Role of telomerase reverse transcriptase in glial scar formation after spinal cord injury in rats

Neurochemical Research

Volumn 38, Issue 9, 2013, Pages 1914-1920

  Tao, Xu ^a   Ming Kun, Yang ^a   Wei Bin, Sheng ^a   Hai Long, Guo ^a   Rui, Kan ^a   Lai Yong, Tu ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Glial scar; Spinal cord injury; Telomerase reverse transcriptase

Indexed keywords

EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; MESSENGER RNA; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN 200; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; GLIA; GLIOSIS; IMMUNOFLUORESCENCE; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA INTERFERENCE; SCAR FORMATION; SPINAL CORD INJURY;

RATTUS;

ANIMALS; CICATRIX; MALE; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD INJURIES; TELOMERASE;

EID: 84881480048     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1097-x     Document Type: Article

References (24)

1. Lu P, Jones LL, Tuszynski MH (2007) Axon regeneration through scars and into sites of chronic spinal cord injury. Exp Neurol 203:8-21
2. Chen Haoxian, Zheng Xinfeng, Sheng Weibin et al (2009) Transplantation of low-power laser-irradiated olfactory ensheathing cells to promote repair of spinal cord injury in rats. Neural Regen Res 4:171-177
3. Frisén J, Haegerstrand A, Risling M, Fried K, Johansson CB, Hammarberg H, Elde R, Hökfelt T, Cullheim S (1995) Spinal axons in central nervous system scar tissue are closely related to laminin-immunoreactive astrocytes. Neuroscience 65:293-304
4. EddlestonM Mucke L (1993) Molecular profile of reactive astrocytes: implications for their role in neurological disease. Neuroscience 54:15-36
5. Eng LF, Ghirnikar RS (1994) GFAP and astrogliosis. Brain Pathol 4:229-237
6. Collins K, Mitchell JR (2002) Telomerase in the human organism. Oncogene 21:564-579
7. de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110
8. Blasco MA (2005) Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J 24:1095-1103
9. Meyerson M, Counter CM, Eaton EN et al (1997) hEST2, the putative human telomere-se catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90:785-795
10. Collins K (2000) Mammalian telomeres and telomerase. Curr Opin Cell Biol 12:378-383
11. Choi J, Southworth LK, Sarin KY et al (2008) TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet 4:e10
12. Geserick C, Blasco MA (2006) Novel roles for telomerase in aging. Mech Ageing Dev 127:579-583
13. Takano H, Murasawa S, Asahara T (2008) Functional and gene expression analysis of hTERT overexpressed endothelial cells. Biologics 2:547-554
14. Zhang RG, Zhao JJ, Yang LQ, Yang SM, Wang RQ, Chen WS, Peng GY, Fang DC (2010) RNA interference-mediated hTERT inhibition enhances TRAIL-induced apoptosis in resistant hepatocellular carcinoma cells. Oncol Rep 23:1013-1019
15. Carlson GD, Gorden C (2002) Current developments in spinal cord injury research. Spine J 2:116-128
16. Yang MK, Sheng WB (2011) The role of astrocytes in spinal cord injury repairment. Zhongguo Jizhu Jisui Zazhi 21:947-951
17. Zhou JJ, Wu GC, Hu R et al (2007) Distribution study for glial scar after experimental spinal cord injury in rats. Zhonghua Shenjing Waike Zazhi 23:347-350
18. Hajós F (2008) Changes in glial fibrillary acidic protein (GFAP) immunoreactivity reflect neuronal states. Neurochem Res 33:1643-1650
19. Okere CO, Waterhouse BD (2004) Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence. NeuroReport 15:255-258
20. Naghdi M, Tiraihi T, Mesbah-Namin SA, Arabkheradmand J (2009) Induction of bone marrow stromal cells into cholinergic-like cells by nerve growth factor. Iran Biomed J 13:117-123
21. De Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110
22. María AB (2005) Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging. EMBO J 24:1095-1103
23. Fu W, Lee J, Guo Z, Mattson MP (2002) Seizures and tissue injury induce telomerase in hippocampal microglial cells. Exp Neurol 178:294-300
24. Reimold I, Domke D, Bender J, Seyfried CA, Radunz HE, Fricker G (2008) Delivery of nanoparticles to the brain detected by fluorescence microscopy. Eur J Pharm Biopharm 70:627-632