Lentivirus-based RNA silencing of nemo-like kinase (NLK) inhibits the CAL 27 human adenosquamos carcinoma cells proliferation and blocks G0/G1 phase to S phase

International Journal of Medical Sciences

Volumn 10, Issue 10, 2013, Pages 1301-1306

  Zhang, Bin ^a,b   Li, Ke Yi ^b   Chen, Hai Ying ^b   Pan, Shao Dong ^b   Chen, Shuang Feng ^b   Zhang, Wei Feng ^b   Xia, Chun Peng ^b   Jiang, Li Cheng ^b   Liu, Xian Bin ^b   Zhao, Feng Jun ^b   Yuan, Dao Ying ^b   Wang, Le Xin ^b,c   Wu, Ya Ping ^b,d   Liu, Shu Wei ^a  

^a SHANDONG UNIVERSITY   (China)

^b LIAOCHENG PEOPLE'S HOSPITAL   (China)

^c CHARLES STURT UNIVERSITY   (Australia)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Lentivirus; Nemo like kinase (NLK); Oral squamous cell carcinoma; RNAi

Indexed keywords

LENTIVIRUS VECTOR; NEMO LIKE KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG; NLK PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRUS INFECTION; MOUTH CARCINOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA ANALYSIS; RNA INTERFERENCE; RNA SEQUENCE; TREATMENT RESPONSE; ADENOSQUAMOUS CARCINOMA; ENZYMOLOGY; GENETICS; LENTIVIRINAE; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CARCINOMA, ADENOSQUAMOUS; CELL LINE, TUMOR; CELL PROLIFERATION; G0 PHASE; G1 PHASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LENTIVIRUS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; S PHASE;

EID: 84881500512     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.6607     Document Type: Article

References (19)

1. Binmadi NO, Basile JR. Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol. 2011;47:1005-10.
2. D-Costa J, Mansfield SG, Humeau LM. Lentiviral vectors in clinical trials: Current status. Curr Opin Mol Ther. 2009; 11: 554-64.
3. Sakuma T, Barry MA, Ikeda Y. Lentiviral vectors: basic to translational. Biochem J. 2012;443:603-18.
4. Yan B, Fu Q, Lai L, et al. Downregulation of microRNA 99a in oral squamous cell carcinomas contributes to the growth and survival of oral cancer cells. Mol Med Report. 2012;6:675-81.
5. Perez-Sayans M, Suarez-Penaranda JM, Herranz-Carnero M, et al. The role of the adenomatous polyposis coli (APC) in oral squamous cell carcinoma. Oral Oncol. 2012;48:56-60.
6. Silva TA, Ribeiro FL, Oliveira-Neto HH, et al. Dual role of CCL3/CCR1 in oral squamous cell carcinoma: implications in tumor metastasis and local host defense. Oncol Rep. 2007;18:1107-13.
7. Rosado P, Lequerica-Fernandez P, Pena I, et al. In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression. Virchows Arch. 2012;461:163-8.
8. Ishitani T, Ishitani S, Matsumoto K et al. Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin. J Neurochem. 2009;111:1104-18.
9. Ishitani T, Hirao T, Suzuki M, et al. Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Nat Cell Biol. 2010;12:278-85.
10. Kanei-Ishii C, Ninomiya-Tsuji J, et al. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev. 2004;18:816-29.
11. Kojima H, Sasaki T, Ishitani T, et al. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. Proc Natl Acad Sci U S A. 2005;102:4524-9.
12. Ishitani T, Ishitani S. Nemo-like kinase, a multifaceted cell signaling regulator. Cell Signal. 2013;25:190-7.
13. Stevens KN, Kelemen LE, Wang X, et al. Common variation in Nemo-like kinase is associated with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2012;21:523-8.
14. Jung KH, Kim JK, Noh JH, et al. Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. J Cell Biochem. 2010;110:687-96.
15. Emami KH, Brown LG, Pitts TE, et al. Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells. Prostate. 2009;69:1481-92.
16. Yasuda J, Tsuchiya A, Yamada T, et al. Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. Biochem Biophys Res Commun. 2003;308:227-33.
17. Tan Z, Li M, Wu W, Zhang L, et al. NLK is a key regulator of proliferation and migration in gallbladder carcinoma cells. Mol Cell Biochem. 2012;369:27-33.
18. Lo Muzio L. A possible role for the WNT-1 pathway in oral carcinogenesis. Crit Rev Oral Biol Med. 2001;12:152-65.
19. Andrade Filho PA, Letra A, Cramer A, et al. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. J Dent Res. 2011;90:740-6.