A biochemical and histopathologic study showing protection and treatment of gentamicin-induced nephrotoxicity in rabbits using vitamin C

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 9, Issue 3, 2012, Pages 360-365

  Rehman, K ^a   Akash, M S H ^a   Azhar, S ^b   Khan, S A ^b   Abid, R ^c   Waseem, A ^b   Murtaza, G ^b   Sherazi, T A ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b Tobe Camp University Road Abbottabad   (Pakistan)

^c BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

Author keywords

Blood urea nitrogen; Gentamicin; Nephroprotective and nephrocurative activities; Serum antioxidant activity; Serum creatinine; Vitamin C

Indexed keywords

ASCORBIC ACID; CREATININE; GENTAMICIN; NITROGEN; UREA; ANTIOXIDANT; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATTENUATION; BIOCHEMISTRY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; HISTOPATHOLOGY; MALE; NEPHROTOXICITY; NONHUMAN; RABBIT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL; WEIGHT REDUCTION; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; KIDNEY; KIDNEY DISEASE; METABOLISM; NEPHROPROTECTIVE AND NEPHROCURATIVE ACTIVITIES; PATHOLOGY; SERUM ANTIOXIDANT ACTIVITY; CHEMICALLY INDUCED; DRUG EFFECTS; KIDNEY DISEASES;

BLOOD UREA NITROGEN; GENTAMICIN; NEPHROPROTECTIVE AND NEPHROCURATIVE ACTIVITIES; SERUM ANTIOXIDANT ACTIVITY; SERUM CREATININE; VITAMIN C;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BLOOD UREA NITROGEN; CREATININE; GENTAMICINS; KIDNEY; KIDNEY DISEASES; MALE; RABBITS; UREA; VITAMINS;

EID: 84881528915     PISSN: None     EISSN: 01896016     Source Type: Journal    
DOI: 10.4314/ajtcam.v9i3.9     Document Type: Article

References (19)

1. Ajith, T.A.; Usha, S. and Nivitha, V. (2007). Ascorbic acid and α-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study. Clin. Chim. Acta, 375: 82-86.
2. Akturk, O.; Demirin, H.; Sutcu, R.; Yilmaz, N.; Koylu, H. and Altuntas, I. (2006). The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C. Cell Biol. Toxicol., 22: 455-461.
3. Belin, S.; Kaya, F.; Duisit, G.; Giacometti, S.; Ciccolini, J. and Fontés, M. (2009). Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression. PLoS ONE, 4: e4409-e4413.
4. Cárcamo, M.J.; Pedraza, A.; Bórquez-Ojeda, O.; Zhang, B.; Sanchez, R. and Golde, D.W. (2004). Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits IκBα Kinase β. Mol. Cell Biol, 24: 6645-6652.
5. Chung, C.H.; Lee, E.Y.; Lee, M.Y.; Hong, S.W. and Hong, S.Y. (2007). Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats. Yonsei Med. J., 48: 847-855.
6. Cojocel, C.; Docius, N.; Maita, K.; Smith, J.H. and Hook, J.B. (1984). Renal ultrastructural and biochemical injuries induced by aminoglycoside. Env. Health Perspect., 57: 298-299.
7. Derakhshanfar, A.; Bidadkosh, A. and Kazeminia, S. (2007) Vitamin E protection against gentamicin-induced nephrotoxicity in rats: a biochemical and histopathologic study. Iranian J. Vet., 8: 231-238.
8. Fischer, H.; Schwarzer, C. and Illek, B. (2004). Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc. Natl. Acad. Sci. USA, 101: 3691-3696.
9. th Ed., Elsevier, London, UK.
10. Harapanhalli, R.S.; Yaghmai, V.; Giuliani, D.; Howell, R.W. and Rao, D.V. (1996). Antioxidant effects of vitamin C in mice following X-irradiation. Res. Commun. Mol. Pathol. Pharmacol., 94: 271-87.
11. Kadkhodaee, M.; Khastar, H.; Faghihi, M.; Ghaznavi R. and Zahmatkesh, M. (2004). Effects of cosupplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat. Exp. Physiol., 90: 571-576.
12. Kadkhodaee, M.; Khastar, H.; Faghihi, M.; Ghaznavi, R. and Zahmatkesh, M. (2004). Effects of cosupplementation of vitamins E and C on gentamicin-induced nephrotoxicity in rat. Exp. Physiol., 90: 571-576.
13. Koracevic, D.; Koracevic, G.; Djordjevic, V.; Andrejevic, S. and Cosic, V. (2001). Method for the measurement of antioxidant activity in human fluids. J. Clin. Pathol., 54: 356-361.
14. Mashhadian, N.V. and Rakhshandeh, H. (2005). Antibacterial and antifungal effects of Nigella sativa extracts against S. aureus, P. aeroginosa and C. albicans. Pak. J. Med. Sci., 21: 47-52.
15. Mingeot-Leclercq, M.P. and Tulkens, P.M. (1999). Aminoglycosides: Nephrotoxicity. Antimicrob. Agents Chemother., 43: 1003-1012.
16. Patra, R.C.; Swarup, D. and Dwivedi SK. (2001). Antioxidant effect of α tocopherol, ascorbic acid and Lmethionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicol., 162: 81-88.
17. Premila, A. (2005). Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage. Clin. Exp. Nephrol., 9: 24-30.
18. Prozialeck W.C. and Edwards, J.R. (2007). Cell Adhesion Molecules in Chemically-Induced Renal Injury. Pharmacol. Ther., 114: 74-93.
19. Varzi, H.N.; Esmailzadeh, S.; Morovvati, H.; Avizeh, R.; Shahriari, A. and Givi, M.E. (2007). Effect of silymarin and vitamin E on gentamicin-induced nephrotoxicity in dogs. J. Vet. Pharmacol. Therap., 30: 477-481.