Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 935, Issue , 2013, Pages 1-9

  Tao, Ye ^a,b   Xu, Haiyu ^a   Wang, Shanshan ^c   Wang, Bing ^d   Zhang, Yingchun ^a   Wang, Weihao ^a   Huang, Bin ^a   Wu, Hongwei ^a   Li, Defeng ^a   Zhang, Yi ^a   Xiao, Xuefeng ^b   Li, Yubo ^b   Yang, Hongjun ^a   Huang, Luqi ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c QILU UNIVERSITY OF TECHNOLOGY   (China)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid; Pharmacokinetic study; RRLC ESI Q TOF MS; Yuanhu Zhitong prescription

Indexed keywords

BIOACTIVE COMPONENTS; CEREBRO SPINAL FLUIDS; PHARMACOKINETIC RESEARCH; PHARMACOKINETIC STUDIES; RAPID RESOLUTION LIQUID CHROMATOGRAPHIES; RRLC-ESI-Q-TOF-MS; TETRAHYDROPALMATINE; YUANHU ZHITONG PRESCRIPTION;

BRAIN; CARDIOVASCULAR SYSTEM; CEREBROSPINAL FLUID; CHROMATOGRAPHY;

LIQUIDS;

ALLOCRYPTOPINE; ANALGESIC AGENT; ANGELICIN; CHINESE DRUG; CORYDALINE; DRUG METABOLITE; PROTOPINE; TETRAHYBERBERINE; TETRAHYDROPALMATINE; UNCLASSIFIED DRUG; YUANHU ZHITONG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84881533351     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.07.015     Document Type: Article

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