3-Carboxy-pyrazolinalanine as a new scaffold for developing potent and selective NMDA receptor antagonists

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 33-37

  Tamborini, Lucia ^a   Pinto, Andrea ^a   Mastronardi, Federica ^a   Iannuzzi, Maria C ^a   Cullia, Gregorio ^a   Nielsen, Birgitte ^b   De Micheli, Carlo ^a   Conti, Paola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Amino acid; Intramolecular cyclization; l Glutamic acid; N Methyl d aspartate receptor antagonist; Pyrazoline

Indexed keywords

1 ETHYL 7 METHYL 6 (TERT BUTOXYCARBONYLAMINO) 2 OXOHEPT 3 ENEDIOATE; 3 CARBOXY PYRAZOLINALANINE; 5 (2 AMINO 2 CARBOXYETHYL) 1 BENZYL 4,5 DIHYDRO 1H PYRAZOLE 3 CARBOXYLIC ACID HYDROCHLORIDE; 5 (2 AMINO 2 CARBOXYETHYL) 4,5 DIHYDRO 1H PYRAZOLE 3 CARBOXYLIC ACID HYDROCHLORIDE; ALANINE DERIVATIVE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CARBOXYLIC ACID; CHLORIDE; ETHYL 1 BENZYL 5 [2 (TERT BUTOXYCARBONYL AMINO) 3 METHOXY 3 OXOPROPYL] 4,5 DIHYDRO 1H PYRAZOLE 3 CARBOXYLATE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PYRAZOLE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

AMINO ACID; INTRAMOLECULAR CYCLIZATION; L-GLUTAMIC ACID; N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST; PYRAZOLINE;

ANILINE COMPOUNDS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRAZOLES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84881539049     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.010     Document Type: Article

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