck A., Helisalmi S., Porcellini E., Hanon O., European Alzheimer's Disease Initiative Investigators, de Pancorbo M.M., Lendon C., Dufouil C., Jaillard C., Leveillard T., Alvarez V., Bosco P., Mancuso M., Panza F., Nacmias B., Bossù P., Piccardi P., Annoni G., Seripa D., Galimberti D., Hannequin D., Licastro F., Soininen H., Ritchie K., Blanché H., Dartigues J.F., Tzourio C., Gut I., Van Broeckhoven C., Alpérovitch A., Lathrop M., Amouyel P. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 2009, 41:1094-1099.
26. Li Y.J., Scott W.K., Hedges D.J., Zhang F., Gaskell P.C., Nance M.A., Watts R.L., Hubble J.P., Koller W.C., Pahwa R., Stern M.B., Hiner B.C., Jankovic J., Allen F.A., Goetz C.G., Mastaglia F., Stajich J.M., Gibson R.A., Middleton L.T., Saunders A.M., Scott B.L., Small G.W., Nicodemus K.K., Reed A.D., Schmechel D.E., Welsh-Bohmer K.A., Conneally P.M., Roses A.D., Gilbert J.R., Vance J.M., Haines J.L., Pericak-Vance M.A. Age at onset in two common neurodegenerative diseases is genetically controlled. Am. J. Hum. Genet. 2002, 70:985-993.
27. Meda S.A., Koran M.E., Pryweller J.R., Vega J.N., Thornton-Wells T.A. Genetic interactions associated with 12-month atrophy in hippocampus and entorhinal cortex in Alzheimer's Disease Neuroimaging Initiative. Neurobiol. Aging 2013, 34:1518.e9-1518.e18.
28. Morris J.C., Weintraub S., Chui H.C., Cummings J., Decarli C., Ferris S., Foster N.L., Galasko D., Graff-Radford N., Peskind E.R., Beekly D., Ramos E.M., Kukull W.A. The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis. Assoc. Disord. 2006, 20:210-216.
29. Mullard A. Sting of Alzheimer's failures offset by upcoming prevention trials. Nat. Rev. Drug Discov. 2012, 11:657-660.
30. Naj A.C., Jun G., Beecham G.W., Wang L.S., Vardarajan B.N., Buros J., Gallins P.J., Buxbaum J.D., Jarvik G.P., Crane P.K., Larson E.B., Bird T.D., Boeve B.F., Graff-Radford N.R., De Jager P.L., Evans D., Schneider J.A., Carrasquillo M.M., Ertekin-Taner N., Younkin S.G., Cruchaga C., Kauwe J.S., Nowotny P., Kramer P., Hardy J., Huentelman M.J., Myers A.J., Barmada M.M., Demirci F.Y., Baldwin C.T., Green R.C., Rogaeva E., St George-Hyslop P., Arnold S.E., Barber R., Beach T., Bigio E.H., Bowen J.D., Boxer A., Burke J.R., Cairns N.J., Carlson C.S., Carney R.M., Carroll S.L., Chui H.C., Clark D.G., Corneveaux J., Cotman C.W., Cummings J.L., DeCarli C., DeKosky S.T., Diaz-Arrastia R., Dick M., Dickson D.W., Ellis W.G., Faber K.M., Fallon K.B., Farlow M.R., Ferris S., Frosch M.P., Galasko D.R., Ganguli M., Gearing M., Geschwind D.H., Ghetti B., Gilbert J.R., Gilman S., Giordani B., Glass J.D., Growdon J.H., Hamilton R.L., Harrell L.E., Head E., Honig L.S., Hulette C.M., Hyman B.T., Jicha G.A., Jin L.W., Johnson N., Karlawish J., Karydas A., Kaye J.A., Kim R., Koo E.H., Kowall N.W., Lah J.J., Levey A.I., Lieberman A.P., Lopez O.L., Mack W.J., Marson D.C., Martiniuk F., Mash D.C., Masliah E., McCormick W.C., McCurry S.M., McDavid A.N., McKee A.C., Mesulam M., Miller B.L., Miller C.A., Miller J.W., Parisi J.E., Perl D.P., Peskind E., Petersen R.C., Poon W.W., Quinn J.F., Rajbhandary R.A., Raskind M., Reisberg B., Ringman J.M., Roberson E.D., Rosenberg R.N., Sano M., Schneider L.S., Seeley W., Shelanski M.L., Slifer M.A., Smith C.D., Sonnen J.A., Spina S., Stern R.A., Tanzi R.E., Trojanowski J.Q., Troncoso J.C., Van Deerlin V.M., Vinters H.V., Vonsattel J.P., Weintraub S., Welsh-Bohmer K.A., Williamson J., Woltjer R.L., Cantwell L.B., Dombroski B.A., Beekly D., Lunetta K.L., Martin E.R., Kamboh M.I., Saykin A.J., Reiman E.M., Bennett D.A., Morris J.C., Montine T.J., Goate A.M., Blacker D., Tsuang D.W., Hakonarson H., Kukull W.A., Foroud T.M., Haines J.L., Mayeux R., Pericak-Vance M.A., Farrer L.A., Schellenberg G.D. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat. Genet. 2011, 43:436-441.
31. Potkin S.G., Guffanti G., Lakatos A., Turner J.A., Kruggel F., Fallon J.H., Saykin A.J., Orro A., Lupoli S., Salvi E., Weiner M., Macciardi F., Alzheimer's Disease Neuroimaging Initiative Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS One 2009, 4:e6501.
32. Ruiz A., Hernandez I., Ronsende-Roca M., Gonzalez-Perez A., Rodriguez-Noriega E., Ramirez-Lorca R., Mauleon A., Moreno-Rey C., Boswell L., Tune L., Valero S., Alegret M., Gayán J., Becker J.T., Real L.M., Tárraga L., Ballard C., Terrin M., Sherman S., Payami H., López O.L., Mintzer J.E., Boada M. Exploratory analysis of seven Alzheimer's disease genes: disease progression. Neurobiol. Aging 2013, 34:e1311-e1317.
33. Schnetz-Boutaud N.C., Hoffman J., Coe J.E., Murdock D.G., Pericak-Vance M.A., Haines J.L. Identification and confirmation of an exonic splicing enhancer variation in exon 5 of the Alzheimer disease associated PICALM gene. Ann. Hum. Genet. 2012, 76:448-453.
34. Schofield P.W., Mosesson R.E., Stern Y., Mayeux R. The age at onset of Alzheimer's disease and an intracranial area measurement. A relationship. Arch. Neurol. 1995, 52:95-98.
35. Scotland P.B., Heath J.L., Conway A.E., Porter N.B., Armstrong M.B., Walker J.A., Klebig M.L., Lavau C.P., Wechsler D.S. The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS One 2012, 7:e44252.
36. Seshadri S., Fitzpatrick A.L., Ikram M.A., DeStefano A.L., Gudnason V., Boada M., Bis J.C., Smith A.V., Carassquillo M.M., Lambert J.C., Harold D., Schrijvers E.M., Ramirez-Lorca R., Debette S., Longstreth W.T., Janssens A.C., Pankratz V.S., Dartigues J.F., Hollingworth P., Aspelund T., Hernandez I., Beiser A., Kuller L.H., Koudstaal P.J., Dickson D.W., Tzourio C., Abraham R., Antunez C., Du Y., Rotter J.I., Aulchenko Y.S., Harris T.B., Petersen R.C., Berr C., Owen M.J., Lopez-Arrieta J., Varadarajan B.N., Becker J.T., Rivadeneira F., Nalls M.A., Graff-Radford N.R., Campion D., Auerbach S., Rice K., Hofman A., Jonsson P.V., Schmidt H., Lathrop M., Mosley T.H., Au R., Psaty B.M., Uitterlinden A.G., Farrer L.A., Lumley T., Ruiz A., Williams J., Amouyel P., Younkin S.G., Wolf P.A., Launer L.J., Lopez O.L., van Duijn C.M., Breteler M.M., CHARGE Consortium, GERAD1 Consortium, EADI1 Consortium Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010, 303:1832-1840.
37. Shang H., Fu J., Zhang X.M., Song R.R., Wang W.Z. Association between EXOC3L2 rs597668 polymorphism and Alzheimer's disease. CNS Neurosci. Ther 2013, [Epub ahead of print].
38. Slooter A.J., Cruts M., Kalmijn S., Hofman A., Breteler M.M., Van Broeckhoven C., van Duijn C.M. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch. Neurol. 1998, 55:964-968.
39. Sweet R.A., Seltman H., Emanuel J.E., Lopez O.L., Becker J.T., Bis J.C., Weamer E.A., DeMichele-Sweet M.A., Kuller L.H. Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study. Am. J. Psychiatry 2012, 169:954-962.
40. Weintraub S., Salmon D., Mercaldo N., Ferris S., Graff-Radford N.R., Chui H., Cummings J., DeCarli C., Foster N.L., Galasko D., Peskind E., Dietrich W., Beekly D.L., Kukull W.A., Morris J.C. The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery. Alzheimer Dis. Assoc. Disord. 2009, 23:91-101.
41. Xiao Q., Gil S.C., Yan P., Wang Y., Han S., Gonzales E., Perez R., Cirrito J.R., Lee J.M. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J.Biol. Chem. 2012, 287:21279-21289.