Comparison of control strategies for fed-batch culture of hybridoma cells based on on-line monitoring of oxygen uptake rate, optical cell density and glucose concentration

Journal of Chemical Technology and Biotechnology

Volumn 88, Issue 9, 2013, Pages 1680-1689

  Casablancas, Antoni ^a   Gámez, Xavier ^a   Lecina, Martí ^a   Solà, Carles ^a   Cairó, Jordi J ^a   Gòdia, Francesc ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Animal cell culture; Bioprocess monitoring; Fed batch culture; Glucose FIA determination; Monoclonal antibodies; Oxygen uptake rate

Indexed keywords

BIOPROCESS MONITORING; CONTROL STRATEGIES; EXPONENTIAL GROWTH; FED-BATCH CULTURES; GLUCOSE CONCENTRATION; MAMMALIAN CELL CULTURE; ON-LINE MONITORING SYSTEM; OXYGEN UPTAKE RATES;

ANIMAL CELL CULTURE; BATCH DATA PROCESSING; CELL GROWTH; CELLS; CYTOLOGY; FEEDING; GLUCOSE; GROWTH KINETICS; METABOLISM; MONITORING; MONOCLONAL ANTIBODIES; OXYGEN; PRODUCTIVITY; TOOLS; VOLTAGE MEASUREMENT;

BATCH CELL CULTURE;

GLUCOSE; OXYGEN;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL GROWTH; CELL METABOLISM; CONTROL STRATEGY; CONTROLLED STUDY; FED BATCH CULTURE; HYBRIDOMA CELL CULTURE; NONHUMAN; ONLINE MONITORING; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION;

EID: 84881514373     PISSN: 02682575     EISSN: 10974660     Source Type: Journal    
DOI: 10.1002/jctb.4019     Document Type: Article

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