Hepatotoxicity from anabolic androgenic steroids marketed as dietary supplements: Contribution from ATP8B1/ABCB11 mutations?

Liver International

Volumn 33, Issue 8, 2013, Pages 1266-1270

  El Sherrif, Yasser ^a   Potts, Jonathan R ^a,b   Howard, Mark R ^a   Barnardo, Adrian ^a   Cairns, Stuart ^a   Knisely, Alex S ^c   Verma, Sumita ^a,b  

^a UK   (United Kingdom)

^b BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Benign recurrent intrahepatic cholestasis; Cholestasis; Drug induced liver injury

Indexed keywords

2ALPHA 17ALPHA DIMETHYL ETIOCHOLAN 3 ONE,17BETA OL; ANABOLIC AGENT; BILE SALT; GAMMA GLUTAMYLTRANSFERASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CAUCASIAN; CHOLESTASIS; CHOLESTATIC HEPATITIS; DIET SUPPLEMENTATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HYPERBILIRUBINEMIA; INTRAHEPATIC CHOLESTASIS; LIVER BIOPSY; LIVER TOXICITY; MALE; TOXIC HEPATITIS;

BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS; CHOLESTASIS; DRUG-INDUCED LIVER INJURY;

ADENOSINE TRIPHOSPHATASES; ADULT; ANABOLIC AGENTS; ANDROGENS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; CHOLESTASIS, INTRAHEPATIC; DIETARY SUPPLEMENTS; DNA MUTATIONAL ANALYSIS; DRUG-INDUCED LIVER INJURY; GAMMA-GLUTAMYLTRANSFERASE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERBILIRUBINEMIA; MALE; MIDDLE AGED; MUTATION; PHENOTYPE; RISK FACTORS;

EID: 84881542640     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12216     Document Type: Article

References (16)

1. Advisory Council on the Misue of Drugs. Consideration of the anabolic steroids. 2010. Available at www.homeoffice.gov.uk/publications/alcohol-drugs/drugs/acmd1/anabolic-steroids-report/anabolic-steroids. Accessed 12 December 2012.
2. Kafrouni MI, Anders RA, Verma S. Hepatotoxicity associated with dietary supplements containing anabolic steroids. Clin Gastroenterol Hepatol 2007; 5: 809-12.
3. Elsharkawy AM, McPherson S, Masson S, et al. Cholestasis secondary to anabolic steroid use in young men. BMJ 2012; 344: e468.
4. Cordaro FG, Lombardo S, Cosentino M. Selling androgenic anabolic steroids by the pound: identification and analysis of popular websites on the Internet. Scand J Med Sci Sports 2011; 21: e247-59.
5. van Mil SW, Houwen RH, Klomp LW. Genetics of familial intrahepatic cholestasis syndromes. J Med Genet 2005; 42: 449-63.
6. Strautnieks SS, Byrne JA, Pawlikowska L, et al. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families. Gastroenterology 2008; 134: 1203-14.
7. Dunckley H. HLA typing by SSO and SSP methods. Methods Mol Biol 2012; 882: 9-25.
8. Danan G, Benichou C. Causality assessment of adverse reactions to drugs-1. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993; 46: 1323-30.
9. Paulusma CC, Groen A, Kunne C, et al. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology 2006; 44: 195-204.
10. Daly AK, Donaldson PT, Bhatnagar P, et al.; DILIGEN Study; International SAE Consortium. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet 2009; 41:816-9.
11. Dawson RT. Drugs in sport - the role of the physician. J Endocrinol 2001; 170: 55-61.
12. Welder AA, Robertson JW, Melchert RB. Toxic effects of anabolic androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods 1995; 33: 187-95.
13. Lang C, Meier Y, Stieger B, et al. Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet Genomics 2007; 17: 47-60.
14. Pauli-Magnus C, Kerb R, Fattinger K, et al. BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. Hepatology 2004; 39: 779-91.
15. Hermeziu B, Sanlaville D, Girard M, et al. Heterozygous bile salt export pump deficiency: a possible genetic predisposition to transient neonatal cholestasis. J Pediatr Gastroenterol Nutr 2006; 42: 114-6.
16. Perez LM, Milkiewicz P, Elias E, et al. Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. J Toxicol Sci 2006; 91: 150-8.